2025
Effect of endometriosis-linked microRNAs on hepatic gene expression
Mamillapalli R, Slutzky R, Mangla A, Gawde N, Taylor H. Effect of endometriosis-linked microRNAs on hepatic gene expression. F&S Science 2025 PMID: 39971156, DOI: 10.1016/j.xfss.2025.02.001.Peer-Reviewed Original ResearchMiR-3613-5pMiR-let-7bMiR-125b-5pMiR-150MiR-150-5pCirculating microRNAsMicroRNAsReactionExpression of IGFBP1Quantitative polymerase chain reactionSuppress target genesExpression of MRC1Polymerase chain reactionBinding sitesReal-time quantitative polymerase chain reactionHepatic gene expressionExpression of CYP2R1Bioinformatics analysisEffect of endometriosisSerum of womenCirculation of womenGene expressionChain reactionMiRsHepatic cells
2023
Donor Mesenchymal Stem Cells Program Bone Marrow, Altering Macrophages, and Suppressing Endometriosis in Mice
Habata S, Mamillapalli R, Ucar A, Taylor H. Donor Mesenchymal Stem Cells Program Bone Marrow, Altering Macrophages, and Suppressing Endometriosis in Mice. Stem Cells International 2023, 2023: 1598127. PMID: 37545483, PMCID: PMC10403325, DOI: 10.1155/2023/1598127.Peer-Reviewed Original ResearchBone marrowMesenchymal stem cellsBM transplantsEndometriotic lesionsM2 macrophagesBone marrow-derived inflammatory cellsTumor necrosis factor alphaImmune system contributionsDonor mesenchymal stem cellsProportion of M1Infiltration of macrophagesDevelopment of endometriosisNecrosis factor alphaNew therapeutic targetsRecipient bone marrowReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionEndometriotic lesion developmentInflammatory markersEndometrial tissueInflammatory cellsRecipient micePolymerase chain reactionInflammatory responseFluorescence-activated cell sorting
2019
Lack of an Association between a Polymorphism in the KRAS 3′ Untranslated Region (rs61764370) and Endometriosis in a Large European Case-Control Study
D'Hooghe TM, Grechukhina O, Cho S, Fassbender A, O D, Peterse D, Weidhaas J, Taylor HS. Lack of an Association between a Polymorphism in the KRAS 3′ Untranslated Region (rs61764370) and Endometriosis in a Large European Case-Control Study. Gynecologic And Obstetric Investigation 2019, 84: 575-582. PMID: 31185482, DOI: 10.1159/000500626.Peer-Reviewed Original ResearchConceptsCase-control studyGerm-line single nucleotide polymorphismsKRAS geneLarge case-control studyReproductive-age womenType of infertilityBody mass indexEuropean case-control studyKRAS 3' untranslated regionLarge European case-control studyMicroRNA-binding sitesMedical therapyPeritoneal biopsiesMass indexPeripheral bloodAge womenPolymerase chain reactionCommon disorderTreatment resistanceEndometriosisCarrier rateVariant allelesCaucasian populationGene variantsKRAS allele
2017
Systemic Inflammation Induced by microRNAs: Endometriosis-Derived Alterations in Circulating microRNA 125b-5p and Let-7b-5p Regulate Macrophage Cytokine Production
Nematian SE, Mamillapalli R, Kadakia TS, Zolbin M, Moustafa S, Taylor HS. Systemic Inflammation Induced by microRNAs: Endometriosis-Derived Alterations in Circulating microRNA 125b-5p and Let-7b-5p Regulate Macrophage Cytokine Production. The Journal Of Clinical Endocrinology & Metabolism 2017, 103: 64-74. PMID: 29040578, DOI: 10.1210/jc.2017-01199.Peer-Reviewed Original ResearchConceptsSera of patientsMacrophage cytokine productionIL-1βIL-6Cytokine productionIL-8Let-7bIL-1β levelsCytokine protein levelsU937 macrophage cell lineCase-control studyTumor necrosis factorLet-7b inhibitorReal-time polymerase chain reactionEnzyme-linked immunosorbentQuantitative real-time polymerase chain reactionMessenger RNA changesSystemic inflammationAberrant inflammationInflammatory cytokinesProinflammatory cytokinesLevels of microRNAsUniversity HospitalPolymerase chain reactionMacrophage cell line
2016
Serum microRNAs as diagnostic markers of endometriosis: a comprehensive array-based analysis
Cosar E, Mamillapalli R, Ersoy GS, Cho S, Seifer B, Taylor HS. Serum microRNAs as diagnostic markers of endometriosis: a comprehensive array-based analysis. Fertility And Sterility 2016, 106: 402-409. PMID: 27179784, DOI: 10.1016/j.fertnstert.2016.04.013.Peer-Reviewed Original ResearchMeSH KeywordsAdultArea Under CurveCase-Control StudiesConnecticutEndometriosisFemaleGene Expression ProfilingGenetic MarkersGenetic Predisposition to DiseaseHospitals, UniversityHumansLogistic ModelsMicroRNAsOligonucleotide Array Sequence AnalysisPhenotypePredictive Value of TestsReal-Time Polymerase Chain ReactionReproducibility of ResultsROC CurveSeoulConceptsMiR-451aMiR-125bSerum microRNAsCase-control studyMiR-150-5pSingle diagnostic biomarkerReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionLogistic regression modelsMiR-342-3pMiR-145-5pPolymerase chain reactionUniversity HospitalDiagnosed subjectsMAIN OUTCOMEEndometriosisDiagnostic biomarkersMiR-500aDiagnostic markerSerum samplesDiagnostic performanceROC curveQRT-PCRChain reactionWomen
2015
Integrative Analysis Reveals Regulatory Programs in Endometriosis
Yang H, Kang K, Cheng C, Mamillapalli R, Taylor HS. Integrative Analysis Reveals Regulatory Programs in Endometriosis. Reproductive Sciences 2015, 22: 1060-1072. PMID: 26134036, PMCID: PMC5933170, DOI: 10.1177/1933719115592709.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChromatin ImmunoprecipitationComputational BiologyCore Binding Factor Alpha 2 SubunitDatabases, GeneticEndometriosisEstrogen Receptor alphaEstrogen Receptor betaFemaleGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksGenetic Association StudiesGenetic MarkersHepatocyte Nuclear Factor 3-betaHumansProtein BindingProtein Interaction MappingProtein Interaction MapsReceptors, AndrogenTranscription Factor AP-2Transcription, GeneticTumor Suppressor Protein p53ConceptsAndrogen receptorFunction of ARReproductive-age womenCommon gynecological diseasePathology of endometriosisEstrogen receptor βEstrogen receptor αReal-time polymerase chain reactionSuch expression changesQuantitative real-time polymerase chain reactionPolymerase chain reactionGynecological diseasesGene expressionGene Expression Omnibus databaseEndometriosisReceptor βReceptor αTranscription factorsCirculating microRNAs as potential biomarkers for endometriosis
Cho S, Mutlu L, Grechukhina O, Taylor HS. Circulating microRNAs as potential biomarkers for endometriosis. Fertility And Sterility 2015, 103: 1252-1260.e1. PMID: 25772772, PMCID: PMC4417410, DOI: 10.1016/j.fertnstert.2015.02.013.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultArea Under CurveCase-Control StudiesCell ProliferationEndometriosisFemaleGenetic MarkersHospitals, UniversityHumansLogistic ModelsMicroRNAsMiddle AgedPredictive Value of TestsReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionROC CurveYoung AdultConceptsProliferative phaseLet-7bSerum CA-125 levelsMiR-135aCA-125 levelsSerum of womenBenign gynecologic diseaseCase-control studyQuantitative reverse transcription polymerase chain reactionReverse transcription-polymerase chain reactionPotential noninvasive biomarkersLogistic regression modelsHighest areaGynecologic diseasePolymerase chain reactionUniversity HospitalMenstrual cycleEndometriosisMAIN OUTCOMENoninvasive biomarkersPotential biomarkersDiagnostic markerSerum samplesWomenChain reaction
2011
Bisphenol-A exposure alters endometrial progesterone receptor expression in the nonhuman primate
Aldad TS, Rahmani N, Leranth C, Taylor HS. Bisphenol-A exposure alters endometrial progesterone receptor expression in the nonhuman primate. Fertility And Sterility 2011, 96: 175-179. PMID: 21536273, PMCID: PMC3215335, DOI: 10.1016/j.fertnstert.2011.04.010.Peer-Reviewed Original ResearchConceptsProgesterone receptor expressionPR expressionReceptor expressionIshikawa cellsNonhuman primatesEstrogen-like effectsAfrican green monkeysQuantitative polymerase chain reactionEffects of bisphenolEndometrial dysfunctionEstrogen inhibitionPolymerase chain reactionBPA exposureMAIN OUTCOMEWeak estrogenGreen monkeysChain reactionVehicle controlPrevious reportsEndocrine disruptorsResultant decreasePrimatesExposureCellsExpression
2009
Diminished vaginal HOXA13 expression in women with pelvic organ prolapse
Connell KA, Guess MK, Tate A, Andikyan V, Bercik R, Taylor HS. Diminished vaginal HOXA13 expression in women with pelvic organ prolapse. Menopause The Journal Of The North American Menopause Society 2009, 16: 529-533. PMID: 19423998, PMCID: PMC2704499, DOI: 10.1097/gme.0b013e31818fb0c2.Peer-Reviewed Original ResearchConceptsPelvic organ prolapsePremenopausal controlsPremenopausal womenOrgan prolapseHOXA13 expressionPOP groupExpression of HOXA13Real-time polymerase chain reactionExtracellular matrix metabolismEstrogen therapyPostmenopausal womenYounger patientsLeuprolide groupSmoking cessationLeuprolide acetatePolymerase chain reactionBiopsy specimensPreventive strategiesGenetic predispositionVaginal expressionProlapseMatrix metabolismWeight lossWomenVagina
2006
Salpingectomy increases peri-implantation endometrial HOXA10 expression in women with hydrosalpinx
Daftary GS, Kayisli U, Seli E, Bukulmez O, Arici A, Taylor HS. Salpingectomy increases peri-implantation endometrial HOXA10 expression in women with hydrosalpinx. Fertility And Sterility 2006, 87: 367-372. PMID: 17173899, DOI: 10.1016/j.fertnstert.2006.06.041.Peer-Reviewed Original ResearchConceptsEndometrial HOXA10 expressionImplantation rateHOXA10 expressionInfertile womenFertile controlsHOXA10 mRNAPolymerase chain reaction findingsProspective clinical trialsReal-time reverse transcription-polymerase chain reactionReverse transcription-polymerase chain reactionHOXA10 protein expressionExpression of HOXA10Academic medical centerHOXA10 mRNA expressionGlandular epithelial cellsHomeobox gene HOXA10Potential molecular mechanismsBilateral hydrosalpinxHydrosalpinx fluidEndometrial stromaMidluteal phasePolymerase chain reactionClinical trialsSalpingectomyMedical Center
2003
A soluble molecule secreted by human blastocysts modulates regulation of HOXA10 expression in an epithelial endometrial cell line
Sakkas D, Lu C, Zulfikaroglu E, Neuber E, Taylor HS. A soluble molecule secreted by human blastocysts modulates regulation of HOXA10 expression in an epithelial endometrial cell line. Fertility And Sterility 2003, 80: 1169-1174. PMID: 14607569, DOI: 10.1016/s0015-0282(03)02163-0.Peer-Reviewed Original ResearchMeSH KeywordsBiological FactorsBlastocystCell LineChorionic GonadotropinCulture Media, ConditionedEmbryonic and Fetal DevelopmentEndometriumEpithelial CellsFemaleFertilization in VitroHomeobox A10 ProteinsHomeodomain ProteinsHumansReverse Transcriptase Polymerase Chain ReactionSolubilitySperm Injections, IntracytoplasmicConceptsEndometrial epithelial cell lineIntracytoplasmic sperm injectionHOXA10 expressionHOXA10 gene expressionEndometrial receptivityEpithelial cell lineIshikawa cellsCell linesSemiquantitative reverse transcriptase-polymerase chain reactionReverse transcriptase-polymerase chain reactionSoluble moleculesTranscriptase-polymerase chain reactionHigh-quality embryosEndometrial cell lineHuman embryosBlastocyst stageBlastocyst-conditioned mediaCell-free mediumFertilization cyclesBlastocyst appositionPolymerase chain reactionEndometrial cellsMAIN OUTCOMEQuality embryosSperm injection
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