2024
Sodium channels in non-excitable cells: powerful actions and therapeutic targets beyond Hodgkin and Huxley
Vasylyev D, Liu C, Waxman S. Sodium channels in non-excitable cells: powerful actions and therapeutic targets beyond Hodgkin and Huxley. Trends In Cell Biology 2024 PMID: 39743470, DOI: 10.1016/j.tcb.2024.11.009.Peer-Reviewed Original ResearchVoltage-gated sodium channelsSodium channelsInvolvement of voltage-gated sodium channelsFunction of voltage-gated sodium channelsCellular functionsTherapeutic targetNon-excitable cellsRegulate diverse cellular functionsDiverse cellular functionsPropagation of action potentialsCardiac myocytesDynamic expression patternCytokine releaseInflammatory disordersAction potentialsMuscle cellsTherapeutic interventionsCell typesPathological conditionsPhysiological processesCellsCurrent knowledgeOsteoarthritisHodgkinWhat Are the Most Current Asthma Guidelines From the National Institutes of Health and What Do I Need to Know About Them?
Bazzy-Asaad A. What Are the Most Current Asthma Guidelines From the National Institutes of Health and What Do I Need to Know About Them? 2024, 113-116. DOI: 10.1201/9781003523611-27.Peer-Reviewed Original Research
2023
Tick salivary glycans – a sugar-coated tick bite
Karim S, Leyva-Castillo J, Narasimhan S. Tick salivary glycans – a sugar-coated tick bite. Trends In Parasitology 2023, 39: 1100-1113. PMID: 37838514, DOI: 10.1016/j.pt.2023.09.012.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCertain tick speciesDisease-causing pathogensNon-natural host speciesTick resistanceTick speciesTick feedingTick salivaPathogen transmissionTick bite siteMeat consumptionHematophagous arthropodsHost speciesTick biteRed meat consumptionMeat allergySuccessful feedingRed meat allergySpeciesTicksFeedingAllergic responsesImmune responseArthropodsCurrent knowledgePathogensA Geriatric Approach to Percutaneous Coronary Interventions in Older Adults, Part II A JACC: Advances Expert Panel
Nanna M, Sutton N, Kochar A, Rymer J, Lowenstern A, Gackenbach G, Hummel S, Goyal P, Rich M, Kirkpatrick J, Krishnaswami A, Alexander K, Forman D, Bortnick A, Batchelor W, Damluji A. A Geriatric Approach to Percutaneous Coronary Interventions in Older Adults, Part II A JACC: Advances Expert Panel. JACC Advances 2023, 2: 100421. PMID: 37575202, PMCID: PMC10419335, DOI: 10.1016/j.jacadv.2023.100421.Peer-Reviewed Original ResearchPercutaneous coronary interventionCoronary interventionOlder adultsPreprocedural risk assessmentGoals of carePatient-centered outcomesInterventional cardiology practiceOlder adult populationHeart team membersGeriatric approachOlder patientsHeart teamGeriatric syndromesPharmacotherapeutic considerationsGeriatric specialistsCardiology practiceGeriatric principlesGeriatric risksAdult populationExpert panelAdultsRisk assessmentInterventionFacilitate uptakeCurrent knowledgeThe Growing Role of Technology in the Care of Older Adults With Diabetes.
Huang E, Sinclair A, Conlin P, Cukierman-Yaffe T, Hirsch I, Huisingh-Scheetz M, Kahkoska A, Laffel L, Lee A, Lee S, Lipska K, Meneilly G, Pandya N, Peek M, Peters A, Pratley R, Sherifali D, Toschi E, Umpierrez G, Weinstock R, Munshi M. The Growing Role of Technology in the Care of Older Adults With Diabetes. Diabetes Care 2023, 46: 1455-1463. PMID: 37471606, PMCID: PMC10369127, DOI: 10.2337/dci23-0021.Peer-Reviewed Original ResearchConceptsOlder adultsAreas of careHealth care servicesDiabetes careContinuous glucose monitorEvidence-based technologiesDiabetes managementCare prioritiesClinical experienceClinical heterogeneityCare servicesDiabetesInsulin pumpCareScientific evidenceAdultsGlucose monitorDistinct subpopulationsCurrent knowledgeMajor barrierImportant populationPotential promiseCaregiversEpigenetic markers and therapeutic targets for metastasis
Kravitz C, Yan Q, Nguyen D. Epigenetic markers and therapeutic targets for metastasis. Cancer And Metastasis Reviews 2023, 42: 427-443. PMID: 37286865, PMCID: PMC10595046, DOI: 10.1007/s10555-023-10109-y.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEpigenomic alterationsLineage integrityTherapeutic targetEpigenetic markersCancer cellsGenetic aberrationsCurrent knowledgeHuman tumorsMalignant cell cloneTumor progressionDNANumber of discoveriesCell clonesDisseminated diseaseCertain organsPrimary tumorTherapeutic responseMetastatic cancerEpigenomeChromatinHistonesLiquid biopsyAlterationsClonesTargetMicrobiota in disease-transmitting vectors
Wang J, Gao L, Aksoy S. Microbiota in disease-transmitting vectors. Nature Reviews Microbiology 2023, 21: 604-618. PMID: 37217793, DOI: 10.1038/s41579-023-00901-6.Peer-Reviewed Original ResearchConceptsSymbiotic associationVector-borne diseasesDisease-transmitting vectorsAlternative control methodsVector competenceUnique key featuresHealth of humansSymbiotic microorganismsVector taxaReproductive strategiesArthropod hostsLife historyVector arthropodsHaematophagous arthropodsTriatomine bugsBlood feedVector populationsTransmission successArthropodsFeeding behaviorCurrent knowledgeMicrobiotaPathogensKnowledge gapsTaxaThe functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium
Bruin W, Abe Y, Alonso P, Anticevic A, Backhausen L, Balachander S, Bargallo N, Batistuzzo M, Benedetti F, Bertolin Triquell S, Brem S, Calesella F, Couto B, Denys D, Echevarria M, Eng G, Ferreira S, Feusner J, Grazioplene R, Gruner P, Guo J, Hagen K, Hansen B, Hirano Y, Hoexter M, Jahanshad N, Jaspers-Fayer F, Kasprzak S, Kim M, Koch K, Bin Kwak Y, Kwon J, Lazaro L, Li C, Lochner C, Marsh R, Martínez-Zalacaín I, Menchon J, Moreira P, Morgado P, Nakagawa A, Nakao T, Narayanaswamy J, Nurmi E, Zorrilla J, Piacentini J, Picó-Pérez M, Piras F, Piras F, Pittenger C, Reddy J, Rodriguez-Manrique D, Sakai Y, Shimizu E, Shivakumar V, Simpson B, Soriano-Mas C, Sousa N, Spalletta G, Stern E, Evelyn Stewart S, Szeszko P, Tang J, Thomopoulos S, Thorsen A, Yoshida T, Tomiyama H, Vai B, Veer I, Venkatasubramanian G, Vetter N, Vriend C, Walitza S, Waller L, Wang Z, Watanabe A, Wolff N, Yun J, Zhao Q, van Leeuwen W, van Marle H, van de Mortel L, van der Straten A, van der Werf Y, Thompson P, Stein D, van den Heuvel O, van Wingen G. The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium. Molecular Psychiatry 2023, 28: 4307-4319. PMID: 37131072, PMCID: PMC10827654, DOI: 10.1038/s41380-023-02077-0.Peer-Reviewed Original ResearchObsessive-compulsive disorderHealthy controlsFunctional connectivitySensorimotor networkOCD patientsResting-state functional connectivityWhole-brain functional connectivityResting-state connectivityPathophysiological modelPatient statusAccurate biomarkersWidespread abnormalitiesPatientsMajority of studiesEntire brainGeneralizability of resultsGroup differencesFunctional connectomeAbnormalitiesBiomarkersFunctional networksDisordersCurrent knowledgeIndividual levelIndependent samplesIntegrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings.
Mastracci T, Apte M, Amundadottir L, Alvarsson A, Artandi S, Bellin M, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, El Ouaamari A, Gaulton K, Geisz A, Goodarzi M, Hara M, Hull-Meichle R, Kleger A, Klein A, Kopp J, Kulkarni R, Muzumdar M, Naren A, Oakes S, Olesen S, Phelps E, Powers A, Stabler C, Tirkes T, Whitcomb D, Yadav D, Yong J, Zaghloul N, Pandol S, Sander M. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023, 72: 433-448. PMID: 36940317, PMCID: PMC10033248, DOI: 10.2337/db22-0942.Peer-Reviewed Original ResearchConceptsPancreatic diseaseEndocrine compartmentExocrine diseaseBasic science investigatorsExocrine disorderIntegrated physiologyMetabolic influencesExocrine pancreasDiseaseDisease mechanismsNormal physiologyNational InstitutePancreas anatomyGenetic driversPancreasMultiple presentationsExocrineCurrent knowledgeThe molecular pathology of schizophrenia: an overview of existing knowledge and new directions for future research
Nakamura T, Takata A. The molecular pathology of schizophrenia: an overview of existing knowledge and new directions for future research. Molecular Psychiatry 2023, 28: 1868-1889. PMID: 36878965, PMCID: PMC10575785, DOI: 10.1038/s41380-023-02005-2.Peer-Reviewed Original ResearchConceptsMolecular pathology of schizophreniaCopy number variantsDiscovery of copy number variantsLarge-scale exome sequencing studiesMolecular pathologyExome sequencing studiesDNA sequencesPathology of schizophreniaEpigenomic analysesSequencing studiesSingle genesGenetic variantsRare mutationsMultiple disease modelsGenesGenetic pathologyDisease modelsCurrent knowledgeSchizophrenia brainDisease riskVariantsPostmortem tissueBiological alterationsDNAEtiological validityCrosstalk within a brain-breast-bone axis regulates mineral and skeletal metabolism during lactation
Athonvarangkul D, Wysolmerski J. Crosstalk within a brain-breast-bone axis regulates mineral and skeletal metabolism during lactation. Frontiers In Physiology 2023, 14: 1121579. PMID: 36875035, PMCID: PMC9979219, DOI: 10.3389/fphys.2023.1121579.Peer-Reviewed Original ResearchBone lossExcess bone lossExcessive bone lossPostmenopausal osteoporosisBone turnoverRare entityMineral metabolismSkeletal metabolismNew therapiesBone qualityCalcium demandOsteoporosisMammary glandCalcium deliveryBone axisReversible physiological responseLactationHormonal signalsCurrent knowledgeMetabolismPhysiological responsesPregnancyHypothalamusPathophysiologyTherapy
2022
The Intersection of Immigrant and Environmental Health: A Scoping Review of Observational Population Exposure and Epidemiologic Studies
Fong K, Heo S, Lim C, Kim H, Chan A, Lee W, Stewart R, Choi H, Son J, Bell M. The Intersection of Immigrant and Environmental Health: A Scoping Review of Observational Population Exposure and Epidemiologic Studies. Environmental Health Perspectives 2022, 130: 096001. PMID: 36053724, PMCID: PMC9438924, DOI: 10.1289/ehp9855.Peer-Reviewed Original ResearchConceptsFull-text reviewHealth effectsEnvironmental exposuresHealth disparitiesAbstract reviewExposure disparitiesText reviewRace/ethnicityEligible studiesEpidemiologic studiesStudy exposureSocioeconomic characteristicsEnvironmental health disparitiesComparison groupMultiple studiesScoping ReviewHigh exposureExposureEnvironmental healthHealthCurrent knowledgeReviewPopulation exposureImmigrant statusDisparitiesTranslational Value of Tumor-Associated Lymphangiogenesis in Cholangiocarcinoma
Cadamuro M, Romanzi A, Guido M, Sarcognato S, Cillo U, Gringeri E, Zanus G, Strazzabosco M, Simioni P, Villa E, Fabris L. Translational Value of Tumor-Associated Lymphangiogenesis in Cholangiocarcinoma. Journal Of Personalized Medicine 2022, 12: 1086. PMID: 35887583, PMCID: PMC9324584, DOI: 10.3390/jpm12071086.Peer-Reviewed Original ResearchTumor-associated lymphangiogenesisTumor-draining lymph nodesTargetable genetic alterationsNovel therapeutic targetCholangiocarcinoma invasivenessLiver transplantationLiver resectionLymph nodesCurative potentialPrimary tumorAvailable treatmentsSurgical proceduresLymphatic metastasisTherapeutic targetTumor microenvironmentTranslational valueMolecular profilingGenetic alterationsLymphangiogenesisCholangiocarcinomaMetastasisProgressionCurrent knowledgeRecent findingsMolecular mechanismsEpigenetics of alcohol-related liver diseases
Habash N, Sehrawat T, Shah V, Cao S. Epigenetics of alcohol-related liver diseases. JHEP Reports 2022, 4: 100466. PMID: 35462859, PMCID: PMC9018389, DOI: 10.1016/j.jhepr.2022.100466.Peer-Reviewed Original ResearchAlcohol-related liver diseaseLiver diseaseMajor public health problemChronic liver diseasePublic health problemProinflammatory roleSignificant morbidityMultiple disease statesHealth problemsDisease statesDiseaseClinical applicationNon-coding RNADiagnosisEpigenetic alterationsPrimary causeCurrent knowledgeEpigenetic changesReview articleStudy of epigeneticsHepatologistsMorbidityComplicationsChemokinesPathophysiologySex Differences in Peripheral Artery Disease
Pabon M, Cheng S, Altin S, Sethi S, Nelson M, Moreau K, Hamburg N, Hess C. Sex Differences in Peripheral Artery Disease. Circulation Research 2022, 130: 496-511. PMID: 35175843, PMCID: PMC8919803, DOI: 10.1161/circresaha.121.320702.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseArtery diseaseManagement of PADSuch sex-based differencesNontraditional risk factorsSex differencesLack of diagnosisSex-based differencesImportant sex differencesIschemic cardiovascularPAD prevalenceVascular stressorSubstantial morbidityClinical presentationClinical manifestationsRisk factorsPrevalent conditionLimb eventsOverall populationVascular substratesDiseaseSex variationWomenCurrent knowledgeManifestations
2021
Real-World, Patient-Reported and Clinic Data from Individuals with Type 1 Diabetes Using the MiniMed 670G Hybrid Closed-Loop System
DuBose SN, Bauza C, Verdejo A, Beck RW, Bergenstal RM, Sherr J, Levy C, Levister C, Lam D, O'Malley G, Ogyaadu S, Lovett J, Abram V, Kudva Y, McCrady Spitzer S, Reid C, Kumari K, Dadlani V, Goland R, Pollak S, Alvarez A, Zagoren E, Deliard J, Kruger D, Hunter H, Smith A, Remtema H, Hiers P, Albanese-O'Neill A, Haller M, Adams J, Greco M, Peters A, Harmel M, Weinstock R, Bzdick S, Bulger J, Agonstini L, Conboy P, Doolittle S, Aleppo G, Bansal A, Thompson M, Arsiniega E, Hubacz L, Monzavi R, Raymond J, Brimberry D, Torres Sanchez A, Simmons J, Rainer K, Brendle F, Williams G, Kelley J, Clements M, McDonough R, Watkins D, Elrod A, Seuferling B, Harding H, James J, Orlich S, Raman V, Foster C, Davis C, Slater H, Ocanovic Z, Kingery S, Wintergerst K, Watson S, Eubanks S, Pierce G, Rush H, Wong J, Dapkus L, Wood J, Adams R, Blomquist G, Sterchi L, Welch S, Gouine D, Racki S, Hodax J, Beauregard N, Pascual C, Franklin C, Bethin K, Majumdar I, Mastrandrea L, Quattrin T, Tabaczynski E, House A. Real-World, Patient-Reported and Clinic Data from Individuals with Type 1 Diabetes Using the MiniMed 670G Hybrid Closed-Loop System. Diabetes Technology & Therapeutics 2021, 23: 791-798. PMID: 34524023, DOI: 10.1089/dia.2021.0176.Peer-Reviewed Original ResearchConceptsHybrid closed-loop systemHybrid closed-loop insulin delivery systemMean percent timeRoutine clinical visitsPatient-reported outcomesType 1 diabetesClosed-loop insulin delivery systemUsual careClinical outcomesClinical visitsInsulin delivery systemsSleep interruptionClinical dataClinic dataType 1Glucose monitor dataPercent timeMonthsTarget rangePatientsContinuous glucose monitor dataAdequate trainingBaselineCurrent knowledgeOutcomesRobotic Coronary Artery Bypass Grafting: History, Current Technique, and Future Perspectives
Guran E, Amabile A, Torregrossa G. Robotic Coronary Artery Bypass Grafting: History, Current Technique, and Future Perspectives. 2021 DOI: 10.5772/intechopen.99399.Peer-Reviewed Original ResearchCoronary Artery Bypass GraftingArtery Bypass GraftingBypass GraftingCABG proceduresInvasive Direct Coronary Artery Bypass GraftingCoronary Artery Bypass Grafting SurgeryDirect Coronary Artery Bypass GraftingAdult cardiac surgery proceduresEndoscopic Coronary Artery Bypass GraftingInvasive CABG proceduresCardiac surgery proceduresLength of stayPostoperative complicationsPostoperative qualityInvasive techniquesSurgery proceduresRobotic-AssistedCurrent knowledgeAdvanced proceduresFuture perspectivesGraftingPainComplicationsPatientsSurgeryChronic Thromboembolic Pulmonary Hypertension: the Bench
Alba GA, Atri D, Darbha S, Singh I, Tapson VF, Lewis MI, Chun HJ, Yu YR, Maron BA, Rajagopal S. Chronic Thromboembolic Pulmonary Hypertension: the Bench. Current Cardiology Reports 2021, 23: 141. PMID: 34410515, DOI: 10.1007/s11886-021-01572-6.Peer-Reviewed Original ResearchConceptsPulmonary embolismAcute pulmonary embolismThromboembolic pulmonary hypertensionPlatelet-rich thrombiPulmonary hypertensionUncommon complicationMedical therapyPulmonary vasculatureImmune cellsAnimal modelsEndothelial cellsPathobiologyPlatelet biologyThrombusHuman samplesTherapyCurrent knowledgeSummaryThe developmentCTEPHHypertensionVasculopathyCellsComplicationsEmbolismInflammationCognitive decline following acute viral infections: literature review and projections for post-COVID-19
Damiano R, Guedes B, de Rocca C, de Pádua Serafim A, Castro L, Munhoz C, Nitrini R, Filho G, Miguel E, Lucchetti G, Forlenza O. Cognitive decline following acute viral infections: literature review and projections for post-COVID-19. European Archives Of Psychiatry And Clinical Neuroscience 2021, 272: 139-154. PMID: 34173049, PMCID: PMC8231753, DOI: 10.1007/s00406-021-01286-4.Peer-Reviewed Original ResearchConceptsAcute viral infectionViral infectionCognitive declineHuman cognitionCoronavirus disease 2019Possible cognitive declineAsymptomatic individualsBrain dysfunctionDisease 2019Human dementiaNeuropsychiatric issuesCognitive sequelaeAlzheimer's diseaseNarrative reviewInfectionInfectious diseasesHealth leadersDiseaseCOVID-19COVID-19 pandemicIndirect pathwaysCognitionCurrent knowledgeRecent findingsLiterature reviewGenetic contributions to anxiety disorders: where we are and where we are heading
Ask H, Cheesman R, Jami ES, Levey DF, Purves KL, Weber H. Genetic contributions to anxiety disorders: where we are and where we are heading. Psychological Medicine 2021, 51: 2231-2246. PMID: 33557968, DOI: 10.1017/s0033291720005486.Peer-Reviewed Original ResearchConceptsLarge-scale genome-wide association studiesGenome-wide association studiesGenetics of anxietyGenome-wide studiesRelated traitsAssociation studiesGeneticsGenetic contributionSpecific gene-environment interactionsGene-environment interactionsCurrent knowledgeTraitsNew therapeuticsSuch discoveriesDiscoveryNew research possibilitiesLifespanTherapeuticsCircuit mechanismsTranslation
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