2025
Unintended Prolonged Opioid Use: Protocol for a Case-Controlled Trial.
Hooten W, Erickson D, Chawarski M, Scholz N, Waljee J, Brummett C, Jeffery M. Unintended Prolonged Opioid Use: Protocol for a Case-Controlled Trial. JMIR Research Protocols 2025, 14: e72032. PMID: 39992690, DOI: 10.2196/72032.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesics, OpioidCase-Control StudiesCOVID-19FemaleHumansMaleOpioid-Related DisordersPrescription Drug MisuseProspective StudiesConceptsINTERNATIONAL REGISTERED REPORT IDENTIFIERElectronic health record systemsPatient recruitmentPractice environment characteristicsPrescribing opioids to patientsOpioid prescriptionsHealth record systemsPatient characteristicsContinuation of opioid therapyIndividual practice environmentsOpioids to patientsOpioid-naive adultsOpioid-naive patientsProlonged opioid useSelf-report surveyNational administrative claims databaseMisuse of prescription opioidsCOVID-19 pandemicPublic health problemClinician recruitmentCase-control trialShort-term useAdministrative claims databaseMayo Clinic sitesCTSA programRetention and dropout from sublingual and extended-release buprenorphine treatment: A comparative analysis of data from a nationally representative sample of commercially-insured people with opiod use disorder in the United States
Ivasiy R, Madden L, Johnson K, Machavariani E, Ahmad B, Oliveros D, Tan J, Kil N, Altice F. Retention and dropout from sublingual and extended-release buprenorphine treatment: A comparative analysis of data from a nationally representative sample of commercially-insured people with opiod use disorder in the United States. International Journal Of Drug Policy 2025, 138: 104748. PMID: 40020306, PMCID: PMC12045481, DOI: 10.1016/j.drugpo.2025.104748.Peer-Reviewed Original ResearchConceptsOpioid use disorderSL-BUPXR-BUPUse disorderRetrospective cohort studyExtended-release buprenorphineReduce treatment discontinuationDays of supplyTreatment discontinuationSublingual buprenorphineReduce overdose riskBuprenorphine treatmentCohort studyHigh dosesPrimary outcomeImpact of dosagePatientsBuprenorphineMonthsMg/dayCommercially-insured individualsProportion of individualsOpioidOverdose riskImprove health outcomesAdaptive decision support for addiction treatment to implement initiation of buprenorphine for opioid use disorder in the emergency department: protocol for the ADAPT Multiphase Optimization Strategy trial
Iscoe M, Hooper C, Levy D, Buchanan L, Dziura J, Meeker D, Taylor R, D’Onofrio G, Oladele C, Sarpong D, Paek H, Wilson F, Heagerty P, Delgado M, Hoppe J, Melnick E. Adaptive decision support for addiction treatment to implement initiation of buprenorphine for opioid use disorder in the emergency department: protocol for the ADAPT Multiphase Optimization Strategy trial. BMJ Open 2025, 15: e098072. PMID: 39979056, PMCID: PMC11842997, DOI: 10.1136/bmjopen-2024-098072.Peer-Reviewed Original ResearchConceptsClinical decision supportMultiphase optimization strategyOpioid use disorderEmergency departmentInitiation of buprenorphineClinical decision support usePlan-Do-Study-Act cyclesLearning health system approachPlan-Do-Study-ActClinical decision support toolHealth system approachAdaptive decision supportUse disorderDecision supportAddiction treatmentPeer-reviewed journalsBuprenorphine initiationOpioid use disorder treatment initiationOpioid-related mortalityIntervention componentsED settingClinician feedbackInstitute Institutional Review BoardTreatment of opioid use disorderParticipating sitesPrescribing methadone in prison predicts linkage to HIV care after release from prison: A randomized and patient preference trial
Mobley A, Wegman M, Bazazi A, Shenoi S, Bromberg D, Ahmad A, Kamarulzaman A, Altice F. Prescribing methadone in prison predicts linkage to HIV care after release from prison: A randomized and patient preference trial. International Journal Of Drug Policy 2025, 137: 104733. PMID: 39923270, PMCID: PMC11875876, DOI: 10.1016/j.drugpo.2025.104733.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHIV InfectionsHumansMalaysiaMaleMethadoneMiddle AgedOpiate Substitution TreatmentOpioid-Related DisordersPatient PreferencePrisonersPrisonsProspective StudiesConceptsLinkage to HIV careHIV careIncrease linkage to HIV careTreatment-as-prevention strategiesHIV treatment cascadeHIV treatment outcomesOpen-label trialCox proportional hazards modelsPatient preference trialOpioid use disorderMalaysia’s largest prison.Impact of methadoneProportional hazards modelTreatment cascadeInverse probability weighted Cox proportional hazards modelAnalytic sampleStudy participantsCareTreatment outcomesPrescribed methadoneOpioidConfounding variablesHIVUse disorderHazards modelAssessing the comparative effectiveness of ECHO and coaching implementation strategies in a jail/provider MOUD implementation trial
Molfenter T, Vechinski J, Kim J, Zhang J, Meng L, Tveit J, Madden L, Taxman F. Assessing the comparative effectiveness of ECHO and coaching implementation strategies in a jail/provider MOUD implementation trial. Implementation Science 2025, 20: 7. PMID: 39901259, PMCID: PMC11792685, DOI: 10.1186/s13012-025-01419-6.Peer-Reviewed Original ResearchConceptsOpioid use disorderIntervention phaseMOUD useJail settingInjectable naltrexoneUse disorderImplementation strategiesCommunity Healthcare OutcomesCommunity-based partnersEffective implementation strategiesPatient countsPublic health opportunityPrevalence of opioid use disorderCommunity-based treatment providersTelementoring modelECHO sessionsTrial registry recordHealthcare outcomesImplementation trialPersistent treatment gapTreatment providersRegistry recordsHealth opportunitiesTreatment gapStudy armsBuprenorphine induces human fetal membrane sterile inflammation
Lynn T, Kelleher M, Georges H, McCauley E, Logan R, Yonkers K, Abrahams V. Buprenorphine induces human fetal membrane sterile inflammation. Journal Of Reproductive Immunology 2025, 168: 104445. PMID: 39914058, PMCID: PMC11890952, DOI: 10.1016/j.jri.2025.104445.Peer-Reviewed Original ResearchConceptsOpioid-use disorderPreterm birthToll-like receptor 4Prostaglandin E2Sterile inflammationRate of preterm birthAssociated with pregnancy complicationsInnate immune toll-like receptor 4Maternal-fetal interfaceNeutrophil chemokine IL-8Induce sterile inflammationM-opioid receptorCytokines IL-1bInflammatory cytokines IL-6Chemokine IL-8Cytokines IL-6Maternal morbidityPregnancy complicationsOpioid useOpioid-usersHuman FMInflammatory profileMembrane weakeningIL-1BPretermA deep learning analysis for dual healthcare system users and risk of opioid use disorder
Yin Y, Workman E, Ma P, Cheng Y, Shao Y, Goulet J, Sandbrink F, Brandt C, Spevak C, Kean J, Becker W, Libin A, Shara N, Sheriff H, Butler J, Agrawal R, Kupersmith J, Zeng-Trietler Q. A deep learning analysis for dual healthcare system users and risk of opioid use disorder. Scientific Reports 2025, 15: 3648. PMID: 39881142, PMCID: PMC11779826, DOI: 10.1038/s41598-024-77602-4.Peer-Reviewed Original ResearchConceptsRisk of opioid use disorderOpioid use disorderDeep neural networksUse disorderClinical factorsIncreased risk of opioid use disorderOpioid use disorder riskOpioid prescribing guidelinesNatural language processing of clinical notesDeep neural network modelU.S. veteransSubstance useOpioid useNatural language processingRetrospective studyBaltimore VA Medical CenterVA Medical CenterIncreased riskPrescribing guidelinesDrug useRisk factorsOpioidMedical CenterVeteransVeterans Health AdministrationEffects of psychedelics on opioid use disorder: a scoping review of preclinical studies
Pulido-Saavedra A, Oliva H, Prudente T, Kitaneh R, Nunes E, Fogg C, Funaro M, Weleff J, Nia A, Angarita G. Effects of psychedelics on opioid use disorder: a scoping review of preclinical studies. Cellular And Molecular Life Sciences 2025, 82: 49. PMID: 39833376, PMCID: PMC11747050, DOI: 10.1007/s00018-024-05519-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnalgesics, OpioidAnimalsDrug Evaluation, PreclinicalHallucinogensHumansOpioid-Related DisordersConceptsOpioid use disorderUse disorderPreclinical studiesClinical studiesReview of preclinical studiesConditioned place preferenceOpioid self-administrationEffects of psychedelicsPreclinical in vivo studiesOpioid use disorder treatmentFrequency of administrationPlace preferencePotential therapeutic effectsSelf-administrationWithdrawal symptomsPreclinical findingsMechanism of actionSafety profilePain studiesPsychedelicsMethodological quality assessmentClinical evidenceCardiovascular riskOpioidWeb of ScienceThe relationship of medical and recreational cannabis laws with opioid misuse and opioid use disorder in the USA: Does it depend on prior history of cannabis use?
Martins S, Bruzelius E, Mauro C, Santaella-Tenorio J, Boustead A, Wheeler-Martin K, Samples H, Hasin D, Fink D, Rudolph K, Crystal S, Davis C, Cerdá M. The relationship of medical and recreational cannabis laws with opioid misuse and opioid use disorder in the USA: Does it depend on prior history of cannabis use? International Journal Of Drug Policy 2025, 136: 104687. PMID: 39793270, PMCID: PMC11821435, DOI: 10.1016/j.drugpo.2024.104687.Peer-Reviewed Original ResearchConceptsCannabis lawsCannabis useNational Survey on Drug Use and Health (NSDUHDrug Use and Health (NSDUHRecreational cannabis lawsState fixed effectsAvailability of cannabisOpioid outcomesOpioid useAssociated with changesHistory of cannabis useLawOpioid misusePast-year cannabis useLifetime cannabis useState policySensitivity to unmeasured confoundingMisuseIndividual level covariatesCannabisLogistic regression modelsAssociated with reductionsOpioidCollider biasFalse discovery rateNeural Variability and Cognitive Control in Individuals With Opioid Use Disorder
Ye J, Mehta S, Peterson H, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Arora J, Tokoglu F, Yip S, Hahn C, Lacadie C, Greene A, Constable R, Barry D, Redeker N, Yaggi H, Scheinost D. Neural Variability and Cognitive Control in Individuals With Opioid Use Disorder. JAMA Network Open 2025, 8: e2455165. PMID: 39821393, PMCID: PMC11742521, DOI: 10.1001/jamanetworkopen.2024.55165.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainCase-Control StudiesCognitionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedOpioid-Related DisordersConceptsDecreased cognitive controlCognitive controlOpioid use disorderCueing paradigmResting-stateHC participantsUse disorderBrain statesBrain dynamicsHealthy controlsNeural mechanismsCognitive processesNeural variabilityFMRIBehavioral implicationsImpaired abilityBrainAccuracy scoresMagnetic resonance imagingDynamic alterationsParticipantsCase-control studyDisordersParadigmImpacts millionsUtility of Candidate Genes From an Algorithm Designed to Predict Genetic Risk for Opioid Use Disorder
Davis C, Jinwala Z, Hatoum A, Toikumo S, Agrawal A, Rentsch C, Edenberg H, Baurley J, Hartwell E, Crist R, Gray J, Justice A, Gelernter J, Kember R, Kranzler H, Muralidhar S, Moser J, Deen J, Tsao P, Gaziano J, Hauser E, Kilbourne A, Matheny M, Oslin D, Churby L, Whitbourne S, Brewer J, Shayan S, Selva L, Pyarajan S, Cho K, DuVall S, Brophy M, Stephens B, Connor T, Argyres D, Assimes T, Hung A, Kranzler H, Aguayo S, Ahuja S, Alexander K, Androulakis X, Balasubramanian P, Ballas Z, Beckham J, Bhushan S, Boyko E, Cohen D, Dellitalia L, Faulk L, Fayad J, Fujii D, Gappy S, Gesek F, Greco J, Godschalk M, Gress T, Gupta S, Gutierrez S, Harley J, Hamner M, Hurley R, Iruvanti P, Jacono F, Jhala D, Kinlay S, Landry M, Liang P, Liangpunsakul S, Lichy J, Mahan C, Marrache R, Mastorides S, Mattocks K, Meyer P, Moorman J, Morgan T, Murdoch M, Norton J, Okusaga O, Oursler K, Poon S, Rauchman M, Servatius R, Sharma S, Smith R, Sriram P, Strollo P, Tandon N, Villareal G, Walsh J, Wells J, Whittle J, Whooley M, Wilson P, Xu J, Yeh S, Bast E, Dryden G, Hogan D, Joshi S, Lo T, Morales P, Naik E, Ong M, Petrakis I, Rai A, Yen A. Utility of Candidate Genes From an Algorithm Designed to Predict Genetic Risk for Opioid Use Disorder. JAMA Network Open 2025, 8: e2453913. PMID: 39786773, PMCID: PMC11718552, DOI: 10.1001/jamanetworkopen.2024.53913.Peer-Reviewed Original ResearchConceptsOpioid use disorder riskElectronic health record dataHealth record dataInternational Classification of DiseasesOpioid use disorderClassification of DiseasesGenetic variantsInternational ClassificationGenetic riskRecord dataRisk of opioid use disorderMillion Veteran ProgramOpioid use disorder diagnosisUse disorderCase-control studyVeteran ProgramMain OutcomesDiagnostic codesClinical careOpioid exposurePharmacy recordsLogistic regressionRisk allelesNagelkerke R2Clinically useful modelRationale and design of a randomized clinical trial of integrated eHealth for PrEP and medications for opioid use disorders for women in the criminal legal system. The Athena study
Meyer J, Brunson S, Price C, Mulrain M, Nguyen J, Altice F, Kyriakides T, Cropsey K, Eaton E. Rationale and design of a randomized clinical trial of integrated eHealth for PrEP and medications for opioid use disorders for women in the criminal legal system. The Athena study. Addiction Science & Clinical Practice 2025, 20: 4. PMID: 39825419, PMCID: PMC11742507, DOI: 10.1186/s13722-024-00534-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultCriminal LawFemaleHIV InfectionsHumansMiddle AgedOpiate Substitution TreatmentOpioid-Related DisordersPre-Exposure ProphylaxisTelemedicineConceptsCriminal legal systemOpioid use disorderLegal systemStandard of careStructural barriersUse disorderEnhanced standard of careRates of opioid use disorderDelivery of PrEPPre-exposure prophylaxisWomen's abilityRandomized clinical trialsLife-saving interventionsRandomized controlled trialsHealth disparitiesImplementation outcomesPrEP initiationPreventive servicesClinical outcomesIntegrated deliveryFollow-upDelivery modelsClinical trialsDecision aidPrEP
2024
Decrease in provider stigma is associated with improved quality health indicators among individuals receiving methadone in primary care centers in Ukraine
Machavariani E, Bromberg D, Dumchev K, Esserman D, Earnshaw V, Pykalo I, Filippovich M, Ivasiy R, Ahmad B, Long J, Haddad M, Madden L, Oliveros D, Dvoriak S, Altice F. Decrease in provider stigma is associated with improved quality health indicators among individuals receiving methadone in primary care centers in Ukraine. International Journal Of Drug Policy 2024, 136: 104682. PMID: 39705875, PMCID: PMC11821433, DOI: 10.1016/j.drugpo.2024.104682.Peer-Reviewed Original ResearchConceptsPrimary care centersQuality health indicatorsProvider stigmaEvidence-based practiceGuideline-concordantPatient outcomesHealth indicatorsReduce provider stigmaCare centerInfluence healthcare utilizationSpecialty health servicesPatient-level outcomesTele-educationImprove patient outcomesProvider fearsImplementation trialHealthcare utilizationPreventive careHealth servicesPoor healthLinear mixed-effects modelsImprove attitudesStigmaIncrease accessMixed-effects modelsComparisons of management approaches in neonatal opioid withdrawal syndrome: The eat, sleep, console approach vs. the Finnegan approach
Johnson K, Berkwitt A, Yankova L, Osborn R. Comparisons of management approaches in neonatal opioid withdrawal syndrome: The eat, sleep, console approach vs. the Finnegan approach. Seminars In Perinatology 2024, 49: 152021. PMID: 39736490, DOI: 10.1016/j.semperi.2024.152021.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidHumansInfant, NewbornNeonatal Abstinence SyndromeOpioid-Related DisordersFour targets: an enhanced framework for guiding causal inference from observational data
Lu H, Li F, Lesko C, Fink D, Rudolph K, Harhay M, Rentsch C, Fiellin D, Gonsalves G. Four targets: an enhanced framework for guiding causal inference from observational data. International Journal Of Epidemiology 2024, 54: dyaf003. PMID: 39868475, PMCID: PMC11769716, DOI: 10.1093/ije/dyaf003.Peer-Reviewed Original ResearchMeSH KeywordsBuprenorphineCausalityHumansObservational Studies as TopicOpioid-Related DisordersResearch DesignTrends in Opioid Use Disorder in the Veterans Health Administration, 2005-2022
Gorfinkel L, Malte C, Fink D, Mannes Z, Wall M, Olfson M, Livne O, Keyhani S, Keyes K, Martins S, Cerdá M, Gutkind S, Maynard C, Saxon A, Simpson T, Gonsalves G, Lu H, McDowell Y, Hasin D. Trends in Opioid Use Disorder in the Veterans Health Administration, 2005-2022. JAMA Network Open 2024, 7: e2451821. PMID: 39705031, PMCID: PMC11662256, DOI: 10.1001/jamanetworkopen.2024.51821.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedOpioid-Related DisordersPrevalenceUnited StatesUnited States Department of Veterans AffairsVeteransYoung AdultConceptsVeterans Health AdministrationOpioid use disorder diagnosisNon-Hispanic white patientsOpioid use disorderPrevalence of opioid use disorderCross-sectional studyHealth AdministrationVHA Corporate Data WarehouseVeterans Health Administration facilitiesElectronic health record dataNational Veterans Health AdministrationVeterans Health Administration patientsRecord dataNon-Hispanic Black patientsElectronic medical record dataContinued public health effortsWhite patientsHealth record dataPublic health effortsCorporate Data WarehouseMedical record dataMultivariate logistic regression modelUse disorderLogistic regression modelsBurden of opioid use disorderSleep Deficiency and Opioid Use Disorder Trajectory, Mechanisms, and Interventions
Langstengel J, Yaggi H. Sleep Deficiency and Opioid Use Disorder Trajectory, Mechanisms, and Interventions. Sleep Medicine Clinics 2024, 19: 625-638. PMID: 39455182, DOI: 10.1016/j.jsmc.2024.07.009.Peer-Reviewed Original ResearchConceptsOpioid use disorderRelapsing brain diseaseSleep deficiencyLoss of controlOpioid usePain perceptionUse disorderMultiple potential causesCognitive functionPoor sleep qualitySleep disordersAutonomic activityTherapeutic targetDisrupted sleepCircadian disruptionOpioidSleep qualityBrain diseasesPotential causesDisordersSleepDeficiencyBidirectional mechanismPainPatientsAlterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder.
Mehta S, Peterson H, Ye J, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Arora J, Tokoglu F, Yip S, Hahn C, Lacadie C, Greene A, Jeon S, Constable R, Barry D, Redeker N, Yaggi H, Scheinost D. Alterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder. Radiology 2024, 313: e240514. PMID: 39656127, PMCID: PMC11694074, DOI: 10.1148/radiol.240514.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainFemaleHumansMagnetic Resonance ImagingMaleOpioid-Related DisordersYoung AdultConceptsHealthy control participantsRight medial temporal lobeOpioid use disorderFunctional brain alterationsMedial temporal lobeOpioid use disorder groupFunctional connectivityUse disorderControl participantsBrain alterationsIntrinsic resting-state functional connectivityTemporal lobeMedial prefrontal cortex volumesVoxel-wise linear regressionT1-weighted MRIResting-state functional connectivityFamily-wise error correctionPrefrontal cortex volumeResting-state functional MRIIncreased functional connectivityIntrinsic connectivity distributionFunctional MRI studiesFemale participantsRegional brain volumesAssess group differencesBuprenorphine: An anesthesia-centric review.
Hickey T, Acampora G. Buprenorphine: An anesthesia-centric review. Journal Of Opioid Management 2024, 20: 503-527. PMID: 39775451, DOI: 10.5055/jom.0901.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidBuprenorphineChronic PainHumansOpioid-Related DisordersPain, PostoperativeTreatment OutcomeConceptsOpioid use disorderEffective analgesic alternativeEffective opioid analgesicOpioid-tolerant patientsMultimodal analgesia strategyLong duration of actionPatients prescribed buprenorphineChronic pain managementDiscontinuation of buprenorphineFormulation of buprenorphineDuration of actionAnalgesic alternativeContinuing buprenorphineDose adjustmentNonopioid analgesicsAnalgesia strategyOpioid analgesicsChronic painImprove patient outcomesTemporary discontinuationPerioperative painPain managementPerioperative periodBuprenorphineUse disorderComparing the brief Holistic Health for HIV (3H+) to the Holistic Health Recovery Program (HHRP+) among people with HIV and opioid use disorder: Results from a randomized, controlled non-inferiority trial
Zelenev A, Huedo-Medina T, Shrestha R, Mistler C, Altice F, Sibilio B, Copenhaver M. Comparing the brief Holistic Health for HIV (3H+) to the Holistic Health Recovery Program (HHRP+) among people with HIV and opioid use disorder: Results from a randomized, controlled non-inferiority trial. PLOS ONE 2024, 19: e0312165. PMID: 39509356, PMCID: PMC11542883, DOI: 10.1371/journal.pone.0312165.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHIV InfectionsHolistic HealthHumansMaleMedication AdherenceMiddle AgedOpioid-Related DisordersRisk-TakingConceptsHolistic Health Recovery ProgramEvidence-based interventionsHolistic healthHIV treatmentRisk behaviorsReduce HIV risk behaviorsDifference-in-differencesEnd-of-interventionControlled non-inferiority trialHIV Epidemic goalsDrug treatment settingsAttainment of viral suppressionNon-inferiority trialRecovery programViral suppressionHigh ART adherenceHIV risk behaviorsNon-inferiorityHHRP+ART adherenceBehavioral interventionsReal-world settingsNon-parametric bootstrappingCondom useOpioid-dependent people
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply