2024
A guideline on the molecular ecosystem regulating ferroptosis
Dai E, Chen X, Linkermann A, Jiang X, Kang R, Kagan V, Bayir H, Yang W, Garcia-Saez A, Ioannou M, Janowitz T, Ran Q, Gu W, Gan B, Krysko D, Zhu X, Wang J, Krautwald S, Toyokuni S, Xie Y, Greten F, Yi Q, Schick J, Liu J, Gabrilovich D, Liu J, Zeh H, Zhang D, Yang M, Iovanna J, Kopf M, Adolph T, Chi J, Li C, Ichijo H, Karin M, Sankaran V, Zou W, Galluzzi L, Bush A, Li B, Melino G, Baehrecke E, Lotze M, Klionsky D, Stockwell B, Kroemer G, Tang D. A guideline on the molecular ecosystem regulating ferroptosis. Nature Cell Biology 2024, 26: 1447-1457. PMID: 38424270, PMCID: PMC11650678, DOI: 10.1038/s41556-024-01360-8.Peer-Reviewed Original ResearchImmunogenicity of ferroptosis in cancer: a matter of context?
Catanzaro E, Demuynck R, Naessens F, Galluzzi L, Krysko D. Immunogenicity of ferroptosis in cancer: a matter of context? Trends In Cancer 2024, 10: 407-416. PMID: 38368244, DOI: 10.1016/j.trecan.2024.01.013.Peer-Reviewed Original ResearchTumor-targeting immune responsesImmune responseCancer cellsKill malignant cellsAdaptive immune responsesInduction of ferroptosisImmunogenicity of ferroptosisAnticancer immunityMicroenvironmental defectMalignant cellsImmune cellsPlasma membrane breakdownFerroptosis inducersNecrotic formCell deathFerroptosisImbalance of cellular redox homeostasisLipid peroxidationCellsMembrane breakdownCellular redox homeostasisRedox homeostasisContext-dependent effectsImmunogenicityAdjuvanticityHypercapnia Causes Injury of the Cerebral Cortex and Cognitive Deficits in Newborn Piglets
Fritz K, Sanidas G, Cardenas R, Ghaemmaghami J, Byrd C, Simonti G, Valenzuela A, Valencia I, Delivoria-Papadopoulos M, Gallo V, Koutroulis I, Dean T, Kratimenos P. Hypercapnia Causes Injury of the Cerebral Cortex and Cognitive Deficits in Newborn Piglets. ENeuro 2024, 11: eneuro.0268-23.2023. PMID: 38233145, PMCID: PMC10913040, DOI: 10.1523/eneuro.0268-23.2023.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitIntensive care unitCare unitCortical neuronsCerebral cortexCritically ill newbornsEnergy failureSevere lung injuryCortical neuronal injuryLong-term suppressionImpaired neurobehaviorExposure to hypercapniaNeurodevelopmental outcomesIll newbornsLung injuryLipid peroxidationElectroencephalogram frequencyNeuronal injuryPersistent dysregulationDeoxyribonucleic acid fragmentationAssociated with changesNewbornsEffect of HCHypercapniaProapoptotic signaling
2023
Urinary biomarkers of exposure to organophosphate, pyrethroid, neonicotinoid insecticides and oxidative stress: A repeated measurement analysis among pregnant women
Wang A, Wan Y, Qi W, Mahai G, Qian X, Zheng T, Li Y, Xu S, Xiao H, Xia W. Urinary biomarkers of exposure to organophosphate, pyrethroid, neonicotinoid insecticides and oxidative stress: A repeated measurement analysis among pregnant women. The Science Of The Total Environment 2023, 912: 169565. PMID: 38145670, DOI: 10.1016/j.scitotenv.2023.169565.Peer-Reviewed Original ResearchOS biomarkersPregnant womenOxidative stressExposure biomarkersInsecticide metabolitesInadequate weight gainUrine samplesChinese pregnant womenHigher urinary levelsMetabolites of pyrethroidsGestational exposureUrinary levelsUrinary biomarkersHNE-MAMixed model analysisMetabolites of organophosphatesPercent changeWeight gainHigher education levelLipid peroxidationElevated levelsVulnerable populationsBiomarkersWomenTrimesterPUFAs dictate the balance of power in ferroptosis
Xin S, Schick J. PUFAs dictate the balance of power in ferroptosis. Cell Calcium 2023, 110: 102703. PMID: 36773492, DOI: 10.1016/j.ceca.2023.102703.Peer-Reviewed Original ResearchConceptsLethal lipid peroxidationIron-dependent formFerroptosis susceptibilityLipid remodelingFerroptosis sensitivityFatty acidsFerroptosis resistanceLipid transportersTumor suppressionMembrane lipidsPhospholipid transporterCell deathFerroptosis inductionBiochemical processesFerroptosisLipid metabolismReceptor alphaLipid componentsTransportersPeroxisome proliferatorLipid peroxidationCholesterol estersRegulatorAcidPPARA
2022
CD74 ablation rescues type 2 diabetes mellitus-induced cardiac remodeling and contractile dysfunction through pyroptosis-evoked regulation of ferroptosis
Chen L, Yin Z, Qin X, Zhu X, Chen X, Ding G, Sun D, Wu NN, Fei J, Bi Y, Zhang J, Bucala R, Ren J, Zheng Q. CD74 ablation rescues type 2 diabetes mellitus-induced cardiac remodeling and contractile dysfunction through pyroptosis-evoked regulation of ferroptosis. Pharmacological Research 2022, 176: 106086. PMID: 35033649, DOI: 10.1016/j.phrs.2022.106086.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntigens, Differentiation, B-LymphocyteCell LineDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2FemaleFerroptosisGene ExpressionHistocompatibility Antigens Class IIHumansMacrophage Migration-Inhibitory FactorsMaleMice, KnockoutMiddle AgedMyocardial ContractionMyocardiumNLR Family, Pyrin Domain-Containing 3 ProteinOxidative StressOxygen ConsumptionPyroptosisRatsVentricular RemodelingConceptsHigh glucose/high fatMacrophage migration inhibitory factorCardiac remodelingContractile dysfunctionCell death domainGene Ontology termsInhibitors of MIFRecombinant macrophage migration inhibitory factorCytokine macrophage migration inhibitory factorType 2 diabetes mellitusOntology termsDeath domainLipid peroxidationGlobal metabolic defectsKEGG analysisPlasma MIF levelsInjection of streptozotocinMitochondrial defectsHigh-fat dietMigration inhibitory factorInhibitor of NLRP3Cell deathPrecise interplayMitochondrial dysfunctionCognate receptors
2021
Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors
Xu S, Chaudhary O, Rodríguez-Morales P, Sun X, Chen D, Zappasodi R, Xu Z, Pinto AFM, Williams A, Schulze I, Farsakoglu Y, Varanasi SK, Low JS, Tang W, Wang H, McDonald B, Tripple V, Downes M, Evans RM, Abumrad NA, Merghoub T, Wolchok JD, Shokhirev MN, Ho PC, Witztum JL, Emu B, Cui G, Kaech SM. Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors. Immunity 2021, 54: 1561-1577.e7. PMID: 34102100, PMCID: PMC9273026, DOI: 10.1016/j.immuni.2021.05.003.Peer-Reviewed Original ResearchConceptsTumor microenvironmentCell dysfunctionLipid peroxidationLipid accumulationOxidized low-density lipoproteinExpression of CD36Low-density lipoproteinCommon metabolic alterationsScavenger receptor CD36Intratumoral CD8Immune dysfunctionEffector TGlutathione peroxidase 4CD8Effector functionsInhibition of p38Metabolic alterationsReceptor CD36Therapeutic avenuesScavenger receptorsDysfunctionWT counterpartsTILsCell functionCD36
2020
Clinical implications of oxidative stress in schizophrenia: Acute relapse and chronic stable phase
Chien Y, Hwu H, Hwang T, Hsieh M, Liu C, Lin-Shiau S, Liu C. Clinical implications of oxidative stress in schizophrenia: Acute relapse and chronic stable phase. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2020, 99: 109868. PMID: 31954755, DOI: 10.1016/j.pnpbp.2020.109868.Peer-Reviewed Original ResearchConceptsChronic stable schizophreniaNon-psychiatric controlsDisorganized symptomsChronic stable patientsStable schizophreniaWeeks of antipsychotic treatmentStages of schizophreniaAcute relapseClinical implicationsAntipsychotic treatmentNegative symptomsSchizophreniaStable patientsOxidative stressPlatelet superoxide dismutasePlatelet oxidative stressTreatment responseNitric oxideLipid peroxidationLevels of nitric oxideSymptomsSuperoxide dismutaseTreatment effectsRelapsed patientsRelapse
2019
Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III
Chang C, Weigel A, Ioannou M, Pasolli H, Xu C, Peale D, Shtengel G, Freeman M, Hess H, Blackstone C, Lippincott-Schwartz J. Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III. Journal Of Cell Biology 2019, 218: 2583-2599. PMID: 31227594, PMCID: PMC6683741, DOI: 10.1083/jcb.201902061.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesAmino Acid MotifsATP Binding Cassette Transporter, Subfamily D, Member 1Biological TransportEndosomal Sorting Complexes Required for TransportFatty AcidsHeLa CellsHumansHydrolysisLauric AcidsLipid DropletsModels, BiologicalMutant ProteinsOncogene ProteinsPeroxisomesSpastinConceptsFA traffickingLipid dropletsESCRT-III componentsNeutral lipid storage organellesLipid storage organellesFatty acid traffickingAAA-ATPaseESCRT-IIIDual roleMIT domainFatty acidsStorage organellesContact sitesPathogenesis of diseaseFA metabolismTraffickingPeroxisomesSpastinIST1OrganellesCHMP1BInterrelated mechanismsLipid peroxidationContact formationATPase
2016
Perinatal complications, lipid peroxidation, and mental health problems in a large community pediatric sample
Mansur R, Cunha G, Asevedo E, Zugman A, Rios A, Salum G, Pan P, Gadelha A, Levandowski M, Belangero S, Manfro G, Stertz L, Kauer-Sant’anna M, Miguel E, Bressan R, Mari J, Grassi-Oliveira R, Brietzke E. Perinatal complications, lipid peroxidation, and mental health problems in a large community pediatric sample. European Child & Adolescent Psychiatry 2016, 26: 521-529. PMID: 27785581, DOI: 10.1007/s00787-016-0914-6.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrazilChecklistChildChild Behavior DisordersCohort StudiesDevelopmental DisabilitiesFemaleHumansLipid PeroxidationLong Term Adverse EffectsMaleMalondialdehydeMental DisordersMental HealthOxidative StressPregnancyPsychopathologySocioeconomic FactorsThiobarbituric Acid Reactive SubstancesConceptsPerinatal complicationsMental health problemsCumulative exposureLipid peroxidationTBARS levelsChild Behavior ChecklistHealth problemsHigh Risk Cohort StudyMini-International Psychiatric InterviewYears of ageCBCL total problemsIndividual cumulative exposureEarly life environmentCohort studyCumulative risk indexSerum levelsPerinatal historyUnexposed groupExploratory mediation analysisPsychiatric interviewComplicationsPsychiatric disordersSocio-economic statusPediatric samplesOxidative stress
2014
Antiplasmodial and Antioxidant Activities of Saye: A Traditional Herbal Remedy for Malaria
Da O, Coulibaly M, Yerbanga R, Koama B, Ouedraogo N, Tamboura S, Dakuyo Z, Sekhoacha M, Nikiema J, Ouedraogo G, Matsabisa M, Ouedraogo J. Antiplasmodial and Antioxidant Activities of Saye: A Traditional Herbal Remedy for Malaria. American Journal Of Biochemistry And Molecular Biology 2014, 4: 155-166. DOI: 10.3923/ajbmb.2014.155.166.Peer-Reviewed Original ResearchLipid peroxidationDay suppressive testDecocted extractTraditional herbal remediesInfected miceSuppressive testAntioxidant activityPreventive agentSame doseRat liver homogenateBody weightOxidative stress diseasesHerbal remediesLiver homogenatesTotal phenol contentInhibition of ionStress diseasesPhyllanthus amarusQE/Antioxidant potentialHighest total phenol contentInhibitionPhyllantus amarusCochlospermum planchoniiMalaria
2012
Aldehyde dehydrogenases in cellular responses to oxidative/electrophilicstress
Singh S, Brocker C, Koppaka V, Chen Y, Jackson BC, Matsumoto A, Thompson DC, Vasiliou V. Aldehyde dehydrogenases in cellular responses to oxidative/electrophilicstress. Free Radical Biology And Medicine 2012, 56: 89-101. PMID: 23195683, PMCID: PMC3631350, DOI: 10.1016/j.freeradbiomed.2012.11.010.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsReactive oxygen speciesOxidative stressMulticellular speciesEukaryotic organismsElectrophilic stressExogenous aldehydesCancer stem cellsLiving systemsStress responseCellular responsesEnvironmental stressorsSimilar functionsAldehyde scavengerSpeciesStem cellsLipid peroxidationROS loadOxygen speciesElevated oxidative stressLipid membranesALDHALDH expressionOrganismsPathological processesPathological conditionsMolecular mechanisms of ALDH3A1-mediated cellular protection against 4-hydroxy-2-nonenal
Black W, Chen Y, Matsumoto A, Thompson DC, Lassen N, Pappa A, Vasiliou V. Molecular mechanisms of ALDH3A1-mediated cellular protection against 4-hydroxy-2-nonenal. Free Radical Biology And Medicine 2012, 52: 1937-1944. PMID: 22406320, PMCID: PMC3457646, DOI: 10.1016/j.freeradbiomed.2012.02.050.Peer-Reviewed Original ResearchConceptsAldehyde dehydrogenasesOxidative stress responseCellular defense mechanismsOxidative stressHuman ALDH3A1Proteasome functionMolecular mechanismsPrevents apoptosisStress responseCellular protectionLipid peroxidationAdverse effectsWestern blot analysisAldehydic moleculesGlutathione homeostasisALDH3A1 expressionCell viability assaysMetabolic functionsALDH3A1Blot analysisDefense mechanismsProtein adduct formationCell linesCell viabilityViability assays
2011
Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer
Chen Y, Orlicky DJ, Matsumoto A, Singh S, Thompson DC, Vasiliou V. Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer. Biochemical And Biophysical Research Communications 2011, 405: 173-179. PMID: 21216231, PMCID: PMC3112362, DOI: 10.1016/j.bbrc.2011.01.002.Peer-Reviewed Original ResearchConceptsHuman colon cancerColon cancerPotential biomarkersLipid peroxidationHigher expression scoresHuman cancersAldehyde dehydrogenase 1B1Cancer stem cellsColonic cancer specimensHuman colonic adenocarcinomaColonic adenocarcinomaImmunohistochemical expressionCancer specimensActivity of ALDHTumor tissueExpression scoreHuman adenocarcinomasTissue arraysAdenocarcinomaALDH activityCancerALDH1A1ALDH isozymesCancerous tissuesStem cells
2000
Interleukin-6–Induced Protection in Hyperoxic Acute Lung Injury
Ward N, Waxman A, Homer R, Mantell L, Einarsson O, Du Y, Elias J. Interleukin-6–Induced Protection in Hyperoxic Acute Lung Injury. American Journal Of Respiratory Cell And Molecular Biology 2000, 22: 535-542. PMID: 10783124, DOI: 10.1165/ajrcmb.22.5.3808.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntioxidantsApoptosisbcl-2-Associated X ProteinBronchoalveolar Lavage FluidCells, CulturedHyperoxiaIn Situ Nick-End LabelingInterleukin-6Lipid PeroxidationLungMiceMice, TransgenicMicroscopy, ElectronProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2Superoxide DismutaseTissue Inhibitor of Metalloproteinase-1ConceptsIL-6Lung injuryTransgene (-) animalsAlveolar-capillary protein leakHyperoxic acute lung injurySuperoxide dismutaseAcute lung injuryLung lipid peroxidationHyperoxic lung injurySignificant alterationsBcl-2Cell deathDNA fragmentationProtein leakManganese superoxide dismutaseProtective effectMetalloproteinase-1TIMP-1Transgenic miceTissue inhibitorInjuryZinc superoxide dismutaseMarked diminutionLipid peroxidationCytopathic response
1998
Role of Caspases in N‐Methyl‐d‐Aspartate‐Induced Apoptosis in Cerebrocortical Neurons
Tenneti L, D'Emilia D, Troy C, Lipton S. Role of Caspases in N‐Methyl‐d‐Aspartate‐Induced Apoptosis in Cerebrocortical Neurons. Journal Of Neurochemistry 1998, 71: 946-959. PMID: 9721720, DOI: 10.1046/j.1471-4159.1998.71030946.x.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid Chloromethyl KetonesAnimalsApoptosisCalciumCaspase 1Cells, CulturedCerebral CortexCysteine EndopeptidasesCysteine Proteinase InhibitorsIntracellular MembranesLipid PeroxidesMembrane PotentialsMitochondriaNeuronsN-MethylaspartateRatsRats, Sprague-DawleyReactive Oxygen SpeciesSignal TransductionConceptsInterleukin-1beta-converting enzymeMitochondrial membrane potentialReactive oxygen speciesRole of caspasesZ-VAD-FMKROS formationMembrane potentialReceptor activationCaspase activationDownstream eventsPseudosubstrate peptideNeuronal apoptosisMitochondrial depolarizationCysteine proteasesLipid peroxidationCaspasesCerebrocortical neuronsSubstrate cleavageIntracellular processesForm of deathN-methyl-D-aspartate (NMDA) receptor activationCortical neuronal apoptosisApoptosisCatalytic siteNMDA receptor activationTargeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation.
Waxman AB, Einarsson O, Seres T, Knickelbein RG, Warshaw JB, Johnston R, Homer RJ, Elias JA. Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation. Journal Of Clinical Investigation 1998, 101: 1970-1982. PMID: 9576762, PMCID: PMC508784, DOI: 10.1172/jci1337.Peer-Reviewed Original ResearchConceptsIL-11Lung injuryTransgene (-) animalsIL-1Alveolar-capillary protein leakPulmonary neutrophil recruitmentAcute lung injuryHyperoxic gas mixtureDNA fragmentationLevels of totalMurine toleranceLung expressionNeutrophil recruitmentProtein leakTNF productionLung antioxidantsTransgenic miceCopper-zinc superoxide dismutaseZinc superoxide dismutaseHyperoxiaGlutathione peroxidaseLipid peroxidationInjuryOxygen toxicityDismutase activity
1997
Mucosal Protection from Intestinal Ischemia–Reperfusion Reduces Oxidant Injury to the Lung
Rossman J, Caty M, Zheng S, Karamanoukian H, Thusu K, Azizkhan R, Dandona P. Mucosal Protection from Intestinal Ischemia–Reperfusion Reduces Oxidant Injury to the Lung. Journal Of Surgical Research 1997, 73: 41-46. PMID: 9441791, DOI: 10.1006/jsre.1997.5196.Peer-Reviewed Original ResearchConceptsIntestinal mucosal injuryLung injuryMucosal injuryOxygenated perfluorocarbonLipid peroxidationDistant organ injuryIntestinal ischemia reperfusionLung lipid peroxidationPortal venous circulationPortal venous effluentOrgan injuryIschemia reperfusionMucosal protectionPortal bloodVenous effluentVenous circulationLung tissueLuminal perfusionIntraluminal oxygenOxidant injurySmall intestineInjuryOxidant generationReactive oxygen speciesPrimary effector
1994
Surfactant Lipid Peroxidation and Inactivation of Protease Inhibitor in the Lung during Oxidant Exposure
Mohsenin V. Surfactant Lipid Peroxidation and Inactivation of Protease Inhibitor in the Lung during Oxidant Exposure. Progress In Respiratory Research 1994, 27: 251-260. DOI: 10.1159/000423046.Peer-Reviewed Original Research
1992
Cortical hypoperfusion following spreading depression is not altered by tirilazad mesylate (U-74006F) in awake rats
Duckrow R, Beard D. Cortical hypoperfusion following spreading depression is not altered by tirilazad mesylate (U-74006F) in awake rats. Brain Research 1992, 572: 296-299. PMID: 1611527, DOI: 10.1016/0006-8993(92)90488-u.Peer-Reviewed Original Research
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply