2022
61. Clinical whole exome/whole transcriptome analysis detects clinically relevant structural alterations in Multiple Myeloma
Calvo M, Caruthers S, Tripodi J, Houldsworth J, Fink M, Newman S, Chen R, Zhang W, Liu L, Shi Y, Jun T, Onel K, Oh W, Edelmann L, Schadt E, Rossi M, Hantash F, Al-Kateb H. 61. Clinical whole exome/whole transcriptome analysis detects clinically relevant structural alterations in Multiple Myeloma. Cancer Genetics 2022, 268: 20. DOI: 10.1016/j.cancergen.2022.10.064.Peer-Reviewed Original ResearchChromosomal copy number alterationsMolecular alterationsManagement of patientsPlasma cell contentDeletion of 13qMM patientsRisk stratificationMultiple myelomaOverexpression of CCND1Bi-allelic inactivationCopy number alterationsPatientsRelevant alterationsMolecular analysisRNA expression analysisNumber alterationsBuccal swabsAlterationsStructural alterationsCell contentMost casesGene fusionsCD138MyelomaCasesAbnormal levels of mitochondrial Ca2+ channel proteins in plasma neuron‐derived extracellular vesicles of early schizophrenia
Goetzl EJ, Srihari VH, Mustapic M, Kapogiannis D, Heninger GR. Abnormal levels of mitochondrial Ca2+ channel proteins in plasma neuron‐derived extracellular vesicles of early schizophrenia. The FASEB Journal 2022, 36: e22466. PMID: 35867070, PMCID: PMC9358927, DOI: 10.1096/fj.202200792rr.Peer-Reviewed Original ResearchConceptsNeuron-derived extracellular vesiclesChannel proteinsExtracellular vesiclesGenome-wide association studiesMitochondrial ion channelsIon channel proteinsIndividual proteinsLeucine zipperAssociation studiesMitochondrial NaMitochondrial levelTransient receptor potential cation channelMitochondrial Ca2Ion channelsSequence studiesProteinMember B1Extracted proteinsCation channelsNeuronal functionΑ-1CMember 4Calcium homeostasisVesiclesStructural alterations
2020
Liver Matrix in Benign and Malignant Biliary Tract Disease
Fabris L, Cadamuro M, Cagnin S, Strazzabosco M, Gores G. Liver Matrix in Benign and Malignant Biliary Tract Disease. Seminars In Liver Disease 2020, 40: 282-297. PMID: 32162285, DOI: 10.1055/s-0040-1705109.Peer-Reviewed Original ResearchConceptsMalignant biliary tract diseasesBiliary tract diseaseExtracellular matrixReactive ductular cellsPro-oncogenic effectsHepatic progenitor cellsExtracellular matrix undergoesBiliary repairDuctular reactionTract diseaseBiliary damageMalignant transformationResident cellsDuctular cellsMain molecular factorsProgenitor cellsMolecular factorsMechanical signalsLiver matrixNoncollagenous glycoproteinsStructural alterationsDirect interactionBiochemical compositionCellsMultifunctional moleculesKetamine Normalizes the Structural Alterations of Inferior Frontal Gyrus in Depression
Dai D, Lacadie CM, Holmes SE, Cool R, Anticevic A, Averill C, Abdallah C, Esterlis I. Ketamine Normalizes the Structural Alterations of Inferior Frontal Gyrus in Depression. Chronic Stress 2020, 4: 2470547020980681. PMID: 33426409, PMCID: PMC7758564, DOI: 10.1177/2470547020980681.Peer-Reviewed Original ResearchMajor depressive disorderPost-traumatic stress disorderMagnetic resonance imagingAcute ketamine administrationKetamine administrationKetamine infusionMDD subjectsInferior frontal gyrusComorbid post-traumatic stress disorderPTSD groupAcute ketamine treatmentFrontal gyrusHealthy control subjectsIntravenous ketamine infusionRegional volume differencesImpact of ketamineSingle ketamine infusionStructural alterationsFuture therapeutic targetsVoxel-wise t-testsKetamine treatmentControl subjectsDepressive disorderHC groupPTSD subjects
2019
P1528The added value of cardiac magnetic resonance to the diagnosis of patients after aborted sudden cardiac death
Szabo L, Czimbalmos C, Dohy Z, Csecs I, Toth A, Suhai F, Becker D, Geller L, Merkely B, Vago H. P1528The added value of cardiac magnetic resonance to the diagnosis of patients after aborted sudden cardiac death. European Heart Journal 2019, 40: ehz748.0290. DOI: 10.1093/eurheartj/ehz748.0290.Peer-Reviewed Original ResearchCardiac magnetic resonance imagingNormal coronary angiographyLate gadolinium enhancementAborted sudden cardiac deathSudden cardiac deathCardiac magnetic resonance imaging examinationRight ventricular parametersCardiac magnetic resonanceCardiac deathVentricular parametersDiagnostic value of cardiac magnetic resonance imagingPrimary cause of sudden cardiac deathPresence of late gadolinium enhancementDiagnostic valueStructural myocardial abnormalitiesStructural myocardial alterationsCause of sudden cardiac deathLate gadolinium enhancement imagingTask Force criteriaDiagnosis of patientsCoronary artery diseaseStructural alterationsMagnetic resonance imagingConsecutive patientsLV dilatation
2013
Decreased food pleasure and disrupted satiety signals in chronic low back pain
Geha P, deAraujo I, Green B, Small DM. Decreased food pleasure and disrupted satiety signals in chronic low back pain. Pain 2013, 155: 712-722. PMID: 24384160, DOI: 10.1016/j.pain.2013.12.027.Peer-Reviewed Original ResearchConceptsChronic low back painCLBP patientsLow back painHealthy controlsBack painSugary drinksFat calorie intakeHedonic perceptionSatiety signalsCalorie intakePatientsIntake testFood pleasureFunctional brainAd libitumPotential mechanismsPainObesityIntakeStructural alterationsPhysiological mechanismsHedonic ratingsAlterationsDrinksSensory evaluation
2012
C-MET as a Novel Target for the Treatment of Renal Cell Carcinoma
Vankayala H, LoRusso P, Vaishampayan U. C-MET as a Novel Target for the Treatment of Renal Cell Carcinoma. 2012, 213-238. DOI: 10.1007/978-1-4614-2400-0_10.Peer-Reviewed Original ResearchDysregulation of METHepatocyte growth factor/scatter factorGrowth factor/scatter factorReceptor tyrosine kinasesHGF/SFGenetic programTyrosine kinaseEmbryo developmentPapillary renal carcinomaReceptor familyCell growthScatter factorNovel targetEpithelial cellsC-MetHuman malignanciesSignalingGermline mutationsStructural alterationsMisexpressionEmbryogenesisKinaseMutationsApoptosisRenal carcinoma
1998
Binding of the 60-kDa Ro autoantigen to Y RNAs: evidence for recognition in the major groove of a conserved helix.
Green C, Long K, Shi H, Wolin S. Binding of the 60-kDa Ro autoantigen to Y RNAs: evidence for recognition in the major groove of a conserved helix. RNA 1998, 4: 750-65. PMID: 9671049, PMCID: PMC1369656, DOI: 10.1017/s1355838298971667.Peer-Reviewed Original ResearchConceptsY RNAsSpecific base pairsRo proteinRRNA precursorConserved helixMajor grooveBase pairsSmall cytoplasmic RNAThree-nucleotide bulgeProtein side chainsProtein bindsCytoplasmic RNARNA sequencesProtein recognitionRNAXenopus oocytesProteinHelixRo autoantigenDistinct classesDiethyl pyrocarbonateProtein bindingStructural alterationsSide chainsDimethyl sulfate
1996
Functional and structural alterations with 24-hour myocardial hibernation and recovery after reperfusion. A pig model of myocardial hibernation.
Chen C, Chen L, Fallon J, Ma L, Li L, Bow L, Knibbs D, McKay R, Gillam L, Waters D. Functional and structural alterations with 24-hour myocardial hibernation and recovery after reperfusion. A pig model of myocardial hibernation. Circulation 1996, 94: 507-16. PMID: 8759096, DOI: 10.1161/01.cir.94.3.507.Peer-Reviewed Original ResearchConceptsRegional coronary flowMyocardial hibernationCoronary flowRegional wall thickeningWall thickeningPig modelShort-term myocardial hibernationRegional lactate productionRate-pressure productCoronary artery stenosisCoronary flow reductionAcute myocardial ischemiaUltrastructural changesLactate productionLocal metabolic changesModerate flow reductionShort-term hibernationRegional oxygen consumptionFlow reductionMyocardium undergoesLAD stenosisArtery stenosisLAD flowMyocardial infarctionStructural alterations
1990
Cytokine-endothelial interactions in inflammation, immunity, and vascular injury.
Cotran RS, Pober JS. Cytokine-endothelial interactions in inflammation, immunity, and vascular injury. Journal Of The American Society Of Nephrology 1990, 1: 225-35. PMID: 2104268, DOI: 10.1681/asn.v13225.Peer-Reviewed Original ResearchConceptsVascular injuryTumor necrosis factorEffects of cytokinesEndothelial adhesion moleculesLeukocyte-endothelial adhesionCytokine-induced activationSuch pathological processesSeptic shockNecrosis factorImmune responseInterleukin-1Shwartzman reactionAdhesion moleculesPathological processesCytokinesInjuryStructural alterationsBiological characteristicsPossible contributionVasculitisInflammationEndotheliumHypersensitivityImmunityImportant role
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