A genetically modulated Toll-like receptor-tolerant phenotype in peripheral blood cells of children with multisystem inflammatory syndrome.
Khan R, Ji W, Guzman Rivera J, Madhvi A, Andrews T, Richlin B, Suarez C, Gaur S, Hasan U, Cuddy W, Singh A, Bukulmez H, Kaelber D, Kimura Y, Ganapathi U, Michailidis I, Ukey R, Moroso-Fela S, Kuster J, Casseus M, Roy J, Burns J, Kleinman L, Horton D, Lakhani S, Gennaro M. A genetically modulated Toll-like receptor-tolerant phenotype in peripheral blood cells of children with multisystem inflammatory syndrome. The Journal Of Immunology 2025 PMID: 40101747, DOI: 10.1093/jimmun/vkaf006.Peer-Reviewed Original ResearchToll-like receptorsLysosomal trafficking regulatorClinical laboratory indicatorsMIS-CMultisystem inflammatory syndromePeripheral blood cellsInflammatory syndromeLaboratory indicatorsHeterozygous carriersAgonists of Toll-like receptorsTLR responsesGut leakage markersDysregulated innate immune responseGenetic background of patientsBlood cells of childrenMIS-C patientsImmune response initiationIncreased plasma levelsNegative regulator of TLR signalingMIS-C childrenAssociated with hyperinflammationGenetic backgroundRegulator of TLR signalingBackground of patientsCells of children
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