2025
The metabolic and cardiovascular effects of amphetamine are partially mediated by the central melanocortin system
Simonds S, Pryor J, Lam B, Dowsett G, Mustafa T, Munder A, Elysee K, Balland E, Cowley L, Yeo G, Lawrence A, Spanswick D, Cowley M. The metabolic and cardiovascular effects of amphetamine are partially mediated by the central melanocortin system. Cell Reports Medicine 2025, 6: 101936. PMID: 39914386, PMCID: PMC11866487, DOI: 10.1016/j.xcrm.2025.101936.Peer-Reviewed Original ResearchConceptsEffects of amphetamineCentral melanocortin systemCardiovascular effectsMelanocortin systemFood intakeInhibition of POMC neuronsAMPH-induced anorexiaMelanocortin 4 receptor-deficientNoradrenergic neurotransmitter systemsHeart rateBrown adipose tissueElevated blood pressureBody weightNoradrenergic inhibitionPOMC neuronsAMPH-inducedSerotonergic activityPresynaptic mechanismsNeurotransmitter systemsMC4R pathwayAmphetamineBlood pressureCardiovascular functionIncreased brown adipose tissueAdipose tissueOlanzapine Induces Adipogenesis and Glucose Uptake by Activating Glycolysis and Synergizing with the PI3K-AKT Pathway
Li S, Fu Y, Wang W, Qiu J, Huang Y, Li X, Yang K, Yu X, Ma Y, Zhang Y, Zhang M, Li J, Li W. Olanzapine Induces Adipogenesis and Glucose Uptake by Activating Glycolysis and Synergizing with the PI3K-AKT Pathway. Current Neuropharmacology 2025, 23: 412-425. PMID: 39150031, DOI: 10.2174/1570159x22666240815120547.Peer-Reviewed Original ResearchAdministration of olanzapineTreated with olanzapineReactive oxygen speciesDownstream PI3K-Akt signal pathwayAssociated with obesityActive glycolysisAssessed body weightWeight gainDifferentiated 3T3-L1 preadipocytesLiver fat levelsPI3K-Akt pathwayOlanzapineDrug doseFemale miceDietary patternsMetabolic markersPI3K-AktFood intakeGlucose uptakeMouse modelGlycolipid abnormalitiesRodent modelsBody weightGAPDH expressionSignaling pathway
2024
Prediagnostic Plasma Nutrimetabolomics and Prostate Cancer Risk: A Nested Case–Control Analysis Within the EPIC Study
Almanza-Aguilera E, Martínez-Huélamo M, López-Hernández Y, Guiñón-Fort D, Guadall A, Cruz M, Perez-Cornago A, Rostgaard-Hansen A, Tjønneland A, Dahm C, Katzke V, Schulze M, Masala G, Agnoli C, Tumino R, Ricceri F, Lasheras C, Crous-Bou M, Sánchez M, Aizpurua-Atxega A, Guevara M, Tsilidis K, Chatziioannou A, Weiderpass E, Travis R, Wishart D, Andrés-Lacueva C, Zamora-Ros R. Prediagnostic Plasma Nutrimetabolomics and Prostate Cancer Risk: A Nested Case–Control Analysis Within the EPIC Study. Cancers 2024, 16: 4116. PMID: 39682302, PMCID: PMC11639937, DOI: 10.3390/cancers16234116.Peer-Reviewed Original ResearchProstate cancer riskProstate cancerPCa riskBiomarkers of food intakeMultivariate conditional logistic regression analysisNested case-control analysisAdvanced PCa riskFatal prostate cancerCancer and NutritionConditional logistic regression analysisOverall PCa riskEuropean Prospective InvestigationMetabolite concentrationsCase-control analysisCase-control pairsLogistic regression analysisClinically relevant tumor subtypesMetabolomics approachTumor subtypesProspective InvestigationClinical subtypesCancer riskFood intakeMetabolic alterationsEPIC studyFear of hypoglycemia relates to glycemic levels during and after real‐world physical activity in adolescents with type 1 diabetes
Patton S, Bergford S, Gal R, Calhoun P, Clements M, Sherr J, Riddell M. Fear of hypoglycemia relates to glycemic levels during and after real‐world physical activity in adolescents with type 1 diabetes. Diabetic Medicine 2024, 42: e15482. PMID: 39645661, DOI: 10.1111/dme.15482.Peer-Reviewed Original ResearchPhysically active youthExercise-induced hypoglycaemiaSelf-reported food intakeType 1 diabetesFear of hypoglycemiaExercise sessionsPost-exercisePhysical activityExercise eventsSelf-reportExerciseSurveyed childrenActive youthYouth Self-ReportSubscalesScoresYouthGlycemic levelsPercent timeAdolescentsFearContinuous glucose monitoring dataT1DGlycaemiaFood intakeThe mouse metabolic phenotyping center (MMPC) live consortium: an NIH resource for in vivo characterization of mouse models of diabetes and obesity
Laughlin M, McIndoe R, Adams S, Araiza R, Ayala J, Kennedy L, Lanoue L, Lantier L, Macy J, Malabanan E, McGuinness O, Perry R, Port D, Qi N, Elias C, Shulman G, Wasserman D, Lloyd K. The mouse metabolic phenotyping center (MMPC) live consortium: an NIH resource for in vivo characterization of mouse models of diabetes and obesity. Mammalian Genome 2024, 35: 485-496. PMID: 39191872, PMCID: PMC11522164, DOI: 10.1007/s00335-024-10067-y.Peer-Reviewed Original ResearchMouse Metabolic Phenotyping CentersMouse model of diabetesModels of diabetesNational Institutes of HealthNational Institute for DiabetesDigestive and Kidney DiseasesBehavioral phenotyping testsRenal functionProcedure in vivoFood intakeIn vivo characterizationMouse modelHeterogeneity of diabetesKidney diseaseBody compositionPhenotyping CentersInstitutes of HealthMiceObesityDiabetesPhenotypic testsWhole-body carbohydrateInsulin actionLipid metabolismLiving miceThe interactions between energy homeostasis and neurovascular plasticity
Chen B, de Launoit E, Meseguer D, Garcia Caceres C, Eichmann A, Renier N, Schneeberger M. The interactions between energy homeostasis and neurovascular plasticity. Nature Reviews Endocrinology 2024, 20: 749-759. PMID: 39054359, DOI: 10.1038/s41574-024-01021-8.Peer-Reviewed Original ResearchWestern dietLifestyle interventionNeurovascular systemCurrent obesity epidemicEnergy homeostasisStable body weightLocal neuronal networksRegulate energy balanceNeuronal networksFood intakeObesity epidemicSedentary lifestylePharmacological interventionsNeurovascular plasticityOverall healthNutritional milieuWeight lossLong-term needsCardiovascular systemBody weightEnergy expenditureAdverse effectsBrain centresLifestyleBrain vasculatureThe homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice
Yu H, Chiang A, Rubinstein M, Low M. The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice. Molecular Metabolism 2024, 87: 101993. PMID: 39025297, PMCID: PMC11327434, DOI: 10.1016/j.molmet.2024.101993.Peer-Reviewed Original ResearchHypothalamic POMC expressionPOMC neuronsPOMC expressionFood intakeMild obesityDaily food intakeFemale micePOMC immunoreactivityAdult micePOMC-expressing neuronsSuppress food intakeMaintenance of physiological levelsPOMC mRNA levelsReduced POMC expressionBody weightKnockout mouse modelMouse hypothalamic neuronsIncreased daily food intakeCentral melanocortinEnhanced energy expenditureExpression of Six3Functional significanceMelanocortin neuronsHypothalamic neuronsAnorexigenic neuropeptides899-P: Combinations of the Mitochondrial Protonophore TLC-6740 and/or the ACC2 Inhibitor TLC-3595 Provide Additive Glycemic Benefits to Semaglutide (SEMA) in db/db Mice
VIJAYAKUMAR A, SRODA N, MURAKAMI E, WENG S, MYERS R, SUBRAMANIAN M, SHULMAN G. 899-P: Combinations of the Mitochondrial Protonophore TLC-6740 and/or the ACC2 Inhibitor TLC-3595 Provide Additive Glycemic Benefits to Semaglutide (SEMA) in db/db Mice. Diabetes 2024, 73 DOI: 10.2337/db24-899-p.Peer-Reviewed Original ResearchOral glucose tolerance testGLP-1R agonistsDb/db miceIncremental AUCGlucose tolerance testMale db/db miceImproved glucose toleranceSemaglutide groupGlycemic parametersSemaglutideTolerance testFood intakeGlucose toleranceGLP-1RLiver-targeted mitochondrial uncouplerDb/dbMiceGlucose bolusVEHAgonistsEvaluation of combinationsHbA1cDiabetesMitochondrial uncouplingAssess effectsLow‐calorie diet‐induced weight loss is associated with altered brain connectivity and food desire in obesity
Hoang H, Lacadie C, Hwang J, Lam K, Elshafie A, Rosenberg S, Watt C, Sinha R, Constable R, Savoye M, Seo D, Belfort‐DeAguiar R. Low‐calorie diet‐induced weight loss is associated with altered brain connectivity and food desire in obesity. Obesity 2024, 32: 1362-1372. PMID: 38831482, PMCID: PMC11211061, DOI: 10.1002/oby.24046.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingIntrinsic connectivity distributionDiet-induced weight lossBrain connectivityAssociated with altered brain connectivityLow-calorie dietEating behavior changesShort-term low-calorie dietRight hippocampusTemporal cortexBrain networksWeight lossBrain clustersEffects of diet-induced weight lossGroup differencesFood desireGlucose levelsDiagnosis of type 2 diabetesBehavioral changesMagnetic resonance imagingType 2 diabetesBrainLeptin levelsFood intakeResonance imagingA mammalian tripartite enhancer cluster controls hypothalamic Pomc expression, food intake, and body weight
Rojo D, Hael C, Soria A, de Souza F, Low M, Franchini L, Rubinstein M. A mammalian tripartite enhancer cluster controls hypothalamic Pomc expression, food intake, and body weight. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2322692121. PMID: 38652744, PMCID: PMC11067048, DOI: 10.1073/pnas.2322692121.Peer-Reviewed Original ResearchConceptsFood intakeControl of food intakeHypothalamic POMC expressionBody weight homeostasisHypothalamic arcuate neuronsConvergent evolutionary processesReporter gene expressionPurifying selectionArcuate neuronsDeletion eventsMouse genomeMolecular evolutionWeight homeostasisFemale miceAdult micePOMC expressionTranscriptional enhancersMutant miceEnhancer mutantsTranscription factorsPlacental mammalsMammalian ordersGene expressionMiceEvolutionary processReciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism
De Solis A, Del Río-Martín A, Radermacher J, Chen W, Steuernagel L, Bauder C, Eggersmann F, Morgan D, Cremer A, Sué M, Germer M, Kukat C, Vollmar S, Backes H, Rahmouni K, Kloppenburg P, Brüning J. Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism. Nature Metabolism 2024, 6: 473-493. PMID: 38378998, PMCID: PMC10963273, DOI: 10.1038/s42255-024-00987-z.Peer-Reviewed Original ResearchInhibition of POMC neuronsPOMC neuronsFood intakeAgRP neuronsEffects of Agrp neuron activationActivation of AgRP neuronsActivating AgRP neuronsActivation of AgRPInhibit POMC neuronsProopiomelanocortin (POMC)-expressing neuronsAgRP neuron activityNucleus tractus solitariiRegulate food intakePromote food consumptionSystemic insulin sensitivityControl of feedingParaventricular nucleusTractus solitariiNeuronal inhibitionTH+ neuronsFemale miceChemogenetic receptorsNeuronal activityAgRPInsulin sensitivityTAAR1 agonists improve glycemic control, reduce body weight and modulate neurocircuits governing energy balance and feeding
Dedic N, Wang L, Hajos-Korcsok E, Hecksher-Sørensen J, Roostalu U, Vickers S, Wu S, Anacker C, Synan C, Jones P, Milanovic S, Hopkins S, Bristow L, Koblan K. TAAR1 agonists improve glycemic control, reduce body weight and modulate neurocircuits governing energy balance and feeding. Molecular Metabolism 2024, 80: 101883. PMID: 38237896, PMCID: PMC10839149, DOI: 10.1016/j.molmet.2024.101883.Peer-Reviewed Original ResearchConceptsTrace amine-associated receptor 1Trace amine-associated receptor 1 agonistAntipsychotic drugsEffects of TAAR1 agonistsOlanzapine-induced weight gainDiet-induced obesityReduced body weightFood intakeHigh-fat dietSub-chronic administrationC-Fos protein expressionDiet-induced obese miceImprove glycemic controlRegulators of metabolic controlGlycemic controlGastric emptyingSchizophrenia patientsTAAR1 agonistsHedonic feedingLimbic structuresBody weightMetabolic parametersMouse modelGlucose toleranceWeight gainSafety and Pharmacokinetics of HRS-2261, a P2X3 Receptor Antagonist, in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Phase 1 Study
Fan Y, Zhang X, Zhang Q, Zheng L, Zhou R, Sun C, Wang X, Song K, He Z, Wang H, Zhang Q, Hu W. Safety and Pharmacokinetics of HRS-2261, a P2X3 Receptor Antagonist, in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Phase 1 Study. Clinical Pharmacokinetics 2024, 63: 293-302. PMID: 38198010, DOI: 10.1007/s40262-023-01330-7.Peer-Reviewed Original ResearchP2X3 receptor antagonistAdverse eventsReceptor antagonistHealthy subjectsChronic coughPlacebo-controlled phase 1 trialModerate adverse eventsMost adverse eventsTwice-daily dosingSelective P2X3 receptor antagonistPhase 1 studyPhase 1 trialUnexplained chronic coughSingle oral doseStudy phaseMedian tmaxPrimary endpointGood tolerabilityOral doseTherapeutic optionsResultsA totalDrug exposureMean t1/2Lower incidenceFood intake
2023
Measuring diet by metabolomics: a 14-d controlled feeding study of weighed food intake
Playdon M, Tinker L, Prentice R, Loftfield E, Hayden K, Van Horn L, Sampson J, Stolzenberg-Solomon R, Lampe J, Neuhouser M, Moore S. Measuring diet by metabolomics: a 14-d controlled feeding study of weighed food intake. American Journal Of Clinical Nutrition 2023, 119: 511-526. PMID: 38212160, PMCID: PMC10884612, DOI: 10.1016/j.ajcnut.2023.10.016.Peer-Reviewed Original ResearchConceptsWomen's Health InitiativeControlled feeding studyFood intakeAssociated with dietary intakeHabitually consumed foodsPotential of metabolomicsFasting serum samplesHealthy postmenopausal femalesHuman food intakeTandem mass spectrometryWeighed intakesEnd-of-studyLiquid chromatography tandem mass spectrometryHealth initiativesBeverage intakePostmenopausal femalesMetabolomics studiesDietary assessmentPartial Pearson correlationsHabitual dietMetabolite correlationsWeighing foodDietary intakeFood groupsMetabolomicsThe Acute Effects of Real-World Physical Activity on Glycemia in Adolescents With Type 1 Diabetes: The Type 1 Diabetes Exercise Initiative Pediatric (T1DEXIP) Study.
Riddell M, Gal R, Bergford S, Patton S, Clements M, Calhoun P, Beaulieu L, Sherr J. The Acute Effects of Real-World Physical Activity on Glycemia in Adolescents With Type 1 Diabetes: The Type 1 Diabetes Exercise Initiative Pediatric (T1DEXIP) Study. Diabetes Care 2023, 47: 132-139. PMID: 37922335, DOI: 10.2337/dc23-1548.Peer-Reviewed Original ResearchConceptsReal-world physical activityPhysical activityType 1Pediatric studiesHeart rateLower baseline HbA1c levelsReal-world observational studySelf-reported physical activityBaseline HbA1c levelsShorter disease durationPeak heart rateType 1 diabetesSelf-management strategiesDisease durationHbA1c levelsMedian durationLess hypoglycemiaLower BMIAcute effectsContinuous glucose monitoring dataObservational studyFood intakeEvent-level factorsInsulin dosingActive adolescentsPrevalence of malnutrition among older adults in a population-based study - the HUNT Study
Kolberg M, Paur I, Sun Y, Gjøra L, Skjellegrind H, Thingstad P, Strand B, Selbæk G, Fagerhaug T, Thoresen L. Prevalence of malnutrition among older adults in a population-based study - the HUNT Study. Clinical Nutrition ESPEN 2023, 57: 711-717. PMID: 37739727, DOI: 10.1016/j.clnesp.2023.08.016.Peer-Reviewed Original ResearchConceptsCommunity-dwelling older adultsPrevalence of malnutritionNursing homesOlder adultsPopulation-based studyLower BMIInverse probability weightingInvoluntary weight lossPopulation of community-dwelling older adultsNursing home residentsReduced food intakeSelf-report questionnairesTreatment of malnutritionHome residentsHUNT StudyFood intakeParticipants' homesStandardised prevalenceHealth StudyNursesOlder peopleHUNT4Older populationStandardised interviewNorwegian populationDaily intranasal insulin at 40IU does not affect food intake and body composition: A placebo-controlled trial in older adults over a 24-week period with 24-weeks of follow-up
Becerra L, Gavrieli A, Khan F, Novak P, Lioutas V, Ngo L, Novak V, Mantzoros C. Daily intranasal insulin at 40IU does not affect food intake and body composition: A placebo-controlled trial in older adults over a 24-week period with 24-weeks of follow-up. Clinical Nutrition 2023, 42: 825-834. PMID: 37084469, PMCID: PMC10330069, DOI: 10.1016/j.clnu.2023.04.008.Peer-Reviewed Original ResearchConceptsBody mass indexType 2 diabetesIntranasal insulinSecondary outcomesFood intakeBody compositionType 2 diabetes trialsOlder adultsPlacebo-controlled studyPlacebo-controlled trialDiabetes (ACCORD) trialPrimary outcomeIntervention visitsMass indexBody fatAnthropometric measuresAnimal studiesBody weightHigh dosesInteraction of treatmentEnergy homeostasisDiabetesInsulinWeight lossAppetiteGastric bypass alters diurnal feeding behavior and reprograms hepatic clock to regulate endogenous glucose flux
Ye Y, Abu El Haija M, Obeid R, Herz H, Tian L, Linden B, Chu Y, Guo D, Levine D, Cedernaes J, Rahmouni K, Bass J, Mokadem M. Gastric bypass alters diurnal feeding behavior and reprograms hepatic clock to regulate endogenous glucose flux. JCI Insight 2023, 8: e166618. PMID: 36787197, PMCID: PMC10070113, DOI: 10.1172/jci.insight.166618.Peer-Reviewed Original ResearchConceptsRoux-en-Y gastric bypassGastric bypassGlucose fluxDiurnal feeding behaviorEffects of Roux-en-Y gastric bypassEating behaviorsMolecular clockWeight-independent effectsRoux-en-YGlucose metabolismWeight loss effectsDiurnal eating patternReporter mouse modelHepatic glucose productionHepatic clockClock activityHepatic glucose fluxesPair-feeding experimentsPeripheral clocksBariatric proceduresClock oscillatorGlucose homeostasisFeeding behaviorMutant miceFood intakeShort-term flaxseed oil, rich in omega 3, protects mice against metabolic damage caused by high-fat diet, but not inflammation
Nakandakari S, Gaspar R, Kuga G, Ramos C, Vieira R, Rios T, Muñoz V, Sant'ana M, Simabuco F, da Silva A, Moura L, Ropelle E, Pauli J, Cintra D. Short-term flaxseed oil, rich in omega 3, protects mice against metabolic damage caused by high-fat diet, but not inflammation. The Journal Of Nutritional Biochemistry 2023, 114: 109270. PMID: 36706930, DOI: 10.1016/j.jnutbio.2023.109270.Peer-Reviewed Original ResearchConceptsControl groupFood intakeAdipose tissueLong-term high-fat diet feedingHigh-fat diet feedingFlaxseed oilHigh-fat dietMesenteric adipose tissueFatty acid incorporationNeuronal signaling pathwaysInflammatory markersHF dietInflammatory effectsDiet feedingEarly inflammationHF groupLipid profileTNFα proteinProtective effectTriggers inflammationMetabolic disordersGlucose homeostasisBody weightInflammationHF consumption
2022
Olfactory decoding is positively associated with ad libitum food intake in sated humans
Perszyk EE, Davis XS, Small DM. Olfactory decoding is positively associated with ad libitum food intake in sated humans. Appetite 2022, 180: 106351. PMID: 36270421, DOI: 10.1016/j.appet.2022.106351.Peer-Reviewed Original ResearchConceptsAd libitum food intakeBody weight regulationFood intakeWeight regulationLong-term body weight regulationHealthy human adultsFunctional magnetic resonancePiriform cortexSatiety stateUnivariate analysisBody weightMeal consumptionPrevious functional magnetic resonanceNonfood odorsWeight changeBrain activationIntakeHuman adultsMulti-voxel pattern analysisHungry stateRole of olfactionOlfactory codingNeural patternsMagnetic resonanceAmygdala
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