2025
(432) Enhanced Recovery After Surgery (ERAS): Early Phrenic Nerve/Diaphragm Dysfunction Analysis and Treatment in Lung Transplant Patients
Onders R, Elmo M, Carl N, Elgudin Y, Abu-Omar Y, Gray K, Pelletier M, Arora R, Kilaru S, Schilz R. (432) Enhanced Recovery After Surgery (ERAS): Early Phrenic Nerve/Diaphragm Dysfunction Analysis and Treatment in Lung Transplant Patients. The Journal Of Heart And Lung Transplantation 2025, 44: s217. DOI: 10.1016/j.healun.2025.02.439.Peer-Reviewed Original ResearchThe prognostic relevance of donor-specific antibodies in facial transplantation – A retrospective cohort study
Huelsboemer L, Hosseini H, Klimitz F, Diatta F, Boroumand S, O'Brien C, Parikh N, Stögner V, Formica R, Ko C, Azzi J, Draper E, Lian C, Murphy G, Pomahac B, Kauke-Navarro M. The prognostic relevance of donor-specific antibodies in facial transplantation – A retrospective cohort study. Journal Of Plastic Reconstructive & Aesthetic Surgery 2025, 103: 286-296. PMID: 40043533, DOI: 10.1016/j.bjps.2025.01.028.Peer-Reviewed Original ResearchDe novo donor-specific antibodiesDonor-specific antibodiesDonor-specific antibody positivityChronic rejectionC4d depositionGraft lossPrognostic relevanceRejection gradeGrades of acute cellular rejectionDonor-specific antibody statusOccurrence of chronic rejectionTime pointsFacial vascularized composite allotransplantationAcute rejection gradeAcute cellular rejectionTissue typing laboratoriesAcute rejection eventsRetrospective cohort studyTransplant-related outcomesFace transplant patientsVascularized composite allotransplantationCellular rejectionTransplant patientsC4d levelsRetrospective analysis
2024
Renal transplant ultrasound: assessment of complications and advanced applications
Langdon J, Sharbidre K, Garner M, Robbin M, Scoutt L. Renal transplant ultrasound: assessment of complications and advanced applications. Abdominal Radiology 2024, 1-28. PMID: 39643733, DOI: 10.1007/s00261-024-04731-9.Peer-Reviewed Original ResearchRenal transplantationSurgical techniqueUltrasound evaluationSolid organ transplant proceduresComplication of renal transplantationLong-term complications of renal transplantationManagement of transplant patientsAssessment of complicationsComprehensive ultrasound evaluationLong-term complicationsRenal transplant evaluationOrgan transplant proceduresTransplant patientsUltrasound findingsSonographic findingsTransplant proceduresTransplant evaluationComplicationsTransplantationUltrasoundSurgeryPracticing radiologistsRelative prevalenceAllograftPatientsA metabolic dependency of EBV can be targeted to hinder B cell transformation
Müller-Durovic B, Jäger J, Engelmann C, Schuhmachers P, Altermatt S, Schlup Y, Duthaler U, Makowiec C, Unterstab G, Roffeis S, Xhafa E, Assmann N, Trulsson F, Steiner R, Edwards-Hicks J, West J, Turner L, Develioglu L, Ivanek R, Azzi T, Dehio P, Berger C, Kuzmin D, Saboz S, Mautner J, Löliger J, Geigges M, Palianina D, Khanna N, Dirnhofer S, Münz C, Bantug G, Hess C, Berger C, Hess C, Koller M, Rossi S, Stampf S, Müller N. A metabolic dependency of EBV can be targeted to hinder B cell transformation. Science 2024, 385: eadk4898. PMID: 38781354, DOI: 10.1126/science.adk4898.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusIndoleamine 2,3-dioxygenase 1B-cell transformationB cellsEBV-driven B-cell transformationIndoleamine 2,3-dioxygenase 1 expressionIndoleamine 2,3-dioxygenase 1 inhibitionInfection of B cellsEBV-infected B cellsEnzyme indoleamine 2,3-dioxygenase 1Epstein-Barr virus protein EBNA2Increased IDO1 activityNicotinamide adenine dinucleotideDevelopment of lymphomaEBV-related diseasesInfected B cellsHumanized miceTransplant patientsImmune dysregulationAdenosine triphosphateMitochondrial complex I activityComplex I activityMetabolic vulnerabilitiesIDO1 activitySerum signatureImmune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions
Knoedler L, Dean J, Diatta F, Thompson N, Knoedler S, Rhys R, Sherwani K, Ettl T, Mayer S, Falkner F, Kilian K, Panayi A, Iske J, Safi A, Tullius S, Haykal S, Pomahac B, Kauke-Navarro M. Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions. Frontiers In Immunology 2024, 15: 1372862. PMID: 38650942, PMCID: PMC11033354, DOI: 10.3389/fimmu.2024.1372862.Peer-Reviewed Original ResearchConceptsRegulatory myeloid cellsSolid organ transplantationVascularized composite allotransplantationMesenchymal stromal cellsT cellsTransplant patientsCellular therapyChimeric antigen receptor T cellsTransplant surgerySide effectsIncreased risk of malignancyProgression to chronic rejectionAcute rejection ratesPerioperative treatment strategiesRegulatory T cellsPromote immune toleranceRisk of malignancySystemic side effectsRelated side effectsCell typesImprove transplant survivalCAR-TCell therapy applicationsImmunosuppressive regimensChronic rejection(721) Current Utilization of Diaphragm Pacing in Lung Transplant Patients: Identifying and Treating Phrenic and Diaphragm Function Abnormalities
Onders R, Elmo M, Carl N, Elgudin Y, Abu-Omar Y, Gray K, Pelletier M, Arora R, Kilaru S, Schilz R. (721) Current Utilization of Diaphragm Pacing in Lung Transplant Patients: Identifying and Treating Phrenic and Diaphragm Function Abnormalities. The Journal Of Heart And Lung Transplantation 2024, 43: s344-s345. DOI: 10.1016/j.healun.2024.02.537.Peer-Reviewed Original ResearchImmunosuppressive strategies in face and hand transplantation: a comprehensive systematic review of current therapy regimens and outcomes
Huelsboemer L, Boroumand S, Kochen A, Dony A, Moscarelli J, Hauc S, Stögner V, Formica R, Pomahac B, Kauke-Navarro M. Immunosuppressive strategies in face and hand transplantation: a comprehensive systematic review of current therapy regimens and outcomes. Frontiers In Transplantation 2024, 3: 1366243. PMID: 38993787, PMCID: PMC11235358, DOI: 10.3389/frtra.2024.1366243.Peer-Reviewed Original ResearchCMV infectionImmunosuppressive regimensImmunosuppressive strategiesTransplant recipientsIncidence of rejection episodesClinical CMV infectionTriple maintenance therapyIncidence of rejectionEpisodes of rejectionIndividualized immunosuppressive regimensEffective immunosuppressive therapySystematic reviewFace transplant patientsHand transplant recipientsHand transplantationFacial graftImmunosuppressive therapyMaintenance therapyRejection episodesFacial mucosaGraft lossGraft rejectionTherapy regimensTransplant patientsRenal failureLymphadenopathy and lymph node rejection following facial vascularized composite allotransplantation
Kauke-Navarro M, Sadigh S, Lee C, Panayi A, Knoedler L, Knoedler S, Stoegner V, Huelsboemer L, Jamil A, Ko C, Lian C, Murphy G, Pomahac B. Lymphadenopathy and lymph node rejection following facial vascularized composite allotransplantation. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 91: 268-275. PMID: 38430863, DOI: 10.1016/j.bjps.2024.02.024.Peer-Reviewed Original ResearchLymph nodesVascularized composite allograftsGranzyme BDonor-derived immune cellsFacial vascularized composite allograftMedian time of presentationFacial vascularized composite allotransplantationImmunological processesGranzyme B expressionCytotoxic T cellsNecrotizing histiocytic lymphadenitisHead and neckRetrospective cohort studyTime of presentationStages of follow-upCoexistence of donorFace transplant patientsBilateral adenopathyIncreased histiocytesSuperficial lymph nodesVascularized composite allotransplantationBilateral lymphadenopathyAllograft rejectionTransplant patientsDendritic cells
2023
Proteome Analysis for Inflammation Related to Acute and Convalescent Infection
Sigdel T, Sur S, Boada P, McDermott S, Arlehamn C, Murray K, Bockenstedt L, Kerwin M, Reed E, Harris E, Stuart K, Peters B, Sesma A, Montgomery R, Sarwal M. Proteome Analysis for Inflammation Related to Acute and Convalescent Infection. Inflammation 2023, 47: 346-362. PMID: 37831367, PMCID: PMC10799112, DOI: 10.1007/s10753-023-01913-3.Peer-Reviewed Original ResearchC motif chemokine ligand 1C motif chemokine receptor 7Human Immunology Project ConsortiumWest Nile virusDengue virusLyme diseaseKidney transplant patientsChemokine ligand 1Chemokine receptor 7Common therapeutic interventionTumor necrosis factor receptorHost defense mechanismsNecrosis factor receptorCell surface markersConvalescent infectionTransplant patientsConvalescent phaseImmune signaturesAcute phaseConvalescent stageReceptor 7Common biological pathwaysHealthy donorsPolyomavirus infectionImmune responseTemporary Diaphragm Pacing Wires in Lung Transplant Patients: Diagnostic and Therapeutic Utilization
Onders R, Elmo M, Carl N, Elgudin Y, Abu-Omar Y, Pelletier M, Schilz R. Temporary Diaphragm Pacing Wires in Lung Transplant Patients: Diagnostic and Therapeutic Utilization. The Journal Of Heart And Lung Transplantation 2023, 42: s101. DOI: 10.1016/j.healun.2023.02.1509.Peer-Reviewed Original ResearchVentilator induced diaphragm dysfunctionDP stimulationLung transplant patientsMechanical ventilationDiaphragm pacingDiaphragmatic dysfunctionTransplant patientsDEMG activityNerve recoveryPhrenic nerve recoveryNo device related complicationsGroup 3 patientsLung transplant recipientsMonths post-transplantDevice related complicationsAverage anesthesia timeHyperinflation of lungsRespiratory neuroplasticityDiaphragm dysfunctionChest closureTransplant recipientsMV timePost-transplantRelated complicationsPre-operativelyACLP Best Practice Guidance: Evaluation and Treatment of Depression in Solid Organ Transplant Recipients
Zimbrean P, Andrews S, Hussain F, Fireman M, Kuntz K, Niazi S, Simpson S, Soeprono T, Winder G, Jowsey-Gregoire S. ACLP Best Practice Guidance: Evaluation and Treatment of Depression in Solid Organ Transplant Recipients. Journal Of The Academy Of Consultation-Liaison Psychiatry 2023, 64: 357-370. PMID: 37003570, DOI: 10.1016/j.jaclp.2023.03.007.Peer-Reviewed Original ResearchConceptsOrgan transplant recipientsSolid organ transplant recipientsTransplant recipientsDepressive disorderFirst-line antidepressantsTreatment of depressionMental health carePosttransplant depressionSOT recipientsTransplant patientsTreating providerClinical evaluationPositive screeningTreatment interventionsPatientsRecipientsHealth careDepressionDisordersConsensus processFrequent problemSpecial Interest GroupTreatmentPractice guidanceBest practice guidance
2022
PET Myocardial Blood Flow for Post-transplant Surveillance and Cardiac Allograft Vasculopathy in Heart Transplant Recipients
Feher A, Miller EJ. PET Myocardial Blood Flow for Post-transplant Surveillance and Cardiac Allograft Vasculopathy in Heart Transplant Recipients. Current Cardiology Reports 2022, 24: 1865-1871. PMID: 36279035, DOI: 10.1007/s11886-022-01804-3.Peer-Reviewed Original ResearchConceptsHeart transplant recipientsAllograft vasculopathyTransplant recipientsPositron emission tomography myocardial perfusionOverall graft survivalPost-transplant surveillanceCardiac allograft vasculopathyHeart transplant patientsTomography myocardial perfusionRecent FindingsMultiple studiesMyocardial perfusion imagingMyocardial blood flowMBF quantificationGraft survivalHeart transplantationTransplant patientsTransplant rejectionSerial monitoringPrognostic performancePET myocardial blood flowBlood flowMyocardial perfusionPerfusion imagingMBF assessmentBlood flow quantificationToxic epidermal necrolysis‐like acute graft‐versus‐host disease in pediatric bone marrow transplant patients: Case series and review of the literature
Song J, Huang JT, del Carmen Fraile Alonso M, Antaya RJ, Price HN, Funk T, Francois RA, Shah SD. Toxic epidermal necrolysis‐like acute graft‐versus‐host disease in pediatric bone marrow transplant patients: Case series and review of the literature. Pediatric Dermatology 2022, 39: 889-895. PMID: 35730149, DOI: 10.1111/pde.15069.Peer-Reviewed Original ResearchConceptsToxic epidermal necrolysisHematopoietic stem cell transplantCase seriesAcute graftHost diseaseTransplant patientsSkin symptomsPediatric bone marrow transplant patientsBone marrow transplant patientsMulti-institutional case seriesMarrow transplant patientsStem cell transplantBone marrow transplantationGVHD involvementGVHD prophylaxisEpidermal necrolysisPain medicationConcurrent medicationsCulprit medicationGeneralized erythrodermaBSA involvementInfection prophylaxisMedian ageMultidisciplinary carePediatric patientsOutcomes of Anesthesiologist-Led Care of Patients Following Liver Transplantation During the COVID-19 Pandemic
Ferrer C, Mokuolu D, Lin H, Ouyang Y, Schiano T, Wang R, Afonin D, Florman S, Tanella A, Katz D, DeMaria S, Smith N. Outcomes of Anesthesiologist-Led Care of Patients Following Liver Transplantation During the COVID-19 Pandemic. The Joint Commission Journal On Quality And Patient Safety 2022, 48: 458-467. PMID: 35792038, PMCID: PMC9186534, DOI: 10.1016/j.jcjq.2022.06.001.Peer-Reviewed Original ResearchConceptsLiver transplantationOne-year graft survivalOne-year patient survivalUrban tertiary care centerKaplan-Meier survival analysisLiver transplant patientsOrthotopic liver transplantationOutcomes of patientsTertiary care centerPostanesthesia care unitProportional hazards regressionDate of procedureSignificant differencesCOVID-19 pandemicGraft survivalHospital lengthICU lengthTransplant patientsAdult patientsCare unitHazards regressionPatient survivalCare centerTreatment weightingPatientsSubstance use screening in transplant populations: Recommendations from a consensus workgroup
Jowsey-Gregoire S, Jannetto PJ, Jesse MT, Fleming J, Winder GS, Balliet W, Kuntz K, Vasquez A, Weinland S, Hussain F, Weinrieb R, Fireman M, Nickels MW, Peipert JD, Thomas C, Zimbrean PC. Substance use screening in transplant populations: Recommendations from a consensus workgroup. Transplantation Reviews 2022, 36: 100694. PMID: 35537285, DOI: 10.1016/j.trre.2022.100694.Peer-Reviewed Original ResearchConceptsSubstance use disordersUse disordersTransplant patientsDrug testingConsultation-liaison psychiatryTransplant populationTransplant teamClinical historyOptimal carePatient practicesPatientsCurrent laboratory testingAmerican SocietyDisordersTransplantationPharmacy communityPossible risksInsurance issuesLaboratory testingOngoing testingRiskCertain substancesGroup discussionsTestingSubstancesCOVID-19 in Kidney Transplant Recipient and Waitlist Patients
Dong Y, Dhingra A, Shamir S, Azzi Y, Ye K, Greenstein S, Haramati L. COVID-19 in Kidney Transplant Recipient and Waitlist Patients. Journal Of Thoracic Imaging 2022, 37: 133-139. PMID: 35439238, PMCID: PMC9018208, DOI: 10.1097/rti.0000000000000640.Peer-Reviewed Original ResearchConceptsKidney transplant recipientsTransplant recipientsICU admissionHospital admissionSecondary outcomesWaitlist patientsIntensive care unit admissionCoronavirus disease 2019 (COVID-19) patientsCOVID-19Care unit admissionKidney transplant patientsPatient's chest radiographReverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionMultivariate regression analysisRadiographic severity scoreUnit admissionTransplant patientsRetrospective cohortPrimary outcomeSeverity scoreTransplant waitlistWorse outcomesChest radiographsPatientsGambling Disorders in Organ Transplant Recipients
Luchsinger W, Zimbrean P. Gambling Disorders in Organ Transplant Recipients. 2022, 183-188. DOI: 10.1007/978-3-031-15052-4_23.Chapters
2021
Emerging Diagnostics for Transplant Infectious Diseases
Azar M, Gaston D, Malinis M. Emerging Diagnostics for Transplant Infectious Diseases. 2021, 1535-1576. DOI: 10.1007/978-3-030-25869-6_69.Peer-Reviewed Original ResearchTransplant infectious diseasesInfectious diseasesPolymerase chain reaction panelHematopoietic stem cell transplantationCommunity-acquired infectionsStem cell transplantationMultidrug-resistant organismsTest performance characteristicsTransplant patientsUncommon pathogenCell transplantationSerious infectionsPatient outcomesClinical impactDiagnostic modalitiesSolid organsMolecular testingClinical specimensPatientsDiseaseDiagnostic advantageInfectionResistance detectionDiagnostic methodsDiagnostic capabilitiesCirculating Donor Lung-specific Exosome Profiles Enable Noninvasive Monitoring of Acute Rejection in a Rodent Orthotopic Lung Transplantation Model
Habertheuer A, Ram C, Schmierer M, Chatterjee S, Hu R, Freas A, Zielinski P, Rogers W, Silvestro EM, McGrane M, Moore JS, Korutla L, Siddiqui S, Xin Y, Rizi R, Tao J, Kreisel D, Naji A, Ochiya T, Vallabhajosyula P. Circulating Donor Lung-specific Exosome Profiles Enable Noninvasive Monitoring of Acute Rejection in a Rodent Orthotopic Lung Transplantation Model. Transplantation 2021, 106: 754-766. PMID: 33993180, DOI: 10.1097/tp.0000000000003820.Peer-Reviewed Original ResearchConceptsAcute rejectionDonor exosomesExosome profileSyngeneic controlsRat orthotopic lung transplant modelChronic lung allograft dysfunctionOrthotopic lung transplantation modelLung transplant modelPosttransplant time pointsAcute rejection episodesLung allograft dysfunctionLung transplant patientsLung transplant rejectionLung transplantation modelEarly therapeutic interventionMajor risk factorTime-sensitive diagnosisDevelopment of biomarkersAllograft dysfunctionRejection episodesLewis recipientsTransplant patientsPulmonary allograftsRecipient bloodAllogeneic graftsImmunoregulatory and lipid presentation pathways are upregulated in human face transplant rejection
Win T, Crisler W, Dyring-Andersen B, Lopdrup R, Teague J, Zhan Q, Barrera V, Sui S, Tasigiorgos S, Murakami N, Chandraker A, Tullius S, Pomahac B, Riella L, Clark R. Immunoregulatory and lipid presentation pathways are upregulated in human face transplant rejection. Journal Of Clinical Investigation 2021, 131 PMID: 33667197, PMCID: PMC8262560, DOI: 10.1172/jci135166.Peer-Reviewed Original ResearchConceptsVCA rejectionTransplant rejectionT cellsTissue injuryGene expression profilingAntigen-presenting cell activationT-cell receptor sequencingSolid organ transplantsCell receptor sequencingT cell activation pathwaysAntigen-specific activationProliferative T cellsCell activation pathwaysNovo Nordisk FoundationAmerican SocietyExpression profilingFace transplant patientsTransplant patientsImmunologic pathwaysImmunoregulatory networkSkin biopsiesImmunomodulatory pathwaysLimb transplantsLundbeck FoundationTransplant Research
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