2025
Pain During Cesarean Delivery: We Can and Must Do Better
Zakowski M, Fardelmann K, Hofkamp M. Pain During Cesarean Delivery: We Can and Must Do Better. Obstetric Anesthesia Digest 2025, 45: 5-5. DOI: 10.1097/01.aoa.0001097496.37736.42.Peer-Reviewed Original ResearchUrology on a changing planet: links between climate change and urological disease
Cole A, Qian Z, Gupta N, Leapman M, Zurl H, Trinh Q, Sherman J, Loeb S, Iyer H. Urology on a changing planet: links between climate change and urological disease. Nature Reviews Urology 2025, 1-15. PMID: 39875561, DOI: 10.1038/s41585-024-00979-4.Peer-Reviewed Original ResearchCare deliveryHealth care delivery strategiesCancer care deliveryCare delivery strategiesHealth care deliveryLow-value careResource-intensive interventionsEnvironmental risk factorsCare providersIntensive longitudinal assessmentCancer diagnosisPlanetary healthRisk factorsDownstream outcomesLongitudinal assessmentHealthNext stepsUrological cancersImpacts of climate-related disastersClimate changeUrological diseasesDeliveryCareProvidersTelemedicine
2024
Labor and delivery unit practices and racial and ethnic disparities in severe maternal and neonatal morbidity among nulliparous individuals with low-risk pregnancies
Leonard S, Xu X, Davies-Balch S, Main E, Bateman B, Rehkopf D, Lee H, Illuzzi J, Igbinosa I, Iwekaogwu I, Lyell D. Labor and delivery unit practices and racial and ethnic disparities in severe maternal and neonatal morbidity among nulliparous individuals with low-risk pregnancies. American Journal Of Epidemiology 2024, kwae459. PMID: 39691947, DOI: 10.1093/aje/kwae459.Peer-Reviewed Original ResearchLow-risk pregnanciesEthnic disparitiesUnit practicesAI/AN individualsNulliparous individualsNeonatal morbidityDisparity measuresAlaska NativesDelivery unitLatino individualsSevere neonatal morbidityWhite individualsLatent class analysisG-estimationSurvey responsesDisparitiesHospitalClass analysisMorbidityDeliveryIndividualsPracticeBirthPregnancyAI/ANBiodistribution of Polymeric Nanoparticles following in utero Delivery to a Nonhuman Primate
Eaton D, Lynn A, Surprenant J, Deschenes E, Guerra M, Rivero R, Yung N, O'Connor M, Glazer P, Bahtiyar M, Saltzman W, Stitelman D. Biodistribution of Polymeric Nanoparticles following in utero Delivery to a Nonhuman Primate. Biomedicine Hub 2024, 10: 543138. PMID: 39845408, PMCID: PMC11753793, DOI: 10.1159/000543138.Peer-Reviewed Original ResearchMonogenic diseasesNon-human primatesBiodistribution of polymeric nanoparticlesPreclinical mouse modelsStem cell populationFetal liverFetal malesSystemic deliveryFetal bonesAccumulation of NPIn-uteroMid-gestationNP accumulationBiodistribution studiesPolymeric NPsTherapeutic accessCell populationsMaternal tissuesZone of proliferationPolymeric nanoparticlesDiseaseBirthMiceDeliveryBiodistributionThe Use of Automated Insulin Delivery around Physical Activity and Exercise in Type 1 Diabetes: A Position Statement of the European Association for the Study of Diabetes (EASD) and the International Society for Pediatric and Adolescent Diabetes (ISPAD)
Moser O, Zaharieva D, Adolfsson P, Battelino T, Bracken R, Buckingham B, Danne T, Davis E, Dovc K, Forlenza G, Gillard P, Hofer S, Hovorka R, Jacobs P, Mader J, Mathieu C, Nørgaard K, Oliver N, O’Neal D, Pemberton J, Rabasa-Lhoret R, Sherr J, Sourij H, Tauschmann M, Yardley J, Riddell M. The Use of Automated Insulin Delivery around Physical Activity and Exercise in Type 1 Diabetes: A Position Statement of the European Association for the Study of Diabetes (EASD) and the International Society for Pediatric and Adolescent Diabetes (ISPAD). Hormone Research In Paediatrics 2024, 1-28. PMID: 39657609, DOI: 10.1159/000542287.Peer-Reviewed Original ResearchEuropean Association for the Study of DiabetesPhysical activityInternational Society for Pediatric and Adolescent DiabetesType 1 diabetesRegular physical activityPosition statementDiabetes careStudy of DiabetesClinical practice pointsResponse to PAManaged PAsEuropean Association for the StudyHealth benefitsAge groupsExerciseAdolescent DiabetesAutomated insulin deliveryDiabetesInsulin deliveryGlucose target rangeTherapy optionsClinical trialsDeliveryGlucose levelsGlucose fluctuationsThe use of automated insulin delivery around physical activity and exercise in type 1 diabetes: a position statement of the European Association for the Study of Diabetes (EASD) and the International Society for Pediatric and Adolescent Diabetes (ISPAD)
Moser O, Zaharieva D, Adolfsson P, Battelino T, Bracken R, Buckingham B, Danne T, Davis E, Dovč K, Forlenza G, Gillard P, Hofer S, Hovorka R, Jacobs P, Mader J, Mathieu C, Nørgaard K, Oliver N, O’Neal D, Pemberton J, Rabasa-Lhoret R, Sherr J, Sourij H, Tauschmann M, Yardley J, Riddell M. The use of automated insulin delivery around physical activity and exercise in type 1 diabetes: a position statement of the European Association for the Study of Diabetes (EASD) and the International Society for Pediatric and Adolescent Diabetes (ISPAD). Diabetologia 2024, 68: 255-280. PMID: 39653802, PMCID: PMC11732933, DOI: 10.1007/s00125-024-06308-z.Peer-Reviewed Original ResearchConceptsEuropean Association for the Study of DiabetesPhysical activityInternational Society for Pediatric and Adolescent DiabetesType 1 diabetesRegular physical activityPosition statementDiabetes careStudy of DiabetesClinical practice pointsResponse to PAManaged PAsEuropean Association for the StudyHealth benefitsAge groupsExerciseAdolescent DiabetesAutomated insulin deliveryDiabetesInsulin deliveryGlucose target rangeTherapy optionsClinical trialsDeliveryGlucose levelsCareArtificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy
Witten J, Raji I, Manan R, Beyer E, Bartlett S, Tang Y, Ebadi M, Lei J, Nguyen D, Oladimeji F, Jiang A, MacDonald E, Hu Y, Mughal H, Self A, Collins E, Yan Z, Engelhardt J, Langer R, Anderson D. Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy. Nature Biotechnology 2024, 1-10. PMID: 39658727, DOI: 10.1038/s41587-024-02490-y.Peer-Reviewed Original ResearchLipid nanoparticlesMRNA deliveryIonizable lipidsImprove nanoparticle deliveryPulmonary gene therapyDelivery in vitroNucleic acid deliveryNeural networkGene therapyNasal mucosaNanoparticle deliveryMouse lungFerret lungsAcid deliveryMouse muscleMessage-passing neural networkDelivery technologiesIn vivoLipid designLungMiceDeliveryDeep learningMRNALipidImpact of electronic health record updates and changes on the delivery and monitoring of interventions in embedded pragmatic clinical trials
Marsolo K, Cheville A, Melnick E, Jarvik J, Simon G, Sluka K, Crofford L, Staman K, Richesson R, Schlaeger J, Curtis L. Impact of electronic health record updates and changes on the delivery and monitoring of interventions in embedded pragmatic clinical trials. Contemporary Clinical Trials 2024, 148: 107744. PMID: 39561918, PMCID: PMC11831575, DOI: 10.1016/j.cct.2024.107744.Peer-Reviewed Original ResearchElectronic health record systemsElectronic health recordsPragmatic clinical trialsElectronic health record platformsDelivery of interventionsHealth recordsTrial interventionMonitoring of interventionsRecord updatesStudy teamMonitoring outcomesClinical trialsInterventionLocal implementationTechnological evolutionTeamDynamic natureTrialsDeliveryCase exampleSystemAccuracy of Spanish and English-generated ChatGPT responses to commonly asked patient questions about labor epidurals: a survey-based study among bilingual obstetric anesthesia experts
Gonzalez Fiol A, Mootz A, He Z, Delgado C, Ortiz V, Reale S. Accuracy of Spanish and English-generated ChatGPT responses to commonly asked patient questions about labor epidurals: a survey-based study among bilingual obstetric anesthesia experts. International Journal Of Obstetric Anesthesia 2024, 61: 104290. PMID: 39579604, DOI: 10.1016/j.ijoa.2024.104290.Peer-Reviewed Original ResearchLabor epiduralsNon-English-speaking patientsMode of deliveryHealth inequalitiesLabor courseCesarean deliveryObstetric anesthesiologistPatient questionsSurvey-based studyMedian scoreMedical adviceAnesthesia expertsEpiduralsLikert scaleEnglishLanguage modelEnglish answersPerpetuate misinformationPatientsLanguageSpanishScoresAccuracy scoresDeliveryQuestionsBurden of non-communicable diseases due to population ageing in China: challenges to healthcare delivery and long term care services
Lv Y, Fan L, Zhou J, Ding E, Shen J, Tang S, He Y, Shi X. Burden of non-communicable diseases due to population ageing in China: challenges to healthcare delivery and long term care services. The BMJ 2024, 387: e076529. PMID: 39424307, PMCID: PMC11484826, DOI: 10.1136/bmj-2023-076529.Peer-Reviewed Original ResearchScaleable production of highly loaded protein nanoparticles for immune modulation
Caplan M, Baldwin R, Yin X, Grishin A, Eisenbarth S, Sampson H, Bottomly K, Prud’homme R. Scaleable production of highly loaded protein nanoparticles for immune modulation. Communications Materials 2024, 5: 191. DOI: 10.1038/s43246-024-00626-w.Peer-Reviewed Original ResearchAdjuvants to antigen-presenting cellsImmune modulationAntigen-presenting cellsMurine immune systemImmune system cellsPeanut-allergic patientsDesensitizer applicationPLG nanoparticlesAntigen deliverySystemic exposurePoly(lactide-co-glycolideBasophil activationClinical investigationAllergic responsesImmune systemSystem cellsProtein antigensClinical applicationDelivery of proteinsE. coli phospholipidsSafety evidenceAntigenProtein nanoparticlesDeliveryCellsIntubation and Lower Saturation in the Delivery Room are Associated with Balloon Atrial Septostomy in Neonates with Transposition of the Great Arteries
Niccum M, Kesman R, Ades A, Bostwick A, Dombroski M, Flohr S, Foglia E, Mathew L, O'Byrne M, Ordonez M, Reynolds T, Rintoul N, Rome J, Rychik J, Shillingford A, Naim M. Intubation and Lower Saturation in the Delivery Room are Associated with Balloon Atrial Septostomy in Neonates with Transposition of the Great Arteries. The Journal Of Pediatrics 2024, 275: 114222. PMID: 39097264, DOI: 10.1016/j.jpeds.2024.114222.Peer-Reviewed Original ResearchBalloon atrial septostomyMaximum oxygen saturationDelivery roomOxygen saturationGreat arteriesAtrial septostomyArterial switch operationReceiver operating characteristic analysisProportion of intubationsRetrospective cohort studyArea under the curveLowest oxygen saturationCharacteristics of patientsNewborn admissionsCohort studyPatientsIntubationSeptostomyCharacteristic analysisArteryDeliveryMinutesNeonatesPrenatallyTransposition326-OR: Activity Feature Attenuates Drop in Glucose for Individuals with Type 1 Diabetes Using Omnipod 5 Automated Insulin Delivery System
TURNER L, SHERR J, ZAHARIEVA D, BARAN J, BODE B, BROWN S, BZDICK S, MEI CHURCH M, HANSEN D, KINGMAN R, LAFFEL L, SHAH V, STONE S, VIENNEAU T, HUYETT L, DUMAIS B, LY T, RIDDELL M, 5 EXERCISE RESEARCH GROUP O. 326-OR: Activity Feature Attenuates Drop in Glucose for Individuals with Type 1 Diabetes Using Omnipod 5 Automated Insulin Delivery System. Diabetes 2024, 73 DOI: 10.2337/db24-326-or.Peer-Reviewed Original ResearchGeneralized estimating equationsInternational Society for Pediatric and Adolescent DiabetesActivity sessionsEstimating equationsType 1 diabetesExerciseAdolescent DiabetesAF-30Glucose declineDeliveryInsulin deliveryInsuletSessionsDelivery systemInsulin delivery systemsDiabetesAutomated deliveryOmnipodRiskGlucoseT1DPeoplePositioning humility within healthcare delivery - From doctors’ and nurses’ perspectives
Michalec B, Cuddy M, Felix K, Gur-Arie R, Tilburt J, Hafferty F. Positioning humility within healthcare delivery - From doctors’ and nurses’ perspectives. Human Factors In Healthcare 2024, 5: 100061. DOI: 10.1016/j.hfh.2023.100061.Peer-Reviewed Original ResearchAssociation Between Hypertensive Disorders of Pregnancy and Cardiovascular Diseases Within 24 Months After Delivery
Ackerman-Banks C, Lipkind H, Palmsten K, Ahrens K. Association Between Hypertensive Disorders of Pregnancy and Cardiovascular Diseases Within 24 Months After Delivery. Obstetric Anesthesia Digest 2024, 44: 72-73. DOI: 10.1097/01.aoa.0001015964.97203.7e.Peer-Reviewed Original ResearchHypertensive disease of pregnancyIncreased risk of long-term morbidityHypertensive disorders of pregnancyRisk of long-term morbidityDisease of pregnancyDisorders of pregnancyLong-term morbidityImmediate postpartum periodCardiovascular diagnosisHypertensive disordersIncreased riskPostpartum periodHypertensive diseaseCardiovascular diseaseCVD outcomesRisk profilePregnancyMonthsDiagnosisRiskDeliveryAssociationMorbidityPrenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery
Rivero R, Stitelman D. Prenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery. Current Stem Cell Reports 2024, 10: 51-57. DOI: 10.1007/s40778-024-00237-8.Peer-Reviewed Original ResearchCongenital diaphragmatic herniaDiaphragmatic herniaAnimal modelsIntra-amniotic injectionLong-term functional outcomeParticle-based deliveryFetal therapyPrenatal therapySpinal defectsTarget specific tissuesCo-morbiditiesCongenital diseaseFunctional outcomesTreatment deliveryStructural diseaseClinical translationMyelomeningoceleTherapyHerniaSpecific tissuesTissueDiseaseDeliveryPrenatallyParticle deliveryPilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation
Grun M, Honhar P, Wang Y, Rossano S, Khang M, Suh H, Fowles K, Kliman H, Cavaliere A, Carson R, Marquez‐Nostra B, Saltzman W. Pilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation. Bioengineering & Translational Medicine 2024, 9: e10661. PMID: 39553429, PMCID: PMC11561825, DOI: 10.1002/btm2.10661.Peer-Reviewed Original ResearchVaginal dosage formsBioadhesive nanoparticlesCynomolgus monkeysAnalysis of inflammatory biomarkersVaginal microbicidesVaginal canalMultiple dosesInflammatory biomarkersTherapeutic efficacyVaginal fluidSystemic circulationLong-term deliveryNoninvasive imagingClinical translationDosage formsNon-human primatesDelivery vehiclesMonkeysDeliveryVaginitisUterusMicrobicidesSafety evaluationBiodistributionDoseThe Necessity of Type and Screen Result Prior to Proceeding to Operating Room for Scheduled Cesarean Delivery in a Low Hemorrhage Risk Population [ID 2683392]
Hoffmann E, Druyan B, Fletcher M, Ridore M, Paidas M, Toledo P. The Necessity of Type and Screen Result Prior to Proceeding to Operating Room for Scheduled Cesarean Delivery in a Low Hemorrhage Risk Population [ID 2683392]. Obstetrics And Gynecology 2024, 143: 52s-53s. DOI: 10.1097/01.aog.0001013676.39387.ba.Peer-Reviewed Original ResearchScheduled cesarean deliveryCesarean deliveryBlood transfusionHemorrhage scoreOperating roomIRB-approved retrospective cohort studyTime of blood transfusionTransfused intra-operativelyRetrospective cohort studyChart reviewIntra-operativelyPhysician dissatisfactionCohort studyTransfusionRisk populationPatientsOR delaysBloodScreening resultsScoresMandatory typeDeliveryFinancial ramificationsScreeningHemorrhageThe Technical and Ethical Framework of Fetal Therapy: Past and Current Advances
Lynn A, Glazer P, Saltzman W, Stitelman D. The Technical and Ethical Framework of Fetal Therapy: Past and Current Advances. Current Stem Cell Reports 2024, 10: 30-36. DOI: 10.1007/s40778-024-00235-w.Peer-Reviewed Original ResearchFetal drug deliverySuccess of nanomedicineDrug deliveryPharmacological drug treatmentsMinimally invasive strategyFetal therapyFetal applicationsClinical studiesCongenital diseaseInvasive strategyDrug treatmentClinical translationClinical practiceTherapyMedical interventionsDeliveryFetalNanomedicineBirthDiseaseFindingsACliniciansPrediction of metabolic syndrome following a first pregnancy
Kawakita T, Greenland P, Pemberton V, Grobman W, Silver R, Bairey Merz C, McNeil R, Haas D, Reddy U, Simhan H, Saade G. Prediction of metabolic syndrome following a first pregnancy. American Journal Of Obstetrics And Gynecology 2024, 231: 649.e1-649.e19. PMID: 38527600, PMCID: PMC11424779, DOI: 10.1016/j.ajog.2024.03.031.Peer-Reviewed Original ResearchDevelopment of metabolic syndromeArea under the receiver operating characteristic curveMetabolic syndromeNational Cholesterol Education Program Adult Treatment Panel III criteriaAdult Treatment Panel III criteriaPrevalence of metabolic syndromePrediction of metabolic syndromeProspective cohort studyIn-personSecondary analysisCohort studyIII criteriaInclusion criteriaPregnant individualsPrimary outcomeReceiver operating characteristic curveVisit 2Regression modelsPregnancySyndromeDeliveryUnited StatesCharacteristic curveLASSO regression modelYears
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply