2025
Oncologic Outcomes with De-Escalation of Axillary Surgery After Neoadjuvant Chemotherapy for Breast Cancer: Results from > 1500 Patients on the I-SPY2 Clinical Trial
Boughey J, Yu H, Switalla K, Velle L, Lopes A, Wallace A, Lancaster R, Reyna C, Tuttle T, Jaskowiak N, Tchou J, Rao R, Lee M, Naik A, Golshan M, Arciero C, Sauder C, Matsen C, Yau C, Esserman L, Mukhtar R. Oncologic Outcomes with De-Escalation of Axillary Surgery After Neoadjuvant Chemotherapy for Breast Cancer: Results from > 1500 Patients on the I-SPY2 Clinical Trial. Annals Of Surgical Oncology 2025, 1-14. PMID: 39946078, DOI: 10.1245/s10434-025-16973-y.Peer-Reviewed Original ResearchEvent-free survivalDe-escalation of axillary surgeryLocoregional recurrenceNeoadjuvant chemotherapyALND groupAxillary surgeryOncological outcomesI-SPY2Breast cancerDe-escalationRate of axillary recurrenceMedian follow-up timeShort-term follow-upAxillary surgery typeOmission of ALNDResidual nodal diseaseReduce patient morbidityYpN+ diseaseAdjuvant radiationAxillary recurrenceNodal diseaseYpN+ patientsSurgery typePatient morbidityTrial patientsCardiovascular Risk Factors in Myeloproliferative Neoplasms: Associations with Survival and Thrombotic Outcomes
How J, Leiva O, Redd R, Marneth A, DeAngelo D, Dieli-Conwright C, El-Jawahri A, Kamaz B, Kim C, Lindsley C, Luskin M, Stahl M, Wazir M, Weeks L, Hobbs G. Cardiovascular Risk Factors in Myeloproliferative Neoplasms: Associations with Survival and Thrombotic Outcomes. Blood Vessels Thrombosis & Hemostasis 2025, 100051. DOI: 10.1016/j.bvth.2025.100051.Peer-Reviewed Original ResearchMyeloproliferative neoplasm patientsCardiovascular risk factorsEssential thrombocythemiaMyeloproliferative neoplasmsPolycythemia veraThrombotic outcomesThrombotic riskRisk factorsDiagnosis of hematological malignanciesMyeloproliferative neoplasm subtypeIncreased risk of deathType 2 diabetes mellitusMyeloproliferative neoplasms diagnosisRetrospective cohort analysisSex-matched controlsManaging cardiovascular risk factorsAssociated with survivalImprove patient morbidityRisk of deathMF patientsHematologic malignanciesMPN diagnosisPatient morbidityDana-FarberArterial/venous thrombosis
2024
Endovascular arterial embolization versus conservative management with nasal packing alone for severe epistaxis: a nationwide cohort study
Chen H, Khunte M, Colasurdo M, Gunawardane S, Malhotra A, Gandhi D. Endovascular arterial embolization versus conservative management with nasal packing alone for severe epistaxis: a nationwide cohort study. Journal Of NeuroInterventional Surgery 2024, jnis-2024-022790. PMID: 39715667, DOI: 10.1136/jnis-2024-022790.Peer-Reviewed Original ResearchEndovascular arterial embolizationNasal packingSevere epistaxisPropensity score matchingNationwide Readmissions DatabaseArtery embolizationIschemic strokeCohort studyRates of patient morbidityHemorrhage risk factorsConservative management groupConservative managementRetrospective cohort studyNationwide cohort studyRate of ischemic strokeBalance patient characteristicsContemporary real-world dataAssociated with lower ratesPatients admitted to hospitalNon-routine dischargeRisk of ischemic strokeRecurrent epistaxisRecurrence ratePatient morbidityPatient characteristicsLeveraging machine learning to develop a postoperative predictive model for postoperative urinary retention following lumbar spine surgery
Malnik S, Porche K, Mehkri Y, Yue S, Maciel C, Lucke-Wold B, Robicsek S, Decker M, Busl K. Leveraging machine learning to develop a postoperative predictive model for postoperative urinary retention following lumbar spine surgery. Frontiers In Neurology 2024, 15: 1386802. PMID: 38988605, PMCID: PMC11233696, DOI: 10.3389/fneur.2024.1386802.Peer-Reviewed Original ResearchPostoperative urinary retentionLumbar spine surgerySpine surgeryUrinary retentionPatient demographicsIncidence of postoperative urinary retentionRetrospective observational cohort studyTertiary academic medical centerIndwelling catheter placementIncreased patient morbidityReceiver operating characteristic curveArea under the receiver operating characteristic curveObservational cohort studyAcademic medical centerBody mass indexPostoperative prediction modelLogistic regression modelsIntraoperative variablesIntraoperative factorsCatheter placementAnesthesia variablesPatient morbidityMass indexSurgical proceduresCohort studyHeterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling
Ohashi Y, Protack C, Aoyagi Y, Gonzalez L, Thaxton C, Zhang W, Kano M, Bai H, Yatsula B, Alves R, Hoshina K, Schneider E, Long X, Perry R, Dardik A. Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling. Scientific Reports 2024, 14: 13287. PMID: 38858395, PMCID: PMC11164895, DOI: 10.1038/s41598-024-64075-8.Peer-Reviewed Original ResearchConceptsGene expression patternsArteriovenous fistula groupArteriovenous fistulaExpression patternsHeterogeneous gene expressionGene expression changesOutcomes of arteriovenous fistulaVenous remodelingArteriovenous fistula maturationPostoperative day 7Reduce patient morbidityRNA sequencingUpregulation of metabolismBioinformatics analysisGene expressionDownregulation of metabolismMetabolic pathwaysExpression changesGenesAVF maturationAVF remodelingFistula creationC57BL/6 miceClinical outcomesPatient morbidityRestarting Antithrombotic Therapies After Endoscopic Sinus Surgery: A Systematic Review
Boyi T, Richmond R, Kayastha D, Manes R, Rimmer R. Restarting Antithrombotic Therapies After Endoscopic Sinus Surgery: A Systematic Review. Annals Of Otology Rhinology & Laryngology 2024, 133: 633-638. PMID: 38557289, DOI: 10.1177/00034894241245840.Peer-Reviewed Original ResearchEndoscopic sinus surgeryAntithrombotic therapySinus surgerySystematic reviewResumption of antithrombotic therapyRisk of perioperative hemorrhageFull-text reviewPreferred Reporting ItemsCase-control studyWeb of ScienceCINAHL databasesReporting ItemsIndependent reviewersUnique articlesPerioperative hemorrhageTherapy resumptionCohort studyAntiplatelet therapyInclusion criteriaPatient morbidityAntiplatelet agentsPrimary outcomeTherapySurgeryAntiplatelet
2023
Now You See It, Now You Don't: Point-of-Care Ultrasound Identification of Left Ventricular Thrombus-in-Transit
Boivin Z, Spooner Z, Jiang C, Acus K, Lu C, She T. Now You See It, Now You Don't: Point-of-Care Ultrasound Identification of Left Ventricular Thrombus-in-Transit. Journal Of Emergency Medicine 2023, 66: e614-e618. PMID: 38702244, DOI: 10.1016/j.jemermed.2023.11.014.Peer-Reviewed Original ResearchLeft ventricular thrombusPOCUS examinationsVasopressor requirementVentricular thrombusIschemic strokeThrombus propagationMiddle cerebral artery distributionCare Ultrasound IdentificationIdentification of thrombusInitial presumptive diagnosisLarge ischemic strokeLeft internal carotidHigh patient morbiditySeizure-like activityEmergent neuroimagingPatients thrombusIntracardiac thrombusArtery distributionCerebrovascular accidentAtrial fibrillationTreatment courseEmergency departmentPatient morbidityMyocardial infarctionPresumptive diagnosisEfficacy and safety of subcutaneous spesolimab for the prevention of generalised pustular psoriasis flares (Effisayil 2): an international, multicentre, randomised, placebo-controlled trial
Morita A, Strober B, Burden A, Choon S, Anadkat M, Marrakchi S, Tsai T, Gordon K, Thaçi D, Zheng M, Hu N, Haeufel T, Thoma C, Lebwohl M. Efficacy and safety of subcutaneous spesolimab for the prevention of generalised pustular psoriasis flares (Effisayil 2): an international, multicentre, randomised, placebo-controlled trial. The Lancet 2023, 402: 1541-1551. PMID: 37738999, DOI: 10.1016/s0140-6736(23)01378-8.Peer-Reviewed Original ResearchConceptsPhysician Global Assessment scoreGPP flaresGlobal assessment scoreFlare preventionDose-response relationshipPrimary endpointAssessment scoresPhase 2b trialPustular psoriasis flarePlacebo-controlled trialReceptor monoclonal antibodyEligible study participantsQuality of lifeDose-response curveSubcutaneous placeboPlacebo groupWeek 48Pustular psoriasisPrimary outcomePsoriasis flareTreatment armsPatient groupHypersensitivity reactionsPatient morbiditySpesolimabConsensus Recommendations on Peripheral Blood Smear Review: Defining Curricular Standards and Fellow Competency
Chase M, Drews R, Zumberg M, Ellis L, Reid E, Gerds A, Lee A, Hobbs G, Berry J, Freed J. Consensus Recommendations on Peripheral Blood Smear Review: Defining Curricular Standards and Fellow Competency. Blood Advances 2023, 7: 3244-3252. PMID: 36930800, PMCID: PMC10336252, DOI: 10.1182/bloodadvances.2023009843.Peer-Reviewed Original ResearchConceptsPeripheral blood smear reviewPeripheral blood smearAccreditation Council for Graduate Medical EducationConsensus recommendationsDiagnosis of acute leukemiaSignificant patient morbidityBlood smear reviewGraduate Medical EducationGraduate medical education trainingWhite blood cellsThrombotic microangiopathyAcute leukemiaConsensus guidelinesPatient morbiditySmear reviewMedical education trainingMalignant hematologyBlood cellsFellow competencyMedical educationBlood smearsVisuospatial tasksClinical careOne-hour focus groupsStrong consensusImproving Care After Sexual Assault: A Needs Assessment for a Standardized, Patient-Centered Educational Resource [ID: 1377465]
Lepore C, Bechtel K, Choi J, Gawel M, Griggs S, Pathy S. Improving Care After Sexual Assault: A Needs Assessment for a Standardized, Patient-Centered Educational Resource [ID: 1377465]. Obstetrics And Gynecology 2023, 141: 91s-91s. DOI: 10.1097/01.aog.0000931112.50405.07.Peer-Reviewed Original ResearchDischarge paperworkTertiary care emergency departmentRetrospective chart reviewInstitutional review board approvalLong-term followReview board approvalWorld Health Organization guidelinesMental health resourcesHealth Organization guidelinesOne-thirdElectronic medical record systemCommunity resourcesChart reviewMedical record systemSSA patientsEmergency departmentPatient morbidityAcute traumaPatient educationAmerican CollegeBoard approvalSuch careMedical followHealth resourcesFollowEfficacy of laser interstitial thermal therapy for biopsy-proven radiation necrosis in radiographically recurrent brain metastases
Chan M, Tatter S, Chiang V, Fecci P, Strowd R, Prabhu S, Hadjipanayis C, Kirkpatrick J, Sun D, Sinicrope K, Mohammadi A, Sevak P, Abram S, Kim A, Leuthardt E, Chao S, Phillips J, Lacroix M, Williams B, Placantonakis D, Silverman J, Baumgartner J, Piccioni D, Laxton A. Efficacy of laser interstitial thermal therapy for biopsy-proven radiation necrosis in radiographically recurrent brain metastases. Neuro-Oncology Advances 2023, 5: vdad031. PMID: 37114245, PMCID: PMC10129388, DOI: 10.1093/noajnl/vdad031.Peer-Reviewed Original ResearchLaser interstitial thermal therapyKarnofsky performance statusRadiation necrosisInterstitial thermal therapyBrain metastasesLocal controlMedian Karnofsky performance statusRecurrent brain metastasesMedian hospitalization timeLow patient morbidityLesional progressionMultivariable FineCumulative incidenceOverall survivalPerformance statusSymptom controlHospitalization timeSystemic therapyMedian timeNeurological deathSymptom managementKaplan-MeierPatient morbiditySeizure prevalenceUS Centers
2022
OXGR1 is a candidate disease gene for human calcium oxalate nephrolithiasis
Majmundar A, Widmeier E, Heneghan J, Daga A, Wu C, Buerger F, Hugo H, Ullah I, Amar A, Ottlewski I, Braun D, Jobst-Schwan T, Lawson J, Zahoor M, Rodig N, Tasic V, Nelson C, Khaliq S, Schönauer R, Halbritter J, Sayer J, Fathy H, Baum M, Shril S, Mane S, Alper S, Hildebrandt F. OXGR1 is a candidate disease gene for human calcium oxalate nephrolithiasis. Genetics In Medicine 2022, 25: 100351. PMID: 36571463, PMCID: PMC9992313, DOI: 10.1016/j.gim.2022.11.019.Peer-Reviewed Original ResearchConceptsExome sequencingChronic kidney diseaseStrong amino acid conservationSignificant patient morbidityCalcium oxalate nephrolithiasisMissense variantsAutosomal dominant inheritance patternTransepithelial calcium transportAmino acid conservationCandidate disease genesDominant inheritance patternCausative genetic variantsKidney diseasePatient morbidityExome Aggregation ConsortiumNC cohortRisk factorsOxalate nephrolithiasisDistal nephronNephrocalcinosisNephrolithiasisLoss of functionChloride-bicarbonate exchangerReceptor 1Genomic approachesDirect relationship between transvalvular velocity and cardiac dysfunction, morbidity, and mortality in patients with aortic stenosis
Yousef S, Amabile A, Ram C, Singh S, Agarwal R, Milewski R, Assi R, Patel P, Krane M, Geirsson A, Vallabhajosyula P. Direct relationship between transvalvular velocity and cardiac dysfunction, morbidity, and mortality in patients with aortic stenosis. Journal Of Cardiac Surgery 2022, 37: 5052-5062. PMID: 36378856, DOI: 10.1111/jocs.17199.Peer-Reviewed Original ResearchConceptsDegree of ASCardiac structural changesAortic stenosisSevere symptomatic aortic stenosisEnd-organ morbiditiesStructural cardiac changesSymptomatic aortic stenosisEnd-organ diseaseKaplan-Meier curvesRisk of mortalityTransvalvular flow velocityCochran-Armitage testCause mortalityPatient characteristicsCardiac changesCardiac dysfunctionPatient morbidityTransvalvular velocityCurrent guidelinesGroup BGroup ACaucasian raceHigh riskCox modelEarly interventionAssessing the Race, Ethnicity, and Gender Inequities in Blood Alcohol Testing After Trauma
Jean RA, O'Neill KM, Johnson DC, Becher RD, Schuster KM, Davis KA, Maung AA. Assessing the Race, Ethnicity, and Gender Inequities in Blood Alcohol Testing After Trauma. Journal Of Surgical Research 2022, 273: 192-200. PMID: 35092878, DOI: 10.1016/j.jss.2021.12.032.Peer-Reviewed Original ResearchConceptsMultivariable logistic regressionWhite patientsOdds ratioInjury mechanismLogistic regressionParticipant User FileNon-Hispanic patientsSubstantial patient morbidityHealth care providersBlood alcohol testingPacific IslandersDemographic factorsHigh rateClinical factorsTrauma admissionsHispanic patientsScreening ratesPatient morbidityAlcohol screeningSerum alcoholInjury categoriesTrauma casesTraumatic injurySurgeons (ACS) verificationHigher odds
2021
Machine learning implicates the IL-18 signaling axis in severe asthma
Camiolo MJ, Zhou X, Wei Q, Bittar H, Kaminski N, Ray A, Wenzel S. Machine learning implicates the IL-18 signaling axis in severe asthma. JCI Insight 2021, 6: e149945. PMID: 34591794, PMCID: PMC8663569, DOI: 10.1172/jci.insight.149945.Peer-Reviewed Original ResearchConceptsLung functionIL-18NF-κBTranscriptional hallmarksExacerbation-prone asthmaSevere asthma pathogenesisSubgroup of patientsVariable natural historySevere Asthma Research Program (SARP) cohortDownstream NF-κBMixed inflammatory processActivator protein-1 (AP-1) activationPathobiological underpinningsCorticosteroid exposureSevere asthmaAsthma clustersAsthma pathogenesisPatient morbidityInflammatory processProtein-1 activationExternal cohortLung tissuePatient clustersAP-1 activityNatural historyEmergency care with lay responders in underserved populations: a systematic review
Orkin A, Venugopal J, Curran J, Fortune M, McArthur A, Mew E, Ritchie S, Drennan I, Exley A, Jamieson R, Johnson D, MacPherson A, Martiniuk A, McDonald N, Osei-Ampofo M, Wegier P, Van de Velde S, VanderBurgh D. Emergency care with lay responders in underserved populations: a systematic review. Bulletin Of The World Health Organization 2021, 99: 514-528h. PMID: 34248224, PMCID: PMC8243031, DOI: 10.2471/blt.20.270249.Peer-Reviewed Original ResearchConceptsLow-resource settingsEmergency careOpioid poisoningUnderserved populationsLow-resource populationsEmergency care trainingCommunity health effectsPediatric malariaMiddle-income countriesCardiac arrestPatient morbidityStudy eligibilityEligible studiesPatient outcomesHigh-income countriesInclusion criteriaAdditional grey literatureHealth of individualsRisk populationsCare professionalsModerate qualitySystematic reviewCommunicable diseasesCare trainingMost studies
2020
Clinical utilization of species‐specific immunoassays for identification of Staphylococcus aureus and Streptococcus agalactiae in orthopedic infections
Sulovari A, Ninomiya MJ, Beck CA, Ricciardi BF, Ketonis C, Mesfin A, Kaplan NB, Soin SP, McDowell SM, Mahmood B, Daiss JL, Schwarz EM, Oh I. Clinical utilization of species‐specific immunoassays for identification of Staphylococcus aureus and Streptococcus agalactiae in orthopedic infections. Journal Of Orthopaedic Research® 2020, 39: 2141-2150. PMID: 33274775, PMCID: PMC8175449, DOI: 10.1002/jor.24935.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsFracture-related infectionMusculoskeletal infectionsOrthopedic infectionsHigh diagnostic potentialCultured peripheral blood mononuclear cellsDiagnostic potentialDeep musculoskeletal infectionSignificant patient morbidityBlood mononuclear cellsDiabetic foot ulcersAntigen-specific IgGPeriprosthetic joint infectionStaphylococcus aureusInfection patientsSeptic arthritisSurgical treatmentCurrent diagnostic methodsFoot ulcersJoint infectionAntibody titersMononuclear cellsPatient morbidityPolymicrobial infectionsAntibiotic useEndoscopic Treatment of Vesicoureteral Reflux
Arlen A, Kirsch A. Endoscopic Treatment of Vesicoureteral Reflux. 2020, 243-249. DOI: 10.1007/978-3-030-57219-8_17.Peer-Reviewed Original ResearchVesicoureteral refluxUreteral reimplantationContinuous low-dose antibiotic prophylaxisLow-dose antibiotic prophylaxisDextranomer hyaluronic acidPrimary vesicoureteral refluxDouble hydrodistention implantation techniqueInjectable bulking agentHydrodistention implantation techniqueSubureteric injectionUreteral hydrodistentionAntibiotic prophylaxisTeflon pasteEndoscopic correctionEndoscopic treatmentPatient morbidityRecurrence rateOnly FDASubmucosal planeReimplantationImplantation techniqueAmbulatory natureRefluxImproved successHyaluronic acidIs there a Difference in Outcomes between Patients who Received a Double or Triple Arthrodesis for Hindfoot Arthritis?
Holleran A, Baumhauer J, Houck J, Homeier D, Flemister A, Ketz J, DiGiovanni B, Oh I. Is there a Difference in Outcomes between Patients who Received a Double or Triple Arthrodesis for Hindfoot Arthritis? Foot & Ankle Orthopaedics 2020, 5: 2473011420s00251. PMCID: PMC8705489, DOI: 10.1177/2473011420s00251.Peer-Reviewed Original ResearchPain interferencePhysical functionDouble arthrodesisTriple arthrodesisOutcomes Measurement Information System Physical FunctionRetrospective medical record reviewPROMIS Pain InterferencePROMIS Physical FunctionProportion of patientsMedical record reviewWound healing problemsStandard of treatmentLess patient morbidityTerms of ageNerve injuryClinical outcomesRecord reviewFoot deformityPatient morbidityLower painMedical recordsHealing problemsHindfoot deformityChi-square analysisComplications
2019
WORKSHOP PANEL REPORT ON EVIDENCE GAPS AND RESEARCH OPPORTUNITIES
Allore H. WORKSHOP PANEL REPORT ON EVIDENCE GAPS AND RESEARCH OPPORTUNITIES. Innovation In Aging 2019, 3: s749-s749. PMCID: PMC6845930, DOI: 10.1093/geroni/igz038.2746.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsOsteoporosis drug therapyDrug therapyWhite postmenopausal womenSequelae of fracturesBone mineral densityNursing home placementPostmenopausal womenHip fractureVertebral fracturesTreatment regimensPatient morbidityFunctional statusMineral densityPatient outcomesElevated riskOutcome assessmentTrial resultsTherapyHome placementIncidenceTrialsFracturesHospitalizationMorbidityRegimens
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