2025
Haptoglobin in pregnancy: Trimester-specific reference intervals
Rivera M, Choucair I, Vera M, Lee E, El-Khoury J, Villalba C. Haptoglobin in pregnancy: Trimester-specific reference intervals. American Journal Of Clinical Pathology 2025, aqaf012. PMID: 40037777, DOI: 10.1093/ajcp/aqaf012.Peer-Reviewed Original ResearchThird trimesterFirst-trimesterHaptoglobin valuesTrimester-specific reference intervalsReference intervalsRemnant serum samplesTrimester of pregnancyMann-Whitney testPregnancy patientsNonpregnant populationNonpregnant counterpartsImmunological markersIntravascular hemolysisTrimesterDecreased haptoglobinPregnancyPregnant individualsMann-WhitneyRoche Cobas 8000Nonparametric reference intervalsSerum samplesCobas 8000Quality improvement projectHemolysisPhysiological changesPrediction of Hepatitis C Virus Perinatal Transmission in Pregnant Individuals With Hepatitis C Virus Infection
Sandoval G, Saade G, Hughes B, Clifton R, Reddy U, Bartholomew A, Salazar A, Chien E, Tita A, Thorp J, Metz T, Wapner R, Sabharwal V, Simhan H, Swamy G, Heyborne K, Sibai B, Grobman W, El-Sayed Y, Casey B, Parry S, Macones G, Prasad M. Prediction of Hepatitis C Virus Perinatal Transmission in Pregnant Individuals With Hepatitis C Virus Infection. Obstetrics And Gynecology 2025, 145: 449-452. PMID: 40014859, PMCID: PMC11925659, DOI: 10.1097/aog.0000000000005872.Peer-Reviewed Original ResearchConceptsHepatitis C virus infectionPerinatal transmissionHepatitis C virusHepatitis C virus perinatal transmissionPregnant individualsEunice Kennedy Shriver National Institute of Child HealthTransmission of HCV infectionPerinatal transmission rateHCV RNA titersNeonatal follow-upC virus infectionPositive HCV antibodyMulticenter observational studyArea under the curveNational Institute of Child HealthInstitute of Child HealthAntibody-positive participantsAntepartum bleedingHCV infectionHCV antibodiesFollow-upRNA titersC virusObservational studyClinical counselingRadon Exposure and Gestational Diabetes
Zhang Y, Angley M, Lu L, Smith B, Grobman W, Wylie B, Zork N, D’Alton M, McNeil B, Mercer B, Silver R, Simhan H, Haas D, Saade G, Parry S, Reddy U, Kahe K. Radon Exposure and Gestational Diabetes. JAMA Network Open 2025, 8: e2454319. PMID: 39792382, PMCID: PMC11724344, DOI: 10.1001/jamanetworkopen.2024.54319.Peer-Reviewed Original ResearchConceptsRadon exposureGestational diabetesCohort studyPopulation-based cohort studyPregnant individualsMedical record abstractionNulliparous Pregnancy Outcomes StudyMultiple logistic regression modelsMonitoring Mothers-to-BeAssociated with greater oddsUS clinical centersMothers-to-beRadon exposure assessmentLogistic regression modelsEnvironmental risk factorsPregnancy Outcomes StudyStatistically significant interactionRecord abstractionImprove pregnancy outcomesMain OutcomesPM2.5 levelsHigher oddsPotential confoundersSmoking statusPregnant participantsPerspectives of the Obstetric Care Environment for Pregnant Individuals Who Have an Opioid Use Disorder
Girasulo S, Maltz C, Weichert M, Kaufman J, Mele A, Hunkele K, Yonkers K, Byatt N, Forray A. Perspectives of the Obstetric Care Environment for Pregnant Individuals Who Have an Opioid Use Disorder. Women's Health Reports 2025, 6: 155-160. PMID: 40130033, PMCID: PMC11931102, DOI: 10.1089/whr.2024.0142.Peer-Reviewed Original ResearchOpioid use disorderObstetric cliniciansCare environmentPregnant individualsPerinatal careUse disorderTrauma-informed carePerinatal care teamLong waiting timesCare teamAccessing careBarriers patientsProvider educationQuality of communicationPeer supportReduce barriersIncreased satisfactionSupport servicesCareInformant interviewsContent analysisMOUDTreatment programsCliniciansParticipants
2024
Association of neighborhood-level socioeconomic disadvantage and Life's Essential 8 in early pregnancy
Venkatesh K, Grobman W, Huang X, Yee L, Catov J, Simhan H, Haas D, Mercer B, Reddy U, Silver R, Levine L, Chung J, Saade G, Greenland P, Merz C, McNeil B, Khan S. Association of neighborhood-level socioeconomic disadvantage and Life's Essential 8 in early pregnancy. American Journal Of Preventive Cardiology 2024, 21: 100925. PMID: 39838971, PMCID: PMC11750432, DOI: 10.1016/j.ajpc.2024.100925.Peer-Reviewed Original ResearchNeighborhood-level socioeconomic disadvantageArea Deprivation IndexLife's Essential 8Socioeconomic disadvantageMaternal cardiovascular healthCardiovascular healthLife's Essential 8 scoreGreater socioeconomic disadvantageEssential 8Cross-sectional analysisBody mass indexPhysical activityDeprivation indexNulliparous individualsDiet qualityHealth StudyEarly pregnancyTobacco useLess-disadvantagedContinuous scoresMaternal ageMass indexPregnant individualsSleep quantityBlood pressureCharacterization of blood bank and transfusion medicine practices for pregnant individuals with fetuses at risk of hemolytic disease in the United States
Jacobs J, Booth G, Moise K, Adkins B, Bakhtary S, Fasano R, Goel R, Hinton H, Laghari S, Stephens L, Tormey C, Crowe E, Bloch E, Abels E. Characterization of blood bank and transfusion medicine practices for pregnant individuals with fetuses at risk of hemolytic disease in the United States. Transfusion 2024, 64: 1870-1880. PMID: 39248602, DOI: 10.1111/trf.18011.Peer-Reviewed Original ResearchRisk of HDFNAntigen testAntibody titersHemolytic diseaseRed blood cellsCell-free fetal DNA testingRisk of hemolytic diseaseCell-free fetal DNAMaternal antibody titersPregnant individualsFetal DNA testingBlood banksTransfusion medicine practiceFetal DNALaboratory testing practicesThird trimesterAntigen statusTransfusion medicine serviceAntigen resultsMedicine serviceFetusesHDFNCritical titerResponse rateDNA testingIntegrated Strategies to Support Diabetes Technology in Pregnancy
Nally L, Blanchette J. Integrated Strategies to Support Diabetes Technology in Pregnancy. Obstetrics And Gynecology 2024, 144: 599-607. PMID: 39208437, PMCID: PMC11486578, DOI: 10.1097/aog.0000000000005710.Peer-Reviewed Original ResearchDiabetes technologyImprove diabetes careQuality of lifeImprove glycemic outcomesDiabetes careBenefits of continuous glucose monitoringManaging diabetesPregnant individualsAutomated insulin delivery systemsConstant diligenceGlycemic outcomesWell-beingType 1 diabetesPregnancyDiabetesContinuous glucose monitoringGlucose monitoringRegulatory approvalCannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function
Metz T, Allshouse A, McMillin G, Greene T, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Silver R. Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function. Obstetric Anesthesia Digest 2024, 44: 139-140. DOI: 10.1097/01.aoa.0001026572.72882.bd.Peer-Reviewed Original ResearchExposure to cannabisCannabis usePlacental functionPregnancy outcomesPrevalence of cannabis usePoor fetal growthAdverse pregnancy outcomesInfluence pregnancy outcomePlacental dysfunctionCannabis exposureFetal growthPregnant individualsSelf-reported useTobacco useCannabisDrug usePregnancyOutcome relationsPotential legal consequencesOutcomesAssociationExposureUseDysfunctionPublished researchDiet quality, community food access, and glycemic control among nulliparous individuals with diabetes
Venkatesh K, Yee L, Wu J, Joseph J, Garner J, McNeil R, Scifres C, Mercer B, Reddy U, Silver R, Saade G, Parry S, Simhan H, Post R, Walker D, Grobman W. Diet quality, community food access, and glycemic control among nulliparous individuals with diabetes. Primary Care Diabetes 2024, 18: 506-510. PMID: 38972826, DOI: 10.1016/j.pcd.2024.06.011.Peer-Reviewed Original ResearchNonadjuvanted Bivalent Respiratory Syncytial Virus Vaccination and Perinatal Outcomes
Son M, Riley L, Staniczenko A, Cron J, Yen S, Thomas C, Sholle E, Osborne L, Lipkind H. Nonadjuvanted Bivalent Respiratory Syncytial Virus Vaccination and Perinatal Outcomes. JAMA Network Open 2024, 7: e2419268. PMID: 38976271, PMCID: PMC11231799, DOI: 10.1001/jamanetworkopen.2024.19268.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusNeonatal intensive care unitPreterm birthWeeks gestationRisk of HDPPerinatal outcomesLogistic regression modelsIncreased riskPregnant individualsPrenatal vaccinationSmall-for-gestational age birth weightNeonatal intensive care unit admissionCohort studyIncreased risk of PTBOdds ratioIncreased risk of HDPRisk of preterm birthRespiratory syncytial virus seasonRespiratory syncytial virus vaccineRetrospective observational cohort studyNeonatal respiratory distressVaccination statusMultivariate logistic regression modelObservational cohort studyCox regression modelsPrediction of metabolic syndrome following a first pregnancy
Kawakita T, Greenland P, Pemberton V, Grobman W, Silver R, Bairey Merz C, McNeil R, Haas D, Reddy U, Simhan H, Saade G. Prediction of metabolic syndrome following a first pregnancy. American Journal Of Obstetrics And Gynecology 2024, 231: 649.e1-649.e19. PMID: 38527600, PMCID: PMC11424779, DOI: 10.1016/j.ajog.2024.03.031.Peer-Reviewed Original ResearchDevelopment of metabolic syndromeArea under the receiver operating characteristic curveMetabolic syndromeNational Cholesterol Education Program Adult Treatment Panel III criteriaAdult Treatment Panel III criteriaPrevalence of metabolic syndromePrediction of metabolic syndromeProspective cohort studyIn-personSecondary analysisCohort studyIII criteriaInclusion criteriaPregnant individualsPrimary outcomeReceiver operating characteristic curveVisit 2Regression modelsPregnancySyndromeDeliveryUnited StatesCharacteristic curveLASSO regression modelYearsThe Cost of Developing and Implementing an Antepartum Referral Program for Penicillin Allergy Evaluation at a Single Academic Tertiary Care Hospital
Burn M, Xu X, Kwah J, Liao J, Son M. The Cost of Developing and Implementing an Antepartum Referral Program for Penicillin Allergy Evaluation at a Single Academic Tertiary Care Hospital. American Journal Of Perinatology 2024, 41: 1290-1297. PMID: 38423122, DOI: 10.1055/a-2278-9279.Peer-Reviewed Original ResearchCost of careReferral programLong-term cost benefitsPenicillin allergyAntibiotic costsAntibiotic stewardshipPregnant individualsProgram developmentAcademic tertiary care hospitalCompare costs of carePenicillin allergy evaluationShort-term costsTertiary care hospitalDelivery hospitalizationsResource utilization dataNo significant differenceNonreferred patientsCare hospitalUtilization dataAllergy evaluationBivariate testsStudy groupEducational initiativesPregnancy periodProgram costsThrombosis risk with haemoglobin C trait and haemoglobin C disease: A systematic review
Jacobs J, Sharma D, Stephens L, Villalba C, Rinder H, Woo J, Wheeler A, Gerberi D, Goel R, Tormey C, Booth G, Bloch E, Adkins B. Thrombosis risk with haemoglobin C trait and haemoglobin C disease: A systematic review. British Journal Of Haematology 2024, 204: 1500-1506. PMID: 38291731, DOI: 10.1111/bjh.19313.Peer-Reviewed Original ResearchRisk of thrombosisHemoglobin C traitHemoglobin C diseaseVenous thromboembolismC diseaseIncreased risk of thrombosisProspective cohort studyFactor to thrombosisAssessment of patientsCohort studySystematic reviewInclusion criteriaPregnant individualsThrombotic riskCase seriesCase reportVTE riskChronic haemolysisSystematic literature reviewArterial thrombosisThrombosis riskHigh blood viscosityIncreased riskThrombosisC traitMaternal and Newborn Outcomes of SARS-CoV-2/COVID-19 and Pregnancy: Parallels and Contrasts with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome
Li D, Zhang J, Zhang X, Chang Y, Vermund S. Maternal and Newborn Outcomes of SARS-CoV-2/COVID-19 and Pregnancy: Parallels and Contrasts with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome. Medical Research Archives 2024, 12: 10.18103/mra.v12i4.5205. PMID: 39118854, PMCID: PMC11309002, DOI: 10.18103/mra.v12i4.5205.Peer-Reviewed Original ResearchHuman immunodeficiency virus/acquired immunodeficiency syndromeHuman immunodeficiency virusHuman immunodeficiency virus-infected womenAdherence to antiretroviral therapyNeonatal outcomesImmunodeficiency virusImmunodeficiency syndromeIntensive care unitAntiretroviral therapySARS-CoV-2Maternal mortalityRisk of mother-to-child transmissionVertical transmissionVertical transmission of human immunodeficiency virusClinical managementTransmission of human immunodeficiency virusImpact of human immunodeficiency virusIncreased risk of maternal mortalityHuman immunodeficiency virus controlPoor adherence to antiretroviral therapySARS-CoV-2 vertical transmissionVertical transmission of SARS-CoV-2Pregnant individualsMother-to-child transmissionNeonatal intensive care unit
2023
Vector-borne disease, climate change and perinatal health
Oberlin A, Wylie B. Vector-borne disease, climate change and perinatal health. Seminars In Perinatology 2023, 47: 151841. PMID: 37852894, DOI: 10.1016/j.semperi.2023.151841.Peer-Reviewed Original ResearchNeighborhood Socioeconomic Disadvantage and Abnormal Birth Weight
Venkatesh K, Yee L, Johnson J, Wu J, McNeil B, Mercer B, Simhan H, Reddy U, Silver R, Parry S, Saade G, Chung J, Wapner R, Lynch C, Grobman W. Neighborhood Socioeconomic Disadvantage and Abnormal Birth Weight. Obstetrics And Gynecology 2023, 142: 1199-1207. PMID: 37769319, PMCID: PMC10972636, DOI: 10.1097/aog.0000000000005384.Peer-Reviewed Original ResearchAbnormal birth weightNeighborhood socioeconomic disadvantageGestational ageBirth weightPregnant individualsADI quartileIncreased oddsSocioeconomic disadvantageWeeks of gestationPotential confounding variablesLogistic regression modelsHigher area deprivationSGA neonatesLGA neonatesMultinomial logistic regression modelsSingleton gestationsCohort enrollmentAnalytic populationParticipant's addressFetal sexConfounding variablesSecondary analysisArea deprivationNeonatesQuartileAssociation of Living in a Food Desert and Poor Periconceptional Diet Quality in a Cohort of Nulliparous Pregnant Individuals
Venkatesh K, Walker D, Yee L, Wu J, Garner J, McNeil B, Haas D, Mercer B, Reddy U, Silver R, Wapner R, Saade G, Parry S, Simhan H, Lindsay K, Grobman W. Association of Living in a Food Desert and Poor Periconceptional Diet Quality in a Cohort of Nulliparous Pregnant Individuals. Journal Of Nutrition 2023, 153: 2432-2441. PMID: 37364682, PMCID: PMC10447609, DOI: 10.1016/j.tjnut.2023.06.032.Peer-Reviewed Original ResearchConceptsDiet qualityPregnant individualsDietary qualityNulliparous Pregnancy Outcomes StudyWorse dietary qualityAdverse pregnancy outcomesHealthy Eating IndexPregnancy Outcomes StudyAdverse social determinantsFood desertsPregnancy outcomesProspective cohortTotal vegetablesMean HEIMonitoring MothersLowest quartileOutcome studiesPoor dietExcess intakeEmpty caloriesSocial determinantsAdequacy componentsAssessed individualsSupermarket accessFood access indicatorsPregnant Patients with a Documented History of Penicillin Allergy and Associated Maternal and Neonatal Outcomes at a Tertiary Care Center
Azmy V, Lundsberg L, Culhane J, Kwah J, Partridge C, Son M. Pregnant Patients with a Documented History of Penicillin Allergy and Associated Maternal and Neonatal Outcomes at a Tertiary Care Center. American Journal Of Perinatology 2023, 41: e2051-e2057. PMID: 37211008, DOI: 10.1055/a-2096-5002.Peer-Reviewed Original ResearchPenicillin allergy historyNon-β-lactam antibioticsPenicillin allergyNeonatal outcomesPregnant patientsAllergy historyPregnant individualsElectronic medical recordsMedical recordsMultivariable analysisPostpartum endometritisHigh riskLactam antibioticsSignificant differencesBad obstetric outcomeRetrospective cohort studyTertiary care centerPostnatal hospital stayWeeks of gestationLarge academic hospitalAssociated maternalEligible deliveriesHospital stayMaternal outcomesObstetric outcomesAntibiotic choice for Group B Streptococcus prophylaxis in mothers with reported penicillin allergy and associated newborn outcomes
Snider J, Mithal L, Kwah J, Rhodes N, Son M. Antibiotic choice for Group B Streptococcus prophylaxis in mothers with reported penicillin allergy and associated newborn outcomes. BMC Pregnancy And Childbirth 2023, 23: 400. PMID: 37254067, PMCID: PMC10228028, DOI: 10.1186/s12884-023-05697-0.Peer-Reviewed Original ResearchConceptsGroup B streptococcus prophylaxisReported penicillin allergyPenicillin allergyGBS prophylaxisLab drawsNeonatal outcomesNewborn outcomesAntibiotic administrationMedical recordsPregnant individualsIntrapartum group B streptococcus prophylaxisNeonatal intensive care unit admissionDesignThis retrospective cohort studyIntensive care unit admissionSelf-reported penicillin allergyNeonates of mothersCare unit admissionIntrapartum antibiotic prophylaxisRetrospective cohort studyWeeks of gestationMother-infant pairsMother-infant dyadsBeta-lactam antibioticsAntibiotic prophylaxisUnit admissionAssociation of Neighborhood Socioeconomic Disadvantage and Postpartum Readmission
Meiman J, Grobman W, Haas D, Yee L, Wu J, McNeil B, Wu J, Mercer B, Simhan H, Reddy U, Silver R, Parry S, Saade G, Lynch C, Venkatesh K. Association of Neighborhood Socioeconomic Disadvantage and Postpartum Readmission. Obstetrics And Gynecology 2023, 141: 967-970. PMID: 37026732, PMCID: PMC10147577, DOI: 10.1097/aog.0000000000005151.Peer-Reviewed Original ResearchConceptsArea Deprivation IndexPostpartum readmissionNeighborhood socioeconomic disadvantageNeighbourhood deprivationSocioeconomic disadvantageWeeks of deliveryAdverse social determinantsProspective cohortPostpartum careDelivery dischargePregnant individualsReadmissionPoisson regressionSecondary analysisSocial determinantsDeprivation indexAssessed individualsRiskDeprivationIndividualsPostpartumCohortQuartileWeeksCare
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