2022
UCP2-dependent redox sensing in POMC neurons regulates feeding
Yoon N, Jin S, Kim J, Liu Z, Sun Q, Cardone R, Kibbey R, Diano S. UCP2-dependent redox sensing in POMC neurons regulates feeding. Cell Reports 2022, 41: 111894. PMID: 36577374, PMCID: PMC9885759, DOI: 10.1016/j.celrep.2022.111894.Peer-Reviewed Original ResearchConceptsPOMC neuronsGlucose metabolismPOMC neuronal activityAnorexigenic pro-opiomelanocortin (POMC) neuronsPro-opiomelanocortin (POMC) neuronsHigh-fat dietFatty acid metabolismMitochondrial respirationLactate levelsCerebrospinal fluidNeuronal activityGlucose utilizationFed stateNeuronsPyruvate levelsExtracellular pyruvate levelsAcid metabolismMalate-aspartate shuttleMetabolismAddition of lactateMitochondrial pyruvate carrierInhibitionObesityPyruvate carrierSatiety
2020
Metabolic Lateralization in the Hypothalamus of Male Rats Related to Reproductive and Satiety States
Kiss DS, Toth I, Jocsak G, Bartha T, Frenyo LV, Barany Z, Horvath TL, Zsarnovszky A. Metabolic Lateralization in the Hypothalamus of Male Rats Related to Reproductive and Satiety States. Reproductive Sciences 2020, 27: 1197-1205. PMID: 32046448, PMCID: PMC7181557, DOI: 10.1007/s43032-019-00131-3.Peer-Reviewed Original ResearchConceptsSatiety stateMale ratsFood intakeImpact of gonadectomyRight hemisphereSleep-wake behaviorHypothalamic functionMale rodentsMetabolic asymmetryScheduled feedingFunctional lateralizationHypothalamusEx vivoRegulatory centersRatsMetabolic differencesHomeostatic processesFunctional asymmetryIntakeLateralizationRecent findingsPresent studyReproductive controlGonadectomySatiety
2018
Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity
Ravussin A, Youm YH, Sander J, Ryu S, Nguyen K, Varela L, Shulman GI, Sidorov S, Horvath TL, Schultze JL, Dixit VD. Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity. Cell Reports 2018, 24: 1085-1092.e6. PMID: 30067966, PMCID: PMC6223120, DOI: 10.1016/j.celrep.2018.06.112.Peer-Reviewed Original ResearchConceptsHigh-fat dietInsulin resistanceFood intakeMetabolic inflammationNucleobindin-2M2-like macrophage polarizationHigh-fat diet feedingWeight lossAdipose tissue macrophagesObesity-associated diseasesNesfatin-1Insulin sensitivityDiet feedingMacrophage polarizationNUCB2 proteinMyeloid cellsTissue macrophagesGlobal deletionClassical M1NUCB2NFκB-dependent mannerWeight gainSatietyIntakeAdiposity
2017
Lateral hypothalamic activity indicates hunger and satiety states in humans
Talakoub O, Paiva R, Milosevic M, Hoexter M, Franco R, Alho E, Navarro J, Pereira J, Popovic M, Savage C, Lopes A, Alvarenga P, Damiani D, Teixeira M, Miguel E, Fonoff E, Batistuzzo M, Hamani C. Lateral hypothalamic activity indicates hunger and satiety states in humans. Annals Of Clinical And Translational Neurology 2017, 4: 897-901. PMID: 29296618, PMCID: PMC5740250, DOI: 10.1002/acn3.466.Peer-Reviewed Original ResearchDeep brain stimulationSatiety stateLateral hypothalamic activityLow gamma activityPrader-Willi patientsFood-related cuesLocal field potentialsHypothalamic activityFood intakeBrain stimulationEarly sensationPatterns of activityAlpha rhythmField potentialsObesityPatientsNeuromodulation studiesHumansSatietyIntakeActivity4.19 Obesity and Appetite: Central Control Mechanisms
Horvath T. 4.19 Obesity and Appetite: Central Control Mechanisms. 2017, 369-376. DOI: 10.1016/b978-0-12-803592-4.00085-7.Peer-Reviewed Original ResearchLate-onset chronic diseasesChronic diseasesPrevalence of obesitySerious comorbiditiesFat massTissue malignancyParkinson's diseaseCardiovascular disordersCentral control mechanismAlzheimer's diseaseDiseaseEpigenetic vulnerabilityCellular energy metabolismObesityVulnerable individualsEnergy metabolismAppetiteDisordersTissueDifferent tissuesComorbiditiesDiabetesMajor roleMalignancySatiety
2015
Mitochondria in Control of Hypothalamic Metabolic Circuits
Nasrallah C, Horvath T. Mitochondria in Control of Hypothalamic Metabolic Circuits. 2015, 186-202. DOI: 10.1002/9781119017127.ch8.Peer-Reviewed Original ResearchPOMC neuronsNutritional statusBody nutritional statusAgRP neuronsGhrelin increasesLeptin levelsFood intakeCentral regulationGlucose levelsMetabolic disordersNeuronal functionPrimary siteLipid metabolismMetabolic principlesMitochondrial dysfunctionNeuronsCessation of feedingBioenergetic adaptationImportant contributorMitochondrial dynamicsMetabolic circuitsHypothalamusDysfunctionSatietyIntake
2012
Neuroimaging the interaction of mind and metabolism in humans
D’Agostino A, Small DM. Neuroimaging the interaction of mind and metabolism in humans. Molecular Metabolism 2012, 1: 10-20. PMID: 24024114, PMCID: PMC3757655, DOI: 10.1016/j.molmet.2012.06.002.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingParticular mental processesNeural circuitsInteraction of mindFood cuesMental processesBrain responsesNeural responsesPsychological stateFunctional neuroimagingNeuroimaging techniquesDecision-making processMagnetic resonance imagingHormonal factorsCuesResonance imagingNeuroimagingMetabolic signalsMindHormonal signalsDesireSatietyBehaviorIntakeResponseFoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake
Ren H, Orozco IJ, Su Y, Suyama S, Gutiérrez-Juárez R, Horvath TL, Wardlaw SL, Plum L, Arancio O, Accili D. FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake. Cell 2012, 149: 1314-1326. PMID: 22682251, PMCID: PMC3613436, DOI: 10.1016/j.cell.2012.04.032.Peer-Reviewed Original ResearchConceptsFood intakeAgRP neuronsG-protein-coupled receptor GPR17Intracerebroventricular injectionHypothalamic neuronsReceptor GPR17Pharmacological modulationGlucose homeostasisNutritional statusTherapeutic potentialMice resultsGenetic ablationNeuronsFoxO1 ablationIntakeSatietyGPR17InsulinExpression profilingAblationPathwayCangrelorObesityLeptinAgonists
2011
Synaptic Plasticity of Feeding Circuits: Hormones and Hysteresis
Dietrich MO, Horvath TL. Synaptic Plasticity of Feeding Circuits: Hormones and Hysteresis. Cell 2011, 146: 863-865. PMID: 21925311, DOI: 10.1016/j.cell.2011.08.031.Peer-Reviewed Original Research
2007
Intragastric Injection of Botulinum Toxin A for the Treatment of Obesity
Mittermair R, Keller C, Geibel J. Intragastric Injection of Botulinum Toxin A for the Treatment of Obesity. Obesity Surgery 2007, 17: 732-736. PMID: 17879570, DOI: 10.1007/s11695-007-9135-x.Peer-Reviewed Original ResearchConceptsTreatment of obesityDistal gastric bodyEarly satietyGastric bodyIntragastric injectionGroup 2Group 1Body weightClass I obesityBotulinum toxin AFeeling of satietyBackgroundBotulinum toxinU BTXObese patientsFemale patientsGastric motilityResultsBoth groupsMethodsAfter approvalToxin ASmooth muscleUniversity Ethics CommitteeEndoscopic proceduresPatientsObesitySatiety
2001
Changes in brain activity related to eating chocolate
Small DM, Zatorre RJ, Dagher A, Evans AC, Jones-Gotman M. Changes in brain activity related to eating chocolate. Brain 2001, 124: 1720-1733. PMID: 11522575, DOI: 10.1093/brain/124.9.1720.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowCerebral blood flowOnly brain regionBrain activityPosterior cingulate cortexNon-specific effectsChemosensory areasBlood flowPET scansCingulate cortexBrain regionsPatterns of activitySensory stimuliFunctional segregationSatietyPiece of chocolateSubjectsReward valueSubjects' ratingsNeural representationSeparate motivational systemsActivityCaudomedialCortex
1992
Regulation of appetite and cholecystokinin secretion in anorexia nervosa
Geracioti T, Liddle R, Altemus M, Demitrack M, Gold P. Regulation of appetite and cholecystokinin secretion in anorexia nervosa. American Journal Of Psychiatry 1992, 149: 958-961. PMID: 1609878, DOI: 10.1176/ajp.149.7.958.Peer-Reviewed Original ResearchConceptsAnorexia nervosaHealthy control subjectsPlasma cholecystokinin concentrationsRegulation of appetiteCholecystokinin concentrationsCholecystokinin secretionControl subjectsFood intakeSame patientAnorexic patientsPatientsEndogenous hormonesNervosaLow levelsWeight normalizationHypersecretionSatietyHormoneIntakeAppetiteSecretion
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