2024
Reducing Filamin A Restores Cortical Synaptic Connectivity and Early Social Communication Following Cellular Mosaicism in Autism Spectrum Disorder Pathways
Binder M, Escobar I, Xu Y, Sokolov A, Zhang L, Bordey A. Reducing Filamin A Restores Cortical Synaptic Connectivity and Early Social Communication Following Cellular Mosaicism in Autism Spectrum Disorder Pathways. Journal Of Neuroscience 2024, 44: e1245232024. PMID: 39164108, PMCID: PMC11426378, DOI: 10.1523/jneurosci.1245-23.2024.Peer-Reviewed Original ResearchPup isolation callsFilamin AIsolation callsAutism spectrum disorderSigns of autism spectrum disorderPyramidal neuronsConstitutively active mutantCommunication deficitsDownstream of ERK1/2MTOR complex 1Actin crosslinkingSynaptic connectionsExpression of RhebSpine densityActive mutantActive RhebCore pathwaysRhebCortical synaptic connectivityCellular mosaicismConstitutively active RhebOne-month-old miceExcitatory synaptic activityNeocortex of miceSocial communicationTransient impairment in microglial function causes sex-specific deficits in synaptic maturity and hippocampal function in mice exposed to early adversity
Ahmed S, Polis B, Jamwal S, Sanganahalli B, MacDowell Kaswan Z, Islam R, Kim D, Bowers C, Giuliano L, Biederer T, Hyder F, Kaffman A. Transient impairment in microglial function causes sex-specific deficits in synaptic maturity and hippocampal function in mice exposed to early adversity. Brain Behavior And Immunity 2024, 122: 95-109. PMID: 39134183, PMCID: PMC11402597, DOI: 10.1016/j.bbi.2024.08.010.Peer-Reviewed Original ResearchEarly-life adversityModel of early-life adversityContextual fear conditioningLimited beddingFear conditioningSynaptic engulfmentLB miceSynaptic pruningSex-specific deficitsHippocampus of maleSex-specific effectsHippocampal deficitsAdolescent miceHippocampal functionEarly adversityChemogenetic activationSynaptic connectionsBehavioral aberrationsPotential compensatory mechanismsSynaptic abnormalitiesHippocampusAblation of microgliaRodent hippocampusDeficitsWeeks of lifePresynaptic Proteins and Their Roles in Visual Processing by the Retina
Thoreson W, Zenisek D. Presynaptic Proteins and Their Roles in Visual Processing by the Retina. Annual Review Of Vision Science 2024, 10: 347-375. PMID: 38621251, PMCID: PMC11536687, DOI: 10.1146/annurev-vision-101322-111204.Peer-Reviewed Original ResearchExtract critical featuresGanglion cellsHorizontal cellsRetinal ganglion cellsDendritic synapsesSynaptic feedbackSpatial frequencySynaptic connectionsRetinaBipolar cellsSynapse typesVisual worldSense of visionRibbon synapsesPresynaptic moleculesMotion directionTemporal frequencyCritical featuresPhotoreceptorsPresynaptic proteinsCellsUnderstanding neural circuit function through synaptic engineering
Rabinowitch I, Colón-Ramos D, Krieg M. Understanding neural circuit function through synaptic engineering. Nature Reviews Neuroscience 2024, 25: 131-139. PMID: 38172626, DOI: 10.1038/s41583-023-00777-8.Peer-Reviewed Original ResearchNeural circuitsNeural circuit functionNew synaptic connectionsVivo neural circuitsNeural circuit manipulationConnexin gap junction proteinsSynaptic plasticitySynaptic connectionsElectrical synapsesGap junction proteinCircuit connectivityJunction proteinsSynapsesCircuit functionNeuronsCircuit manipulationsSpecific signalingSpecific connectionsLight-gated channelsNeuropeptides
2023
Brain developmental and cortical connectivity changes in transgenic monkeys carrying the human-specific duplicated gene SRGAP2C
Meng X, Lin Q, Zeng X, Jiang J, Li M, Luo X, Chen K, Wu H, Hu Y, Liu C, Su B. Brain developmental and cortical connectivity changes in transgenic monkeys carrying the human-specific duplicated gene SRGAP2C. National Science Review 2023, 10: nwad281. PMID: 38090550, PMCID: PMC10712708, DOI: 10.1093/nsr/nwad281.Peer-Reviewed Original ResearchTransgenic monkeysDeep layer neuronsFetal neurogenesisMyelination levelsSynaptic maturationLongitudinal MRITransgenic miceSynaptic connectionsBrain developmentConnectivity changesBrain connectivityOccipital regionMolecular pathwaysBrainMotor planningMonkeysEnergy metabolismHuman brainCellular levelEnlarged brainExtracellular matrixPrior studiesHumansNeurogenesisGenesMasterminding Hippocampal Circuits by Transplanting Human GABAergic Interneurons to Treat Temporal Lobe Epilepsy
Gupta J, Naegele J. Masterminding Hippocampal Circuits by Transplanting Human GABAergic Interneurons to Treat Temporal Lobe Epilepsy. Epilepsy Currents 2023, 23: 268-270. PMID: 37662454, PMCID: PMC10470101, DOI: 10.1177/15357597231175010.Peer-Reviewed Original ResearchModel of epilepsyTemporal lobe epilepsyLong-term efficacySpecific synaptic connectionsAbort seizuresGraft functionMishra AHost neuronsSeizure controlLobe epilepsyIntractable epilepsySeizure activityGABAergic interneuronsMonosynaptic tracingCortical interneuronsHippocampal circuitsOptogenetic activationProlonged efficacyHost inhibitionSynaptic connectionsEpilepsySeizuresEfficacyInterneuronsClinical translationThe cellular architecture of memory modules in Drosophila supports stochastic input integration
Hafez O, Escribano B, Ziegler R, Hirtz J, Niebur E, Pielage J. The cellular architecture of memory modules in Drosophila supports stochastic input integration. ELife 2023, 12: e77578. PMID: 36916672, PMCID: PMC10069864, DOI: 10.7554/elife.77578.Peer-Reviewed Original ResearchConceptsKenyon cellsDecision moduleEfficient storageComputational principlesMushroom bodiesMB output neuronsPatch-clamp recordingsSpiking behaviorOutput neuronsMemory modulesInput integrationOdor inputSynaptic inputsStochastic connectionsArchitectureSynaptic localizationSynaptic connectionsDecision makingComputational modelInputMemoryNeuronsCellular architectureValenced informationModulation
2022
En bloc preparation of Drosophila brains enables high-throughput FIB-SEM connectomics
Lu Z, Xu C, Hayworth K, Pang S, Shinomiya K, Plaza S, Scheffer L, Rubin G, Hess H, Rivlin P, Meinertzhagen I. En bloc preparation of Drosophila brains enables high-throughput FIB-SEM connectomics. Frontiers In Neural Circuits 2022, 16: 917251. PMID: 36589862, PMCID: PMC9801301, DOI: 10.3389/fncir.2022.917251.Peer-Reviewed Original ResearchUsing NeuroPAL Multicolor Fluorescence Labeling to Identify Neurons in C. elegans
Santiago E, Shelar A, Christie N, Lewis‐Hayre M, Koelle M. Using NeuroPAL Multicolor Fluorescence Labeling to Identify Neurons in C. elegans. Current Protocols 2022, 2: e610. PMID: 36521003, PMCID: PMC10257892, DOI: 10.1002/cpz1.610.Peer-Reviewed Original ResearchA 3D atlas of functional human brain energetic connectome based on neuropil distribution
Yu Y, Akif A, Herman P, Cao M, Rothman D, Carson R, Agarwal D, Evans A, Hyder F. A 3D atlas of functional human brain energetic connectome based on neuropil distribution. Cerebral Cortex 2022, 33: 3996-4012. PMID: 36104858, PMCID: PMC10068297, DOI: 10.1093/cercor/bhac322.Peer-Reviewed Original ResearchConceptsSynaptic densityCortical regionsHigher synapse densityHuman cortical circuitsFunctional imaging studiesCortical activity mapsVivo PET imagingNeuropil distributionGlucose oxidationSynapse densityCortical circuitsMetabolic rateSynaptic connectionsCortical energeticsImaging studiesHuman cortexPET imagingHistological stainingRecent evidenceCortexHuman brainBrainVoxel levelActivity ratesAtlasImaging the effect of ketamine on synaptic density (SV2A) in the living brain
Holmes SE, Finnema SJ, Naganawa M, DellaGioia N, Holden D, Fowles K, Davis M, Ropchan J, Emory P, Ye Y, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Imaging the effect of ketamine on synaptic density (SV2A) in the living brain. Molecular Psychiatry 2022, 27: 2273-2281. PMID: 35165397, PMCID: PMC9133063, DOI: 10.1038/s41380-022-01465-2.Peer-Reviewed Original ResearchConceptsKetamine's therapeutic effectsMajor depressive disorderTherapeutic effectPositron emission tomographyPosttraumatic stress disorderHealthy controlsSynaptic connectionsSynaptic vesicle protein 2APost-synaptic mechanismsEffects of ketamineDiscovery of ketamineNon-human primatesAntidepressant effectsDepressive disorderSingle administrationSynaptic densityPsychiatric disordersDepression severityKetamineEmission tomographyTerminal densityLiving brainStress disorderRobust reductionDissociative symptoms
2021
Connectomic features underlying diverse synaptic connection strengths and subcellular computation
Liu TX, Davoudian PA, Lizbinski KM, Jeanne JM. Connectomic features underlying diverse synaptic connection strengths and subcellular computation. Current Biology 2021, 32: 559-569.e5. PMID: 34914905, PMCID: PMC8825683, DOI: 10.1016/j.cub.2021.11.056.Peer-Reviewed Original ResearchConceptsSomatic postsynaptic potentialsSingle presynaptic spikeElectrical compartmentalizationPostsynaptic potentialsSynapse densityDiverse neuronsSynaptic connectionsSynaptic connection strengthsOlfactory networkPresynaptic spikesNeural tissueDrosophila brainNeuronal biophysicsConnectivity mapsNeuronsBrainSynapsesThe development and function of neuronal subtypes processing color and skylight polarization in the optic lobes of Drosophila melanogaster
Sancer G, Wernet M. The development and function of neuronal subtypes processing color and skylight polarization in the optic lobes of Drosophila melanogaster. Arthropod Structure & Development 2021, 61: 101012. PMID: 33618155, DOI: 10.1016/j.asd.2020.101012.Peer-Reviewed Original ResearchConceptsDorsal rim areaOptic lobeSpecific cellular elementsCell typesMedulla neuropilPhotoreceptor terminalsNeuronal subtypesRim areaOmmatidial subtypesDistinct subtypesSynaptic connectionsNeural circuitsCellular elementsSubtypesDistal portionRetinal mosaicsMolecular mechanismsCell type-specific transcriptomicsResponse propertiesPhotoreceptorsLobeCellsR7 photoreceptorsR8 cellsR8 photoreceptors
2020
Insights into Cognitive Disorders in Aging and Mental Illness: Molecular Influences on Circuits of the Prefrontal Cortex
Arnsten A. Insights into Cognitive Disorders in Aging and Mental Illness: Molecular Influences on Circuits of the Prefrontal Cortex. 2020 DOI: 10.1093/oxfordhb/9780190069162.013.4.Peer-Reviewed Original ResearchPrefrontal cortexAbsence of sensory stimulationGoal-directed behaviorTop-down controlWorking memoryPrefrontal microcircuitsAffective disordersDynamic network connectivityMental disordersArousal systemCognitive disordersMental illnessCortical synaptic connectivityAbstract thoughtCortexRepresentation of informationDisordersSensory stimulationSynaptic strengthAlzheimer's diseaseRecurrent excitatory connectionsSynaptic connectionsExcitatory connectionsSchizophreniaNetwork connectivity
2019
Lower synaptic density is associated with depression severity and network alterations
Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations. Nature Communications 2019, 10: 1529. PMID: 30948709, PMCID: PMC6449365, DOI: 10.1038/s41467-019-09562-7.Peer-Reviewed Original ResearchConceptsMajor depressive disorderPost-traumatic stress disorderLower synaptic densitySynaptic densityPositron emission tomographyFunctional connectivityNetwork alterationsSynaptic vesicle glycoprotein 2ASymptoms of depressionSynaptic lossDepressive disorderHealthy controlsNerve terminalsDepressive symptomsDepression severityUnmedicated individualsSynaptic connectionsEmission tomographyStress disorderVivo evidenceSymptomsDepressionSeverityDisordersAlterations
2017
Selective synaptic connections in the retinal pathway for night vision
Beaudoin DL, Kupershtok M, Demb JB. Selective synaptic connections in the retinal pathway for night vision. The Journal Of Comparative Neurology 2017, 527: 117-132. PMID: 28856684, PMCID: PMC5832573, DOI: 10.1002/cne.24313.Peer-Reviewed Original ResearchConceptsAII amacrine cellsRetinal ganglion cellsAmacrine cellsRGC typesBipolar terminalsSynaptic connectionsCertain retinal ganglion cellsConnected retinal ganglion cellsIonotropic glutamate receptor antagonistsOFF alpha cellsGlutamate receptor antagonistsInner plexiform layerBipolar cell terminalsSelective synaptic connectionsBipolar cell activityOFF alphaRetinal connectionsRetinal pathwaysPlexiform layerReceptor antagonistDirect synapsesGanglion cellsGlycinergic synapsesInhibitory currentsMammalian retinaThe malleable brain: plasticity of neural circuits and behavior – a review from students to students
Schaefer N, Rotermund C, Blumrich E, Lourenco MV, Joshi P, Hegemann RU, Jamwal S, Ali N, Romero E, Sharma S, Ghosh S, Sinha JK, Loke H, Jain V, Lepeta K, Salamian A, Sharma M, Golpich M, Nawrotek K, Paidi RK, Shahidzadeh SM, Piermartiri T, Amini E, Pastor V, Wilson Y, Adeniyi PA, Datusalia AK, Vafadari B, Saini V, Suárez‐Pozos E, Kushwah N, Fontanet P, Turner AJ. The malleable brain: plasticity of neural circuits and behavior – a review from students to students. Journal Of Neurochemistry 2017, 142: 790-811. PMID: 28632905, DOI: 10.1111/jnc.14107.Peer-Reviewed Original ResearchLong-term depressionLong-term potentiationSynaptic plasticityNeural circuitsNeuronal activity patternsPlasticity-related proteinsSynaptic plasticity mechanismsFirst International SocietySynaptic connectionsSynaptic scalingSynaptic strengthEditorial HighlightNeural circuitryHomeostatic mechanismsMotor learningPersistent changesSustained changesSensory inputPotentiationBehavioral relevanceInternational SocietyPlasticity mechanismsBrainCritical developmental stagesCurrent knowledgeA connectome of a learning and memory center in the adult Drosophila brain
Takemura SY, Aso Y, Hige T, Wong A, Lu Z, Xu CS, Rivlin PK, Hess H, Zhao T, Parag T, Berg S, Huang G, Katz W, Olbris DJ, Plaza S, Umayam L, Aniceto R, Chang LA, Lauchie S, Ogundeyi O, Ordish C, Shinomiya A, Sigmund C, Takemura S, Tran J, Turner GC, Rubin GM, Scheffer LK. A connectome of a learning and memory center in the adult Drosophila brain. ELife 2017, 6: e26975. PMID: 28718765, PMCID: PMC5550281, DOI: 10.7554/elife.26975.Peer-Reviewed Original ResearchConceptsMB output neuronsDopaminergic neuronsKenyon cellsΑ-lobeMushroom bodiesAdult Drosophila brainUnderlying neuronal circuitsDirect synapseSlow depolarizationNeuronal circuitsSynaptic connectionsMemory centerDrosophila brainSynapsesNeuronsMemory formationOutput neuronsMajor siteSensory informationDAN activationSparse activitySensory modalitiesMemory recallUnanticipated classBrain
2016
Dendrite Maintenance
Katrancha S, Koleske A. Dendrite Maintenance. 2016, 317-355. DOI: 10.1007/978-4-431-56050-0_14.Peer-Reviewed Original ResearchDendritic spinesArbor stabilityDendrite arborsCytoplasmic nonreceptor tyrosine kinaseDendritic spine formationDendritic spine stabilityProper brain functionPsychiatric illnessSpine stabilityDifferent pathological statesSynaptic connectionsSpine formationBrain functionNormal agingNeurodegenerative diseasesMajor contributing factorSpinePathological statesReceptorsArborsEph receptorsContributing factorTyrosine kinaseCell surface adhesion receptorsMolecular mechanismsmGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions
Jin LE, Wang M, Yang ST, Yang Y, Galvin VC, Lightbourne TC, Ottenheimer D, Zhong Q, Stein J, Raja A, Paspalas CD, Arnsten AFT. mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions. Molecular Psychiatry 2016, 22: 1615-1625. PMID: 27502475, PMCID: PMC5298940, DOI: 10.1038/mp.2016.129.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexLow dosesPostsynaptic actionsGroup II metabotropic glutamate receptorsN-methyl-D-aspartate receptorsPrefrontal cortexPrimate dorsolateral prefrontal cortexGlial glutamate uptakeMetabotropic glutamate receptorsAge-related disordersAstrocytic locationGlutamate releaseIontophoretic applicationClinical trialsSystemic administrationGlutamate receptorsTherapeutic effectGlutamate uptakeDendritic spinesNeuronal firingTherapeutic interventionsHigh dosesPostsynaptic cAMPSynaptic connectionsCognitive deficits
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