2024
A virus associated with the zoonotic pathogen Plasmodium knowlesi causing human malaria is a member of a diverse and unclassified viral taxon
Petrone M, Charon J, Grigg M, William T, Rajahram G, Westaway J, Piera K, Shi M, Anstey N, Holmes E. A virus associated with the zoonotic pathogen Plasmodium knowlesi causing human malaria is a member of a diverse and unclassified viral taxon. Virus Evolution 2024, 10: veae091. PMID: 39619416, PMCID: PMC11605544, DOI: 10.1093/ve/veae091.Peer-Reviewed Original ResearchViral taxaRNA virusesAnalysis of metagenomic dataPlasmodium speciesSingle-celled eukaryotesHuman-infecting Plasmodium speciesPathogen life cycleGenome architectureGroup of virusesMetagenomic dataMetagenomic sequencingDisease-causingVirus discoveryTaxaViral diversityParasite PlasmodiumRNAInfecting protozoaPlasmodium knowlesiViromeHuman malariaParasite fitnessSpeciesApicomplexaInfect humansEffectiveness of Two New Endochin-like Quinolones, ELQ-596 and ELQ-650, in Experimental Mouse Models of Human Babesiosis
Vydyam P, Chand M, Pou S, Winter R, Liebman K, Nilsen A, Doggett J, Riscoe M, Mamoun C. Effectiveness of Two New Endochin-like Quinolones, ELQ-596 and ELQ-650, in Experimental Mouse Models of Human Babesiosis. ACS Infectious Diseases 2024, 10: 1405-1413. PMID: 38563132, PMCID: PMC11127568, DOI: 10.1021/acsinfecdis.4c00143.Peer-Reviewed Original ResearchConceptsRadical cureEndochin-like quinolonesAgent of human malariaLethal infection modelTreatment of human babesiosisLow toxicity profileExperimental mouse modelImmunocompetent miceImmunocompromised miceFavorable pharmacological propertiesHuman malariaToxicity profileChronic modelHuman babesiosisAnimal modelsInfection modelPharmacological limitationsActivity in vitroPharmacological propertiesReduce infectionQuinolonesMiceMitochondrial electron transport chainFavorable physicochemical propertiesMonotherapy
2019
In Silico Karyotyping of Chromosomally Polymorphic Malaria Mosquitoes in the Anopheles gambiae Complex
Love R, Redmond S, Pombi M, Caputo B, Petrarca V, della Torre A, Consortium T, Besansky N. In Silico Karyotyping of Chromosomally Polymorphic Malaria Mosquitoes in the Anopheles gambiae Complex. G3: Genes, Genomes, Genetics 2019, 9: 3249-3262. PMID: 31391198, PMCID: PMC6778791, DOI: 10.1534/g3.119.400445.Peer-Reviewed Original ResearchConceptsInversion genotypesSingle nucleotide polymorphismsInversion polymorphismTag single nucleotide polymorphismsChromosomal inversion polymorphismTag SNP genotypesAnopheles gambiae complexParacentric inversion polymorphismEnvironmental heterogeneityChromosomal rearrangementsImportant phenotypesMalaria mosquitoesSilico karyotypingNatural variationGambiae complexMosquito speciesTraditional cytogeneticsCytogenetic methodsBiallelic genotypesSignificant vectorSNP genotypesGonotrophic stagesNucleotide polymorphismsGenomeHuman malariaEvidence for vesicle-mediated antigen export by the human pathogen Babesia microti
Thekkiniath J, Kilian N, Lawres L, Gewirtz MA, Graham MM, Liu X, Ledizet M, Mamoun C. Evidence for vesicle-mediated antigen export by the human pathogen Babesia microti. Life Science Alliance 2019, 2: e201900382. PMID: 31196872, PMCID: PMC6572159, DOI: 10.26508/lsa.201900382.Peer-Reviewed Original ResearchConceptsApicomplexan parasitesCell fractionation studiesImmunoelectron microscopy analysisMode of secretionInvasion of erythrocytesParasite effectorsTrafficking motifsPlasma membraneExport mechanismClose relativesParasitophorous vacuoleHost erythrocyteMorphogenic changesFractionation studiesNovel mechanismHuman malariaFatal tick-borne diseaseMalaria-like illnessMouse red blood cellsParasitesAntigen exportTick-borne diseaseRed blood cellsHuman babesiosisImmunodominant antigens
2016
Plant-Mediated Effects on Mosquito Capacity to Transmit Human Malaria
Hien D, Dabiré K, Roche B, Diabaté A, Yerbanga R, Cohuet A, Yameogo B, Gouagna L, Hopkins R, Ouedraogo G, Simard F, Ouedraogo J, Ignell R, Lefevre T. Plant-Mediated Effects on Mosquito Capacity to Transmit Human Malaria. PLOS Pathogens 2016, 12: e1005773. PMID: 27490374, PMCID: PMC4973987, DOI: 10.1371/journal.ppat.1005773.Peer-Reviewed Original ResearchConceptsImportant African malaria vectorsHost resource availabilityMalaria parasitesMalaria vectorsSugar sourcesSugar mealsAfrican malaria vectorsToxic secondary metabolitesNutritional ecologyPlant speciesMosquito traitsMosquito competenceNatural diversityFeeding assaysLannea microcarpaMosquito's capacityEcological contextSecondary metabolitesMolecular aspectsMalaria transmissionParasite growthResource availabilityDirect membrane feeding assaysDevelopment durationHuman malaria
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