2025
Pain Management in the Older Adults A Narrative Review
Rajput K, Ng J, Zwolinski N, Chow R. Pain Management in the Older Adults A Narrative Review. Clinics In Geriatric Medicine 2025, 41: 131-151. PMID: 39551538, DOI: 10.1016/j.cger.2024.03.011.Peer-Reviewed Original ResearchConceptsPain managementOlder adult populationOlder adult patientsOlder adultsAdult populationMultiple medicationsLife expectancyClinical practiceAdult patientsMedical managementPreexisting comorbiditiesPainUnited StatesDegenerative processPracticeNonagenariansMedicationAdultsComorbiditiesReviewManagementOctogenariansPatientsPain Coping Skills Training for Patients Receiving Hemodialysis
Dember L, Hsu J, Mehrotra R, Cavanaugh K, Kalim S, Charytan D, Fischer M, Jhamb M, Johansen K, Becker W, Pellegrino B, Eneanya N, Schrauben S, Pun P, Unruh M, Morasco B, Mehta M, Miyawaki N, Penfield J, Bernardo L, Brintz C, Cheatle M, Doorenbos A, Heapy A, Keefe F, Krebs E, Kuzla N, Nigwekar S, Schmidt R, Steel J, Wetmore J, White D, Kimmel P, Cukor D, Adams M, Almonte-Then S, Amonu C, Anderson L, Argega Leon A, Argyropoulos C, Ashley E, Bajana Meza M, Bansal N, Barbosa M, Barrell T, Bart G, Barton A, Beach S, Beeks L, Belcher J, Berman N, Berry D, Bhatraju E, Bishop N, Blazes C, Busch A, Cameron S, Cardona M, Casilli V, Cazes M, Chacon Palma G, Chalamidas K, Chaudry S, Chen N, Chicos I, Clark C, Collins D, Connelly L, Contreras B, Cosmin A, Crowley S, Dalton C, Dirks J, Donahue S, Dutka P, Dyer V, Edeh O, Edwards D, Edwards D, Ekor K, Esserman D, Falker C, Farkas L, Farrar J, Felson S, Flores Y, Fraticelli Ortiz D, Garcia G, Gear L, Geibel A, Gilmartin C, Goldfarb D, Goldfeld K, Goldstein A, Gong A, Grant C, Grindstaff R, Guajardo E, Guy C, Hamm M, Hammond J, Harris K, Hoffman S, Holden C, Howell H, Ikizler T, Joffe S, Joffe J, Johnson S, Kalam E, Kampman K, Keane C, Kimura G, Kirsch O, Kourany W, Krishnamurthy P, Kubrick P, Lacey P, Landis J, Lash J, Lazlo K, Lee J, Lefler J, Leon Cupe A, Lerner S, Liebschutz J, Lietz P, Linke L, Lockwood M, Luo H, Macina A, McCarthy A, McDaniels K, McLaren S, McNeil D, Meinel M, Mejia V, Mengesha B, Merriman D, Michael W, Mims R, Mishra P, Modersitzki F, Moss A, Mullins C, Munet U, O'Connell K, Okereke U, Olejniczak D, Opeke S, Pacheco-Hernandez M, Pankratz S, Park D, Payne K, Pegues H, Percy S, Pleasant S, Purdy T, Quinn D, Quintana N, Rice K, Robinson G, Roche C, Rodriguez Sosa G, Rudow G, Rudy Q, Rutledge J, Sanchez S, Sands B, Scherer J, Schopp M, Self B, Shallcross A, Silva K, Stallings T, Stauffer C, Steffen A, Stewart T, Stringfellow S, Sullivan L, Torres R, Torres J, Trejo G, Varela D, Vassilieva S, Vilchis H, Villareal D, Walsh J, Ways J, Weidner T, Weimer M, Weiner D, Weisbord S, Wilkie C, Wilkinson M, Williams S, Williams J, Wilson O, Wood V, Yabes J, Zamora G, Zaniga S. Pain Coping Skills Training for Patients Receiving Hemodialysis. JAMA Internal Medicine 2025, 185: 197-207. PMID: 39786400, PMCID: PMC11791705, DOI: 10.1001/jamainternmed.2024.7140.Peer-Reviewed Original ResearchConceptsPain coping skills trainingPain coping skills training groupUsual care groupBrief Pain InventoryUsual carePain interferenceCoping skills trainingCare groupQuality of lifePain catastrophizingPain intensityBPI interferenceOutcomes of pain intensityRandomized clinical trialsSecondary outcomesChronic painSecondary outcomes of pain intensitySkills trainingBPI interference scoreCognitive behavioral interventionProportion of participantsOutpatient dialysis facilitiesClinically meaningful improvementsPain interventionsRandomized clinical trial of patientsThe bidirectional relationship between pain and tobacco use: Insights from the longitudinal Population Assessment of Tobacco and Health (PATH) study
Costa G, Nunes J, Suh R, Sofuoglu M, Aquino J. The bidirectional relationship between pain and tobacco use: Insights from the longitudinal Population Assessment of Tobacco and Health (PATH) study. Drug And Alcohol Dependence 2025, 268: 112552. PMID: 39848133, PMCID: PMC11832315, DOI: 10.1016/j.drugalcdep.2025.112552.Peer-Reviewed Original ResearchConceptsDaily smokingDaily cigarette smokingChronic painDevelopment of painCigarette smokingTobacco smokePopulation Assessment of Tobacco and Health StudyBaseline painAlternative tobacco product usePersistent painTobacco product useDevelopment of persistent painYears of longitudinal dataHealth StudyTobacco useNo/low painPreventable causeSmoking outcomesBidirectional relationshipSurvival analysisSmokingPopulation AssessmentAge categoriesIncreased riskSurvey populationFrom Chronic Opioids for Pain to Microgram Buprenorphine: Key Factors in an Increasingly Recommended Transition.
Hickey T, Hitt J. From Chronic Opioids for Pain to Microgram Buprenorphine: Key Factors in an Increasingly Recommended Transition. Pain Physician 2025, 28: 59-67. PMID: 39903018.Peer-Reviewed Original ResearchConceptsOpioid therapyBuprenorphine exposureTotal dose of opioidsVeterans Health AdministrationChronic opioid therapyDoses of opioidsChronic pain managementOutpatient opioid prescriptionsReducing opioid useFull-agonist opioidsPrescription of buprenorphineTransition to buprenorphineAssociated with lower oddsVeterans Affairs Corporate Data WarehouseBaseline opioidChronic opioidsOpioid doseAgonist opioidsOpioid exposureHealth AdministrationOpioid prescriptionsOpioid useSurrogate markerLarge-scale observational studiesBuprenorphine initiation
2024
Pain can’t be carved at the joints: defining function-based pain profiles and their relevance to chronic disease management in healthcare delivery design
Barron D, Saltoun K, Kiesow H, Fu M, Cohen-Tanugi J, Geha P, Scheinost D, Isaac Z, Silbersweig D, Bzdok D. Pain can’t be carved at the joints: defining function-based pain profiles and their relevance to chronic disease management in healthcare delivery design. BMC Medicine 2024, 22: 594. PMID: 39696368, PMCID: PMC11656997, DOI: 10.1186/s12916-024-03807-z.Peer-Reviewed Original ResearchConceptsChronic diseasesPain ProfileChronic conditionsPatient functionPain conditionsManagement of chronic diseasesChronic disease managementContinuum of careHealthcare delivery systemImprove quality of lifeQuality of lifePainful body partPain interferenceAssociated with clinical variablesUK BiobankWhole-body perspectiveHealth strategiesTreatment of individual patientsPain intensityClinically relevant differencesPatient wellbeingPain managementTreat painful conditionsICD codesMedical specialtiesBuprenorphine: An anesthesia-centric review.
Hickey T, Acampora G. Buprenorphine: An anesthesia-centric review. Journal Of Opioid Management 2024, 20: 503-527. PMID: 39775451, DOI: 10.5055/jom.0901.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidBuprenorphineChronic PainHumansOpioid-Related DisordersPain, PostoperativeTreatment OutcomeConceptsOpioid use disorderEffective analgesic alternativeEffective opioid analgesicOpioid-tolerant patientsMultimodal analgesia strategyLong duration of actionPatients prescribed buprenorphineChronic pain managementDiscontinuation of buprenorphineFormulation of buprenorphineDuration of actionAnalgesic alternativeContinuing buprenorphineDose adjustmentNonopioid analgesicsAnalgesia strategyOpioid analgesicsChronic painImprove patient outcomesTemporary discontinuationPerioperative painPain managementPerioperative periodBuprenorphineUse disorderScreening, brief intervention, and referral to treatment for pain management for veterans separating from military service: study protocol of a hybrid type 2 study testing implementation facilitation versus training-as-usual
Sellinger J, Rosen M, Lazar C, Gilstad-Hayden K, Dziura J, Li F, Mattocks K, Weede A, Sullivan-Tibbs M, Rose L, Vassallo G, Manhapra A, Turner A, Vogt D, Woodward E, Hartmann C, Haskell S, Mohammad A, Martino S. Screening, brief intervention, and referral to treatment for pain management for veterans separating from military service: study protocol of a hybrid type 2 study testing implementation facilitation versus training-as-usual. Pain Medicine 2024, 25: s99-s106. PMID: 39514877, DOI: 10.1093/pm/pnae062.Peer-Reviewed Original ResearchConceptsTraining-as-usualImplementation facilitatorsReferral to treatmentCase managementBrief interventionHybrid type 2 effectiveness-implementation trialPain managementImplementation strategiesPrimary implementation outcomeSubstance misuseProportion of participantsPain careUsefulness of screeningVeteran engagementVA sitesImplementation outcomesPragmatic trialPain serviceVeteran participantsCase management systemPain intensityDischarged veteransStudy enrollmentVeteransChronic painImpact of the COVID-19 pandemic on participants in pragmatic clinical trials for chronic pain: implications for trial outcomes and beyond
Sellinger J, Gilstad-Hayden K, Lazar C, Seal K, Purcell N, Burgess D, Martino S, Heapy A, Higgins D, Rosen M. Impact of the COVID-19 pandemic on participants in pragmatic clinical trials for chronic pain: implications for trial outcomes and beyond. Pain Medicine 2024, 25: s17-s27. PMID: 39514885, PMCID: PMC11548862, DOI: 10.1093/pm/pnae060.Peer-Reviewed Original ResearchConceptsPragmatic clinical trialsHealth careSocial supportChronic painEmotional healthHigher levels of painPain Management CollaboratoryEffective pain managementClinical trialsLevel of painEffectiveness of treatment outcomesPandemic impactAlcohol use disorder screeningCOVID-19-related impactsCOVID-19 pandemicChronic pain treatmentMental healthPain managementDisorder screeningNonpharmacological treatmentsPain treatmentStudy enrollmentCOVID-19HealthCareStrategies to Deimplement Opioid Prescribing in Primary Care
Quanbeck A, Robinson J, Jacobson N, Li X, Hennessy-Garza R, Landeck J, Cohen A, Madden L, Pulvermacher A, Brown R. Strategies to Deimplement Opioid Prescribing in Primary Care. JAMA Network Open 2024, 7: e2438325. PMID: 39388183, PMCID: PMC11581553, DOI: 10.1001/jamanetworkopen.2024.38325.Peer-Reviewed Original ResearchConceptsCluster randomized clinical trialDeimplementation strategiesMorphine milligram equivalent doseMorphine milligram equivalentsPractice facilitationOpioid prescribingIncreased screeningTreatment agreementsUS health care systemCenters for Disease Control and Prevention guidelinesRandomized clinical trialsUrine drug screensPrimary care clinicsPrimary care settingPrimary outcomeMental health screeningPain-related interferenceHealth care systemHigh-intensity groupEnjoyment of lifeChronic pain managementPrimary careCare clinicsCare settingsHealth screeningLong-Term Use of Muscle Relaxant Medications for Chronic Pain
Oldfield B, Gleeson B, Morford K, Adams Z, Funaro M, Becker W, Merlin J. Long-Term Use of Muscle Relaxant Medications for Chronic Pain. JAMA Network Open 2024, 7: e2434835. PMID: 39298168, DOI: 10.1001/jamanetworkopen.2024.34835.Peer-Reviewed Original ResearchConceptsLow back painBack painSkeletal muscle relaxantsChronic painRandomized clinical trialsNeck painCohort studyEfficacy of long-term useLong-term useSystematically searched Ovid MEDLINEMuscle relaxant medicationsModerate risk of biasOpioid prescribing guidelinesRisk of biasQuality of cohort studiesWeb of SciencePainful crampsRelaxant medicationsChronic pain syndromesPainful spasmsOvid MEDLINEPrescribing guidelinesSystematic reviewIncreased prescriptionModerate riskGender differences in PTSD severity and pain outcomes: Baseline results from the LAMP trial
Friedman J, Taylor B, Campbell E, Allen K, Bangerter A, Branson M, Bronfort G, Calvert C, Cross L, Driscoll M, Evans R, Ferguson J, Haley A, Hennessy S, Meis L, Burgess D. Gender differences in PTSD severity and pain outcomes: Baseline results from the LAMP trial. PLOS ONE 2024, 19: e0293437. PMID: 38753651, PMCID: PMC11098421, DOI: 10.1371/journal.pone.0293437.Peer-Reviewed Original ResearchConceptsPain outcomesPost-traumatic stress disorder symptomsChronic painPost-traumatic stress disorderWomen veteransChronic pain clinical trialsPain clinical trialsSensation of painHierarchical linear regression modelsGender differencesPain intensityPain catastrophizingPain interferenceClinical trialsPainAssociated with higher levelsComorbid conditionsExamined gender differencesLinear regression modelsSevere outcomesMultivariate modelMutual maintenanceClinical implicationsSymptomsVeteransAlcohol Use Disorder and Chronic Pain: An Overlooked Epidemic
De Aquino J, Sloan M, Nunes J, Costa G, Katz J, de Oliveira D, Ra J, Tang V, Petrakis I. Alcohol Use Disorder and Chronic Pain: An Overlooked Epidemic. American Journal Of Psychiatry 2024, 181: 391-402. PMID: 38706339, PMCID: PMC11521207, DOI: 10.1176/appi.ajp.20230886.Peer-Reviewed Original ResearchConceptsAlcohol use disorderChronic painAUD studiesChronic pain disordersChronic pain outcomesRisk of relapseAlcohol withdrawal syndromeAssessment of painHigher levels of alcohol consumptionLevels of alcohol consumptionWithdrawal syndromePain disordersPain outcomesAcute toleranceNeurobiological changesClinical significanceUse disorderPainClinical relevanceSelf-reportAlcohol intoxicationAlcohol consumptionGeneral populationMedical conditionsNarrative reviewPain: The Silent Public Health Epidemic
Katzman J, Mac Gallagher R. Pain: The Silent Public Health Epidemic. Journal Of Primary Care & Community Health 2024, 15: 21501319241253547. PMID: 38742616, PMCID: PMC11095171, DOI: 10.1177/21501319241253547.Peer-Reviewed Original ResearchConceptsPain carePain educationPain managementVulnerable populationsEffective pain careMental health diagnosesEffective pain managementSuffering of patientsExperience of painTherapeutic allianceLong-term opioidsHealth inequalitiesModerate to severe painEffective careHealth professionalsIneffective careHealthcare providersSubstance use disordersHealth diagnosisPatient carePain SocietyAdvanced painHealthcare systemOpioid educationTraining deficits
2023
Health disparities in preterm births
Brown J, Chang X, Matson A, Lainwala S, Chen M, Cong X, Casavant S. Health disparities in preterm births. Frontiers In Public Health 2023, 11: 1275776. PMID: 38162611, PMCID: PMC10757361, DOI: 10.3389/fpubh.2023.1275776.Peer-Reviewed Original ResearchConceptsPreterm birth rateNeonatal intensive care unitPreterm infantsPreterm birthNon-Hispanic white (WNeonatal Infant Stressor ScaleBirth rateClinical treatment informationHealth disparitiesImprove social determinants of healthIntensive care unitSocial determinants of healthOutcome inequalityDeterminants of healthImprove social determinantsElectronic health recordsNeurodevelopmental outcomesPretermHospital stayAdverse health outcomesAnthropometric measurementsLifesaving procedureLife course approachCross-sectional analysisCare unitIs psychiatric diagnostic remission associated with reduced prevalence of moderate to severe pain interference and improved functioning among adults with lifetime psychiatric disorders?
Manhapra A, Zhou B, Rhee T, Rosenheck R. Is psychiatric diagnostic remission associated with reduced prevalence of moderate to severe pain interference and improved functioning among adults with lifetime psychiatric disorders? Journal Of Affective Disorders 2023, 344: 585-591. PMID: 37863364, DOI: 10.1016/j.jad.2023.10.094.Peer-Reviewed Original ResearchMeSH KeywordsAdultChronic PainComorbidityHealth SurveysHumansMental DisordersPrevalenceSubstance-Related DisordersConceptsLifetime psychiatric disordersPast-year psychiatric disordersSevere pain interferencePain interferencePsychiatric disordersPD remissionChronic painNon-substance use psychiatric disordersPrevalence of painMental functioningLower physical functioningNational Epidemiologic SurveyRelated Conditions-IIIPoor mental functioningCommon comorbiditiesPhysical functionAdjusted oddsPhysical functioningObservational studyReduced prevalenceRemissionUS adultsDiagnostic remissionEpidemiologic SurveyPainChronic pain, cannabis legalisation, and cannabis use disorder among patients in the US Veterans Health Administration system, 2005 to 2019: a repeated, cross-sectional study
Hasin D, Wall M, Alschuler D, Mannes Z, Malte C, Olfson M, Keyes K, Gradus J, Cerdá M, Maynard C, Keyhani S, Martins S, Fink D, Livne O, McDowell Y, Sherman S, Saxon A. Chronic pain, cannabis legalisation, and cannabis use disorder among patients in the US Veterans Health Administration system, 2005 to 2019: a repeated, cross-sectional study. The Lancet Psychiatry 2023, 10: 877-886. PMID: 37837985, PMCID: PMC10627060, DOI: 10.1016/s2215-0366(23)00268-7.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationMedical cannabis lawsRecreational cannabis lawsCannabis use disorder prevalenceDisorder prevalenceChronic painCannabis use disorderVA Centers of ExcellenceUse disorderUS Veterans Health AdministrationVeterans Health Administration systemPresence of chronic painMental health visitsElectronic health record datasetAbsolute increaseHealth Administration systemDifference-in-differences analysisCross-sectional studyPainful medical conditionsPalliative careBinomial regression modelsPrimary careRisk of cannabis use disorderOlder age groupsHealth visitsA Tool to Identify and Engage Patients on Risky Opioid Regimens
Griffin A, Perez T, Avoundjian T, Becker W, Midboe A. A Tool to Identify and Engage Patients on Risky Opioid Regimens. Applied Clinical Informatics 2023, 14: 1018-1026. PMID: 38151042, PMCID: PMC10752654, DOI: 10.1055/s-0043-1777126.Peer-Reviewed Original ResearchConceptsMedication regimensHigh-risk patient populationHigh-dose opioidsHigh-risk opioidPrimary care clinicsPrimary care appointmentsPrimary care staffPatient-centered careHealth care systemClinical informatics toolsOutreach letterOpioid regimensCare appointmentsCare clinicsChronic painOpioid safetyPatient populationCase reportClinic staffPatientsRegimensClinical initiativesCare staffCare initiativesOpioidsWhen harms outweigh benefits of long‐term opioid therapy for pain: Need for a new diagnostic entity, research and improved treatments
Becker W, Frank J, Edmond S, Starrels J. When harms outweigh benefits of long‐term opioid therapy for pain: Need for a new diagnostic entity, research and improved treatments. Addiction 2023, 119: 4-5. PMID: 37766414, DOI: 10.1111/add.16348.Peer-Reviewed Original ResearchA cognitive–behavioral digital health intervention for sickle cell disease pain in adolescents: a randomized, controlled, multicenter trial
Palermo T, Lalloo C, Zhou C, Dampier C, Zempsky W, Badawy S, Bakshi N, Ko Y, Nishat F, Stinson J. A cognitive–behavioral digital health intervention for sickle cell disease pain in adolescents: a randomized, controlled, multicenter trial. Pain 2023, 165: 164-176. PMID: 37733479, PMCID: PMC10723646, DOI: 10.1097/j.pain.0000000000003009.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnemia, Sickle CellChronic PainCognitionCognitive Behavioral TherapyFemaleHumansMaleConceptsSickle cell diseaseEducation controlSickle Cell Disease PainEvidence-based cognitive behavioral therapySickle cell painAverage pain intensitySignificant healthcare costsCognitive behavioral therapy programCognitive behavioral therapyDigital health interventionsPain daysSCD clinicSecondary outcomesCommon complicationDisease painMulticenter trialPain intensityPain interferenceChronic painPain interventionsEffective implementation strategiesGlobal ImpressionCell diseasePsychosocial distressPainGenetically Regulated Gene Expression in the Brain Associated With Chronic Pain: Relationships With Clinical Traits and Potential for Drug Repurposing
Johnston K, Cote A, Hicks E, Johnson J, Huckins L. Genetically Regulated Gene Expression in the Brain Associated With Chronic Pain: Relationships With Clinical Traits and Potential for Drug Repurposing. Biological Psychiatry 2023, 95: 745-761. PMID: 37678542, PMCID: PMC10924073, DOI: 10.1016/j.biopsych.2023.08.023.Peer-Reviewed Original ResearchConceptsGenetically regulated gene expressionMultisite chronic painGene-tissue associationsMean pain scoreUnique genesChronic painAssociation studiesS-PrediXcanGene expressionPain scoresTranscriptome-wide association studyPhenome-wide association studyCardiac dysrhythmiasMetabolic syndromeGenome-wide association studiesAssociated with cardiac dysrhythmiasDrug targetsGenotype-phenotype gapChronic pain developmentAssociation study resultsGene expression changesJoint/ligament sprainsDirection of effectTranscriptome imputationPain traits
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