2022
Drug-Induced Acute Kidney Injury
Perazella MA, Rosner MH. Drug-Induced Acute Kidney Injury. Clinical Journal Of The American Society Of Nephrology 2022, 17: 1220-1233. PMID: 35273009, PMCID: PMC9435983, DOI: 10.2215/cjn.11290821.Peer-Reviewed Original ResearchConceptsKidney injuryTubular injuryDrug-induced acute kidney injuryT cell-mediated immune responsesDrug-related kidney injuryCell-mediated immune responsesAcute interstitial nephritisDirect tubular injuryTreatment of AKIAcute kidney injuryAcute tubular injuryIntensive care unitInduction of inflammationAKI riskIntratubular obstructionTubulointerstitial injuryInterstitial nephritisCare unitInflammation leadInjury resultsCommon causeImmune responseHospital wardsProximal tubulesAKIAblation of T cell-associated PD-1H enhances functionality and promotes adoptive immunotherapy
Hu L, Chen L, Xiao Z, Zheng X, Chen Y, Xian N, Cho C, Luo L, Huang G, Chen L. Ablation of T cell-associated PD-1H enhances functionality and promotes adoptive immunotherapy. JCI Insight 2022, 7: e148247. PMID: 34905507, PMCID: PMC8855794, DOI: 10.1172/jci.insight.148247.Peer-Reviewed Original ResearchConceptsPD-1HT cellsAdoptive immunotherapyT cell-mediated immune responsesT-cell adoptive immunotherapyAdoptive T-cell therapyCell-mediated immune responsesTumor-infiltrating CD8Antitumor activityT-cell therapySyngeneic mouse tumorsCAR T cellsDeath-1 homologExperimental tumor modelsAdoptive transferActivated CD8Coinhibitory moleculesCytokine productionDeficient miceImmune responseHuman xenograftsCD8Tumor microenvironmentTumor modelMouse tumors
2021
Mitochondrial fission in allograft endothelial cells: A novel actionable target
Mullan CW, Pober JS. Mitochondrial fission in allograft endothelial cells: A novel actionable target. American Journal Of Transplantation 2021, 22: 337-338. PMID: 34865296, DOI: 10.1111/ajt.16911.Commentaries, Editorials and Letters
2013
Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania
KAWAI K, MEYDANI SN, URASSA W, WU D, MUGUSI FM, SAATHOFF E, BOSCH RJ, VILLAMOR E, SPIEGELMAN D, FAWZI WW. Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania. Epidemiology And Infection 2013, 142: 1505-1509. PMID: 24093552, PMCID: PMC5639693, DOI: 10.1017/s0950268813002495.Peer-Reviewed Original ResearchConceptsCell-mediated immune responsesTB patientsMicronutrient supplementationMicronutrient supplementsImmune responseProliferative responseT cell-mediated immune responsesHIV-negative TB patientsHIV-positive TB patientsLymphocyte proliferative responsesLymphocyte proliferation responseHigher proliferative responsesT cell mitogensPlacebo groupPulmonary TBTB treatmentDaily doseEligible participantsNutritional interventionTuberculosis treatmentTime of initiationClinical relevanceMicronutrient groupProliferation responsePatients
2005
Cross-Comparison of Patch Test and Lymphocyte Proliferation Responses in Patients With a History of Acute Generalized Exanthematous Pustulosis
Girardi M, Duncan KO, Tigelaar RE, Imaeda S, Watsky KL, McNiff JM. Cross-Comparison of Patch Test and Lymphocyte Proliferation Responses in Patients With a History of Acute Generalized Exanthematous Pustulosis. American Journal Of Dermatopathology 2005, 27: 343-346. PMID: 16121058, DOI: 10.1097/01.dad.0000160982.75176.6c.Peer-Reviewed Original ResearchConceptsAcute generalized exanthematous pustulosisPatch test resultsPositive patch test resultsGeneralized exanthematous pustulosisLymphocyte proliferative responsesProliferative responseExanthematous pustulosisPeripheral T-cell proliferative responsesT cell-mediated immune responsesDrug-specific T cellsVitro lymphocyte proliferative responseCalcium channel blocker diltiazemCell-mediated immune responsesDelayed-type hypersensitivity reactionT cell proliferative responsesAdverse cutaneous reactionsLymphocyte proliferation responseChannel blocker diltiazemCell proliferative responsesPatch test sitesNeutrophilic pustulesClinical responsePerivascular lymphocytesCutaneous reactionsHypersensitivity reactions
2002
Salp15, an Ixodes scapularis Salivary Protein, Inhibits CD4+ T Cell Activation
Anguita J, Ramamoorthi N, Hovius JW, Das S, Thomas V, Persinski R, Conze D, Askenase PW, Rincón M, Kantor FS, Fikrig E. Salp15, an Ixodes scapularis Salivary Protein, Inhibits CD4+ T Cell Activation. Immunity 2002, 16: 849-859. PMID: 12121666, DOI: 10.1016/s1074-7613(02)00325-4.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceCalcium SignalingCD4-Positive T-LymphocytesCell DivisionDrosophilaFemaleInterleukin-2IxodesLymphocyte ActivationMiceMice, Inbred BALB CMolecular Sequence DataRabbitsRatsReceptors, Antigen, T-CellReceptors, Interleukin-2Salivary Proteins and PeptidesConceptsT cell activationVector-host interactionsI. scapularis salivaCell activationMolecular basisFunctional importanceTCR ligationSalp15ProteinSalivary proteinsTick salivaCalcium fluxIxodes scapularis salivaActivationArthropodsRepressionImmune responseLow productionPleiotropic propertiesHostInhibits CD4T cell-mediated immune responsesVivo
1996
Delayed-type hypersensitivity in mast cell-deficient mice: dependence on platelets for expression of contact sensitivity.
Geba GP, Ptak W, Anderson GM, Paliwal V, Ratzlaff RE, Levin J, Askenase PW. Delayed-type hypersensitivity in mast cell-deficient mice: dependence on platelets for expression of contact sensitivity. The Journal Of Immunology 1996, 157: 557-65. PMID: 8752902, DOI: 10.4049/jimmunol.157.2.557.Peer-Reviewed Original ResearchConceptsMast cell-deficient miceCell-deficient miceDelayed-type hypersensitivityContact sensitivityPlatelet depletionMast cellsCS responsesT cell-mediated immune responsesMast cell-deficient strainsDelayed-type hypersensitivity responseT cell-mediated responsesCell-mediated immune responsesTissue levelsCutaneous sensitivity responsesVasoactive amine serotoninCell-mediated responsesLocal mast cellsMast cell numbersNormal mast cell numbersHypersensitivity responseCutaneous responseImmunologic evidenceBeige miceImmune responseAmine serotoninThe Specificity and Orientation of a TCR to its Peptide–MHC Class II Ligands
Sant'Angelo D, Waterbury G, Preston-Hurlburt P, Yoon S, Medzhitov R, Hong S, Janeway C. The Specificity and Orientation of a TCR to its Peptide–MHC Class II Ligands. Immunity 1996, 4: 367-376. PMID: 8612131, DOI: 10.1016/s1074-7613(00)80250-2.Peer-Reviewed Original Research
1991
Signal requirements for the generation of CD4+ and CD8+ T-cell responses to human allogeneic microvascular endothelium.
Pardi R, Bender J. Signal requirements for the generation of CD4+ and CD8+ T-cell responses to human allogeneic microvascular endothelium. Circulation Research 1991, 69: 1269-1279. PMID: 1934357, DOI: 10.1161/01.res.69.5.1269.Peer-Reviewed Original ResearchConceptsT cell precursorsEndothelial cellsInterleukin-2T cellsT lymphocytesMicrovascular endotheliumT cell-mediated immune responsesMajor T cell subsetsSpecific cytotoxic T lymphocytesMonocyte/macrophage seriesMHC class II determinantsCD3/T cell receptor complexIndividual cell subsetsGeneration of CD4Effector T cellsClass II determinantsT cell responsesT cell subsetsAdoptive transfer experimentsAllogeneic endothelial cellsClass I determinantsSelf-MHC moleculesCytotoxic T lymphocytesMonocytes/macrophagesT cell receptor complex
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