2024
Inducing representational change in the hippocampus through real-time neurofeedback
Peng K, Wammes J, Nguyen A, Iordan C, Norman K, Turk-Browne N. Inducing representational change in the hippocampus through real-time neurofeedback. Philosophical Transactions Of The Royal Society B Biological Sciences 2024, 379: 20230091. PMID: 39428880, PMCID: PMC11491844, DOI: 10.1098/rstb.2023.0091.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingReal-time functional magnetic resonance imagingPatterns of fMRI activityCategorical perception taskReal-time neurofeedbackNeurocognitive mechanismsFMRI sessionStimulus similarityFMRI activationTask demandsBehavioral consequencesUntrained objectsNeural representationPerception taskMemory integrationRepresentational changeEndogenous neuromodulatorNeurofeedbackHippocampusCortical representationIncreased coactivationMagnetic resonance imagingVisual cortexMemoryMultiple theoriesBrain-state mediated modulation of inter-laminar dependencies in visual cortex
Das A, Sheffield A, Nandy A, Jadi M. Brain-state mediated modulation of inter-laminar dependencies in visual cortex. Nature Communications 2024, 15: 5105. PMID: 38877026, PMCID: PMC11178935, DOI: 10.1038/s41467-024-49144-w.Peer-Reviewed Original ResearchConceptsBrain state fluctuationsUnique dependenceSpatial attentionBehavioral outcomesState fluctuationsDeployment of spatial attentionDeployment of attentionBehaviorally relevant objectsComputational goalCluttered environmentsVisual cortexObject recognitionExcitatory populationHierarchical computationVisual area V4Internal fluctuationsDependenceRelevant objectsModulation patternsTask demandsEnhance information transferCortical networksNeural activityInformation transferArea V4Task–Rest Reconfiguration Efficiency of the Reward Network Across Adolescence and Its Association With Early Life Stress and Depressive Symptoms
Lee Y, Yuan J, Winkler A, Kircanski K, Pine D, Gotlib I. Task–Rest Reconfiguration Efficiency of the Reward Network Across Adolescence and Its Association With Early Life Stress and Depressive Symptoms. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024, 64: 290-300. PMID: 38878818, PMCID: PMC11638404, DOI: 10.1016/j.jaac.2024.04.018.Peer-Reviewed Original ResearchEarly life stressReward networkDepressive symptomsLife stressReconfiguration efficiencyFunctional connectivityExperiences of early life stressExposure to early life stressEffects of early life stressTask-based fMRI scansHigher levels of depressive symptomsLevels of depressive symptomsSevere early life stressReward processingAge-related associationsFMRI scanningAdolescent depressionCommunity sampleTask demandsResting-stateAsymptomatic youthOlder adolescentsEffects of ageRewardBrain states
2023
The Relationship between Short- and Long-Term Memory Is Preserved across the Age Range
Čepukaitytė G, Thom J, Kallmayer M, Nobre A, Zokaei N. The Relationship between Short- and Long-Term Memory Is Preserved across the Age Range. Brain Sciences 2023, 13: 106. PMID: 36672087, PMCID: PMC9856639, DOI: 10.3390/brainsci13010106.Peer-Reviewed Original ResearchLong-term memoryMemory durationLong-term memory performanceEarly to late adulthoodCompared memory functionsHealthy agingLonger memory durationMemory deficitsMemory performanceTask demandsShort-term memoryStimulus materialMemory functionAge rangeLate adulthoodMemory systemMemoryExperimental controlTaskDeficits
2022
Transient beta activity and cortico-muscular connectivity during sustained motor behaviour
Echeverria-Altuna I, Quinn A, Zokaei N, Woolrich M, Nobre A, van Ede F. Transient beta activity and cortico-muscular connectivity during sustained motor behaviour. Progress In Neurobiology 2022, 214: 102281. PMID: 35550908, PMCID: PMC9742854, DOI: 10.1016/j.pneurobio.2022.102281.Peer-Reviewed Original ResearchConceptsMotor behaviorMeasured magnetoencephalographyIsometric contractionBeta activitySingle-trial levelSustained isometric contractionCortico-muscular connectivityTask demandsMotor demandsMotor stateMotor requirementsDistant neural populationsFrequency-specific connectivityNeural oscillationsBeta connectivityHuman participantsContralateral musclesMotor cortexNeural populationsNeural synchronisationDownstream muscles
2021
Modulation of Amygdala Response by Cognitive Conflict in Adolescents with Conduct Problems and Varying Levels of CU Traits
Sebastian C, Stafford J, McCrory E, Sethi A, De Brito S, Lockwood P, Viding E. Modulation of Amygdala Response by Cognitive Conflict in Adolescents with Conduct Problems and Varying Levels of CU Traits. Research On Child And Adolescent Psychopathology 2021, 49: 1043-1054. PMID: 33728508, PMCID: PMC8222043, DOI: 10.1007/s10802-021-00787-z.Peer-Reviewed Original ResearchConceptsCallous-unemotional traitsNegative emotional stimuliAmygdala responseConduct problemsEmotional stimuliCognitive conflictTask demandsCognitive task demandsCognitive conflict tasksLow callous-unemotional traitsCP/HCUHealthy adult sampleCognitive controlEmotional facesReactive aggressionAtypical modulationConflict taskNeurocognitive responsesAffect regulationCU traitsPotential translational relevanceConflict conditionsPrefrontal areasHigh conflictAdult samplesTemporal orienting in Parkinson’s disease
Zokaei N, Gillebert C, Chauvin J, Gresch D, Board A, Rolinski M, Hu M, Nobre A. Temporal orienting in Parkinson’s disease. European Journal Of Neuroscience 2021, 53: 2713-2725. PMID: 33450082, PMCID: PMC8290223, DOI: 10.1111/ejn.15114.Peer-Reviewed Original ResearchConceptsSpeeded-response taskPerceptual discriminationTemporal orientationIndependent group of individualsParkinson's diseasePerceptual-discrimination taskTemporal orienting of attentionMultiple stages of processingTemporal orienting effectsStream of lettersOrienting of attentionDetect target stimuliImproved perceptual discriminationStages of processingDistracter lettersTarget letterTarget stimuliTask demandsExperiment 1Experiment 2Motor preparationTask contextDopaminergic medicationTemporal expectationsAdaptive behavior
2020
Functional biases in attentional templates from associative memory
Boettcher S, van Ede F, Nobre A. Functional biases in attentional templates from associative memory. Journal Of Vision 2020, 20: 7-7. PMID: 33296459, PMCID: PMC7729124, DOI: 10.1167/jov.20.13.7.Peer-Reviewed Original ResearchConceptsParticipants learned associationsCurrent task demandsLong-term memoryAttentional templatesTask demandsTask performanceBehavioral responsesExperimental blocksAssociative memoryMemoryLuresFunctional biasParticipantsContext-dependentEncode informationNonmatchEveryday lifeAssociationFeature dimensionsCombination of colorColored gratingsTaskRetrievalPerceptionHypothesisTemporal Expectations Prepare Visual Working Memory for Behavior
Jin W, Nobre A, van Ede F. Temporal Expectations Prepare Visual Working Memory for Behavior. Journal Of Cognitive Neuroscience 2020, 32: 2320-2332. PMID: 32897120, PMCID: PMC8357348, DOI: 10.1162/jocn_a_01626.Peer-Reviewed Original ResearchConceptsVisual working memoryWorking memoryTemporal expectationsTask demandsContext of working memoryWorking memory retentionAnticipated task demandsChange-detection taskContralateral delay activityMemory-guided behaviorInfluence of temporal expectationEEG signaturesAlpha activityAlpha lateralizationMemory retentionElectrophysiological markersBehavioral performanceDelayed activationEEG measuresEEGMemoryAlphaHeightened degree connectivity of the striatum in obsessive-compulsive disorder induced by symptom provocation
Beucke J, Simon D, Sepulcre J, Talukdar T, Feusner J, Kaufmann C, Kathmann N. Heightened degree connectivity of the striatum in obsessive-compulsive disorder induced by symptom provocation. Journal Of Affective Disorders 2020, 276: 1069-1076. PMID: 32768879, DOI: 10.1016/j.jad.2020.07.062.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSymptom provocationPassive viewingMeta-analysis of functional neuroimaging studiesSymptoms of obsessive-compulsive disorderVentral striatum/nucleus accumbensSelf-referential evaluationFunctional neuroimaging studiesNeutral control conditionConcurrent task demandsNeutral picturesStriatum/nucleus accumbensVentral striatumOCD symptomsStriatal subdivisionsDorsal striatumNAc connectivityUnmedicated patientsCorticostriatal areasNeuroimaging evidenceNeuroimaging studiesTask demandsConnectivity differencesNetwork abnormalitiesGroup differences
2019
Individualized functional networks reconfigure with cognitive state
Salehi M, Karbasi A, Barron DS, Scheinost D, Constable RT. Individualized functional networks reconfigure with cognitive state. NeuroImage 2019, 206: 116233. PMID: 31574322, PMCID: PMC7216521, DOI: 10.1016/j.neuroimage.2019.116233.Peer-Reviewed Original ResearchConceptsCognitive stateFunctional networksMultiple cognitive statesFunctional network organizationFunctional organizationBrain functional networksTask demandsFMRI dataSimilar tasksParcellation approachHuman brainNetwork organizationExtensive evidenceMultiple subjectsBrainNetwork membershipTaskOrganizationSubjectsParcellationSuch reconfigurationMeasuresMembershipFindingsSuch definitions
2018
Benefits of Flexible Prioritization in Working Memory Can Arise Without Costs
Myers N, Chekroud S, Stokes M, Nobre A. Benefits of Flexible Prioritization in Working Memory Can Arise Without Costs. Journal Of Experimental Psychology Human Perception & Performance 2018, 44: 398-411. PMID: 28816476, PMCID: PMC5868459, DOI: 10.1037/xhp0000449.Peer-Reviewed Original Research
2017
Task relevance modulates the behavioural and neural effects of sensory predictions
Auksztulewicz R, Friston K, Nobre A. Task relevance modulates the behavioural and neural effects of sensory predictions. PLOS Biology 2017, 15: e2003143. PMID: 29206225, PMCID: PMC5730187, DOI: 10.1371/journal.pbio.2003143.Peer-Reviewed Original ResearchConceptsTask-relevantMeasure participants' brain activityParticipants' brain activityInfluence of predictabilityGamma-band activityAlpha-band activityIdeal observer modelNeural effectsPredictive signalsTask demandsBrain activityNeural responsesTask performanceSpatial/temporal informationSensory predictionsVisual regionsBrain functionBehavioral responsesSpectral correlationAuditory regionsAuditory cuesInternal predictionsSubjects' predictionsVisual targetDiscrimination accuracyPrioritizing Information during Working Memory: Beyond Sustained Internal Attention
Myers N, Stokes M, Nobre A. Prioritizing Information during Working Memory: Beyond Sustained Internal Attention. Trends In Cognitive Sciences 2017, 21: 449-461. PMID: 28454719, PMCID: PMC7220802, DOI: 10.1016/j.tics.2017.03.010.Peer-Reviewed Original ResearchModulation of amygdala response to task-irrelevant emotion
Sebastian C, McCrory E, De Brito S, Viding E. Modulation of amygdala response to task-irrelevant emotion. Social Cognitive And Affective Neuroscience 2017, 12: 643-650. PMID: 28119506, PMCID: PMC5390695, DOI: 10.1093/scan/nsw174.Peer-Reviewed Original ResearchConceptsAmygdala responseTask demandsPerceptual inputTask performanceConflict conditionsTask-irrelevant emotional stimuliTask-irrelevant emotionFearful facial expressionsCognitive conflict tasksCognitive task performanceSlower reaction timesHigh-conflict conditionPsychophysiological interaction analysisRight amygdala responseLow-conflict conditionsMiddle frontal gyrusFunctional couplingEmotion regulationExecutive demandsEmotional informationConflict taskEmotional stimuliCognitive conflictCognitive demandsEmotional contextStress and Cognitive Flexibility: Cortisol Increases Are Associated with Enhanced Updating but Impaired Switching
Goldfarb EV, Froböse MI, Cools R, Phelps EA. Stress and Cognitive Flexibility: Cortisol Increases Are Associated with Enhanced Updating but Impaired Switching. Journal Of Cognitive Neuroscience 2017, 29: 14-24. PMID: 27576026, DOI: 10.1162/jocn_a_01029.Peer-Reviewed Original ResearchConceptsCognitive flexibilityDifferent task demandsTask demandsParticipants' cortisol responsesAcute stress manipulationCortisol responseDMS taskStress-related increasesStress manipulationMultifaceted constructImpaired switchingEffects of stressPFC functionSubjects designDimensions of flexibilityWorse performanceDorsal striatumAcute stressCortisol increaseRelevant informationTaskMost studiesParticipantsConstructsParadigm
2014
Physiological evidence of a deficit to enhance the empathic response in schizophrenia
Corbera S, Ikezawa S, Bell MD, Wexler BE. Physiological evidence of a deficit to enhance the empathic response in schizophrenia. European Psychiatry 2014, 29: 463-472. PMID: 24630376, DOI: 10.1016/j.eurpsy.2014.01.005.Peer-Reviewed Original ResearchConceptsEvent-related potentialsEmpathic responsesERP responsesPersonal distressRegulatory deficitsLate cognitive componentsSocial cognition processesPictures of handsEffective social interactionsLate ERP responsesOwn emotional engagementCognitive empathyTask demandsPerspective takingCognition processEmpathic conditionEmotional engagementSocial situationsSocial interactionEmpathyPainful situationsSubjective ratingsOwn painPain paradigmDistress
2013
Fronto-limbic-striatal dysfunction in pediatric and adult patients with bipolar disorder: impact of face emotion and attentional demands
Brotman MA, Tseng WL, Olsavsky AK, Fromm SJ, Muhrer EJ, Rutenberg JG, Deveney CM, Adleman NE, Zarate CA, Pine DS, Leibenluft E. Fronto-limbic-striatal dysfunction in pediatric and adult patients with bipolar disorder: impact of face emotion and attentional demands. Psychological Medicine 2013, 44: 1639-1651. PMID: 23930595, PMCID: PMC3922892, DOI: 10.1017/s003329171300202x.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexFunctional magnetic resonance imagingNeutral facesInferior frontal gyrusTask demandsImplicit processingHappy facesPassive viewingAmygdala hyperactivationCognitive control circuitsFace emotion processingBipolar disorderPediatric bipolar disorderHealthy comparison subjectsExplicit processingFamily-wise errorFearful facesAttentional conditionsFace emotionsAttentional demandsEmotion processingFrontal gyrusCingulate cortexHypoactivationComparison subjects
2012
Lacking Control over the Trade-Off between Quality and Quantity in Visual Short-Term Memory
Murray A, Nobre A, Astle D, Stokes M. Lacking Control over the Trade-Off between Quality and Quantity in Visual Short-Term Memory. PLOS ONE 2012, 7: e41223. PMID: 22905099, PMCID: PMC3414487, DOI: 10.1371/journal.pone.0041223.Peer-Reviewed Original ResearchConceptsVisual short-term memoryShort-term memoryMemory-based judgmentsStimulus-driven factorsTop-down controlPrecision of itemsMnemonic demandsExperiment 4Experiment 3Task demandsQuality of itemsItemsMemoryStrategic trade-offsContextual informationParticipantsLack controlJudgmentTaskMotivationTrade-offsComparing language experience and task demands in Mandarin tone processing: Neurophysiological evidence
Yu Y, Shafer V, Sussman E, Whalen D. Comparing language experience and task demands in Mandarin tone processing: Neurophysiological evidence. The Journal Of The Acoustical Society Of America 2012, 131: 3233-3233. DOI: 10.1121/1.4708060.Peer-Reviewed Original ResearchMismatch negativityISI conditionLanguage experienceMandarin listenersMemory tracesMonolingual English speakersEnglish-speaking groupShort-term memory traceEvent-related potentialsLong ISI conditionPassive oddball paradigmLong-term memoryShort ISI conditionEnglish listenersNative MandarinEnglish speakersTone contrastTone perceptionTone processingNonword contextPhonemic informationTask demandsSpeech processingMandarinShort ISI
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