2025
Concurrent Aortic Valve Replacement and Splenectomy for Q-Fever Endocarditis with Massive Splenomegaly and Pancytopenia
Weininger G, Pedroza A, Shou B, Forrester J, Lin Y. Concurrent Aortic Valve Replacement and Splenectomy for Q-Fever Endocarditis with Massive Splenomegaly and Pancytopenia. JTCVS Techniques 2025 DOI: 10.1016/j.xjtc.2025.01.021.Peer-Reviewed Original Research
2016
Synchronous rectal adenocarcinoma and splenic marginal zone lymphoma
Srikumar T, Markow M, Centeno B, Hoffe S, Tao J, Fernandez H, Strosberg J, Shibata D. Synchronous rectal adenocarcinoma and splenic marginal zone lymphoma. Current Oncology 2016, 23: 70-74. PMID: 26966416, PMCID: PMC4754072, DOI: 10.3747/co.23.2711.Peer-Reviewed Original ResearchMarginal zone lymphomaSplenic marginal zone lymphomaRectal adenocarcinomaMassive splenomegalyExternal beam radiation therapyAdjuvant FOLFOX chemotherapyDifferent primary originsEn bloc splenectomySynchronous rectal adenocarcinomaLow anterior resectionAdvanced rectal cancerBone marrow biopsyComplete blood countComputed tomography (CT) imagingFOLFOX chemotherapyPelvic radiationStage T3N1M0Abdominal painAnterior resectionDistal pancreatectomySynchronous cancersConcomitant diagnosisRectal cancerClinical presentationMarrow biopsy
2014
Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes
Espitia CM, Saldarriaga OA, Travi BL, Osorio EY, Hernandez A, Band M, Patel MJ, Medina AA, Cappello M, Pekosz A, Melby PC. Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes. BMC Immunology 2014, 15: 38. PMID: 25424735, PMCID: PMC4253007, DOI: 10.1186/s12865-014-0038-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCluster AnalysisCricetinaeCytokinesDisease ProgressionDNA, ComplementaryExpressed Sequence TagsGene Expression ProfilingGene Expression RegulationGene OntologyHumansInterferon-gammaLeishmania donovaniLeishmaniasis, VisceralMesocricetusMolecular Sequence AnnotationOligonucleotide Array Sequence AnalysisPrincipal Component AnalysisRNA, MessengerSignal TransductionSpleenUp-RegulationConceptsSyrian golden hamstersVisceral leishmaniasisHamster modelGolden hamstersProgressive visceral leishmaniasisIL-4/ILIFN-γ responsesAlternative macrophage activationProgression of diseaseStudy of immunopathogenesisHamster infection modelPolarization of macrophagesImmune cell traffickingImmune response genesImmune-related genesSpleen responseImmunopathological featuresMassive splenomegalyInfected groupMacrophage activationIntracellular protozoanCell traffickingType 1Infection modelLeishmaniasis
2012
Splenic Irradiation as a Component of a Reduced-Intensity Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Myelofibrosis with Massive Splenomegaly
Ito T, Akagi K, Kondo T, Kawabata H, Ichinohe T, Takaori-Kondo A. Splenic Irradiation as a Component of a Reduced-Intensity Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Myelofibrosis with Massive Splenomegaly. The Tohoku Journal Of Experimental Medicine 2012, 228: 295. PMID: 23117264, DOI: 10.1620/tjem.228.295.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantationAllogeneic hematopoietic stem cell transplantationStem cell transplantationSplenic irradiationMassive splenomegalyCell transplantationSurgical morbidityPrimary myelofibrosisPeripheral blood stem cell transplantationBlood stem cell transplantationReduced-intensity conditioning regimenReduced-intensity conditioning regimensUnrelated bone marrow transplantationPost-essential thrombocythemia myelofibrosisOnly curative strategyHLA-identical siblingsProportion of patientsTime of transplantationBone marrow transplantationBone marrow fibrosisDonor cell engraftmentSimilar clinical conditionsConditioning regimenConditioning regimensElderly patients
1979
Treatment of refractory splenomegaly in myeloproliferative disease by splenic artery infusion.
Canellos G, Sutliffe S, DeVita V, Lister T. Treatment of refractory splenomegaly in myeloproliferative disease by splenic artery infusion. Blood 1979, 53: 1014-7. PMID: 435637, DOI: 10.1182/blood.v53.5.1014.bloodjournal5351014.Peer-Reviewed Original ResearchConceptsSplenic artery infusionArterial infusionBlastic phase of chronic granulocytic leukemiaRefractory to previous therapyPhase of chronic granulocytic leukemiaChronic granulocytic leukemiaResponse to treatmentBlastic phasePrevious therapyMassive splenomegalyMyeloproliferative diseaseSystemic toxicityGranulocytic leukemiaSpleen sizeSymptomatic reliefCytosine arabinosidePatientsSplenomegalyInfusionTreatmentHypersplenismPainLeukemiaTherapyArabinosideTreatment of Refractory Splenomegaly in Myeloproliferative Disease by Splenic Artery Infusion
Canellos G, Sutliffe S, DeVita V, Lister T. Treatment of Refractory Splenomegaly in Myeloproliferative Disease by Splenic Artery Infusion. Blood 1979, 53: 1014-1017. DOI: 10.1182/blood.v53.5.1014.1014.Peer-Reviewed Original ResearchSplenic artery infusionArterial infusionBlastic phase of chronic granulocytic leukemiaRefractory to previous therapyPhase of chronic granulocytic leukemiaChronic granulocytic leukemiaResponse to treatmentBlastic phasePrevious therapyMassive splenomegalyMyeloproliferative diseaseSystemic toxicityGranulocytic leukemiaSpleen sizeSymptomatic reliefCytosine arabinosidePatientsSplenomegalyInfusionTreatmentHypersplenismPainLeukemiaTherapyArabinoside
1976
Splenectomy in the chronic phase of chronic granulocytic leukemia. Effects in 32 patients.
Ihde D, Canellos G, Schwartz J, DeVita V. Splenectomy in the chronic phase of chronic granulocytic leukemia. Effects in 32 patients. Annals Of Internal Medicine 1976, 84: 17-21. PMID: 1060395, DOI: 10.7326/0003-4819-84-1-17.Peer-Reviewed Original ResearchConceptsChronic phase of chronic granulocytic leukemiaPhase of chronic granulocytic leukemiaChronic granulocytic leukemiaChronic phaseGranulocytic leukemiaPhiladelphia chromosome-positive patientsSurvival of patientsYear of diagnosisChronic phase of diseasePhase of diseaseMedian survivalProphylactic splenectomySplenectomy patientsPlatelet transfusionsElective splenectomyAdequate therapyMassive splenomegalyBlastic transformationEarly diseaseSplenectomyInfluence survivalPatientsStage of illnessLeukemiaSurvival
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