2024
A human autoimmune organoid model reveals IL-7 function in coeliac disease
Santos A, van Unen V, Lin Z, Chirieleison S, Ha N, Batish A, Chan J, Cedano J, Zhang E, Mu Q, Guh-Siesel A, Tomaske M, Colburg D, Varma S, Choi S, Christophersen A, Baghdasaryan A, Yost K, Karlsson K, Ha A, Li J, Dai H, Sellers Z, Chang H, Dunn J, Zhang B, Mellins E, Sollid L, Fernandez-Becker N, Davis M, Kuo C. A human autoimmune organoid model reveals IL-7 function in coeliac disease. Nature 2024, 632: 401-410. PMID: 39048815, PMCID: PMC11747932, DOI: 10.1038/s41586-024-07716-2.Peer-Reviewed Original ResearchMeSH KeywordsAutoantibodiesAutoimmunityB-LymphocytesBiopsyCeliac DiseaseDuodenumEpitopesGlutensGTP-Binding ProteinsHLA-DQ AntigensHumansInterleukin-7Intestinal MucosaKiller Cells, NaturalModels, BiologicalMyeloid CellsOrganoidsProtein Glutamine gamma Glutamyltransferase 2Receptors, Antigen, B-CellReceptors, Antigen, T-CellT-LymphocytesConceptsInterleukin-7Major histocompatibility complexT cellsEpithelial destructionNatural killer (NK) cellsCoeliac diseaseTissue-resident immune cellsB cell receptor repertoiresOrganoid modelsModels of autoimmunityAir-liquid interfaceGluten-free dietActive CeDRemission diseaseIn vitro modelImmune microenvironmentEndoscopic biopsyMyeloid subsetsAutoantibody productionMyeloid cellsPatient biopsiesHLA-DQ8Immune cellsAnti-transglutaminasePlasma cells
2023
Guidelines for best practices in monitoring established coeliac disease in adult patients
Elli L, Leffler D, Cellier C, Lebwohl B, Ciacci C, Schumann M, Lundin K, Chetcuti Zammit S, Sidhu R, Roncoroni L, Bai J, Lee A, Dennis M, Robert M, Rostami K, Khater S, Comino I, Cebolla A, Branchi F, Verdu E, Stefanolo J, Wolf R, Bergman-Golden S, Trott N, Scudeller L, Zingone F, Scaramella L, Sanders D. Guidelines for best practices in monitoring established coeliac disease in adult patients. Nature Reviews Gastroenterology & Hepatology 2023, 21: 198-215. PMID: 38110546, DOI: 10.1038/s41575-023-00872-2.Peer-Reviewed Original ResearchConceptsCoeliac diseaseLevel of evidenceLife-long gluten-free dietGluten-free dietMucosal atrophyAdult patientsCirculating autoantibodiesFollow-upGenetic predispositionImmunological diseasesRecommendations AssessmentMonitoring patientsClinical guidelinesEvidence levelPatientsConsumption of glutenDiagnosisDiseaseGuidelinesScientific societiesCeDAutoantibodiesGastroenterologistsAtrophy
2022
Environmental risk factors for non-Hodgkin's lymphoma: umbrella review and comparison of meta-analyses of summary and individual participant data
Shi X, Zhuo H, Du Y, Nyhan K, Ioannidis J, Wallach J. Environmental risk factors for non-Hodgkin's lymphoma: umbrella review and comparison of meta-analyses of summary and individual participant data. BMJ Medicine 2022, 1: e000184. PMID: 36936582, PMCID: PMC9978687, DOI: 10.1136/bmjmed-2022-000184.Peer-Reviewed Original ResearchIndividual participant dataEnvironmental risk factorsHodgkin's lymphomaRisk factorsUmbrella reviewSummary-level dataParticipant dataInternational Lymphoma Epidemiology ConsortiumIndividual participant-level dataAMSTAR-2 toolRelated risk factorsConfidence intervalsParticipant-level dataRandom-effects modelUnique environmental risk factorsSummary effect sizeCoeliac diseasePotential confoundersCochrane LibraryMethodological qualityEligibility criteriaLymphomaRegistration numberEpidemiology ConsortiumEvidence synthesis
2017
ROC-king onwards: intraepithelial lymphocyte counts, distribution & role in coeliac disease mucosal interpretation
Rostami K, Marsh M, Johnson M, Mohaghegh H, Heal C, Holmes G, Ensari A, Aldulaimi D, Bancel B, Bassotti G, Bateman A, Becheanu G, Bozzola A, Carroccio A, Catassi C, Ciacci C, Ciobanu A, Danciu M, Derakhshan M, Elli L, Ferrero S, Fiorentino M, Fiorino M, Ganji A, Ghaffarzadehgan K, Going J, Ishaq S, Mandolesi A, Mathews S, Maxim R, Mulder C, Neefjes-Borst A, Robert M, Russo I, Rostami-Nejad M, Sidoni A, Sotoudeh M, Villanacci V, Volta U, Zali M, Srivastava A. ROC-king onwards: intraepithelial lymphocyte counts, distribution & role in coeliac disease mucosal interpretation. Gut 2017, 66: 2080. PMID: 28893865, PMCID: PMC5749338, DOI: 10.1136/gutjnl-2017-314297.Peer-Reviewed Original ResearchConceptsIntraepithelial lymphocyte countsReceiver operating characteristicIntraepithelial lymphocytesCoeliac diseaseMarsh III lesionsIII lesionsHistological diagnosis of coeliac diseaseNormal controlsReceiver operating characteristic curve analysisDiagnosis of coeliac diseaseOptimal cut-off pointReceiver operating characteristic analysisOptimal cut-offCount intraepithelial lymphocytesCut-off pointCut-offHistological diagnosisLymphocyte countMulticentre studyDuodenal biopsiesAntigenic influenceCurve analysisBiopsyDose responseControl group
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