2024
Acute Effects of Growth Hormone on the Cellular Immunologic Landscape in Pediatric Patients
Gujral J, Kidd B, Becker C, Golden E, Lee H, Kim-Schulze S, Yau M, Dudley J, Rapaport R. Acute Effects of Growth Hormone on the Cellular Immunologic Landscape in Pediatric Patients. Cureus 2024, 16: e57383. PMID: 38566781, PMCID: PMC10984134, DOI: 10.7759/cureus.57383.Peer-Reviewed Original ResearchTime-of-flight mass cytometryComplete blood countGrowth hormoneImmune systemDendritic cellsPediatric patientsAcute effectsAcute effects of growth hormoneMonocyte countProspective study of pediatric patientsStudy of pediatric patientsMass cytometryEffects of growth hormoneGH stimulation testsComplete blood count analysisAbsolute lymphocyte countWhite blood cell countAbsolute neutrophil countAbsolute monocyte countAbsolute eosinophil countTertiary care centerBlood cell countTotal white blood cell countGH statusGH response
2023
Luspatercept Modulates Inflammation in the Bone Marrow, Restores Effective Erythropoiesis/Hematopoiesis, and Provides Sustained Clinical Benefit Versus Epoetin Alfa (EA): Biomarker Analysis from the Phase 3 COMMANDS Study
Hayati S, Zeidan A, Garcia-Manero G, Platzbecker U, Ahsan A, Verma A, Aluri S, Guerrero M, Gandhi A, Suragani R, Vodala S. Luspatercept Modulates Inflammation in the Bone Marrow, Restores Effective Erythropoiesis/Hematopoiesis, and Provides Sustained Clinical Benefit Versus Epoetin Alfa (EA): Biomarker Analysis from the Phase 3 COMMANDS Study. Blood 2023, 142: 1845. DOI: 10.1182/blood-2023-178674.Peer-Reviewed Original ResearchBM mononuclear cellsLow-risk MDSEpoetin alfaWk 48Myelodysplastic syndromeWk 24Clinical benefitPg/Bone marrowErythroid precursorsITT populationIL-1Ring sideroblastsN-terminal pro-brain natriuretic peptideLower-risk myelodysplastic syndromesPro-brain natriuretic peptideHematopoietic stem cellsDysplastic erythroid precursorsRBC transfusion independencePhase 3 trialSuperior clinical benefitSerum cytokine analysisAnti-inflammatory signalingIL-10 signalingComplete blood countInvestigating the effects of maltreatment and acute stress on the concordance of blood and DNA methylation methods of estimating immune cell proportions
Apsley A, Etzel L, Hastings W, Heim C, Noll J, O’Donnell K, Schreier H, Shenk C, Ye Q, Shalev I. Investigating the effects of maltreatment and acute stress on the concordance of blood and DNA methylation methods of estimating immune cell proportions. Clinical Epigenetics 2023, 15: 33. PMID: 36855187, PMCID: PMC9976543, DOI: 10.1186/s13148-023-01437-5.Peer-Reviewed Original ResearchConceptsComplete blood countImmune cell proportionsAcute psychosocial stressCell proportionPsychosocial stressPsychosocial stress altersImmune cell subtypesAcute laboratory stressorEarly life adversityStress-exposed individualsChild maltreatmentPediatric cohortBlood countCell subtypesAcute stressStress-induced changesPathophysiological statesLife adversityCritical covariatesLaboratory stressorYoung adultsEffects of maltreatmentDNAm alterationsClinical populationsDNA methylation
2022
Cross-sectional study to assess etiology and associated factors for anaemia during first trimester of pregnancy in Anuradhapura District, Sri Lanka: a protocol.
Amarasinghe G, Mendis V, Agampodi T, Agampodi S. Cross-sectional study to assess etiology and associated factors for anaemia during first trimester of pregnancy in Anuradhapura District, Sri Lanka: a protocol. F1000Research 2022, 10: 223. PMID: 35528960, PMCID: PMC9039368, DOI: 10.12688/f1000research.28226.3.Peer-Reviewed Original ResearchConceptsStrong public health systemCross-sectional studyPregnant womenFirst trimesterSignificant global health problemEtiology of anemiaInterviewer-administered questionnaireComplete blood countGlobal health problemPublic health systemAnuradhapura districtDietary questionnaireFetal outcomesMaternal anemiaAntenatal careAnemia controlBlood countSectional studyAnemia casesAnemiaHealth problemsPregnancySimilar etiologyField clinicsEtiology
2021
The Use of Oligo Fucoidan in Cancer Bearing Dogs Undergoing Chemotherapy: A Double-Blinded Study
Post G, Lustgarten J. The Use of Oligo Fucoidan in Cancer Bearing Dogs Undergoing Chemotherapy: A Double-Blinded Study. Topics In Companion Animal Medicine 2021, 46: 100616. PMID: 34864255, DOI: 10.1016/j.tcam.2021.100616.Peer-Reviewed Original ResearchConceptsOligo-FucoidanComplete blood countLife metricsLife scoresDouble-blinded studyMinimal adverse side effectsCase-control studyPlacebo control groupAdverse side effectsSignificant differencesQuality of lifeDiagnosis of cancerSerum biochemical parametersSerum biochemistry profilePlacebo groupUndergoing ChemotherapyProspective studyPhysical examinationBlood countCancer CenterFucoidan groupBlinded cliniciansLife QuestionnaireVeterinary patientsSide effectsCan the complete blood count be used as a reliable screening tool for obstructive sleep apnea?
Cummins E, Waseem R, Piyasena D, Wang CY, Suen C, Ryan C, Wong J, Kryger M, Chung F. Can the complete blood count be used as a reliable screening tool for obstructive sleep apnea? Sleep And Breathing 2021, 26: 613-620. PMID: 34185230, DOI: 10.1007/s11325-021-02383-3.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexComplete blood countMean SpO2Intermittent hypoxiaBlood countScreening toolObstructive sleep apneaMean oxygen saturationBody mass indexMethodsThis retrospective studyNormal clinical rangeObstructive sleep apnea screeningHome sleep studiesReliable screening toolSleep apnea screeningSevere OSAOSA severityRed blood cellsSurgical patientsIndependent predictorsMass indexSleep apneaAHI scoreRetrospective studySleep studiesCross-sectional study to assess etiology and associated factors for anaemia during first trimester of pregnancy in Anuradhapura District, Sri Lanka: a protocol
Amarasinghe G, Mendis V, Agampodi T, Agampodi S. Cross-sectional study to assess etiology and associated factors for anaemia during first trimester of pregnancy in Anuradhapura District, Sri Lanka: a protocol. F1000Research 2021, 10: 223. DOI: 10.12688/f1000research.28226.2.Peer-Reviewed Original ResearchStrong public health systemCross-sectional studyPregnant womenFirst trimesterSignificant global health problemEtiology of anemiaInterviewer-administered questionnaireComplete blood countGlobal health problemPublic health systemAnuradhapura districtDietary questionnaireFetal outcomesMaternal anemiaAntenatal careAnemia controlBlood countSectional studyAnemia casesAnemiaHealth problemsPregnancySimilar etiologyField clinicsEtiologyGestational Age-Specific Complete Blood Count Signatures in Necrotizing Enterocolitis
Pantalone JM, Liu S, Olaloye OO, Prochaska EC, Yanowitz T, Riley MM, Buland JR, Brozanski BS, Good M, Konnikova L. Gestational Age-Specific Complete Blood Count Signatures in Necrotizing Enterocolitis. Frontiers In Pediatrics 2021, 9: 604899. PMID: 33718296, PMCID: PMC7952609, DOI: 10.3389/fped.2021.604899.Peer-Reviewed Original ResearchComplete blood countNecrotizing enterocolitisGestational ageAntibiotic completionNEC onsetNeonatal intensive care unitMedical necrotizing enterocolitisIntensive care unitSurgical necrotizing enterocolitisLeukocyte patternImmune abnormalitiesNEC casesCare unitIllness onsetBlood countSingle institutionAcute dropCell abnormalitiesPercent changeCBC valuesInfantsWeeksDiagnosisEnterocolitisMonocytes
2020
Multi-modal immune phenotyping of maternal peripheral blood in normal human pregnancy
Apps R, Kotliarov Y, Cheung F, Han K, Chen J, Biancotto A, Babyak A, Zhou H, Shi R, Barnhart L, Osgood S, Belkaid Y, Holland S, Tsang J, Zerbe C. Multi-modal immune phenotyping of maternal peripheral blood in normal human pregnancy. JCI Insight 2020, 5 PMID: 32163376, PMCID: PMC7205264, DOI: 10.1172/jci.insight.134838.Peer-Reviewed Original ResearchConceptsMajor immune cell populationsImmune cell populationsGestational ageB cell subset frequenciesCell populationsFlow cytometryPeripheral immune phenotypeCell subset frequenciesNormal human pregnancyHigh-parameter flow cytometryComplete blood countMaternal peripheral bloodComplete blood count testT cell polarizationBlood count testMore persistent alterationsSerum proteomic analysisResource-limited settingsClinical flow cytometryParameter flow cytometrySomaLogic platformImmunological changesImmune phenotypingNormal pregnancyHuman pregnancy
2019
Doxorubicin-Induced Cardiotoxicity in Collaborative Cross (CC) Mice Recapitulates Individual Cardiotoxicity in Humans
Zeiss CJ, Gatti DM, Toro-Salazar O, Davis C, Lutz CM, Spinale F, Stearns T, Furtado MB, Churchill GA. Doxorubicin-Induced Cardiotoxicity in Collaborative Cross (CC) Mice Recapitulates Individual Cardiotoxicity in Humans. G3: Genes, Genomes, Genetics 2019, 9: 2637-2646. PMID: 31263061, PMCID: PMC6686936, DOI: 10.1534/g3.119.400232.Peer-Reviewed Original ResearchConceptsCardiac diseaseCardiac pathologyCardiac troponin I levelsUltimate severityChronic cardiac injuryTroponin I levelsPotential predictive biomarkersDoxorubicin-Induced CardiotoxicityComplete blood countPanel of biomarkersCurrent mouse modelsEffect of treatmentCardiac troponin IProgressive cardiotoxicityLight chain 3Acute periodAcute phaseCardiac injuryRenal toxicityBlood countPredictive biomarkersChronic timepointsCollaborative Cross miceSame doseI levelsUse of Routine Complete Blood Count Results to Rule Out Anaplasmosis Without the Need for Specific Diagnostic Testing
Turbett SE, Anahtar MN, Pattanayak V, Azar MM, Coffey KC, Eng G, Rudolf JW, Lewandrowski KB, Baron J, Rosenberg ES, Branda JA. Use of Routine Complete Blood Count Results to Rule Out Anaplasmosis Without the Need for Specific Diagnostic Testing. Clinical Infectious Diseases 2019, 70: 1215-1221. PMID: 31044232, PMCID: PMC7346887, DOI: 10.1093/cid/ciz346.Peer-Reviewed Original ResearchConceptsComplete blood countWhite blood cellsPolymerase chain reactionBlood countLiver function test resultsRoutine complete blood countMedical record reviewSpecific diagnostic testingFunction test resultsRoutine laboratory testsPositive PCR resultsTrue positive casesTrue negative casesLaboratory abnormalitiesRecord reviewRetrospective reviewPlatelet countClinical criteriaTime of testingProspective phasePCR testingPLT countStewardship programsClinical situationsDiagnostic testingHemoglobin level and macular thinning in sickle cell disease
Hussnain SA, Coady PA, Slade MD, Carbonella J, Pashankar F, Adelman RA, Stoessel KM. Hemoglobin level and macular thinning in sickle cell disease. Clinical Ophthalmology 2019, 13: 627-632. PMID: 31114143, PMCID: PMC6489663, DOI: 10.2147/opth.s195168.Peer-Reviewed Original ResearchSickle cell diseaseSD-OCT parametersComplete blood countMacular thinningSD-OCT imagingSS groupCBC valuesMacular thicknessHemoglobin levelsSCD patientsCell diseaseRetinopathy stageHb valuesSpectral-domain optical coherence tomographyConsecutive SCD patientsDomain optical coherence tomographySerum hemoglobin levelLevel of anemiaDisease genotypeRegression analysisElectronic medical recordsOptical coherence tomographyOuter subfieldsTemporal innerEligible eyesSUN-253 Effects of Growth Hormone Stimulation on the Immunologic Cellular Landscape in Pediatric Patients
Gujral J, Kidd B, Lee H, Golden E, Yau M, Dudley J, Rapaport R. SUN-253 Effects of Growth Hormone Stimulation on the Immunologic Cellular Landscape in Pediatric Patients. Journal Of The Endocrine Society 2019, 3: sun-253. PMCID: PMC6552874, DOI: 10.1210/js.2019-sun-253.Peer-Reviewed Original ResearchComplete blood countChronic GH administrationImmune systemGHS groupsPediatric patientsGH administrationGH statusAcute effectsTime pointsCyTOF analysisB cellsInterleukin-2 receptor levelsGrowth factor-1 axisTotal white blood cell countWhite blood cell countPeripheral blood mononuclear cellsGrowth hormone stimulation testPercent B cellsT cell percentageAbsolute lymphocyte countAbsolute neutrophil countPlasmacytoid dendritic cellsGH-deficient childrenPeak GH levelsAbsolute eosinophil count
2018
Elevated Levels of CD64 MFI on Monocyte Subsets Are Associated with a History of Stroke in Sickle Cell Disease
Curtis S, Balbuena-Merle R, Devine L, Zelterman D, Roberts J, Dearborn-Tomazos J, Sansing L, Hendrickson J. Elevated Levels of CD64 MFI on Monocyte Subsets Are Associated with a History of Stroke in Sickle Cell Disease. Blood 2018, 132: 1093. DOI: 10.1182/blood-2018-99-117504.Peer-Reviewed Original ResearchHistory of strokeSickle cell diseaseRole of monocytesIschemic strokeTotal neutrophil countComplete blood countMonocyte subsetsStroke historyNeutrophil countIntermediate monocytesMonocyte subtypesBlood countClassical monocytesCell diseaseFuture stroke riskIschemic stroke historyVaso-occlusive crisisPro-inflammatory monocytesPathophysiology of strokeCause of morbidityMultivariate logistic regressionNon-classical monocytesT-testHigh-affinity receptorStudent's t-test
2017
Stereotactic radiosurgery of early melanoma brain metastases after initiation of anti-CTLA-4 treatment is associated with improved intracranial control
An Y, Jiang W, Kim BYS, Qian JM, Tang C, Fang P, Logan J, D'Souza NM, Haydu LE, Wang XA, Hess KR, Kluger H, Glitza IC, Mahajan A, Welsh JW, Lin SH, Yu JB, Davies MA, Hwu P, Sulman EP, Brown PD, Chiang VLS, Li J. Stereotactic radiosurgery of early melanoma brain metastases after initiation of anti-CTLA-4 treatment is associated with improved intracranial control. Radiotherapy And Oncology 2017, 125: 80-88. PMID: 28916225, DOI: 10.1016/j.radonc.2017.08.009.Peer-Reviewed Original ResearchConceptsIntracranial disease controlNew brain metastasesIntracranial controlStereotactic radiosurgeryBrain metastasesOverall survivalDisease controlLymphocyte countMulti-institutional retrospective analysisYale-New Haven HospitalMD Anderson cohortMelanoma brain metastasesAbsolute lymphocyte countAntitumor immune responseImmune checkpoint blockadeMetastatic melanoma patientsComplete blood countTumor-specific antigensIndependent validation cohortMulti-institutional studyIpilimumab therapyMedian followLast doseCheckpoint blockadeIntracranial recurrence
2016
Characterizing absolute lymphocyte count profiles in dimethyl fumarate–treated patients with MS
Fox R, Chan A, Gold R, Phillips J, Selmaj K, Chang I, Novas M, Rana J, Marantz J, Ambler Z, Ehler E, Havrdova E, Meluzinova E, Rektor I, Talab R, Gold R, Hartung H, Csanyi A, Csiba L, Jakab G, Hintzen R, Polman C, Drozdowski W, Fryze W, Kochanowicz J, Kwiecinski H, Maciejek Z, Schimrigk S, Selmaj K, Szczudlik A, Wajgt A, Belova A, Boiko A, Elchaninov A, Kozlov V, Odinak M, Shvarkov S, Skoromets A, Stolyarov I, Vorobieva O, Zavalishin I, Hillert J, Olsson T, Kappos L, Eraksoy M, Karabudak R, Siva A, Giovannoni G, Hawkins C, Sharief M, Sharrack B, Confavreux C, Ware J, Barnett M, Paine M, Lechner-Scott J, Beran R, Chapman C, Schwartz R, Butzkueven H, Casse R, Macdonell R, Berger T, Fazekas F, Ransmayr G, Vass K, Belachew S, De Deyn P, Decoo D, Dubois B, Medaer R, Seeldrayers P, Sindic C, Gaer L, Vanopdenbosch L, Grgic S, Bar-Or A, Bhan V, Bouchard J, Christie S, Grammond P, Jacques F, Veloso F, Vorobeychik G, Brinar V, Demarin V, Rudež J, Soldo-Butković S, Vurdelja R, Ambler Z, Doležil D, Havrdova E, Kanovsky P, Meluzinova E, Nova'k J, Rektor I, Skoda O, Duchcovská M, Camu W, Antoanela P, Coman I, Confavreux C, Edan G, Gout O, Lebrun-Frenay C, Papeix A, Vermersch P, Bachus-Banaschak K, Berghoff M, Bethke F, Boldt H, Chan A, Diener H, Eisensehr I, Emrich P, Griewing B, Haas J, Heesen C, Hoffmann F, Hufnagel A, Heidenreich F, Kleiter I, Lüer W, Marckmann-Böenke S, Marziniak M, Stangel M, Oschmann P, Rosenkranz T, Schneider H, Siefjediers V, Springub J, Stangel M, Stögbauer F, Bergh F, Tiel-Wilck K, Tinschert K, Grigoriadis N, Karageorgiou C, Kyritsis A, Papadimitriou A, Thomaides T, Vlaikidis N, Salguero Gonzalez L, Chon D, Ordoñez Sarg H, Agrawal C, Behari M, Cu V, Dwivedee S, Kothari S, Kulkarni R, Kushwaha S, Meena A, Mehndiratta M, Chandra Mukherjee S, Pandit L, Shah A, Shukla R, Vijayan K, Achiron A, Flechter S, Milo R, Vaknin-Dembinsky A, Pozzilli C, Daskalovska V, Castro Farfan F, Rangel Guerra R, Leyva I, Oropeza de Alba J, Revilla R, Rivera J, Gavriliuc M, Groppa S, Odainic O, Sanders E, Hupperts R, Mason D, Timmings P, Willoughby E, Czlonkowska A, Dorobek M, Drozdowski W, Fryze W, Hertmanowska H, Kleczkowska M, Kochanowicz J, Kwieciński H, Nowacki P, Podemski R, Potemkowski A, Selmaj K, Stelmasiak Z, Wajgt A, Zielinski T, Daskalovska V, Bajenaru A, Muresanu F, Nica S, Simu M, Drakulić S, Nadj C, Obradovic D, Vojinovic S, Turčáni P, Kahancová E, Kurca E, Lisý L, Krajnak V, Badenhorst F, Green J, Heckmann J, Isaacs M, Kappos L, Linnebank M, Müller S, Buchakchyys'ka N, Goloborodko A, Kobys T, Lebedynets V, Lytvynenko N, Nehrych T, Pasyura I, Ryabichenko T, Voloshina N, Duddy M, Hawkins C, Nicholas R, Palace J, Sharrack B, Silber E, Turner B, Camac A, Chumley W, Crayton H, Dixit S, Edwards K, English J, Freedman S, Gordon N, Gazda S, Goldstick L, Gottschalk P, Grazioli E, Grainger W, Green B, Grelinger B, Gudesblatt M, Gupta A, Hayat G, Hendin B, Henson L, Hentati A, Herrman C, Itkin A, Janus T, Kasper L, Lathi E, Mowry E, Parry G, Perel A, Rao T, Riskind P, Rizvi S, Rossman H, Scott T, Shafer S, Storey J, Thrower B, Rossen M, Tosches W, Trefts L, Turel A, Weinstock-Guttman B, Gold R, Kappos L, Arnold D, Bar-Or A, Giovannoni G, Selmaj K, Dawson K, Gallacher P, Milla C, Yang M, Antel J, Bakris G, Chung R, Kowey P, Polman C, Richert J, Seibert B, Ware J, Brandes D, Brassat D, Cohen B, Diem R, Goldman M, Herndon R, Miller A, Tumani H, Kneebone C, Fedulau A, Likhachev S, Mikhailova E, Naumova H, Decoo D, Sindic C, Gaer L, Grgic S, Sinanovic O, Suljic E, Deleva N, Georgiev D, Haralanov L, Ivanova S, Manchev I, Minchev D, Stamenova P, Tournev I, Vacheva E, Zahariev Z, Howell R, Vindas A, Bar-Or A, Blevins G, Kremenchutzky M, Veloso F, Witt N, Habek M, Rudež J, Soldo-Butković S, Vurdelja R, Doležil D, Havrdova E, Nova'k J, Vaclavik D, Antsov K, Gross-Paju K, Haldre S, Palu A, Toomsoo T, Al Khedr A, Camu W, De Seze J, Debouverie M, Defer G, Labauge P, Moreau T, Rumbach L, Angnstwurm K, Benes H, Berthele A, Boldt H, Christopher A, Derfuß T, Eisensehr I, Emrich P, Feneberg W, Hoffmann F, Hohlfeld R, Hüntemann R, Kallmann B, Kieseier B, Kleiter I, Landefeld H, Lüer W, Masri S, Mäurer M, Nelles G, Oschmann P, Paschen C, Reifschneider G, Sailer M, Schimrigk S, Spiegel-Meixensberger M, Steinbrecher A, Storch-Hagenlocher B, Tackenberg B, Tiel-Wilck K, Karageorgiou C, Papathanasopoulos P, Thomaides T, Vlaikidis N, Arjundas D, Behari M, Shah S, Ghosh A, Ghosh P, Ichaporia N, Khurana D, Kulkarni R, Mehndiratta M, Mehta N, Misra U, Mukherji J, Nellikunja S, Radhakrishnan S, Salem A, Sethi P, Singh G, Lines C, Singh M, Singh Y, Srinivasa R, Vijayan K, Hutchinson M, Sweeney B, Gilad R, Shahien R, Metra M, Paegle A, Daskalovska V, Delgado C, Escamilla J, Estañol B, Lopez N, Macias M, Punzo G, Quiñones S, Renteria M, Santos C, Gavriliuc M, Groppa S, Odainic O, Timmings P, Czlonkowska A, Dorobek M, Drozdowski W, Fryze W, Hertmanowska H, Kaminska A, Kapelusiak-Pielok M, Kleczkowska M, Kochanowicz J, Kwieciński H, Losy J, Nowacki P, Nyka W, Pierzchala K, Podemski R, Potemkowski A, Selmaj K, Stelmasiak Z, Szczudlik A, Tutaj A, Wajgt A, Zielinski T, Chinea A, Balasa R, Ionescu-Dimancea V, Mihancea P, Popescu C, Protosevici L, Drakulić S, Nadj C, Raicevic R, Vojinovic S, Kahancová E, Kurca E, Lisý L, Turčáni P, Arroyo R, Fernández O, Guijarro C, Izquierdo G, Montalbán X, Oreja-Guevara C, Prieto J, Lopez F, Buchakchyys'ka N, Chmyr G, Goloborodko A, Grytsay N, Kobys T, Kushnir G, Lebedynets V, Lytvynenko N, Moskovko S, Nehrych T, Palamar B, Pasyura I, Ryabichenko T, Voloshina N, Apperson M, Applebee A, Asher S, Ayala R, Ayres D, Azizi S, Baker M, Bauer B, Bomprezzi R, Buckler R, Carlini W, Cohan S, Crowell G, Edwards K, Eubank G, Felton W, Fodor P, Foley J, Ford C, Forester M, Fox E, Fox R, Freedman S, Garmany G, Gazda S, Giang D, Glaun B, Gold S, Gottesman M, Gudesblatt M, Herbert J, Herskowitz A, Honeycutt W, Huddlestone J, Hull R, Hunter S, Hutton G, Jacobs D, Janicki M, Khatri B, Kinkel R, Kita M, Krolczyk S, Krupp L, LaGanke C, Levin M, Licht J, Luzzio C, Lynch S, Mattson D, Mikol D, Miller T, Minagar A, Mitchell G, Moses H, Negroski D, Newman S, Pardo G, Patel M, Perel A, Phillips J, Picone M, Rammohan K, Rao T, Rinker J, Sadiq S, Schaeffer J, Sheremata W, Shin R, Shubin R, Silverman S, Smith R, Stein L, Stein M, Steiner D, Steingo B, Sullivan H, Sunter W, Vaishnav A, Vasquez A, Voci J, Warach J, Weinstock-Guttman B, Williams M, Wray S, Fox R, Phillips J, Hutchinson M, Havrdova E, Kita M, Wilson K, Yang M, Dawson K, Antel J, Ware J, Polman C, Kowey P, Chung R, Bakris G, Richert J, Seibert B, Brandes D, Brassat D, Cohen B, Diem R, Goldman M, Herndon R, Miller A, Tumani H, Alfaro-Vidal T, Crespo C, Foster J, Hunter K, Garcia-Gomez A, MacManus D, Miller D, Santana V, Tozer D, Kingshott-Wheeler C, Yousry T. Characterizing absolute lymphocyte count profiles in dimethyl fumarate–treated patients with MS. Neurology Clinical Practice 2016, 6: 220-229. PMID: 27347439, PMCID: PMC4909524, DOI: 10.1212/cpj.0000000000000238.Peer-Reviewed Original ResearchDelayed-release dimethyl fumarateAbsolute lymphocyte countMultiple sclerosisLymphocyte countDelayed-release dimethyl fumarate treatmentDMF discontinuationMean absolute lymphocyte countsEarly identification of patientsRelapsing-remitting multiple sclerosisUS prescribing informationTreatment of patientsIdentification of patientsComplete blood countDisease-modifying therapiesWhite blood cellsLymphocyte monitoringProlonged lymphopeniaBlood countClinical trialsPrescribing informationPatientsExtension studyBlood cellsDimethyl fumarateNeuroprotective effectsExit Survey of Senior Residents: Cost Conscious but Uninformed
Long T, Silvestri MT, Dashevsky M, Halim A, Fogerty RL. Exit Survey of Senior Residents: Cost Conscious but Uninformed. Journal Of Graduate Medical Education 2016, 8: 248-51. PMID: 27168897, PMCID: PMC4857517, DOI: 10.4300/jgme-d-15-00168.1.Peer-Reviewed Original ResearchA 17-Year-Old With Steroid-Resistant Nephrotic Syndrome
Band ME, Sheldon C, Brancato J, Parikh NS, D’Alessandri-Silva C. A 17-Year-Old With Steroid-Resistant Nephrotic Syndrome. Pediatrics 2016, 137: e20153205. PMID: 27244796, DOI: 10.1542/peds.2015-3205.Peer-Reviewed Original ResearchConceptsRenal biopsy resultsComplete blood countBiopsy resultsBlood countElevated serum uric acidNormal complete blood countSteroid-resistant nephrotic syndromeInitial laboratory workupShortness of breathOutside emergency departmentSerum uric acidLow back painMinimal change diseaseNormal echotextureImmunomodulator therapyNight sweatsRenal ultrasoundLaboratory workupCreatinine ratioRecurrent edemaBack painChange diseaseFacial swellingNephrotic syndromeEmergency departmentSynchronous rectal adenocarcinoma and splenic marginal zone lymphoma
Srikumar T, Markow M, Centeno B, Hoffe S, Tao J, Fernandez H, Strosberg J, Shibata D. Synchronous rectal adenocarcinoma and splenic marginal zone lymphoma. Current Oncology 2016, 23: 70-74. PMID: 26966416, PMCID: PMC4754072, DOI: 10.3747/co.23.2711.Peer-Reviewed Original ResearchMarginal zone lymphomaSplenic marginal zone lymphomaRectal adenocarcinomaMassive splenomegalyExternal beam radiation therapyAdjuvant FOLFOX chemotherapyDifferent primary originsEn bloc splenectomySynchronous rectal adenocarcinomaLow anterior resectionAdvanced rectal cancerBone marrow biopsyComplete blood countComputed tomography (CT) imagingFOLFOX chemotherapyPelvic radiationStage T3N1M0Abdominal painAnterior resectionDistal pancreatectomySynchronous cancersConcomitant diagnosisRectal cancerClinical presentationMarrow biopsy
2014
Coagulopathy Predicts Mortality in Pediatric Patients with Traumatic Brain Injury
Doshi B, Meeks S, Hendrickson J, Reisner A, Leong T, Winkler A, Meyer E. Coagulopathy Predicts Mortality in Pediatric Patients with Traumatic Brain Injury. Blood 2014, 124: 2891. DOI: 10.1182/blood.v124.21.2891.2891.Peer-Reviewed Original ResearchInjury Severity ScoreTraumatic brain injuryGlasgow Coma ScaleHigher Injury Severity ScoreAbnormal coagulation studiesPediatric trauma patientsCoagulation studiesBrain injuryPediatric patientsTrauma patientsSeverity scoreAdult studiesInitial complete blood countLower Glasgow Coma ScaleAbnormal fibrinogen levelsBlood product replacementPediatric TBI patientsPediatric TBI populationLower GCS scoreMechanism of injuryBaseline demographic dataRetrospective pilot studyComplete blood countCause of deathChildren ages 1
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