2024
A Phase 2 study of Savolitinib in Patients with MET Amplified Metastatic Colorectal Cancer
Jia J, Moyer A, Lowe M, Bolch E, Kortmansky J, Cho M, Lenz H, Kalyan A, Niedzwiecki D, Strickler J. A Phase 2 study of Savolitinib in Patients with MET Amplified Metastatic Colorectal Cancer. Journal Of Gastrointestinal Cancer 2024, 56: 29. PMID: 39652198, DOI: 10.1007/s12029-024-01156-x.Peer-Reviewed Original ResearchConceptsTreatment-emergent adverse eventsMetastatic colorectal cancerPhase 2 studyEpidermal growth factor receptorAnti-tumor activityStable diseaseProgressive diseaseChemotherapy refractory metastatic colorectal cancerOral small-molecule tyrosine kinase inhibitorColorectal cancerResistance to epidermal growth factor receptorSmall molecule tyrosine kinase inhibitorsRefractory metastatic colorectal cancerBest overall responseRAS wild-typeAdvanced solid tumorsBiomarker-selected patientsTyrosine kinase inhibitorsWild-typeGrowth factor receptorResultsFive patientsPrimary endpointSecondary endpointsSolid tumorsSavolitinib
2022
Long-term outcomes from a multi-institutional experience with prefabricated composite gracilis-buccal mucosal flap for reconstruction of devastated urethras
Sterling J, Schardein J, Joshi PM, Kulkarni SB, Nikolavsky D. Long-term outcomes from a multi-institutional experience with prefabricated composite gracilis-buccal mucosal flap for reconstruction of devastated urethras. International Urology And Nephrology 2022, 54: 1047-1052. PMID: 35247151, DOI: 10.1007/s11255-022-03154-z.Peer-Reviewed Original ResearchConceptsPatient-reported outcome measuresGlobal response assessmentBuccal mucosal graftOutcome measuresMulti-institutional retrospective reviewSecondary outcome measuresPrimary outcome measureLong-term outcomesMulti-institutional experiencePost-operative surveyStage 2 repairStage 1Mean IPSSMean PVRStricture lengthCase seriesResultsFive patientsRetrospective reviewStricture recurrenceSuprapubic tubeSurgical optionsBulbar urethraMean ageMucosal graftPerineal urethrostomy
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