2025
Effect of digital adherence technologies on treatment outcomes in people with drug-susceptible tuberculosis: four pragmatic, cluster-randomised trials
Jerene D, van Kalmthout K, Levy J, Alacapa J, Deyanova N, Dube T, Mganga A, Tasca B, Bogdanov A, Efo E, Gamazina K, Garfin A, Kochanov V, Leung A, Madden N, Maraba N, McQuaid C, Mleoh L, Onjare B, Powers R, Terleiva Y, van Rest J, Gebhard A, Fielding K, Charalambous S. Effect of digital adherence technologies on treatment outcomes in people with drug-susceptible tuberculosis: four pragmatic, cluster-randomised trials. The Lancet 2025 PMID: 40086457, DOI: 10.1016/s0140-6736(24)02847-2.Peer-Reviewed Original ResearchDrug-susceptible tuberculosisTreatment outcomesPoor treatment outcomesPrimary outcomeDigital adherence technologiesIntervention armCluster randomised trialIntention-to-treat populationStandard of care armTuberculosis treatment outcomesDocumented treatment failureLoss to follow-upStandard of careAdherence technologiesTreatment failureTreatment startAdult patientsFollow-upPatientsTreatment statusPatient outcomesCare armTuberculosisMedicationTrialsMedications for opioid use disorder in traditional medicare beneficiaries: associations with age
Ganz D, Lai J, Cantor J, Agniel D, Simon K, Stein B, Taylor E. Medications for opioid use disorder in traditional medicare beneficiaries: associations with age. Health Affairs Scholar 2025, 3: qxaf036. PMID: 40040649, PMCID: PMC11878533, DOI: 10.1093/haschl/qxaf036.Peer-Reviewed Original ResearchOpioid use disorderMOUD initiationIndex eventUse disorderTreat opioid use disorderAssociated with female sexRates of opioid use disorderIncreasing comorbidity scoreMultivariate logistic regressionAssociated with ageComorbidity scoreMedicare beneficiariesFemale sexOlder adultsAge-specific strategiesIncreased uptakeLogistic regressionOlder ageTraditional Medicare beneficiariesMOUDClaims dataMedicationPatient-reported strategies for prevention and treatment of chemotherapy-induced peripheral neuropathy
Hertz D, Tanay M, Tofthagen C, Rossi E, Bernasconi D, Sheffield K, Carlson M, Nekhlyudov L, Grech L, Von Ah D, Mayo S, Ruddy K, Chan A, Alberti P, Lustberg M. Patient-reported strategies for prevention and treatment of chemotherapy-induced peripheral neuropathy. Supportive Care In Cancer 2025, 33: 142. PMID: 39899120, DOI: 10.1007/s00520-025-09190-6.Peer-Reviewed Original ResearchConceptsSelf-reported peripheral neuropathyCross-sectional online surveyGuideline-recommended strategyEvidence of effectivenessNon-prescribed medicationTreating CIPNPurposeChemotherapy-induced peripheral neuropathyChemotherapy-induced peripheral neuropathyPeripheral neuropathyClinical teamStrategies patientsPrescription medicationsNeurotoxic chemotherapy treatmentMultinational AssociationDescriptive statisticsPrescribed medicationsSurvey participantsPrevention strategiesGuideline-recommendedTreatment of chemotherapy-induced peripheral neuropathyOnline surveyCIPNDebilitating toxicityImprove treatment outcomesMedicationPain Management in the Older Adults A Narrative Review
Rajput K, Ng J, Zwolinski N, Chow R. Pain Management in the Older Adults A Narrative Review. Clinics In Geriatric Medicine 2025, 41: 131-151. PMID: 39551538, DOI: 10.1016/j.cger.2024.03.011.Peer-Reviewed Original ResearchConceptsPain managementOlder adult populationOlder adult patientsOlder adultsAdult populationMultiple medicationsLife expectancyClinical practiceAdult patientsMedical managementPreexisting comorbiditiesPainUnited StatesDegenerative processPracticeNonagenariansMedicationAdultsComorbiditiesReviewManagementOctogenariansPatientsAficamten vs Metoprolol for Obstructive Hypertrophic Cardiomyopathy MAPLE-HCM Rationale, Study Design, and Baseline Characteristics
Garcia-Pavia P, Bilen O, Burroughs M, Costabel J, de Barros Correia E, Dybro A, Elliott P, Lakdawala N, Mann A, Nair A, Nassif M, Poulsen S, Reant P, Schulze P, Wang A, Berhane I, Heitner S, Jacoby D, Kupfer S, Malik F, Meng L, Sohn R, Wohltman A, Fifer M, Investigators M. Aficamten vs Metoprolol for Obstructive Hypertrophic Cardiomyopathy MAPLE-HCM Rationale, Study Design, and Baseline Characteristics. JACC Heart Failure 2025, 13: 346-357. PMID: 39909646, DOI: 10.1016/j.jchf.2024.11.011.Peer-Reviewed Original ResearchConceptsObstructive hypertrophic cardiomyopathyStandard-of-careCardiac myosin inhibitorStandard-of-care medicationsBaseline characteristicsSymptomatic obstructive hypertrophic cardiomyopathyNondihydropyridine calcium channel blockersBaseline characteristics of patientsStandard-of-care drugsSecond-line therapyFirst-line therapyCalcium channel blockersCharacteristics of patientsImprove exercise capacityMyosin inhibitorFirst-lineBeta-blockersHypertrophic cardiomyopathyExercise capacityAlleviate symptomsPatientsAficamtenMedicationTherapyStudy designWhat Is Science-Based Therapy?
Tolin D, Hupp S. What Is Science-Based Therapy? 2025, 1-10. DOI: 10.1017/9781009086264.002.Peer-Reviewed Original ResearchPostscript
Boness C, Hupp S, Tolin D. Postscript. 2025, 399-405. DOI: 10.1017/9781009086264.023.Peer-Reviewed Original ResearchPregnant Patient for Non-Obstetric Surgery
Salimi N, Fardelmann K. Pregnant Patient for Non-Obstetric Surgery. 2025, 345-357. DOI: 10.1093/med/9780190902001.003.0031.Peer-Reviewed Original ResearchNon-obstetric surgeryPregnant patientsFetal outcomesAdverse fetal outcomesFetal morbidityGestational ageNon-obstetricSurgeryNeurocognitive developmentOrthopedic proceduresAnesthetic exposurePatientsAnesthetic agentsMultidisciplinary approachPregnancyDelayed careOutcomesNeonatologyObstetricsMorbidityTeratogenicityAnesthesiaMedicationMortalityEthical principles
2024
Efficacy of antiobesity medications for weight reduction in older adults: a systematic review
Chen A, Hajduk A, Grimshaw A, Fried T, Jastreboff A, Lipska K. Efficacy of antiobesity medications for weight reduction in older adults: a systematic review. Obesity 2024 PMID: 39725567, DOI: 10.1002/oby.24160.Peer-Reviewed Original ResearchOlder adultsAntiobesity medicationsStudy of older adultsOlder adults ageAdult ageCardiovascular diseaseRisk of biasAdverse events associated with useWeight reductionStatistically significant weight reductionFood and Drug AdministrationClinical careSystematic reviewInclusion criteriaLimited evidenceBaseline weightPlacebo groupObservational studySeven medicationsAdverse eventsAdultsDrug AdministrationEvaluation studiesMedicationSignificant weight reductionHepatotoxicity Score: A New Method to Adjust for Use of Potentially Hepatotoxic Medications by Chronic Liver Disease Status
Re V, Newcomb C, Carbonari D, Mezochow A, Hennessy S, Rentsch C, Park L, Tate J, Bräu N, Bhattacharya D, Lim J, Mezzacappa C, Njei B, Roy J, Taddei T, Justice A, Torgersen J. Hepatotoxicity Score: A New Method to Adjust for Use of Potentially Hepatotoxic Medications by Chronic Liver Disease Status. Pharmacoepidemiology And Drug Safety 2024, 33: e70069. PMID: 39662972, PMCID: PMC11634562, DOI: 10.1002/pds.70069.Peer-Reviewed Original ResearchConceptsProton pump inhibitor initiationHazard ratioVeterans Health AdministrationSevere acute liver injuryProton pump inhibitorsChronic liver diseaseAcute liver injuryRates of hospitalizationSafety of medicationsPPI initiativesHealth AdministrationLiver disease statusMedication exposurePharmacoepidemiological studiesMedicationConfoundingScoresReports of hepatotoxicityDisease statusHepatotoxic medicationsDrug exposurePump inhibitorsHepatotoxic drugsOutpatient initiationHepatic safetyIntegrating Drug Target Information in Deep Learning Models to Predict the Risk of Adverse Events in Patients with Comorbid Post-Traumatic Stress Disorder and Alcohol Use Disorder
Miranda O, Qi X, Brannock M, Whitworth R, Kosten T, Ryan N, Haas G, Kirisci L, Wang L. Integrating Drug Target Information in Deep Learning Models to Predict the Risk of Adverse Events in Patients with Comorbid Post-Traumatic Stress Disorder and Alcohol Use Disorder. Biomedicines 2024, 12: 2772. PMID: 39767679, PMCID: PMC11673068, DOI: 10.3390/biomedicines12122772.Peer-Reviewed Original ResearchPost-traumatic stress disorderAlcohol use disorder patientsAlcohol use disorderComorbid post-traumatic stress disorderUse disorderOpioid use disorderStress disorderSuicidal behaviorPotential therapeutic medicationsDeep learning modelsTarget informationDisordersElectronic medical recordsLearning modelsDepressionPotential therapeutic effectsNeighborhood-level social determinants of healthUniversity of Pittsburgh Medical CenterRisk of adverse eventsNeighborhood-level social determinantsSocial determinants of healthAdverse eventsMedicationAdverse outcomesDeterminants of healthAll Paths Do Not Lead to Rome or Adherence: Innovative Antipsychotic Prescribing in Partnership With People in Recovery as They Define
Sebastian D, Carr E. All Paths Do Not Lead to Rome or Adherence: Innovative Antipsychotic Prescribing in Partnership With People in Recovery as They Define. Psychiatric Rehabilitation Journal 2024, 47: 303-312. PMID: 39052409, DOI: 10.1037/prj0000623.Peer-Reviewed Original ResearchShared decision-makingRecovery-oriented careExperience psychosisImplementation of shared decision-makingRecovery-oriented caring approachAntipsychotic prescribingRecovery-oriented approachInpatient psychiatric settingsCare approachPsychiatric settingsPrescribing practicesCollaborative practicePrescribingPsychiatric fieldCollaborative approachTherapeutic allianceMedicationCareAdherencePrescribed antipsychoticsPsychosisDecision-makingSymptom ameliorationAntipsychotic medicationPracticeNovel Pharmacologic and Other Somatic Treatment Approaches for Posttraumatic Stress Disorder in Adults: State of the Evidence
Sippel L, Hamblen J, Kelmendi B, Alpert J, Carpenter L, Grzenda A, Kraguljac N, McDonald W, Rodriguez C, Widge A, Nemeroff C, Schnurr P, Holtzheimer P, Biomarkers and Treatments T. Novel Pharmacologic and Other Somatic Treatment Approaches for Posttraumatic Stress Disorder in Adults: State of the Evidence. American Journal Of Psychiatry 2024, 181: 1045-1058. PMID: 39616450, DOI: 10.1176/appi.ajp.20230950.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderStress disorderPathophysiology of posttraumatic stress disorderNon-trauma-focused psychotherapyTrauma-focused psychotherapySomatic treatment approachesEvidence-based treatmentsAntidepressant medicationSomatic treatmentsPsychiatric disordersSomatic interventionsTranscranial magnetic stimulationPsychotherapyMagnetic stimulationTreatment approachesDisordersRecommended first-line treatmentAdultsFirst-line treatmentMedicationMechanism of actionMonotherapy strategySalienceSpecific treatmentEvidenceAvailability of Medications for Opioid Use Disorder in US Psychiatric Hospitals
Cohen S, Beetham T, Fiellin D, Muvvala S. Availability of Medications for Opioid Use Disorder in US Psychiatric Hospitals. JAMA Network Open 2024, 7: e2444679. PMID: 39535800, PMCID: PMC11561693, DOI: 10.1001/jamanetworkopen.2024.44679.Peer-Reviewed Original ResearchHerbal Supplement Use Among Adolescent and Young Adult Women in a Family Planning Clinic
Friedman J, Sheeder J, Polotsky A, Lazorwitz A. Herbal Supplement Use Among Adolescent and Young Adult Women in a Family Planning Clinic. Obstetrical & Gynecological Survey 2024, 79: 643-644. DOI: 10.1097/01.ogx.0001095056.57063.30.Peer-Reviewed Original ResearchThrombotic thrombocytopenic purpuraFamily planning clinicsReproductive-age womenHerbal supplementsOral contraceptivesThrombocytopenic purpuraAdverse eventsPlanning clinicsDrug interactionsSupplement useCardiac arrhythmiasHerbal supplement useDepression medicationPrescription medicationsDrugGastrointestinal illnessMedicationRisk associated with interactionsSupplementationPurpuraContraceptionArrhythmiasPrimary Prevention of Stroke: Identifying High-Risk Patients
Kaslow J, Kernan W. Primary Prevention of Stroke: Identifying High-Risk Patients. 2024, 431-443. DOI: 10.1007/978-3-031-66289-8_36.Peer-Reviewed Original ResearchRisk factorsPrimary careHealthy behaviorsPatient-centeredCoronary artery diseaseRisk of strokeChronic diseasesPreventable deathsMedical practicePublic healthUnhealthy onesIncreased riskRisk reductionHigh riskHigh-risk patientsStrokeRiskArtery diseaseCareHealthDisabilityPatientsMedicationFactorsGuidelinesAssociations Among Sleep, Pain, and Medications for Opioid Use Disorder: a Scoping Review
Hsaio C, DiMeola K, Jegede O, Funaro M, Langstengel J, Yaggi H, Barry D. Associations Among Sleep, Pain, and Medications for Opioid Use Disorder: a Scoping Review. Current Addiction Reports 2024, 11: 965-981. PMID: 39886383, PMCID: PMC11781152, DOI: 10.1007/s40429-024-00606-7.Peer-Reviewed Original ResearchOpioid use disorderOUD severityUse disorderTreatment characteristicsOpioid use disorder treatment settingsTreatment of sleepDosing scheduleDisorder severityOpioidPainWeb of ScienceAssessed patientsCochrane LibraryMeasures of sleepMOUD treatmentCurrent evidenceMOUDSleepSleep disturbanceProvider preferencesPatientsStudy examined sleepDisordersTreatment settingsMedicationIdentifying Genetically Inferred Effects Linking Posttraumatic Stress Disorder to Women’s Health, Lipid Disorders, and Malaria Medications
Pathak G, Wendt F, Maihofer A, Consortium P, Ressler K, Stein M, Koenen K, Nievergelt C, Polimanti R. Identifying Genetically Inferred Effects Linking Posttraumatic Stress Disorder to Women’s Health, Lipid Disorders, and Malaria Medications. American Journal Of Psychiatry 2024, 181: 1127-1130. PMID: 39380377, DOI: 10.1176/appi.ajp.20230832.Peer-Reviewed Original ResearchCore Concepts in Pharmacoepidemiology: Quantitative Bias Analysis
Brown J, Hunnicutt J, Ali M, Bhaskaran K, Cole A, Langan S, Nitsch D, Rentsch C, Galwey N, Wing K, Douglas I. Core Concepts in Pharmacoepidemiology: Quantitative Bias Analysis. Pharmacoepidemiology And Drug Safety 2024, 33: e70026. PMID: 39375940, DOI: 10.1002/pds.70026.Peer-Reviewed Original ResearchConceptsQuantitative bias analysisBias analysisValidity of study findingsPharmacoepidemiological studiesRobustness of studiesEffects of medicationStudy designEffect estimatesResidual biasStudy findingsSelection biasConfoundingEstimated effectsPotential biasPharmacoepidemiologyBiasMedicationCore conceptsStudyMeasurement error127 Medications for Alcohol Use Disorder and Withdrawal: A National Sample of Patients Discharged From the Emergency Department
Hawk K, Weiner S, Rothenberg C, Sharma P, Shahid S, Sambell M, Goyal P, Venkatsh A. 127 Medications for Alcohol Use Disorder and Withdrawal: A National Sample of Patients Discharged From the Emergency Department. Annals Of Emergency Medicine 2024, 84: s60. DOI: 10.1016/j.annemergmed.2024.08.132.Peer-Reviewed Original Research
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