2024
Monitoring and management of hemolytic disease of the fetus and newborn based on an international expert Delphi consensus
Mustafa H, Sambatur E, Shamshirsaz A, Johnson S, Moise K, Baschat A, Verweij E, Javinani A, Kilby M, Lopriore E, Rose R, Devlieger R, Snowise S, Sachs U, Khalil A, Group H, Nassr A, Baschat A, Hohnecker A, Shamshirsaz A, Luciano A, Debeer A, Geipel A, Borrell A, Khalil A, Llorente A, Mayer B, Poljak B, van der Schoot C, Taillefer C, Dame C, Berg C, Coutinho C, de Winter D, Oepkes D, Verweij E, Moratonas E, Tiblad E, Bendel-Stenzel E, Maisonneuve E, Lopriore E, Vlachodimitropoulou E, Prefumo F, Maia F, Filho P, Molina F, Gonzalez G, Gardener G, Sago H, Liley H, Mustafa H, Schwach I, Bedei I, Castleman J, Krivec J, jouannic J, Miller J, Nunes J, Middeldorp J, Martinez J, Sundberg K, Bligard K, Kohari K, Ishii K, Moise K, Le Duc K, Lewi L, Van Wyk L, Otaño L, Sun L, Geerts L, Sanchez-Duran M, Bennasar M, Vaena M, Gil M, Weems M, Kilby M, de Haas M, Saxonhouse M, Schenone M, Bahtiyar M, Zaretsky M, Rodriguez M, Habli M, Khalek N, Frost N, Griffiths P, Maurice P, Dar P, Lindgren P, Chaveeva P, Klaritsch P, Radhakrishnan P, Schuler R, Chmait R, Rose R, van 't Oever R, Jernman R, Christensen R, Cincotta R, Axt-Fliedner R, Devlieger R, Donepudi R, Kumar S, Verlohren S, Emery S, Sainio S, Mehra S, Premru-Srsen T, Legler T, Sachs U, Basal V, Stefanovic V, Goodnight W, Blumenfeld Y. Monitoring and management of hemolytic disease of the fetus and newborn based on an international expert Delphi consensus. American Journal Of Obstetrics And Gynecology 2024, 232: 280-300. PMID: 39547350, DOI: 10.1016/j.ajog.2024.11.003.Peer-Reviewed Original ResearchManagement of hemolytic diseaseIntrauterine transfusionPostnatal managementHemolytic diseaseHospital dischargeExpert Delphi consensusCut-off levelInternational panel of expertsMonths of ageFetal/neonatal deathLt;24 weeksPrenatal workupFetal medicineAffected neonatesFetal monitoringExchange transfusionAntigen statusPrenatal monitoringWeeks of dischargeTransfusionCritical titerClinical guidancePanel of expertsDelphi consensusNewbornsCharacterization of blood bank and transfusion medicine practices for pregnant individuals with fetuses at risk of hemolytic disease in the United States
Jacobs J, Booth G, Moise K, Adkins B, Bakhtary S, Fasano R, Goel R, Hinton H, Laghari S, Stephens L, Tormey C, Crowe E, Bloch E, Abels E. Characterization of blood bank and transfusion medicine practices for pregnant individuals with fetuses at risk of hemolytic disease in the United States. Transfusion 2024, 64: 1870-1880. PMID: 39248602, DOI: 10.1111/trf.18011.Peer-Reviewed Original ResearchRisk of HDFNAntigen testAntibody titersHemolytic diseaseRed blood cellsCell-free fetal DNA testingRisk of hemolytic diseaseCell-free fetal DNAMaternal antibody titersPregnant individualsFetal DNA testingBlood banksTransfusion medicine practiceFetal DNALaboratory testing practicesThird trimesterAntigen statusTransfusion medicine serviceAntigen resultsMedicine serviceFetusesHDFNCritical titerResponse rateDNA testing
2023
Assessing Recommendations for Determining Fetal Risk in Alloimmunized Pregnancies in the United States: Is It Time to Update a Decades-Old Practice?
Abels E, Adkins B, Cedeno K, Booth G, Allen E, Stephens L, Woo J, Tormey C, Jacobs J. Assessing Recommendations for Determining Fetal Risk in Alloimmunized Pregnancies in the United States: Is It Time to Update a Decades-Old Practice? Transfusion Medicine Reviews 2023, 38: 150810. PMID: 38194730, DOI: 10.1016/j.tmrv.2023.150810.Peer-Reviewed Original ResearchAntigen testingEvidence-based recommendationsFetal risksAlloimmunized pregnanciesPoor outcomeHemolytic diseasePractice guidelinesDecades-old practiceNarrative reviewTransfusion medicineUnnecessary riskRecent evidencePregnancyUnited StatesFetusesRiskCurrent United StatesValuable alternativeTesting algorithmObstetriciansCurrent landscapeDiseaseRecommendationsAntibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression
Jajosky R, Patel K, Allen J, Zerra P, Chonat S, Ayona D, Maier C, Morais D, Wu S, Luckey C, Eisenbarth S, Roback J, Fasano R, Josephson C, Manis J, Chai L, Hendrickson J, Hudson K, Arthur C, Stowell S. Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression. Blood 2023, 142: 1082-1098. PMID: 37363865, PMCID: PMC10541552, DOI: 10.1182/blood.2022018591.Peer-Reviewed Original ResearchConceptsAntibody-mediated immunosuppressionRBC alloantigensImmune responseFetal red blood cell antigensTarget antigenRed blood cell antigensRh immune globulinMaternal immune responseBlood cell antigensInclusion of antibodiesRBC removalAnti-RhD antibodiesAbility of antibodiesImmune globulinAntibody responseHemolytic diseaseRBC clearanceCell antigensFetal RBCsAntibody characteristicsAlloantigensSimilar interventionsAntibodiesAntigenPolyclonal antibody preparationPassive transfer of alloantibodies through breast milk as a mediator of hemolytic anemia
Abels E, Jacobs J, Prior D, Willets L, Sostin N, Tormey C, Binns T. Passive transfer of alloantibodies through breast milk as a mediator of hemolytic anemia. Transfusion 2023, 63: 2188-2196. PMID: 37706556, DOI: 10.1111/trf.17548.Peer-Reviewed Original ResearchConceptsMaternal breast milkBreast milkNeonatal circulationRed blood cellsPassive transferAntiviral IgG antibodiesResolution of anemiaPaucity of dataNeonatal red blood cellsIntravenous immunoglobulinMaternal alloantibodiesMaternal antibodiesPlacental transferRBC antibodiesIgG antibodiesHemolytic diseaseHemolytic anemiaPlasma titersAlloantibodiesHDFNBlood cellsAntibodiesSignificant decreasePatientsAnemiaHemolytic disease of the fetus and newborn mediated by anti-Dia in a U.S. hospital
Jacobs J, Abels E, Binns T, Tormey C, Sostin N. Hemolytic disease of the fetus and newborn mediated by anti-Dia in a U.S. hospital. Immunohematology 2023, 39: 32-34. PMID: 37017601, DOI: 10.21307/immunohematology-2023-006.Peer-Reviewed Case Reports and Technical NotesConceptsHemolytic diseaseCases of HDFNU.S. hospitalsHemolytic transfusion reactionsDirect antiglobulin testNeonatal bilirubin levelsSouth American descentAntibody detection testsLow-prevalence antigensU.S. patient populationNear universal absenceHDFN casesBilirubin levelsPatient populationTransfusion reactionsAntiglobulin testUnexpected causeHispanic ethnicityBlood group systemAntigenAntibodiesHDFNHospitalFetusesDisease
2022
Cholecystitis and Gallstone Disease
Maassel N, Stitelman D. Cholecystitis and Gallstone Disease. 2022, 837-841. DOI: 10.1007/978-3-031-07524-7_90.Peer-Reviewed Original ResearchLow gallbladder ejection fractionLimited hospital stayMost surgical candidatesPediatric laparoscopic cholecystectomyAbsence of gallstonesGallbladder ejection fractionNuclear medicine scansTreatment of childrenBiliary colicBiliary dyskinesiaHospital stayComplicated cholecystitisSurgical candidatesEjection fractionGallstone diseaseLaparoscopic cholecystectomyMotility disordersBlood testsPhysical examinationChronic hemolytic diseaseHemolytic diseaseFocused historyPediatric specialistsObesity ratesCholecystitisFcγRIV is required for IgG2c mediated enhancement of RBC alloimmunization
Qiu A, Miller A, Dei Zotti F, Santhanakrishnan M, Hendrickson JE, Tredicine M, Stowell SR, Luckey CJ, Zimring JC, Hudson KE. FcγRIV is required for IgG2c mediated enhancement of RBC alloimmunization. Frontiers In Immunology 2022, 13: 972723. PMID: 36189253, PMCID: PMC9519184, DOI: 10.3389/fimmu.2022.972723.Peer-Reviewed Original ResearchConceptsAlloantibody productionRBC alloimmunizationPassive immunizationRBC clearanceSplenic dendritic cell subsetsRed blood cell transfusionSplenic conventional DCsBlood cell transfusionDendritic cell subsetsConventional DCsFc gamma receptorsHumoral alloimmunizationAlloantibody responsesCell transfusionMaternal alloimmunizationCell subsetsFcγR expressionIgG antibodiesHemolytic diseaseBlocking antibodiesAlloimmunizationImmune complexesMouse modelKnockout miceAntibodies
2020
Immunohematologic aspects of alloimmunization and alloantibody detection: A focus on pregnancy and hemolytic disease of the fetus and newborn
Gupta GK, Balbuena-Merle R, Hendrickson JE, Tormey CA. Immunohematologic aspects of alloimmunization and alloantibody detection: A focus on pregnancy and hemolytic disease of the fetus and newborn. Transfusion And Apheresis Science 2020, 59: 102946. PMID: 32962917, DOI: 10.1016/j.transci.2020.102946.Peer-Reviewed Original ResearchConceptsRed blood cellsHemolytic diseaseCurrent pathophysiologic mechanismsSetting of pregnancyPeri-partum periodPregnant patientsRBC alloantibodiesPathophysiologic mechanismsTransfusion practiceAlloantibody detectionTransfusion therapyClinical impactAlloimmunizationTransfusion communityBlood bankPregnancyDeadliest formBlood cellsAlloantibodiesFetusesDiseaseLaboratory toolPatientsTherapySettingPoly(I:C) causes failure of immunoprophylaxis to red blood cells expressing the KEL glycoprotein in mice
Escamilla-Rivera V, Liu J, Gibb DR, Santhanakrishnan M, Liu D, Forsmo JE, Eisenbarth S, Foxman EF, Stowell SR, Luckey CJ, Zimring JC, Hudson KE, Hendrickson J. Poly(I:C) causes failure of immunoprophylaxis to red blood cells expressing the KEL glycoprotein in mice. Blood 2020, 135: 1983-1993. PMID: 32266378, PMCID: PMC7256361, DOI: 10.1182/blood.2020005018.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCytokinesDisease Models, AnimalErythroblastosis, FetalErythrocyte TransfusionErythrocytesFemaleHumansImmunization, PassiveInterferon Type IIsoantigensKell Blood-Group SystemMembrane GlycoproteinsMetalloendopeptidasesMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicPhagocytosisPoly I-CPregnancyConceptsRed blood cellsSerum monocyte chemoattractant protein-1Monocyte chemoattractant protein-1Blood cellsHuman KEL glycoproteinPolyinosinic-polycytidilic acidTransfused red blood cellsType 1 IFNType I IFN receptorChemoattractant protein-1Type 1 interferonI IFN receptorMurine red blood cellsRecipient CD4Recipient inflammationIFN administrationSerum cytokinesInflammatory monocytesRecipient treatmentInterleukin-6Hemolytic diseaseT cellsMurine modelAlloimmunizationKnockout mice
2019
Transfusion-related red blood cell alloantibodies: induction and consequences
Tormey CA, Hendrickson JE. Transfusion-related red blood cell alloantibodies: induction and consequences. Blood 2019, 133: 1821-1830. PMID: 30808636, PMCID: PMC6484385, DOI: 10.1182/blood-2018-08-833962.Peer-Reviewed Original ResearchConceptsTransfusion recipientsBlood donorsPreventative strategiesBlood product exposureCompatible RBC unitsRBC alloantibody formationHemolytic transfusion reactionsDevelopment of alloantibodiesAdaptive immune factorsJudicious transfusionRBC alloimmunizationImmunomodulatory therapyAlloantibody formationBlood transfusionRBC alloantibodiesRecipient variablesFuture pregnanciesImmune factorsTransfusion reactionsBlood productsHemolytic diseaseFuture transfusionsHuman studiesTransfusionAlloantibodies
2018
Chapter 4 Common Significant Non-ABO Antibodies and Blood Group Antigen Alloimmunization
Baine I, Hendrickson J, Tormey C. Chapter 4 Common Significant Non-ABO Antibodies and Blood Group Antigen Alloimmunization. 2018, 25-39. DOI: 10.1016/b978-0-323-54458-0.00004-0.ChaptersNon-ABO antibodiesBlood group antibodiesGroup antibodiesCompatible RBC unitsEnd-organ damageHemolytic transfusion reactionsSetting of pregnancyCommon adverse outcomeFormation of alloantibodiesSickle cell diseaseRBC alloimmunizationPregnant patientsOrgan damageMyelodysplastic syndromePregnant womenAdverse outcomesGeneral patientsTransfusion reactionsHemolytic diseaseCell diseaseHigh riskRed blood cell surfaceImmunologic conceptsClinical practiceAlloimmunization
2016
Cholecystitis
Tackett J, Cowles R. Cholecystitis. 2016, 641-645. DOI: 10.1007/978-3-319-27443-0_80.ChaptersLimited hospital stayMost surgical candidatesPediatric laparoscopic cholecystectomyTreatment of childrenHospital stayComplicated cholecystitisSurgical candidatesLaparoscopic cholecystectomyBlood testsPhysical examinationChronic hemolytic diseaseHemolytic diseaseFocused historyPediatric specialistsObesity ratesCholecystitisCholecystectomyStayDiseaseIncidence
2015
Diagnosis and management of rare congenital nonimmune hemolytic disease.
Gallagher PG. Diagnosis and management of rare congenital nonimmune hemolytic disease. Hematology 2015, 2015: 392-9. PMID: 26637748, DOI: 10.1182/asheducation-2015.1.392.Peer-Reviewed Original ResearchConceptsErythrocyte hydrationHemolytic diseaseErythrocyte metabolismGroup of disordersEpisodic hemolysisLaboratory manifestationsPathophysiologic mechanismsClinical findingsHemolytic anemiaChronic hemolysisHemolytic disordersImportant causeDiseaseHeterogeneous groupDisordersAnemiaErythrocyte structureAbnormalitiesHemoglobin stabilityPathway leadUnstable hemoglobinopathiesMetabolismManagement considerationsUnstable hemoglobinHemolysisA Pediatrician’s Practical Guide to Diagnosing and Treating Hereditary Spherocytosis in Neonates
Christensen RD, Yaish HM, Gallagher PG. A Pediatrician’s Practical Guide to Diagnosing and Treating Hereditary Spherocytosis in Neonates. Pediatrics 2015, 135: 1107-1114. PMID: 26009624, PMCID: PMC4444801, DOI: 10.1542/peds.2014-3516.Peer-Reviewed Original ResearchConceptsHereditary spherocytosisDiagnosis of HSABO hemolytic diseaseGlucose-6-phosphate dehydrogenase deficiencyHazardous hyperbilirubinemiaErythrocyte transfusionSymptomatic anemiaNeurologic dysfunctionPrompt diagnosisAdverse outcomesEmergency departmentNewborn periodNeonatal presentationNewborn infantsHemolytic diseaseAppropriate treatmentEarly suspicionHemolytic anemiaHemolytic conditionsAnticipatory guidanceNeonatesFirst monthAnemiaDehydrogenase deficiencyHyperbilirubinemia
2014
Red Blood Cell Alloimmunization Mitigation Strategies
Hendrickson JE, Tormey CA, Shaz BH. Red Blood Cell Alloimmunization Mitigation Strategies. Transfusion Medicine Reviews 2014, 28: 137-144. PMID: 24928468, DOI: 10.1016/j.tmrv.2014.04.008.Peer-Reviewed Original ResearchConceptsHemolytic transfusion reactionsRBC alloantibodiesRBC alloimmunizationTransfusion reactionsImmune systemRed blood cell alloantibodiesCompatible RBC unitsRBC alloimmunization rateTransfusion-associated morbidityRecipient's immune systemTransfusion-associated deathForms of anemiaAlloimmunization rateAntigen exposureSignificant morbidityTransfusion recipientsHemolytic diseaseAlloantibodiesHuman studiesAnimal studiesDanger signalsAnimal dataMorbidityAlloimmunizationRBC units
2013
Red Blood Cell Alloimmunization and Hemolytic Disease of the Fetus and Newborn: New Approaches Using Animal Models
Hendrickson J. Red Blood Cell Alloimmunization and Hemolytic Disease of the Fetus and Newborn: New Approaches Using Animal Models. Blood 2013, 122: sci-49. DOI: 10.1182/blood.v122.21.sci-49.sci-49.Peer-Reviewed Original ResearchRed blood cellsMurine red blood cellsPreventive therapyRBC alloantibodiesTransfusion settingsRBC precursorsHemolytic diseaseAnimal modelsAntigen-negative red blood cellsNewborn pupsRed blood cell alloimmunizationPositive indirect antiglobulin testBone marrow erythroid precursorsMature red blood cellsFetal liverNegative red blood cellsPotential preventive therapyRBC-specific expressionRh immune globulinFlow cytometric crossmatchPregnancy/deliveryFetus/neonateForeign red blood cellsWeeks of deliveryIndirect antiglobulin test
2010
Hemolytic Disease of the Newborn
Shamsi T, Hossain N, Paidas M. Hemolytic Disease of the Newborn. 2010, 28-40. DOI: 10.1002/9781444328332.ch3.Peer-Reviewed Original ResearchHemolytic diseaseRed cell antigensCell antigensMiddle cerebral artery peak systolic velocityFetal middle cerebral artery peak systolic velocityAppropriate blood productsFetus/neonatePeak systolic velocityMaternal red cellsRed cellsRed cell sensitizationRed cell destructionClasses of antibodiesRhesus blood groupsIntrauterine transfusionAntenatal managementTerm neonatesFetal anemiaPaternal antigensSubsequent pregnancyFirst pregnancyNegative pregnancyAntenatal prophylaxisDoppler interrogationProphylaxis program
2009
Incidence of Retinopathy of Prematurity in the United States: 1997 through 2005
Lad E, Hernandez-Boussard T, Morton J, Moshfeghi D. Incidence of Retinopathy of Prematurity in the United States: 1997 through 2005. American Journal Of Ophthalmology 2009, 148: 451-458.e2. PMID: 19541285, DOI: 10.1016/j.ajo.2009.04.018.Peer-Reviewed Original ResearchConceptsIncidence of retinopathyNational Inpatient SampleLength of stayIntraventricular hemorrhageBirth weightInpatient SampleFetal hemorrhageRespiratory conditionsBlood transferScleral buckle surgeryLow birth weightLaser photocoagulation therapyMultivariate logistic regressionROP incidenceBaseline characteristicsBuckle surgeryPremature infantsROP developmentPlana vitrectomyRetrospective studySurgical interventionPhotocoagulation therapyRisk factorsNewborn infantsHemolytic disease
1990
Vel isoimmunization in pregnancy
Stiller R, Lardas O, de Regt R. Vel isoimmunization in pregnancy. American Journal Of Obstetrics And Gynecology 1990, 162: 1071-1072. PMID: 2327448, DOI: 10.1016/0002-9378(90)91319-8.Peer-Reviewed Original Research
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