2025
Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation
Liu J, Shen Y, Liu J, Xu D, Chang C, Wang J, Zhou J, Haffty B, Zhang L, Bargonetti J, De S, Hu W, Feng Z. Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation. Nature Communications 2025, 16: 1762. PMID: 39971971, PMCID: PMC11839913, DOI: 10.1038/s41467-025-57099-9.Peer-Reviewed Original ResearchConceptsGain-of-functionTumor suppressive function of p53Mutp53 accumulationAccumulate to high levelsFunction of p53Mutant p53 accumulationTumor suppressive functionMutant p53Subcutaneous xenograft tumor modelMutp53Promote tumorigenesisP53 accumulationPalmitoylationPotential therapeutic strategyXenograft tumor modelFASNTumor modelTumor organoidsTransgenic miceTherapeutic strategiesP53
2016
Distinct pathways of pathogenesis of intraductal oncocytic papillary neoplasms and intraductal papillary mucinous neoplasms of the pancreas
Basturk O, Chung S, Hruban R, Adsay N, Askan G, Iacobuzio-Donahue C, Balci S, Zee S, Memis B, Shia J, Klimstra D. Distinct pathways of pathogenesis of intraductal oncocytic papillary neoplasms and intraductal papillary mucinous neoplasms of the pancreas. Virchows Archiv 2016, 469: 523-532. PMID: 27591765, PMCID: PMC5083199, DOI: 10.1007/s00428-016-2014-x.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmIntraductal oncocytic papillary neoplasmPapillary mucinous neoplasmMucinous neoplasmsClaudin-4Papillary neoplasmDuctal adenocarcinomaB-catenin expressionExpression of mesothelinLesions expressed MUC5ACResults of immunolabelingNuclear p53 accumulationPancreatic ductal neoplasmsIntraductal componentSMAD4 lossHepPar-1Tumor typesDuctal neoplasmsGenetic alterationsMUC proteinsP53 accumulationNeoplasmsNeoplastic cellsDifferentiation markersMesothelin
2010
Promotion of CHIP-Mediated p53 Degradation Protects the Heart From Ischemic Injury
Naito AT, Okada S, Minamino T, Iwanaga K, Liu ML, Sumida T, Nomura S, Sahara N, Mizoroki T, Takashima A, Akazawa H, Nagai T, Shiojima I, Komuro I. Promotion of CHIP-Mediated p53 Degradation Protects the Heart From Ischemic Injury. Circulation Research 2010, 106: 1692-1702. PMID: 20413784, DOI: 10.1161/circresaha.109.214346.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornApoptosisBase SequenceBenzoquinonesCell HypoxiaChlorocebus aethiopsCOS CellsDisease Models, AnimalGenetic TherapyHSP90 Heat-Shock ProteinsHumansHypoxia-Inducible Factor 1, alpha SubunitLactams, MacrocyclicMaleMiceMice, Inbred C57BLMice, KnockoutMolecular Sequence DataMutationMyocardial InfarctionMyocytes, CardiacPromoter Regions, GeneticProteasome Endopeptidase ComplexProtein Processing, Post-TranslationalRatsRats, WistarRNA InterferenceTranscriptional ActivationTumor Suppressor Protein p53Ubiquitin-Protein LigasesUbiquitinationVentricular RemodelingConceptsMyocardial infarctionP53 accumulationCardiomyocyte apoptosisCoronary heart diseaseNumber of patientsNovel therapeutic strategiesP53 degradationApoptosis of cardiomyocytesHeat shock proteinsHeart failureIschemic injuryCardioprotective effectsVentricular remodelingCHIP overexpressionHeart diseaseInfarctionTherapeutic strategiesProteasomal degradationMyocardial apoptosisAmount of p53Molecular mechanismsShock proteinsP53 antagonistP53 accumulatesProtein levels
2002
Genetic and Immunohistochemical Analysis of Pancreatic Acinar Cell Carcinoma Frequent Allelic Loss on Chromosome 11p and Alterations in the APC/β-Catenin Pathway
Abraham S, Wu T, Hruban R, Lee J, Yeo C, Conlon K, Brennan M, Cameron J, Klimstra D. Genetic and Immunohistochemical Analysis of Pancreatic Acinar Cell Carcinoma Frequent Allelic Loss on Chromosome 11p and Alterations in the APC/β-Catenin Pathway. American Journal Of Pathology 2002, 160: 953-962. PMID: 11891193, PMCID: PMC1867188, DOI: 10.1016/s0002-9440(10)64917-6.Peer-Reviewed Original ResearchMeSH KeywordsAdenomatous Polyposis Coli ProteinAdolescentAdultAgedbeta CateninCarcinoma, Acinar CellChild, PreschoolChromosomes, Human, Pair 11Chromosomes, Human, Pair 5Cytoskeletal ProteinsFemaleGenes, Tumor SuppressorHumansImmunohistochemistryLoss of HeterozygosityMaleMiddle AgedMutationPancreatic NeoplasmsSignal TransductionTrans-ActivatorsConceptsAllelic lossChromosome 11pAcinar cell carcinomaAPC/beta-catenin pathwayAllelic shiftsAPC/beta-cateninFrequency of allelic lossChromosome arm 11pPancreatic ductal adenocarcinomaFrequent allelic lossDpc4 protein expressionBeta-catenin oncogeneMicrosatellite markersDuctal adenocarcinomaPolymerase chain amplificationMolecular alterationsMicrosatellite instabilityTruncating APC mutationsSomatic alterationsChromosomeRare pancreatic neoplasmP53 accumulationGenetic alterationsBeta-cateninMicrosatellite
2000
p53 gene mutation, tumor p53 protein overexpression, and serum p53 autoantibody generation in patients with breast cancer
Angelopoulou K, Yu H, Bharaj B, Giai M, Diamandis E. p53 gene mutation, tumor p53 protein overexpression, and serum p53 autoantibody generation in patients with breast cancer. Clinical Biochemistry 2000, 33: 53-62. PMID: 10693987, DOI: 10.1016/s0009-9120(99)00084-3.Peer-Reviewed Original ResearchConceptsAntibody-positive patientsP53 gene mutationsP53 protein accumulationAntibody-negative patientsP53 antibodiesSeronegative patientsGene mutationsP53 accumulationBreast cancerProportion of patientsPrimary breast cancerFormer patient groupP53 protein overexpressionPatient groupAutoantibody generationProtein accumulationImmune responseSuch antibodiesDirect DNA sequencingCorresponding tumorsPatientsImmunofluorometric assayGene abnormalitiesCancerP53 gene
1999
Accumulation of p53 protein is frequent in ovarian cancers associated with BRCA1 and BRCA2 germline mutations.
Zweemer R, Shaw P, Verheijen R, Ryan A, Berchuck A, Ponder B, Risch H, McLaughlin J, Narod S, Menko F, Kenemans P, Jacobs I. Accumulation of p53 protein is frequent in ovarian cancers associated with BRCA1 and BRCA2 germline mutations. Journal Of Clinical Pathology 1999, 52: 372. PMID: 10560359, PMCID: PMC1023075, DOI: 10.1136/jcp.52.5.372.Peer-Reviewed Original ResearchConceptsOvarian cancer casesBRCA2 germline mutationsHereditary ovarian cancerOvarian cancerCancer casesP53 accumulationGermline mutationsSomatic genetic eventsInvasive ovarian cancer casesBRCA2 germline mutation carriersOvarian cancer patientsP53 proteinGermline mutation carriersGenetic eventsRole of p53Cancer patientsAntigen retrieval techniqueBRCA mutationsBRCA2 mutationsStudy groupMutation carriersP53 alterationsP53 immunohistochemistryGermline BRCA1Positive cases
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