2019
Epiretinal stimulation with local returns enhances selectivity at cellular resolution.
Fan VH, Grosberg LE, Madugula SS, Hottowy P, Dabrowski W, Sher A, Litke AM, Chichilnisky EJ. Epiretinal stimulation with local returns enhances selectivity at cellular resolution. Journal Of Neural Engineering 2019, 16: 025001. PMID: 30523958, PMCID: PMC6416068, DOI: 10.1088/1741-2552/aaeef1.Peer-Reviewed Original Research
2016
Hypomorphic mutations identified in the candidate Leber congenital amaurosis gene CLUAP1
Soens ZT, Li Y, Zhao L, Eblimit A, Dharmat R, Li Y, Chen Y, Naqeeb M, Fajardo N, Lopez I, Sun Z, Koenekoop RK, Chen R. Hypomorphic mutations identified in the candidate Leber congenital amaurosis gene CLUAP1. Genetics In Medicine 2016, 18: 1044-1051. PMID: 26820066, PMCID: PMC4965339, DOI: 10.1038/gim.2015.205.Peer-Reviewed Original ResearchConceptsLeber congenital amaurosisLCA genesRescue experimentsEarly-onset formPhotoreceptor cell deathWhole-exome sequencingDysfunctional photoreceptorsRetinal disease genesCause of diseaseSystemic abnormalitiesLCA cohortMouse retinaRetinal degenerationHypomorphic mutationsCongenital amaurosisLCA patientsCilia-associated genesPhotoreceptor functionProband's mutationCell deathDiseaseProbandsSingle probandHuman diseasesCilia function
2015
A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa
Guo X, Wang SB, Xu H, Ribic A, Mohns EJ, Zhou Y, Zhu X, Biederer T, Crair MC, Chen B. A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa. Nature Communications 2015, 6: 8005. PMID: 26272629, PMCID: PMC4538705, DOI: 10.1038/ncomms9005.Peer-Reviewed Original ResearchConceptsRetinitis pigmentosaVisual functionRd1 miceCone photoreceptor deathMultiple cell death pathwaysRd1 mutationPhotoreceptor protectionPhotoreceptor deathEffective treatmentAnimal modelsPhotoreceptor degenerationRod deathCone photoreceptorsRod survivalInvaluable animal modelHDAC4 proteinMicePigmentosaCell death pathwaysRod photoreceptorsProtein therapyTherapyHDAC4DeathSurvival
2012
The Active Site of Melanopsin: The Biological Clock Photoreceptor
Sekharan S, Wei J, Batista V. The Active Site of Melanopsin: The Biological Clock Photoreceptor. Journal Of The American Chemical Society 2012, 134: 19536-19539. PMID: 23145979, DOI: 10.1021/ja308763b.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBiological ClocksCatalytic DomainDecapodiformesMiceModels, BiologicalPhotoreceptor CellsRod OpsinsSequence Alignment
2011
Qilin Is Essential for Cilia Assembly and Normal Kidney Development in Zebrafish
Li J, Sun Z. Qilin Is Essential for Cilia Assembly and Normal Kidney Development in Zebrafish. PLOS ONE 2011, 6: e27365. PMID: 22102889, PMCID: PMC3216947, DOI: 10.1371/journal.pone.0027365.Peer-Reviewed Original ResearchConceptsCilia assemblyIFT complex B proteinsKidney developmentForward genetic screenCoiled-coil domainEssential roleKidney cystsNormal kidney developmentGenetic screenMutant phenotypeVestigial organelleNovel genesPolycystic kidney diseaseCilia formationDeletion analysisB geneB proteinB mutantsGenetic analysisMeckel-Gruber syndromeN-terminusFunctional analysisRescue experimentsZebrafishHuman diseasesTransplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice
Tucker BA, Park IH, Qi SD, Klassen HJ, Jiang C, Yao J, Redenti S, Daley GQ, Young MJ. Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice. PLOS ONE 2011, 6: e18992. PMID: 21559507, PMCID: PMC3084746, DOI: 10.1371/journal.pone.0018992.Peer-Reviewed Original ResearchConceptsRetinal functionNormal retinal physiologyOuter nuclear layerRetinal precursorsC-MycRetinal degenerative diseasesRetinal outer nuclear layerDelivery of neurotransmittersRetinal degenerative (rd) miceRetinal transplantationSubretinal transplantationNuclear layerAdult miceDsRed miceTransplantationRetinal structureRetinal physiologyPhotoreceptor markersDegenerative diseasesMiceRetroviral inductionFunctional anatomyPhotoreceptor precursorsPhotoreceptor cellsFibroblast-derived iPSCs
2006
Safety in Nonhuman Primates of Ocular AAV2-RPE65, a Candidate Treatment for Blindness in Leber Congenital Amaurosis
Jacobson SG, Boye SL, Aleman TS, Conlon TJ, Zeiss CJ, Roman AJ, Cideciyan AV, Schwartz SB, Komaromy AM, Doobrajh M, Cheung AY, Sumaroka A, Pearce-Kelling SE, Aguirre GD, Kaushal S, Maguire AM, Flotte TR, Hauswirth WW. Safety in Nonhuman Primates of Ocular AAV2-RPE65, a Candidate Treatment for Blindness in Leber Congenital Amaurosis. Human Gene Therapy 2006, 17: 845-858. PMID: 16942444, DOI: 10.1089/hum.2006.17.845.Peer-Reviewed Original ResearchConceptsLeber congenital amaurosisOptic nerveGood Laboratory Practice safety studiesCongenital amaurosisObserved adverse effect levelSafety studiesRPE65-mutant dogsSingle intraocular injectionVector-injected eyesHeterogeneous disease groupNormal cynomolgus monkeysAdverse effect levelFuture human trialsGene transfer trialsDose-dependent mannerHigh vector dosesPresurgical recordingsRetinal histopathologyInjected eyeControl eyesIntraocular injectionRetinal injuryCentral retinaThickness abnormalitiesClinical examination
2005
Insulin Receptor Substrate 2 Is Essential for Maturation and Survival of Photoreceptor Cells
Yi X, Schubert M, Peachey N, Suzuma K, Burks D, Kushner J, Suzuma I, Cahill C, Flint C, Dow M, Leshan R, King G, White M. Insulin Receptor Substrate 2 Is Essential for Maturation and Survival of Photoreceptor Cells. Journal Of Neuroscience 2005, 25: 1240-1248. PMID: 15689562, PMCID: PMC6725974, DOI: 10.1523/jneurosci.3664-04.2005.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAnimals, NewbornApoptosisCell SurvivalDiabetic RetinopathyEye ProteinsGene DeletionHomeodomain ProteinsHyperglycemiaHyperinsulinismInsulin Receptor Substrate ProteinsInsulin ResistanceInsulin-Like Growth Factor IIntracellular Signaling Peptides and ProteinsMiceMice, KnockoutPhosphoproteinsPhosphorylationPhotic StimulationPhotoreceptor CellsProtein Processing, Post-TranslationalProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktRetinal Ganglion CellsSignal TransductionTrans-ActivatorsConceptsIrs2-/- micePhotoreceptor cellsPlexiform layerInsulin receptor substrate 2Insulin receptor substrateInsulin-like growth factor 1 receptorGrowth factor 1 receptorMost photoreceptor cellsInner plexiform layerOuter plexiform layerFactor 1 receptorFinal common pathwaySurvival of photoreceptorsNormal electrical functionMonths of ageWeeks of ageReceptor substrateCellular growthSubstrate 2Akt phosphorylationGanglion cellsIRS2 expressionPharmacological strategiesControl littermatesPhotoreceptor degeneration
2004
QM/MM Study of Energy Storage and Molecular Rearrangements Due to the Primary Event in Vision
Gascon J, Batista V. QM/MM Study of Energy Storage and Molecular Rearrangements Due to the Primary Event in Vision. Biophysical Journal 2004, 87: 2931-2941. PMID: 15339806, PMCID: PMC1304767, DOI: 10.1529/biophysj.104.048264.Peer-Reviewed Original ResearchConceptsMolecular rearrangementQuantum mechanics/molecular mechanics (QM/MM) hybrid methodsEnergy storageQM/MM studyPolyene chainEnergy storage mechanismElectronic excitation energiesHigh-resolution structural dataBovine visual rhodopsinMolecular structureMM studyNet positive chargePrimary photochemical eventSchiff baseC13 positionSchiff base linkageStorage mechanismSteric interactionsTrans productsSteric constraintsPreferential senseFirst-principles understandingPositive chargePhotochemical eventsStructural data
2001
Light Control of Arabidopsis Development Entails Coordinated Regulation of Genome Expression and Cellular Pathways[W]
Ma L, Li J, Qu L, Hager J, Chen Z, Zhao H, Deng X. Light Control of Arabidopsis Development Entails Coordinated Regulation of Genome Expression and Cellular Pathways[W]. The Plant Cell 2001, 13: 2589-2607. PMID: 11752374, PMCID: PMC139475, DOI: 10.1105/tpc.010229.Peer-Reviewed Original ResearchMeSH KeywordsArabidopsisArabidopsis ProteinsCryptochromesDrosophila ProteinsExpressed Sequence TagsEye ProteinsFlavoproteinsGene Expression Regulation, DevelopmentalGene Expression Regulation, PlantGenome, PlantLightOligonucleotide Array Sequence AnalysisPhotoreceptor CellsPhotoreceptor Cells, InvertebratePhytochromePhytochrome APhytochrome BPlant ProteinsPlant ShootsReceptors, G-Protein-CoupledTranscription FactorsConceptsArabidopsis developmentExpression profilesGenome expressionCellular pathwaysLight-regulated genesSimilar gene expression profilesGenome expression profilesDistinct expression profilesGene expression profilesDifferent light qualitiesPhytochrome BSequence tagsCoordinated regulationPhytochrome ARegulatory pathwaysLight qualityLight conditionsDark transitionGenesPathwayLight treatmentLight controlBlue lightExpressionCryptochromes
1998
Tweaking the human circadian clock with light.
Oren D, Terman M. Tweaking the human circadian clock with light. Science 1998, 279: 333-4. PMID: 9454328, DOI: 10.1126/science.279.5349.333.Peer-Reviewed Original Research
1997
Physiological properties of inhibitory interneurons in cat striate cortex.
Azouz R, Gray C, Nowak L, McCormick D. Physiological properties of inhibitory interneurons in cat striate cortex. Cerebral Cortex 1997, 7: 534-545. PMID: 9276178, DOI: 10.1093/cercor/7.6.534.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAxonsCatsDendritesInterneuronsMembrane PotentialsOrientationPhotic StimulationPhotoreceptor CellsVisual CortexVisual FieldsConceptsBrief action potentialsReceptive field propertiesReceptive field typesSpike frequency adaptationSimple receptive fieldsAxonal arborizationIntracellular recordingsInhibitory interneuronsBasket cellsSpontaneous activityStriate cortexLayers IIAction potentialsFiring patternsResponsive cellsVisual stimulationFrequency adaptationDirection preferenceInterneuronsHigh rateReceptive fieldsCortexCatsCellsSpike trainsEarly emergence of photoreceptor mosaicism in the primate retina revealed by a novel cone‐specific monoclonal antibody
Wikler K, Rakic P, Bhattacharyya N, Macleish P. Early emergence of photoreceptor mosaicism in the primate retina revealed by a novel cone‐specific monoclonal antibody. The Journal Of Comparative Neurology 1997, 377: 500-508. PMID: 9007188, DOI: 10.1002/(sici)1096-9861(19970127)377:4<500::aid-cne2>3.0.co;2-6.Peer-Reviewed Original ResearchConceptsPrimate retinaFetal retinaMonoclonal antibodiesAdult primate retinaEmbryonic day 80Opsin-positive conesOuter plexiform layerNovel monoclonal antibodyPopulation of conesShort-wavelength sensitive conesDouble-labeling experimentsSynaptic contactsPlexiform layerPhotoreceptor layerWavelength-sensitive conesMacaque monkeysSynaptic connectionsFetal ageRetinaDay 80Cone genesisCone opsinsImmunoreactivityAntibodiesInitial differentiation
1994
An array of early differentiating cones precedes the emergence of the photoreceptor mosaic in the fetal monkey retina.
Wikler K, Rakic P. An array of early differentiating cones precedes the emergence of the photoreceptor mosaic in the fetal monkey retina. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 6534-6538. PMID: 7912829, PMCID: PMC44237, DOI: 10.1073/pnas.91.14.6534.Peer-Reviewed Original ResearchConceptsFetal monkey retinaMonkey retinaRetinal ganglion cellsSubset of conesRed/green opsinImportant developmental markersGanglion cellsPrimate retinaGreen-sensitive conesDistinct antigensPhotoreceptor phenotypeRetinaMonoclonal antibodiesPhotoreceptor mosaicCone differentiationDevelopmental markersAntibodiesImmature regionsSame patternGreen opsinsAntigenSynaptogenesisSubset
1992
Mouse cortical collecting duct cells show nonselective cation channel activity and express a gene related to the cGMP-gated rod photoreceptor channel.
Ahmad I, Korbmacher C, Segal A, Cheung P, Boulpaep E, Barnstable C. Mouse cortical collecting duct cells show nonselective cation channel activity and express a gene related to the cGMP-gated rod photoreceptor channel. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 10262-10266. PMID: 1279673, PMCID: PMC50318, DOI: 10.1073/pnas.89.21.10262.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBlotting, NorthernCell LineCyclic GMPDNAIon Channel GatingIon ChannelsKidney CortexKidney Tubules, CollectingMembrane PotentialsMiceMolecular Sequence DataOligodeoxyribonucleotidesPhotoreceptor CellsPoly APolymerase Chain ReactionRatsRNARNA, MessengerSequence Homology, Nucleic AcidConceptsNonselective cation channelsPhotoreceptor channelDuct cellsCation channel probeCation channelsChannel activityPolymerase chain reactionNonselective cation channel activityCGMP decreaseCation channel activityChannel subunitsCytoplasmic applicationChain reactionRod photoreceptorsNorthern blot analysisRetinal cGMPBlot analysisCGMPRat kidney cDNA libraryChannel genesMiceSingle-channel conductanceOpen probabilityCellsCalcium removalUnconventional myosins
Cheney R, Mooseker M. Unconventional myosins. Current Opinion In Cell Biology 1992, 4: 27-35. PMID: 1558751, DOI: 10.1016/0955-0674(92)90055-h.Peer-Reviewed Original ResearchThe role of inositol phosphates in neuronal function.
Perney T, Kaczmarek L. The role of inositol phosphates in neuronal function. 1992, 26: 311-33. PMID: 1419361.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1991
Relation of an array of early-differentiating cones to the photoreceptor mosaic in the primate retina
Wikler K, Rakic P. Relation of an array of early-differentiating cones to the photoreceptor mosaic in the primate retina. Nature 1991, 351: 397-400. PMID: 1827876, DOI: 10.1038/351397a0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationEye ProteinsGestational AgeImmunologic TechniquesMacaca mulattaPhotoreceptor CellsRetinaRod OpsinsConceptsSubset of conesCone subtypesAdult rhesus monkeysRetinal mosaicsBlue-sensitive conesPrimate retinaRetinal surfaceImmunocytochemical evidenceRhesus monkeysPhenotypic specificationInner segmentsConfocal laser microscopySubtypesRetinaWeeksUndifferentiated regionDiurnal primatesLaser microscopyMonthsSynapsesTreatment of seasonal affective disorder with green light and red light
Oren D, Brainard G, Johnston S, Joseph-Vanderpool J, Sorek E, Rosenthal N. Treatment of seasonal affective disorder with green light and red light. American Journal Of Psychiatry 1991, 148: 509-511. PMID: 2006698, DOI: 10.1176/ajp.148.4.509.Peer-Reviewed Original ResearchMeSH KeywordsAmbulatory CareColorDepressive DisorderFemaleHumansLightMalePersonality InventoryPhotoreceptor CellsPhototherapyRadiationSeasons
1990
Distribution of photoreceptor subtypes in the retina of diurnal and nocturnal primates
Wikler K, Rakic P. Distribution of photoreceptor subtypes in the retina of diurnal and nocturnal primates. Journal Of Neuroscience 1990, 10: 3390-3401. PMID: 2145402, PMCID: PMC6570186, DOI: 10.1523/jneurosci.10-10-03390.1990.Peer-Reviewed Original ResearchConceptsRhesus monkey retinaMonkey retinaRhesus monkeysNew World owl monkeysOwl monkeysCone inner segmentsAbnormal colour visionBlue cone opsinDensity of conesColor visionBlue-sensitive conesDorsal retinaGreen cone opsinRetinaSpecific antibodiesCSA-1Inner segmentsMonkeysFoveaAntibodiesPhotoreceptor subtypesRed/green
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