2024
GLP-1 programs the neurovascular landscape
Chen B, Yu X, Horvath-Diano C, Ortuño M, Tschöp M, Jastreboff A, Schneeberger M. GLP-1 programs the neurovascular landscape. Cell Metabolism 2024, 36: 2173-2189. PMID: 39357509, DOI: 10.1016/j.cmet.2024.09.003.Peer-Reviewed Original ResearchConceptsGLP-1R agonismGLP-1RMetabolic healthChronic low-grade inflammationLow-grade inflammationGlucagon-like peptide-1 receptorPersistent health issuesCognitive well-beingNutrient-rich foodsPeptide-1 receptorMetabolic syndromeHealth issuesMetabolic defectsBrain healthMetabolic environmentObesityWell-beingWeight lossHealthMetabolic conditionsAgonismNeurological conditions899-P: Combinations of the Mitochondrial Protonophore TLC-6740 and/or the ACC2 Inhibitor TLC-3595 Provide Additive Glycemic Benefits to Semaglutide (SEMA) in db/db Mice
VIJAYAKUMAR A, SRODA N, MURAKAMI E, WENG S, MYERS R, SUBRAMANIAN M, SHULMAN G. 899-P: Combinations of the Mitochondrial Protonophore TLC-6740 and/or the ACC2 Inhibitor TLC-3595 Provide Additive Glycemic Benefits to Semaglutide (SEMA) in db/db Mice. Diabetes 2024, 73 DOI: 10.2337/db24-899-p.Peer-Reviewed Original ResearchOral glucose tolerance testGLP-1R agonistsDb/db miceIncremental AUCGlucose tolerance testMale db/db miceImproved glucose toleranceSemaglutide groupGlycemic parametersSemaglutideTolerance testFood intakeGlucose toleranceGLP-1RLiver-targeted mitochondrial uncouplerDb/dbMiceGlucose bolusVEHAgonistsEvaluation of combinationsHbA1cDiabetesMitochondrial uncouplingAssess effects
2023
Weight Loss-Independent Effect of Liraglutide on Insulin Sensitivity in Individuals With Obesity and Prediabetes.
Mashayekhi M, Nian H, Mayfield D, Devin J, Gamboa J, Yu C, Silver H, Niswender K, Luther J, Brown N. Weight Loss-Independent Effect of Liraglutide on Insulin Sensitivity in Individuals With Obesity and Prediabetes. Diabetes 2023, 73: 38-50. PMID: 37874653, PMCID: PMC10784656, DOI: 10.2337/db23-0356.Peer-Reviewed Original ResearchConceptsEndogenous GLP-1Glucagon-like peptide-1 receptor agonistsPeptide-1 receptor agonistsImproved insulin sensitivityInsulin sensitivityGLP-1GLP-1RGlucagon levelsGlucose levelsMatsuda indexWeight lossHypocaloric dietPostprandial glucoseInhibitor sitagliptinReceptor agonistMetabolic effectsDiet-induced weight lossDipeptidyl peptidase-4 inhibitor sitagliptinGLP-1R agonist liraglutideWeight loss-independent effectsDPP-4 inhibitor sitagliptinDipeptidyl peptidase-4 inhibitionPeptidase-4 inhibitionMixed meal testGLP-1R antagonist
2018
Long-Term Use of GLP-1 Receptor Agonists Alter GLP-1 Receptor mRNA Expression in Hindbrain Pathways That Regulate Gastric Motility in Mice
WANG P, MAMILLAPALLI R, ZHU W, CHAN O. Long-Term Use of GLP-1 Receptor Agonists Alter GLP-1 Receptor mRNA Expression in Hindbrain Pathways That Regulate Gastric Motility in Mice. Diabetes 2018, 67 DOI: 10.2337/db18-1088-p.Peer-Reviewed Original ResearchGLP-1R expressionGLP-1R mRNA expressionGastric motilityGLP-1RAsMRNA expressionGLP-1 receptor mRNA expressionSuppressive effectGLP-1 receptor agonistsPost-prandial glucose levelsType 2 diabetesReceptor mRNA expressionAdeno-associated viral vectorLong-term useHindbrain pathwaysIncretin systemSolitary tractGlucagon releaseReceptor agonistC57BL6 micePretreatment levelsGLP-1RGlucose levelsTherapeutic strategiesReceptor desensitizationGLP-1R.
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