2024
Short‐Course TNT Improves Rectal Tumor Downstaging in a Retrospective Study of the US Rectal Cancer Consortium
Bauer P, Gamboa A, Otegbeye E, Chapman W, Rivard S, Regenbogen S, Hrebinko K, Holder‐Murray J, Wiseman J, Ejaz A, Edwards‐Hollingsworth K, Hawkins A, Hunt S, Balch G, Wise P. Short‐Course TNT Improves Rectal Tumor Downstaging in a Retrospective Study of the US Rectal Cancer Consortium. Journal Of Surgical Oncology 2024 PMID: 39400312, DOI: 10.1002/jso.27908.Peer-Reviewed Original ResearchLong-course chemoradiationPathological complete responseComplete responseCR rateTumor downstagingConsolidation chemotherapyRate of pathological complete responseNeoadjuvant long-course chemoradiationRate of complete responseClinically node-negative diseaseClinical complete responseShort-course radiationNode-negative diseaseSingle-center reviewMulti-institutional experiencePredictors of CRRAPIDO trialTNT patientsLow tumorsRectal adenocarcinomaRectal cancerNonoperative managementRetrospective studyCancer care centerNonoperative options
2022
S208 Increased Primary Tumor Sutterella Bacterial RNAseq Signatures Are Associated With Increased M2 Macrophage Abundance and Worse Overall Survival in Rectal Adenocarcinoma
Zaman S, Chen G, Segarra D, Patel A, Protiva P. S208 Increased Primary Tumor Sutterella Bacterial RNAseq Signatures Are Associated With Increased M2 Macrophage Abundance and Worse Overall Survival in Rectal Adenocarcinoma. The American Journal Of Gastroenterology 2022, 117: e150-e151. DOI: 10.14309/01.ajg.0000857472.84764.69.Peer-Reviewed Original ResearchSingle agent PD-1 blockade as curative-intent treatment in mismatch repair deficient locally advanced rectal cancer.
Cercek A, Lumish M, Sinopoli J, Weiss J, Shia J, Stadler Z, Yaeger R, Smith J, Saltz L, El Dika I, Crane C, Romesser P, Iyer K, Paty P, Garcia-Aguilar J, Gonen M, Gollub M, Weiser M, Schalper K, Diaz L. Single agent PD-1 blockade as curative-intent treatment in mismatch repair deficient locally advanced rectal cancer. Journal Of Clinical Oncology 2022, 40: lba5-lba5. DOI: 10.1200/jco.2022.40.17_suppl.lba5.Peer-Reviewed Original ResearchPD-1 blockadeAdvanced rectal cancerSingle-agent PD-1 blockadeClinical complete responseRectal cancerCo-primary endpointsComplete responseAnti-PD-1 monoclonal antibodyProspective phase II studyPD-1 monoclonal antibodyMismatch repair-deficient colorectal cancersCurative-intent treatmentPhase II studySerious adverse eventsCase of progressionEvidence of tumorDigital rectal examDeficient colorectal cancerMetastatic settingNeoadjuvant chemotherapyAdverse eventsCheckpoint blockadeII studySurgical resectionRectal adenocarcinoma
2020
Cryptic Cachexia
Odio CD, O'Brien CR, Jacox J, Jain D, Lee AI. Cryptic Cachexia. New England Journal Of Medicine 2020, 383: 68-74. PMID: 32609985, DOI: 10.1056/nejmcps1817531.Peer-Reviewed Original Research
2019
Semiautomated Measure of Abdominal Adiposity Using Computed Tomography Scan Analysis
Srikumar T, Siegel E, Gu Y, Balagurunathan Y, Garcia A, Chen Y, Zhou J, Zhao X, Gillies R, Clark W, Gamenthaler A, Choi J, Shibata D. Semiautomated Measure of Abdominal Adiposity Using Computed Tomography Scan Analysis. Journal Of Surgical Research 2019, 237: 12-21. PMID: 30694786, PMCID: PMC7771581, DOI: 10.1016/j.jss.2018.11.027.Peer-Reviewed Original ResearchConceptsVisceral fat areaSubcutaneous fat areaTotal fat areaFat areaTomography scan analysisAbdominal adiposityIntraclass correlationL4-L5 intervertebral levelAverage body mass indexSubcutaneous fat ratioBody mass indexMedian ageRectal adenocarcinomaRisk stratificationMass indexIntervertebral levelObesity epidemicRadiologic methodsAdipose tissueSemiautomated measureAdiposityFat ratioHuman pathophysiologyImaging suiteSemiautomated method
2017
Cetuximab Combined With Induction Oxaliplatin and Capecitabine, Followed by Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer: SWOG 0713
Leichman CG, McDonough SL, Smalley SR, Billingsley KG, Lenz HJ, Beldner MA, Hezel AF, Velasco MR, Guthrie KA, Blanke CD, Hochster HS. Cetuximab Combined With Induction Oxaliplatin and Capecitabine, Followed by Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer: SWOG 0713. Clinical Colorectal Cancer 2017, 17: e121-e125. PMID: 29233486, PMCID: PMC6598683, DOI: 10.1016/j.clcc.2017.10.008.Peer-Reviewed Original ResearchConceptsPathologic complete responseAdvanced rectal cancerNeoadjuvant chemoradiationRectal cancerInduction chemotherapyKRAS wild-type metastatic colorectal cancerWild-type metastatic colorectal cancerThree-year disease-free survivalLocally Advanced Rectal CancerMetastatic colorectal cancerDisease-free survivalPhase III trialsAdequate hematologicEligible patientsBowel obstructionSame regimenIII trialsPerformance statusRenal functionComplete responseImproved survivalClinical outcomesMicroscopic cancerRectal adenocarcinomaPatient eligibility
2016
TTF-1 Expression in Rectal Adenocarcinoma: A Case Report and Review of the Literature
Belalcazar A, Krishnamurti U, Shaib W. TTF-1 Expression in Rectal Adenocarcinoma: A Case Report and Review of the Literature. Case Reports In Oncology 2016, 9: 747-751. PMID: 27990111, PMCID: PMC5156892, DOI: 10.1159/000450973.Peer-Reviewed Original ResearchRectal adenocarcinomaCase reportTTF-1Primary lung adenocarcinomaThyroid transcription factor-1Year retrospective studyTTF-1 expressionLung metastasesRetrospective studyTranscription factor 1Colorectal adenocarcinomaLung adenocarcinomaAdenocarcinomaColon adenocarcinomaMedical literatureTumor samplesSpecific markersFactor 1Synchronous rectal adenocarcinoma and splenic marginal zone lymphoma
Srikumar T, Markow M, Centeno B, Hoffe S, Tao J, Fernandez H, Strosberg J, Shibata D. Synchronous rectal adenocarcinoma and splenic marginal zone lymphoma. Current Oncology 2016, 23: 70-74. PMID: 26966416, PMCID: PMC4754072, DOI: 10.3747/co.23.2711.Peer-Reviewed Original ResearchMarginal zone lymphomaSplenic marginal zone lymphomaRectal adenocarcinomaMassive splenomegalyExternal beam radiation therapyAdjuvant FOLFOX chemotherapyDifferent primary originsEn bloc splenectomySynchronous rectal adenocarcinomaLow anterior resectionAdvanced rectal cancerBone marrow biopsyComplete blood countComputed tomography (CT) imagingFOLFOX chemotherapyPelvic radiationStage T3N1M0Abdominal painAnterior resectionDistal pancreatectomySynchronous cancersConcomitant diagnosisRectal cancerClinical presentationMarrow biopsy
2015
Time to Chemotherapy After Abdominoperineal Resection: Comparison Between Primary Closure and Perineal Flap Reconstruction
Althumairi AA, Canner JK, Ahuja N, Sacks JM, Safar B, Efron JE. Time to Chemotherapy After Abdominoperineal Resection: Comparison Between Primary Closure and Perineal Flap Reconstruction. World Journal Of Surgery 2015, 40: 225-230. PMID: 26336877, DOI: 10.1007/s00268-015-3224-0.Peer-Reviewed Original ResearchConceptsFlap reconstruction groupAdjuvant chemotherapyFlap reconstructionPrimary closureAbdominoperineal resectionWound complicationsRectal adenocarcinomaReconstruction groupWound healingPerineal flap reconstructionPerineal wound complicationsPrimary closure groupPerineal wound closureLength of healingRetrospective reviewClosure groupChemotherapyPatientsPerineal defectsWound closureHealingResectionComplicationsAdenocarcinomaLength of timeStaphylococcal Purpura Fulminans
Honarpisheh H, Camp R, Lazova R. Staphylococcal Purpura Fulminans. American Journal Of Dermatopathology 2015, 37: 643-646. PMID: 25099358, DOI: 10.1097/dad.0000000000000175.Peer-Reviewed Original ResearchConceptsPurpura fulminansPerivascular lymphocytic inflammationProgressive hemodynamic instabilityStaphylococcal purpura fulminansSolitary lung metastasisSmall cutaneous vesselsMultiorgan failureHemodynamic instabilityLymphocytic inflammationLung metastasesRectal adenocarcinomaSubepidermal bullaeCase reportEpidermal necrosisGeneralized eruptionAutopsy examinationSkin biopsiesBlack maculeCutaneous vesselsDay 3FulminansS. aureusStaphylococcus aureusAureusReport
2005
Long-term Oncologic Outcome Following Preoperative Combined Modality Therapy and Total Mesorectal Excision of Locally Advanced Rectal Cancer
Guillem J, Chessin D, Cohen A, Shia J, Mazumdar M, Enker W, Paty P, Weiser M, Klimstra D, Saltz L, Minsky B, Wong W. Long-term Oncologic Outcome Following Preoperative Combined Modality Therapy and Total Mesorectal Excision of Locally Advanced Rectal Cancer. Annals Of Surgery 2005, 241: 829-838. PMID: 15849519, PMCID: PMC1357138, DOI: 10.1097/01.sla.0000161980.46459.96.Peer-Reviewed Original ResearchConceptsLong-term oncologic outcomesRecurrence-free survivalPreoperative combined modality therapyLocally advanced rectal cancerCombined modality therapyAdvanced rectal cancerOncological outcomesOverall survivalModality therapyPerineural invasionRectal adenocarcinomaRectal cancerPathological responseTreatment of locally advanced rectal cancerYear recurrence-free survivalLocally advanced rectal adenocarcinomaLong-term oncological resultsPrediction of oncological outcomesPathologic tumor responsePredictive clinicopathological factorsAdvanced rectal adenocarcinomaPositive lymph nodesMedian follow-upAssociated with OSTotal mesorectal excision
2002
Increased Endocrine Cells in Treated Rectal Adenocarcinomas
Shia J, Tickoo S, Guillem J, Qin J, Nissan A, Hoos A, Stojadinovic A, Ruo L, Wong W, Paty P, Weiser M, Minsky B, Klimstra D. Increased Endocrine Cells in Treated Rectal Adenocarcinomas. The American Journal Of Surgical Pathology 2002, 26: 863-872. PMID: 12131153, DOI: 10.1097/00000478-200207000-00004.Peer-Reviewed Original ResearchConceptsChromogranin-positive cellsTreat rectal adenocarcinomaRectal adenocarcinomaChromogranin positivityNeoadjuvant therapyResected specimenTreatment responsePosttreatment specimensPretreatment biopsiesTumor cellsAbnormal p53 protein expressionTumors treated with radiotherapyCases of rectal adenocarcinomaEndocrine cellsDense chromatin patternPosttreatment resection specimensSubstantial treatment responsePretreatment biopsy specimensHematoxylin and eosin sectionsEndocrine differentiationResidual tumor cellsKi67 labeling indexP53 protein expressionDegree of treatment responseChromogranin staining
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