2025
Behavior engineering using quantitative reinforcement learning models
Dan O, Plonsky O, Loewenstein Y. Behavior engineering using quantitative reinforcement learning models. Nature Communications 2025, 16: 4109. PMID: 40316521, PMCID: PMC12048583, DOI: 10.1038/s41467-025-58888-y.Peer-Reviewed Original ResearchConceptsTwo-alternative taskReinforcement learning modelModel of choiceReward schedulePsychological principlesMethods of model comparisonEffects of engineeringCognitive scienceExperimental participantsShape behaviorQuantitative modelTheoretical importanceAnimal behaviorLearning modelsEngine behaviorBehavioral engineeringEngineeringEngineering approachModel comparisonTaskAcademic competitionQualitative principlesCurrent interpretations of the I-PACE model of behavioral addictions.
Brand M, Müller A, Wegmann E, Antons S, Brandtner A, Müller S, Stark R, Steins-Loeber S, Potenza M. Current interpretations of the I-PACE model of behavioral addictions. Journal Of Behavioral Addictions 2025, 14: 1-17. PMID: 40063161, DOI: 10.1556/2006.2025.00020.Peer-Reviewed Original ResearchMeSH KeywordsBehavior, AddictiveCognitionCompulsive BehaviorExecutive FunctionHumansImpulsive BehaviorModels, PsychologicalReinforcement, PsychologySelf-ControlConceptsI-PACE modelI-PACEBehavioral addictionsInteraction of Person-Affect-Cognition-ExecutionBehavioral addiction researchCue-reactivityDesire thinkingCompulsive behaviorsExecutive functionAddictive behaviorsNegative reinforcementAddiction researchPermissive beliefsAddiction theoryAddiction fieldSelf-controlAddictionCravingEmpirical findingsTheory buildingClinical careStimulate researchGratificationBehaviorContext of changesDifferential gray matter correlates and machine learning prediction of abuse and internalizing psychopathology in adolescent females
Heyn S, Keding T, Cisler J, McLaughlin K, Herringa R. Differential gray matter correlates and machine learning prediction of abuse and internalizing psychopathology in adolescent females. Scientific Reports 2025, 15: 651. PMID: 39753729, PMCID: PMC11698963, DOI: 10.1038/s41598-024-84616-5.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChild AbuseCohort StudiesFemaleGray MatterHumansMachine LearningModels, PsychologicalNeural Networks, ComputerPsychopathologyConceptsGray matter volumeVoxel-based morphometryInternalizing psychopathologyChildhood abuseAbuse experiencesPrefrontal cortexCingulate cortexAssociated with increased GMVVoxel-based morphometry analysisInterpersonal violenceDorsal prefrontal cortexDevelopment of psychopathologyAnterior cingulate cortexChildhood abuse historyChildhood abuse exposureT1 structural MRIDifferentiating gray matterPredictive of abuseAdolescent femalesSeverity of abuseDegree of overlapSupramarginal gyrusTrauma exposureStudy of interpersonal violenceIndividual psychopathology
2020
Evaluating a Longitudinal Mediation Model of Perceived Stress, Depressive Symptoms, and Substance Use Treatment Outcomes
Roos CR, Kiluk BD, McHugh RK, Carroll KM. Evaluating a Longitudinal Mediation Model of Perceived Stress, Depressive Symptoms, and Substance Use Treatment Outcomes. Psychology Of Addictive Behaviors 2020, 34: 660-668. PMID: 32297754, PMCID: PMC7483283, DOI: 10.1037/adb0000581.Peer-Reviewed Original ResearchConceptsIllicit opioid useOpioid useDepressive symptomsUse disordersSubstance use outcomesMethadone treatmentStandard methadone treatmentTrial of galantamineUse outcomesOpioid use disorderSubstance Use Treatment OutcomesSubstance use disordersCocaine use disorderCognitive behavioral therapyLongitudinal treatment studyTreatment outcomesPredictors of endPosttreatment outcomesSymptomsTreatment studiesSignificant total effectSubstance useBaselineOutcomesDisordersA Life‐Course Model of Trauma Exposure and Mental Health Among Low‐Income Survivors of Hurricane Katrina
Lowe SR, Raker EJ, Arcaya MC, Zacher ML, Waters MC, Rhodes JE. A Life‐Course Model of Trauma Exposure and Mental Health Among Low‐Income Survivors of Hurricane Katrina. Journal Of Traumatic Stress 2020, 33: 950-961. PMID: 32816358, PMCID: PMC7725975, DOI: 10.1002/jts.22581.Peer-Reviewed Original ResearchConceptsPosttraumatic stress symptomsPsychological distressMental healthTrauma exposureNon-Hispanic black mothersPostdisaster mental healthMental health outcomesTime point 1Low-income survivorsLifetime PTERole of exposureNonspecific psychological distressHealth outcomesSymptomsLife course modelSurvivorsLongitudinal studyAssaultive violenceBlack mothersStress symptomsTrauma survivorsExposureTraumatic eventsClinical workHealthA flexible framework for simulating and fitting generalized drift-diffusion models
Shinn M, Lam NH, Murray JD. A flexible framework for simulating and fitting generalized drift-diffusion models. ELife 2020, 9: e56938. PMID: 32749218, PMCID: PMC7462609, DOI: 10.7554/elife.56938.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsData AnalysisDecision MakingHumansModels, NeurologicalModels, PsychologicalSoftwareConceptsDrift-diffusion modelArbitrary user-defined functionsImportant decision-making modelFokker-Planck equationEfficient numerical methodDecision-making mechanismUser-defined functionsDrift diffusion model frameworkFlexible frameworkSoftware packageGDDMHuman datasetsNumerical methodDecision-making modelResponse time distributionsDecision-making taskLatest methodologiesModel formGood accuracyFrameworkMaximum likelihoodModel innovationTime distributionDDM parametersModel frameworkModeling the influence of working memory, reinforcement, and action uncertainty on reaction time and choice during instrumental learning
McDougle SD, Collins AGE. Modeling the influence of working memory, reinforcement, and action uncertainty on reaction time and choice during instrumental learning. Psychonomic Bulletin & Review 2020, 28: 20-39. PMID: 32710256, PMCID: PMC7854965, DOI: 10.3758/s13423-020-01774-z.Peer-Reviewed Original ResearchMeSH KeywordsChoice BehaviorHumansMemory, Short-TermModels, PsychologicalReaction TimeReinforcement, PsychologyUncertaintyConceptsInstrumental learningInstrumental learning processesReaction time effectsStages of learningDegree of deliberationReward contingenciesPerceptual evidenceParsimonious accountTask complexityInternal representationAction uncertaintyUnique predictionDecision dynamicsAction valuesPast experienceLearning processReaction timeMemoryLearningProcess modelTime effectsTaskDecision-making frameworkContingenciesPrior uncertaintyParanoia as a deficit in non-social belief updating
Reed EJ, Uddenberg S, Suthaharan P, Mathys C, Taylor JR, Groman SM, Corlett PR. Paranoia as a deficit in non-social belief updating. ELife 2020, 9: e56345. PMID: 32452769, PMCID: PMC7326495, DOI: 10.7554/elife.56345.Peer-Reviewed Original ResearchConceptsParanoid individualsSocial threatLearning differencesTask environmentLearning behaviorOnline participantsMethamphetamine exposureParanoiaBeliefsVolatile environmentMental illnessComputational modelingIndividualsElevated sensitivityDeficitsAnticipationParticipantsParadigmThreatMethamphetamineDifferencesFurther assessmentBehaviorHarmAlexithymia, Emotion‐Regulation Strategies, and Traumatic Experiences in Prenatally Cocaine‐Exposed Young Adults
Morie KP, Zhai ZW, Potenza MN, Mayes LC. Alexithymia, Emotion‐Regulation Strategies, and Traumatic Experiences in Prenatally Cocaine‐Exposed Young Adults. American Journal On Addictions 2020, 29: 492-499. PMID: 32436341, PMCID: PMC7657982, DOI: 10.1111/ajad.13056.Peer-Reviewed Original ResearchApophenia as the Disposition to False Positives: A Unifying Framework for Openness and Psychoticism
Blain S, Longenecker J, Grazioplene R, Klimes-Dougan B, DeYoung C. Apophenia as the Disposition to False Positives: A Unifying Framework for Openness and Psychoticism. Journal Of Psychopathology And Clinical Science 2020, 129: 279-292. PMID: 32212749, PMCID: PMC7112154, DOI: 10.1037/abn0000504.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitionCreativityFemaleHumansIntelligenceMaleModels, PsychologicalPersonalityPersonality InventoryProblem SolvingPsychotic DisordersYoung AdultConceptsPositive symptomsOpenness aspectsEmotion recognition taskTheory of mindReport indicatorsWord association taskFalse positive error rateAuditory signal detectionStructural equation modelComputerized tasksPositive schizotypyAssociation taskFalse positive errorsMental contentRecognition taskNormal personality variationDigit identificationPersonality traitsPromising constructPersonality variationPsychosis spectrumPsychoticismSample 2ApopheniaSample 1The Blue Zones as a Model for Physician Well-Being
Doolittle BR. The Blue Zones as a Model for Physician Well-Being. The American Journal Of Medicine 2020, 133: 653-654. PMID: 32017892, DOI: 10.1016/j.amjmed.2019.12.045.Peer-Reviewed Original Research
2019
Ready, willing and able: a model to explain successful use of feedback
Garino A. Ready, willing and able: a model to explain successful use of feedback. Advances In Health Sciences Education 2019, 25: 337-361. PMID: 31598884, DOI: 10.1007/s10459-019-09924-2.Peer-Reviewed Original ResearchA consensus guide to capturing the ability to inhibit actions and impulsive behaviors in the stop-signal task
Verbruggen F, Aron AR, Band GP, Beste C, Bissett PG, Brockett AT, Brown JW, Chamberlain SR, Chambers CD, Colonius H, Colzato LS, Corneil BD, Coxon JP, Dupuis A, Eagle DM, Garavan H, Greenhouse I, Heathcote A, Huster RJ, Jahfari S, Kenemans JL, Leunissen I, Li C, Logan G, Matzke D, Morein-Zamir S, Murthy A, Paré M, Poldrack RA, Ridderinkhof KR, Robbins TW, Roesch M, Rubia K, Schachar RJ, Schall JD, Stock AK, Swann NC, Thakkar KN, van der Molen MW, Vermeylen L, Vink M, Wessel JR, Whelan R, Zandbelt BB, Boehler CN. A consensus guide to capturing the ability to inhibit actions and impulsive behaviors in the stop-signal task. ELife 2019, 8: e46323. PMID: 31033438, PMCID: PMC6533084, DOI: 10.7554/elife.46323.Peer-Reviewed Original ResearchConcurrent visual and motor selection during visual working memory guided action
van Ede F, Chekroud S, Stokes M, Nobre A. Concurrent visual and motor selection during visual working memory guided action. Nature Neuroscience 2019, 22: 477-483. PMID: 30718904, PMCID: PMC6420070, DOI: 10.1038/s41593-018-0335-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlpha RhythmBeta RhythmBrainFemaleHumansMaleMemory, Short-TermModels, PsychologicalMotor ActivityPsychomotor PerformanceVisual PerceptionYoung AdultLongitudinal Drinking Patterns and Their Clinical Correlates in Million Veteran Program Participants
Smith R, Kranzler HR, Justice AC, Tate JP, Program T. Longitudinal Drinking Patterns and Their Clinical Correlates in Million Veteran Program Participants. Alcohol Clinical And Experimental Research 2019, 43: 465-472. PMID: 30592535, PMCID: PMC6691890, DOI: 10.1111/acer.13951.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DrinkingFemaleHumansMaleMiddle AgedModels, PsychologicalPsychiatric Status Rating ScalesUnited StatesVeteransConceptsMean AUDIT-C scoreAUDIT-C scoresAlcohol Use Disorders Identification Test-ConsumptionTrajectory groupsU.S. Preventive Services Task ForceDrinking trajectoriesAge-adjusted mean scoresVeterans Affairs Health SystemPrimary care patientsLarger patient populationMillion Veteran Program cohortAlcohol use disorder diagnosisHigh trajectory groupPosttraumatic stress disorderElectronic health recordsHepatitis CCare patientsLiver cirrhosisClinical correlatesPatient populationLongitudinal drinking patternsHigher oddsClinical relevanceHarmful drinkingAnnual administrationModel-Free and Model-Based Influences in Addiction-Related Behaviors
Groman SM, Massi B, Mathias SR, Lee D, Taylor JR. Model-Free and Model-Based Influences in Addiction-Related Behaviors. Biological Psychiatry 2019, 85: 936-945. PMID: 30737015, PMCID: PMC6534429, DOI: 10.1016/j.biopsych.2018.12.017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AddictiveDecision MakingMaleMethamphetamineModels, PsychologicalRatsReinforcement, PsychologyConceptsDecision-making taskModel-based behaviorModel-free learningModel-based learningAbility of ratsChronic drug useUnrewarded outcomesIndividual differencesDrug-induced disruptionHabitual systemAddiction vulnerabilityModel-free reinforcementBehavioral platformAction selectionDrug useSubsequent methamphetamineCore featuresLearning mechanism
2018
Neurochemical and Behavioral Dissections of Decision-Making in a Rodent Multistage Task
Groman SM, Massi B, Mathias SR, Curry DW, Lee D, Taylor JR. Neurochemical and Behavioral Dissections of Decision-Making in a Rodent Multistage Task. Journal Of Neuroscience 2018, 39: 295-306. PMID: 30413646, PMCID: PMC6325257, DOI: 10.1523/jneurosci.2219-18.2018.Peer-Reviewed Original ResearchConceptsMultistage taskBehavioral platformDopamine toneDecision Making TaskValue-based choiceDecision-making taskNovel behavioral paradigmModel-based learningConsequences of actionsReinforcement learning systemNeuroscience studiesBehavioral paradigmsBiobehavioral mechanismsVentral striatumNeurobehavioral levelBehavioral dissectionNovel analytic approachCortex correlatesRetrospective appraisalChoice behaviorTaskBehavioral mechanismsMental disordersModel-based systemLearningPrediction of prodromal symptoms and schizophrenia-spectrum personality disorder traits by positive and negative schizotypy: A 3-year prospective study
Racioppi A, Sheinbaum T, Gross G, Ballespí S, Kwapil T, Barrantes-Vidal N. Prediction of prodromal symptoms and schizophrenia-spectrum personality disorder traits by positive and negative schizotypy: A 3-year prospective study. PLOS ONE 2018, 13: e0207150. PMID: 30408119, PMCID: PMC6224105, DOI: 10.1371/journal.pone.0207150.Peer-Reviewed Original ResearchConceptsNegative schizotypyPersonality traitsYoung adult samplePrevious cross-sectional findingsSchizophrenia-spectrum psychopathologyAvoidant personality traitsPsychotic-like symptomsPsychometric high-risk strategyMental health treatmentCross-sectional findingsPositive schizotypyPersonality disorder traitsSchizotypy dimensionsResilience factorsSchizotypyLongitudinal findingsAdult samplesNegative dimensionsDisorder traitsEmotional disturbancePredictive validityGeneral psychopathologyMultidimensional modelHealth treatmentMultidimensional structureAn International Interprofessional Study of Mental Models and Factors Delaying Neuroimaging of Critically Head-Injured Children Presenting to Emergency Departments
Auerbach M, Cole J, Violano P, Roney L, Doherty C, Shepherd M, MacKinnon R. An International Interprofessional Study of Mental Models and Factors Delaying Neuroimaging of Critically Head-Injured Children Presenting to Emergency Departments. Pediatric Emergency Care 2018, 34: 797-801. PMID: 27753711, DOI: 10.1097/pec.0000000000000915.Peer-Reviewed Original ResearchConceptsHead-injured childrenEmergency departmentInterprofessional health care providersProvider perspectivesSevere head injuryHead-injured patientsHealth care providersPercentage of providersSystem factorsTime-consuming interventionCushing's triadHead injuryResuscitation bayCare providersMental modelsTeam decisionScanner availabilityDiverse teamsInterprofessional teamInterventionNeuroimagingPatientsChildrenFrequent factorsInterprofessional studyCredibility-enhancing displays promote the provision of non-normative public goods
Kraft-Todd G, Bollinger B, Gillingham K, Lamp S, Rand D. Credibility-enhancing displays promote the provision of non-normative public goods. Nature 2018, 563: 245-248. PMID: 30356217, DOI: 10.1038/s41586-018-0647-4.Peer-Reviewed Original Research
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