2025
The prognostic relevance of donor-specific antibodies in facial transplantation – A retrospective cohort study
Huelsboemer L, Hosseini H, Klimitz F, Diatta F, Boroumand S, O'Brien C, Parikh N, Stögner V, Formica R, Ko C, Azzi J, Draper E, Lian C, Murphy G, Pomahac B, Kauke-Navarro M. The prognostic relevance of donor-specific antibodies in facial transplantation – A retrospective cohort study. Journal Of Plastic Reconstructive & Aesthetic Surgery 2025, 103: 286-296. PMID: 40043533, DOI: 10.1016/j.bjps.2025.01.028.Peer-Reviewed Original ResearchDe novo donor-specific antibodiesDonor-specific antibodiesDonor-specific antibody positivityChronic rejectionC4d depositionGraft lossPrognostic relevanceRejection gradeGrades of acute cellular rejectionDonor-specific antibody statusOccurrence of chronic rejectionTime pointsFacial vascularized composite allotransplantationAcute rejection gradeAcute cellular rejectionTissue typing laboratoriesAcute rejection eventsRetrospective cohort studyTransplant-related outcomesFace transplant patientsVascularized composite allotransplantationCellular rejectionTransplant patientsC4d levelsRetrospective analysis
2024
Ten-year follow-up after face transplantation—A single-center retrospective cohort study
Huelsboemer L, Kauke-Navarro M, Boroumand S, Parikh N, Hosseini H, Yu C, Stögner V, Ko C, Perry B, Formica R, Hung P, Mahajan A, Azzi J, Murphy G, Pomahac B. Ten-year follow-up after face transplantation—A single-center retrospective cohort study. American Journal Of Transplantation 2024, 25: 611-622. PMID: 39413877, DOI: 10.1016/j.ajt.2024.10.007.Peer-Reviewed Original ResearchChronic rejectionFace transplantationFollow-upSingle center retrospective cohort studyFunctional outcomesSensory returnAnalysis of functional outcomesMedian follow-upIncidence of malignancyMetabolic side effectsGraft rejection episodesComputed tomography angiogramRetrospective cohort studyEvidence of vasculopathyFollow-up periodLong-term outcomesYear follow-upFacial motor functionRejection episodesInfectious complicationsTransplant recipientsPatient ageGraft retentionMedical complicationsCohort studyEvolution of Vascularized Composite Allotransplantation
Huelsboemer L, Pomahac B. Evolution of Vascularized Composite Allotransplantation. 2024, 15-27. DOI: 10.1007/978-3-031-57132-9_3.Peer-Reviewed Original ResearchVascularized composite allotransplantationSolid organ transplantationProlongation of ischemia timeReconstruction of complex tissue defectsContext of vascularized composite allotransplantationDevelopment of non-toxicTolerogenic strategiesChronic rejectionImmunosuppressive medicationsTolerance inductionComplex tissue defectsPatient selectionIschemia timeThe nature of chronic rejection after lung transplantation: a murine orthotopic lung transplant study
Heigl T, Kaes J, Aelbrecht C, Serré J, Yamada Y, Geudens V, Van Herck A, Vanstapel A, Sacreas A, Ordies S, Frick A, Gimenez B, Van Slambrouck J, Beeckmans H, Oztürk N, Orlitova M, Vaneylen A, Claes S, Schols D, Velde G, Schupp J, Kaminski N, Boesch M, Korf H, van der Merwe S, Dupont L, Vanoirbeek J, Godinas L, Van Raemdonck D, Janssens W, Gayan-Ramirez G, Ceulemans L, McDonough J, Verbeken E, Vos R, Vanaudenaerde B. The nature of chronic rejection after lung transplantation: a murine orthotopic lung transplant study. Frontiers In Immunology 2024, 15: 1369536. PMID: 38736881, PMCID: PMC11084670, DOI: 10.3389/fimmu.2024.1369536.Peer-Reviewed Original ResearchConceptsChronic lung allograft dysfunctionChronic rejectionLung transplantationSingle cell RNASingle cell RNA profilingOrthotopic left lung transplantationComplications post-transplantationLung allograft dysfunctionMouse lung transplantationLeft lung transplantationLung transplantation studiesAllograft dysfunctionPleural infiltrationPost-transplantationBronchiolitis obliteransInnate inflammationChronic complicationsPrimary onsetEndothelial destructionTransplantationDay 7Immunological perspectiveArterial responseTransplantation studiesLungImmune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions
Knoedler L, Dean J, Diatta F, Thompson N, Knoedler S, Rhys R, Sherwani K, Ettl T, Mayer S, Falkner F, Kilian K, Panayi A, Iske J, Safi A, Tullius S, Haykal S, Pomahac B, Kauke-Navarro M. Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions. Frontiers In Immunology 2024, 15: 1372862. PMID: 38650942, PMCID: PMC11033354, DOI: 10.3389/fimmu.2024.1372862.Peer-Reviewed Original ResearchConceptsRegulatory myeloid cellsSolid organ transplantationVascularized composite allotransplantationMesenchymal stromal cellsT cellsTransplant patientsCellular therapyChimeric antigen receptor T cellsTransplant surgerySide effectsIncreased risk of malignancyProgression to chronic rejectionAcute rejection ratesPerioperative treatment strategiesRegulatory T cellsPromote immune toleranceRisk of malignancySystemic side effectsRelated side effectsCell typesImprove transplant survivalCAR-TCell therapy applicationsImmunosuppressive regimensChronic rejection
2023
18 years of face transplantation: Adverse outcomes and challenges
Longo B, Pomahac B, Giacalone M, Cardillo M, Cervelli V. 18 years of face transplantation: Adverse outcomes and challenges. Journal Of Plastic Reconstructive & Aesthetic Surgery 2023, 87: 187-199. PMID: 37879143, DOI: 10.1016/j.bjps.2023.09.043.Peer-Reviewed Original ResearchConceptsAllograft lossAdverse outcomesFace transplantationMedian timeStandard of careGoogle Scholar databasesFace transplant teamHeterogeneity of casesAllograft removalChronic rejectionInfectious complicationsIrreversible rejectionMajor complicationsTransplant centersTransplant casesTransplant teamPatient deathPRISMA guidelinesComplicationsSystematic reviewTransplantationScholar databasesSingle center approachSignificant riskPeer-reviewed literatureNovel Strategies in Transplantation: Genetic Engineering and Vascularized Composite Allotransplantation
Kauke-Navarro M, Noel O, Knoedler L, Knoedler S, Panayi A, Stoegner V, Huelsboemer L, Pomahac B. Novel Strategies in Transplantation: Genetic Engineering and Vascularized Composite Allotransplantation. Journal Of Surgical Research 2023, 291: 176-186. PMID: 37429217, DOI: 10.1016/j.jss.2023.04.028.Peer-Reviewed Original ResearchConceptsImmunosuppressive regimensAllograft rejectionComposite allotransplantationDonor-derived immune cellsDonor-derived T lymphocytesRecipient-derived T cellsPotent immunosuppressive regimensToxic immunosuppressive regimensSolid organ transplantationAntigen-presenting cellsSystemic side effectsVascularized Composite AllotransplantationCD40 knockoutChronic rejectionRejection episodesSystemic immunosuppressionMost patientsImmunomodulatory strategiesTolerance inductionImmune cellsOrgan transplantationT cellsT lymphocytesSide effectsClinical successA ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells
Li X, Jiang Q, Song G, Barkestani M, Wang Q, Wang S, Fan M, Fang C, Jiang B, Johnson J, Geirsson A, Tellides G, Pober J, Jane-wit D. A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells. Nature Communications 2023, 14: 3002. PMID: 37225719, PMCID: PMC10209169, DOI: 10.1038/s41467-023-38684-2.Peer-Reviewed Original ResearchConceptsEndothelial cellsInflammasome activityMembrane attack complexCaspase-1Potential therapeutic targetChronic rejectionComplement membrane attack complexTissue inflammationNLRP3 inflammasomeTissue injuryMouse modelTherapeutic targetDependent mannerInflammationAttack complexInflammasomeHuman tissuesFlightless IInhibitory associationsSkin modelRNF34CellsEphB4 monomer inhibits chronic graft vasculopathy in an aortic transplant model
Langford J, Gonzalez L, Taniguchi R, Brahmandam A, Zhang W, Dardik A. EphB4 monomer inhibits chronic graft vasculopathy in an aortic transplant model. JVS Vascular Science 2023, 4: 100109. PMID: 37519335, PMCID: PMC10372308, DOI: 10.1016/j.jvssci.2023.100109.Peer-Reviewed Original ResearchAortic transplant modelAllograft vasculopathyT cellsTransplant modelEphrin-B2Immune cell accumulationChronic graftCardiac transplantChronic rejectionTransplanted graftAortic allograftsNeointima formationCell accumulationTissue damageMonocyte adhesionLess neointima formationVasculopathyAdherent monocytesEndothelial surfaceReceptor EphB4MacrophagesGraftMonocytesImportant targetCellsTissue-resident memory T cell maintenance during antigen persistence requires both cognate antigen and interleukin-15
Tieu R, Zeng Q, Zhao D, Zhang G, Feizi N, Manandhar P, Williams A, Popp B, Wood-Trageser M, Demetris A, Tso J, Johnson A, Kane L, Abou-Daya K, Shlomchik W, Oberbarnscheidt M, Lakkis F. Tissue-resident memory T cell maintenance during antigen persistence requires both cognate antigen and interleukin-15. Science Immunology 2023, 8: eadd8454. PMID: 37083450, PMCID: PMC10334460, DOI: 10.1126/sciimmunol.add8454.Peer-Reviewed Original ResearchConceptsAntigen persistenceIL-15Dendritic cellsT cellsAntigen presentationGraft-infiltrating dendritic cellsTissue-resident memory TCognate antigenAbsence of cognate antigenIL-15 transpresentationMemory T cell maintenanceT cell maintenanceChronic transplant rejectionKidney transplant modelIL-15 receptorAcute infection modelMemory TReceptor blockadeChronic rejectionTransplantation modelTransplant rejectionAcute infectionInterleukin-15Allograft pathologySterilizing immunityInsights from immunoproteomic profiling of a rejected full-face transplant
Lee C, Wang D, Kauke-Navarro M, Russell-Goldman E, Xu S, Mucciarone K, Sohrabi S, Lian C, Pomahac B, Murphy G. Insights from immunoproteomic profiling of a rejected full-face transplant. American Journal Of Transplantation 2023, 23: 1058-1061. PMID: 37037378, DOI: 10.1016/j.ajt.2023.04.008.Peer-Reviewed Original ResearchConceptsVascularized Composite AllograftsT cellsChronic rejectionCD8-positive T cellsEffector T cellsFull face transplantArteriosclerotic alterationsIntragraft arteriesVCA rejectionGraft arteryAccelerated arteriosclerosisRecipient originPunch biopsyAtherogenic responseComposite allograftsImmunoproteomic profilingDioxygenase 1Target endotheliumArteryEndotheliumProteomic profilingPathway componentsCellsRejectionAllograftsSingle-Cell Rna Sequencing of the Mouse Isograft and Allograft Lung after Orthotopic Lung Transplantation
Hooft C, Kaes J, Heigl T, Beeckmans H, Kerckhof P, Vanstapel A, Jin X, Slambrouck J, Vandervelde C, Van Raemdonck D, Kaminski N, McDonough J, Ceulemans L, Vos R, Vanaudenaerde B. Single-Cell Rna Sequencing of the Mouse Isograft and Allograft Lung after Orthotopic Lung Transplantation. The Journal Of Heart And Lung Transplantation 2023, 42: s539. DOI: 10.1016/j.healun.2023.02.1473.Peer-Reviewed Original ResearchLung transplantationImmune cellsImmune responseEndothelial cellsMouse lung transplant modelSingle-cell RNA sequencingCell RNA sequencingLung transplant modelOrthotopic lung transplantationAdaptive immune cellsInnate immune cellsRNA sequencingSingle-cell RNA profilingAllograft lungChronic rejectionInnate inflammationTransplant modelEndothelial upregulationMHC expressionPrimary onsetSham controlsSingle cell suspensionsWeek 10Week 1TransplantationDownregulation of a tumor suppressor gene LKB1 in lung transplantation as a biomarker for chronic murine lung allograft rejection
Rahman M, Ravichandran R, Sankpal N, Bansal S, Sureshbabu A, Fleming T, Perincheri S, Bharat A, Smith M, Bremner R, Mohanakumar T. Downregulation of a tumor suppressor gene LKB1 in lung transplantation as a biomarker for chronic murine lung allograft rejection. Cellular Immunology 2023, 386: 104690. PMID: 36812767, PMCID: PMC11019891, DOI: 10.1016/j.cellimm.2023.104690.Peer-Reviewed Original ResearchConceptsLung allograft rejectionLung transplantationAllograft rejectionChronic lung allograft rejectionBronchiolitis obliterans syndromeLung transplant recipientsTumor suppressor gene LKB1Phosphorylated mammalian targetBEAS-2B cellsObliterans syndromeChronic rejectionTransplant recipientsDonor lungsSingle lungB6D2F1 miceMurine modelDBA/2J miceMTOR expressionMammalian targetLKB1 overexpressionSignificant downregulationLungLKB1 knockdownA549 cellsLKB1 activityTolerance Induction in Vascularized Composite Allotransplantation—A Brief Review of Preclinical Models
Huelsboemer L, Kauke-Navarro M, Reuter S, Stoegner V, Feldmann J, Hirsch T, Kueckelhaus M, Dermietzel A. Tolerance Induction in Vascularized Composite Allotransplantation—A Brief Review of Preclinical Models. Transplant International 2023, 36: 10955. PMID: 36846605, PMCID: PMC9946984, DOI: 10.3389/ti.2023.10955.Peer-Reviewed Original ResearchConceptsTolerance inductionLong-term effectsAnimal modelsImmune systemDonor-specific toleranceLong-term outcomesRecipient's immune systemPreclinical animal modelsNovel therapeutic strategiesPre-clinical studiesVascularized Composite AllotransplantationChronic rejectionImmunosuppressive protocolsTransplant recipientsAllograft rejectionOrgan dysfunctionPreclinical modelsComposite allograftsTherapeutic strategiesComposite allotransplantationClinical practiceIS protocolClinical translationInductionReview article
2022
Duplex Ultrasound of Renal Transplants
Mathur M, Scoutt L. Duplex Ultrasound of Renal Transplants. 2022, 1003-1037. DOI: 10.1007/978-3-030-60626-8_68.ChaptersRenal vein thrombosisUrinary tract obstructionTract obstructionVein thrombosisEnd-stage renal diseaseRenal transplant complicationsAcute tubular necrosisRenal artery thrombosisNonspecific clinical presentationUrinary tract infectionAcute rejectionChronic rejectionMedication toxicityArtery thrombosisRenal transplantRenal transplantationSpectral Doppler imagingTransplant complicationsVein stenosisCompartment syndromeLate complicationsTime-dependent mannerTract infectionsTubular necrosisRenal disease
2021
Long-term Outcomes After Facial Allotransplantation: Systematic Review of the Literature
Tchiloemba B, Kauke M, Haug V, Abdulrazzak O, Safi AF, Kollar B, Pomahac B. Long-term Outcomes After Facial Allotransplantation: Systematic Review of the Literature. Transplantation 2021, 105: 1869-1880. PMID: 33148976, DOI: 10.1097/tp.0000000000003513.Peer-Reviewed Original ResearchConceptsSystematic reviewAcute cell-mediated rejectionPositive risk-benefit ratioRecurrent acute rejection episodesLong-term outcome dataAcute rejection episodesChronic vascular rejectionFirst year posttransplantImmunosuppression-related complicationsCell-mediated rejectionSingle-center experiencePubMed/MEDLINE databaseLong-term outcomesRisk-benefit ratioEnglish full-text articlesQuality of lifeFull-text articlesAcute rejectionAllograft lossChronic rejectionRejection episodesVascular rejectionInfectious complicationsInfectious episodesMetabolic complicationsChronic Lung Allograft Dysfunction: Role for Tumor Suppressor Gene Liver Kinase B1
Rahman M, Ravichandran R, Bansal S, Liu W, Perincheri S, Angara S, Fleming T, Bharat A, Hachem R, Smith M, Bremner R, Mohanakumar T. Chronic Lung Allograft Dysfunction: Role for Tumor Suppressor Gene Liver Kinase B1. The Journal Of Heart And Lung Transplantation 2021, 40: s60. DOI: 10.1016/j.healun.2021.01.1886.Peer-Reviewed Original ResearchChronic lung allograft dysfunctionBronchiolitis obliterans syndromeLung transplant modelLung transplant recipientsLiver kinase B1Epithelial-mesenchymal transformationΑ-SMAChronic rejectionTransplant recipientsBEAS-2BTransplant modelHypoxia/reperfusion (H/R) modelKnockdown of LKB1Lung allograft dysfunctionQRT-PCRAirway epithelial cell lineMiR-155 levelsExosome releaseHypoxia/reperfusionRole of LKB1Upregulation of vimentinAllograft dysfunctionLung transplantationObliterans syndromeCLAD developmentDuplex Ultrasound of Renal Transplants
Mathur M, Scoutt L. Duplex Ultrasound of Renal Transplants. 2021, 1-36. DOI: 10.1007/978-3-030-49616-6_68-1.ChaptersRenal vein thrombosisUrinary tract obstructionTract obstructionVein thrombosisEnd-stage renal diseaseRenal transplant complicationsAcute tubular necrosisRenal artery thrombosisNonspecific clinical presentationUrinary tract infectionAcute rejectionChronic rejectionMedication toxicityArtery thrombosisRenal transplantRenal transplantationSpectral Doppler imagingTransplant complicationsVein stenosisCompartment syndromeLate complicationsTime-dependent mannerTract infectionsTubular necrosisRenal disease
2020
Formation and function of resident memory t cells in renal allografts
Daya K, Zhao D, Tieu R, Rammal R, Oberbarnscheidt M, Lakkis F. Formation and function of resident memory t cells in renal allografts. The Journal Of Immunology 2020, 204: 161.24-161.24. DOI: 10.4049/jimmunol.204.supp.161.24.Peer-Reviewed Original ResearchOT-IT cellsEndogenous T-cell populationMouse kidney transplant modelOT-I T cellsResident memory T cellsMemory T cellsT cell populationsPreserved kidney functionKidney transplant modelTRM cellsAdoptive transferB6 recipientsTeff cellsChronic rejectionKidney allograftsRe-transplantationRenal allograftsNo significant differenceGraft histologyKidney graftsTransplantation modelBone marrowAllo groupKidney functionOutcomes of Heart Re-Transplantation: Analysis of the United Network for Organ Sharing (UNOS)
Briasoulis A, Akintoye E, Alvarez P. Outcomes of Heart Re-Transplantation: Analysis of the United Network for Organ Sharing (UNOS). The Journal Of Heart And Lung Transplantation 2020, 39: s286-s287. DOI: 10.1016/j.healun.2020.01.632.Peer-Reviewed Original ResearchCardiac allograft vasculopathyPrimary HTLong-term survivalHT recipientsUnited NetworkLong-term graft survivalHeart transplantation recipientsPrimary graft failureOrgan Sharing registryRecipient-related factorsAllograft vasculopathyChronic rejectionGraft dysfunctionHRT recipientsFrequent etiologyGraft survivalGraft failureMedian survivalTransplantation recipientsOperative characteristicsOrgan SharingSurvival analysisLikely femalesStudy periodRecipients
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