2024
Understanding and overcoming resistance to immunotherapy in genitourinary cancers
Evans S, Jani Y, Jansen C, Yildirim A, Kalemoglu E, Bilen M. Understanding and overcoming resistance to immunotherapy in genitourinary cancers. Cancer Biology & Therapy 2024, 25: 2342599. PMID: 38629578, PMCID: PMC11028033, DOI: 10.1080/15384047.2024.2342599.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsB7-H1 AntigenHumansImmunotherapyNeoplasmsNivolumabUrogenital NeoplasmsConceptsImmune checkpoint inhibitorsResistance to immunotherapyImmunotherapy resistanceTargeted therapyGenitourinary (GU) cancersCombined immune checkpoint inhibitorsIntroduction of novel immunotherapiesMechanisms of immunotherapy resistanceOvercome resistance to immunotherapyCancer cellsHost immune profileResponse to immunotherapyNovel targeted therapiesImmune system's rolePredictors of responseAttack cancer cellsImmune system's abilityStandard of careCheckpoint inhibitorsSequential therapyNovel immunotherapiesCombination therapyTreatment failureGU cancersTreatment landscape
2023
Changes in Perception of Cure Among Patients With Genitourinary Cancers Initiating Immune Checkpoint Inhibitors: A Longitudinal Study
Bergerot C, Philip E, Govindarajan A, Castro D, Malhotra J, Bergerot P, Salgia S, Salgia M, Salgia N, Hsu J, Meza L, Zengin Z, Liu S, Chehrazi-Raffle A, Tripathi A, Dorff T, Pal S. Changes in Perception of Cure Among Patients With Genitourinary Cancers Initiating Immune Checkpoint Inhibitors: A Longitudinal Study. Clinical Genitourinary Cancer 2023, 21: 626-630.e3. PMID: 37391301, PMCID: PMC11225089, DOI: 10.1016/j.clgc.2023.05.018.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansImmune Checkpoint InhibitorsImmunotherapyKidney NeoplasmsLongitudinal StudiesMalePerceptionRetrospective StudiesUrogenital NeoplasmsConceptsPerception of cureExpectation of cureGenitourinary cancersImmune checkpoint inhibitor therapyCheckpoint inhibitor therapyImmune checkpoint inhibitorsProportion of patientsSevere side effectsLongitudinal studyChi-square testICI therapyCheckpoint inhibitorsInhibitor therapyECOG scoreGeneral linear modelingPatients' perceptionsMetastatic cancerPatientsSide effectsDecreased anxietyTherapyCancerCureLower ratesAnxiety ScaleTwelve-Month Follow-up of the Immune Response After COVID-19 Vaccination in Patients with Genitourinary Cancers: A Prospective Cohort Analysis
Meza L, Zengin Z, Salgia S, Malhotra J, Karczewska E, Dorff T, Tripathi A, Ely J, Kelley E, Mead H, Hsu J, Dizman N, Salgia N, Chawla N, Chehrazi-Raffle A, Muddasani R, Govindarajan A, Rock A, Liu S, Salgia R, Trent J, Altin J, Pal S. Twelve-Month Follow-up of the Immune Response After COVID-19 Vaccination in Patients with Genitourinary Cancers: A Prospective Cohort Analysis. The Oncologist 2023, 28: e748-e755. PMID: 36971500, PMCID: PMC10485287, DOI: 10.1093/oncolo/oyad067.Peer-Reviewed Original ResearchConceptsCOVID-19 vaccinationGenitourinary cancersRenal cell carcinomaBooster doseCell carcinomaImmune responseBlood samplesSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2T-cell receptor sequencingRespiratory syndrome coronavirus 2Baseline blood samplesMajority of patientsMinority of patientsProspective cohort analysisSyndrome coronavirus 2Twelve-month followAntibody titer analysisCOVID-19 vaccineSeroconversion ratesMedian ageUrothelial cancerCoronavirus 2Prostate cancerCohort analysisPerceptions of COVID-19 Vaccination in Patients with Genitourinary Cancers: A Survey Study
Castro D, Zengin Z, Malhotra J, Bergerot C, Meza L, Dizman N, Govindarajan A, Hsu J, Chehrazi-Raffle A, Chawla N, Mercier B, Chen S, Feng M, Prajapati S, Lee K, Philip E, Dorff T, Lyou Y, Pal S. Perceptions of COVID-19 Vaccination in Patients with Genitourinary Cancers: A Survey Study. Cancer Investigation 2023, 41: 70-76. PMID: 36239609, DOI: 10.1080/07357907.2022.2136683.Peer-Reviewed Original Research
2017
Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors
Hendry S, Salgado R, Gevaert T, Russell PA, John T, Thapa B, Christie M, van de Vijver K, Estrada MV, Gonzalez-Ericsson PI, Sanders M, Solomon B, Solinas C, Van den Eynden GGGM, Allory Y, Preusser M, Hainfellner J, Pruneri G, Vingiani A, Demaria S, Symmans F, Nuciforo P, Comerma L, Thompson EA, Lakhani S, Kim SR, Schnitt S, Colpaert C, Sotiriou C, Scherer SJ, Ignatiadis M, Badve S, Pierce RH, Viale G, Sirtaine N, Penault-Llorca F, Sugie T, Fineberg S, Paik S, Srinivasan A, Richardson A, Wang Y, Chmielik E, Brock J, Johnson DB, Balko J, Wienert S, Bossuyt V, Michiels S, Ternes N, Burchardi N, Luen SJ, Savas P, Klauschen F, Watson PH, Nelson BH, Criscitiello C, O’Toole S, Larsimont D, de Wind R, Curigliano G, André F, Lacroix-Triki M, van de Vijver M, Rojo F, Floris G, Bedri S, Sparano J, Rimm D, Nielsen T, Kos Z, Hewitt S, Singh B, Farshid G, Loibl S, Allison KH, Tung N, Adams S, Willard-Gallo K, Horlings HM, Gandhi L, Moreira A, Hirsch F, Dieci MV, Urbanowicz M, Brcic I, Korski K, Gaire F, Koeppen H, Lo A, Giltnane J, Rebelatto MC, Steele KE, Zha J, Emancipator K, Juco JW, Denkert C, Reis-Filho J, Loi S, Fox SB. Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors. Advances In Anatomic Pathology 2017, 24: 311-335. PMID: 28777143, PMCID: PMC5638696, DOI: 10.1097/pap.0000000000000161.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorBiopsyBrain NeoplasmsCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellEndometrial NeoplasmsFemaleGastrointestinal NeoplasmsHead and Neck NeoplasmsHumansImmunohistochemistryLung NeoplasmsLymphocytes, Tumor-InfiltratingMelanomaMesotheliomaOvarian NeoplasmsPathologyPhenotypePredictive Value of TestsSkin NeoplasmsSquamous Cell Carcinoma of Head and NeckUrogenital NeoplasmsConceptsTumor-infiltrating lymphocytesDifferent tumor typesSolid tumorsTumor typesTIL assessmentImmune responsePrimary brain tumorsCommon solid tumorsInvasive breast carcinomaRoutine clinical biomarkersWorking Group guidelinesPrognostic implicationsBreast carcinomaGroup guidelinesGynecologic systemGastrointestinal tractSimple biomarkerBrain tumorsGenitourinary systemPredictive valueClinical biomarkersStandardized methodologyTumorsAvailable evidenceImmunotherapy
2012
A unique pattern of extranodal involvement in Korean adults with sporadic Burkitt lymphoma: a single center experience
Jang S, Yoon D, Kim S, Yoon S, Kim D, Park C, Huh J, Lee S, Lee D, Ryu J, Suh C. A unique pattern of extranodal involvement in Korean adults with sporadic Burkitt lymphoma: a single center experience. Annals Of Hematology 2012, 91: 1917-1922. PMID: 22864762, DOI: 10.1007/s00277-012-1531-1.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdolescentAdultAgedAged, 80 and overBone Marrow ExaminationBone Marrow NeoplasmsBone NeoplasmsBurkitt LymphomaCohort StudiesFemaleFollow-Up StudiesGastrointestinal NeoplasmsHospitals, VeteransHumansMaleMiddle AgedNeoplasm StagingRepublic of KoreaRetrospective StudiesSurvival AnalysisTomography, X-Ray ComputedUrogenital NeoplasmsYoung AdultConceptsComplete response rateExtranodal involvementExtranodal sitesSporadic Burkitt lymphomaBurkitt's lymphomaClinical outcomesGenitourinary tractBone marrowTwo-year overall survival ratesResponse rateCentral nervous system involvementMore extranodal sitesNervous system involvementProgression-free survivalSingle-center cohortSingle-center experienceAsan Medical CenterOverall survival rateAdult Korean patientsNon-Hodgkin lymphomaBL patientsBaseline characteristicsOverall survivalCenter cohortCenter experienceThe Emerging Role of Circulating Tumor Cell Detection in Genitourinary Cancer
Small A, Gong Y, Oh W, Hall S, van Rijn C, Galsky M. The Emerging Role of Circulating Tumor Cell Detection in Genitourinary Cancer. Journal Of Urology 2012, 188: 21-26. PMID: 22578722, DOI: 10.1016/j.juro.2012.02.2558.Peer-Reviewed Original ResearchMeSH KeywordsDiagnosis, DifferentialDiagnostic Techniques, UrologicalHumansNeoplastic Cells, CirculatingUrogenital NeoplasmsConceptsCirculating tumor cellsGenitourinary cancersTumor cellsTumor cell detectionCell carcinomaCirculating tumor cell capture technologiesSignificance of circulating tumor cellsCastration resistant prostate cancerReal-time liquid biopsyClinically localized cancerHeterogeneous natural historyCirculating tumor cell detectionResistant prostate cancerTransitional cell carcinomaTreatment response biomarkersRenal cell carcinomaClinical applicationPotential clinical applicationsMetastatic sitesPrimary tumorLocalized cancerProstate cancerCurative therapyPeripheral bloodMalignant cells
2008
Clinical Cancer Advances 2008: Major Research Advances in Cancer Treatment, Prevention, and Screening—A Report From the American Society of Clinical Oncology
Winer E, Gralow J, Diller L, Karlan B, Loehrer P, Pierce L, Demetri G, Ganz P, Kramer B, Kris M, Markman M, Mayer R, Pfister D, Raghavan D, Ramsey S, Reaman G, Sandler H, Sawaya R, Schuchter L, Sweetenham J, Vahdat L, Schilsky RL. Clinical Cancer Advances 2008: Major Research Advances in Cancer Treatment, Prevention, and Screening—A Report From the American Society of Clinical Oncology. Journal Of Clinical Oncology 2008, 27: 812-826. PMID: 19103723, PMCID: PMC2645086, DOI: 10.1200/jco.2008.21.2134.Peer-Reviewed Original ResearchConceptsCancer preventionClinical OncologyAmerican SocietyCancer treatmentCancer researchScreening—A ReportThird of peopleNational Cancer InstituteSignificant clinical researchField of oncologyNational Cancer ActAnnual American SocietyCancer survivorsCancer patientsCancer incidenceCurable stageASCO'S PRESIDENTNew therapiesCancer InstituteCancer todayOncology reportsPatientsCancerClinical researchCancer development
2006
Clinical Cancer Advances 2006: Major Research Advances in Cancer Treatment, Prevention, and Screening—A Report From the American Society of Clinical Oncology
Ozols RF, Herbst RS, Colson YL, Gralow J, Bonner J, Curran WJ, Eisenberg BL, Ganz PA, Kramer BS, Kris MG, Markman M, Mayer RJ, Raghavan D, Reaman GH, Sawaya R, Schilsky RL, Schuchter LM, Sweetenham JW, Vahdat LT, Winn RJ. Clinical Cancer Advances 2006: Major Research Advances in Cancer Treatment, Prevention, and Screening—A Report From the American Society of Clinical Oncology. Journal Of Clinical Oncology 2006, 25: 146-162. PMID: 17158528, DOI: 10.1200/jco.2006.09.7030.Peer-Reviewed Original ResearchConceptsHuman papillomavirusClinical OncologyHER-2 positive breast cancerCancer researchCancer treatmentScreening—A ReportHalf of menChronic myelogenous leukemiaAmerican SocietyClinical cancer researchCertain common cancersGroup of diseasesBasic science discoveriesASCO recommendationsUseful therapyCervical cancerPreventive vaccineCancer careCancer deathCancer patientsCommon cancerNeck cancerClinical trialsBreast cancerGlobal burden
2005
Clinical Cancer Advances 2005: Major Research Advances in Cancer Treatment, Prevention, and Screening—A Report From the American Society of Clinical Oncology
Herbst RS, Bajorin DF, Bleiberg H, Blum D, Hao D, Johnson BE, Ozols RF, Demetri GD, Ganz PA, Kris MG, Levin B, Markman M, Raghavan D, Reaman GH, Sawaya R, Schuchter LM, Sweetenham JW, Vahdat LT, Vokes EE, Winn RJ, Mayer RJ. Clinical Cancer Advances 2005: Major Research Advances in Cancer Treatment, Prevention, and Screening—A Report From the American Society of Clinical Oncology. Journal Of Clinical Oncology 2005, 24: 190-205. PMID: 16326753, DOI: 10.1200/jco.2005.04.8678.Peer-Reviewed Original ResearchConceptsClinical OncologyCancer typesClinical researchCancer treatmentScreening—A ReportRisk of recurrenceCancer therapyAmerican SocietyQuality of lifeSignificant clinical researchStudy of drugsCancer survivorsCommon cancerClinical trialsEffective therapyTargeted cancer therapyLong-term effectsNew chemotherapySurvival ratePatient careCancerTherapyEnormous tollDiseaseCancer research
2002
Prostaglandin E2 Production and Cyclooxygenase-2 Induction in Human Urinary Tract Infections and Bladder Cancer
Wheeler MA, Hausladen DA, Yoon JH, Weiss RM. Prostaglandin E2 Production and Cyclooxygenase-2 Induction in Human Urinary Tract Infections and Bladder Cancer. Journal Of Urology 2002, 168: 1568-1573. PMID: 12352459, DOI: 10.1016/s0022-5347(05)64522-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBCG VaccineCyclooxygenase 1Cyclooxygenase 2DinoprostoneEnzyme InductionFemaleGene Expression Regulation, EnzymologicHumansIsoenzymesMaleMembrane ProteinsMiddle AgedProstaglandin-Endoperoxide SynthasesRNA, MessengerUreterUrinary BladderUrinary Bladder NeoplasmsUrinary Tract InfectionsUrogenital NeoplasmsUrotheliumConceptsUrinary prostaglandin E2 levelsUrinary tract infectionProstaglandin E2 levelsUrinary prostaglandin E2Tract infectionsBladder cancerProstaglandin E2 productionBCG treatmentCOX-2 mRNAUrogenital cancersE2 levelsUrine particulatesBladder muscleInflammatory processProstaglandin E2E2 productionBacillus Calmette-Guerin treatmentCOX-2 protein levelsCOX-2 protein expressionHuman urinary tract infectionsUrinary prostaglandin levelsCOX-2 expressionHuman bladder muscleBladder cancer casesCyclooxygenase-2 induction
2001
Urine Detection of Survivin and Diagnosis of Bladder Cancer
Smith SD, Wheeler MA, Plescia J, Colberg JW, Weiss RM, Altieri DC. Urine Detection of Survivin and Diagnosis of Bladder Cancer. JAMA 2001, 285: 324-328. PMID: 11176843, DOI: 10.1001/jama.285.3.324.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkers, TumorBlotting, WesternFemaleHumansInhibitor of Apoptosis ProteinsMaleMicrotubule-Associated ProteinsMiddle AgedNeoplasm ProteinsNeoplasm Recurrence, LocalPrognosisProteinsReverse Transcriptase Polymerase Chain ReactionSensitivity and SpecificityStatistics, NonparametricSurvivinUrinary Bladder NeoplasmsUrogenital NeoplasmsUrologic DiseasesConceptsRecurrent bladder cancerUrinary tract diseaseBladder cancerUrine samplesTract diseaseHealthy volunteersSurvivin levelsProstate-specific antigen levelLow-grade bladder cancerPrognostic molecular markersNoninvasive diagnostic testTranscriptase-polymerase chain reactionCommon human cancersUrine survivinGenitourinary cancersProgression of cancerAggressive diseaseAntigen levelsCervical cancerUrology clinicPolymerase chain reactionUnfavorable outcomeCystoscopy resultsRT-PCR methodSurvivin detection
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