2023
High-resolution visualization of pial surface vessels by flattened whole mount staining
Xu Y, Zhang J, Lee H, Zhang G, Bai Y, Simons M. High-resolution visualization of pial surface vessels by flattened whole mount staining. IScience 2023, 26: 106467. PMID: 37020957, PMCID: PMC10067958, DOI: 10.1016/j.isci.2023.106467.Peer-Reviewed Original ResearchBlood vesselsCerebral vasculatureWhole cerebral cortexCerebral blood vesselsParticular blood vesselCentral nervous system researchCLARITY technologyCerebral cortexStroke settingsCerebral vesselsWhole-mount techniqueDisease settingsEndothelial proliferationNervous system researchPostnatal developmentTherapeutic developmentWhole-mount stainingVasculatureVesselsMount stainingMount techniqueConfocal imagingNormal developmentHigh-resolution visualizationImagingDiagnosis, Workup, Risk Reduction of Transient Ischemic Attack in the Emergency Department Setting: A Scientific Statement From the American Heart Association
Amin H, Madsen T, Bravata D, Wira C, Johnston S, Ashcraft S, Burrus T, Panagos P, Wintermark M, Esenwa C, Disease O. Diagnosis, Workup, Risk Reduction of Transient Ischemic Attack in the Emergency Department Setting: A Scientific Statement From the American Heart Association. Stroke 2023, 54: e109-e121. PMID: 36655570, DOI: 10.1161/str.0000000000000418.Peer-Reviewed Original ResearchConceptsTransient ischemic attackIschemic attackMaximal medical therapyHigh-risk patientsCorrect clinical diagnosisRisk stratification scaleAmerican Heart AssociationEmergency department settingFuture cerebrovascular eventsScientific statementTime of evaluationCerebrovascular eventsSecondary preventionStroke riskMedical therapyNeurological examinationAcute phaseIndex eventHeart AssociationDepartment settingPatient educationAncillary testingCerebral vasculatureConfirmatory testingClinical diagnosis
2020
New Insights Into Blood-Brain Barrier Maintenance: The Homeostatic Role of β-Amyloid Precursor Protein in Cerebral Vasculature
Ristori E, Donnini S, Ziche M. New Insights Into Blood-Brain Barrier Maintenance: The Homeostatic Role of β-Amyloid Precursor Protein in Cerebral Vasculature. Frontiers In Physiology 2020, 11: 1056. PMID: 32973564, PMCID: PMC7481479, DOI: 10.3389/fphys.2020.01056.Peer-Reviewed Original ResearchCerebral amyloid angiopathyΒ-amyloid precursor proteinBlood-brain barrierCentral nervous systemAlzheimer's diseaseBlood-brain barrier maintenanceΒ-amyloid accumulationPeripheral blood circulationPrecursor proteinEndothelial cell homeostasisCAA pathogenesisBBB dysfunctionBBB functionAmyloid angiopathyVascular dysfunctionAD onsetCerebrovascular homeostasisCerebral vasculatureVascular endotheliumPathological outcomesNervous systemHomeostatic roleBrain vasculatureNeurodegenerative disordersBarrier maintenance
2015
Structure and vascular function of MEKK3–cerebral cavernous malformations 2 complex
Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ, Su B. Structure and vascular function of MEKK3–cerebral cavernous malformations 2 complex. Nature Communications 2015, 6: 7937. PMID: 26235885, PMCID: PMC4526114, DOI: 10.1038/ncomms8937.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBlood VesselsCapillary PermeabilityCerebrovascular CirculationCrystallizationHemangioma, Cavernous, Central Nervous SystemIntracranial HemorrhagesMAP Kinase Kinase Kinase 3MiceMice, KnockoutMicrofilament ProteinsNeovascularization, Physiologicrho GTP-Binding Proteinsrho-Associated KinasesSignal TransductionNeuropathology of Traumatic Brain Injury: Comparison of Penetrating, Nonpenetrating Direct Impact and Explosive Blast Etiologies
de Lanerolle NC, Kim JH, Bandak FA. Neuropathology of Traumatic Brain Injury: Comparison of Penetrating, Nonpenetrating Direct Impact and Explosive Blast Etiologies. Seminars In Neurology 2015, 35: 012-019. PMID: 25714863, DOI: 10.1055/s-0035-1544240.Peer-Reviewed Original ResearchConceptsClosed head injuryTraumatic brain injuryDiffuse axonal injuryAxonal injuryMild TBIHead injuryBrain injurySevere closed head injuryModerate traumatic brain injuryModerate closed head injuryMild traumatic brain injuryAnimal TBI modelsMicroglial activationNeuronal injuryTBI modelCerebral vasculatureInjuryNeuropathologyGross disruptionHuman brainBlunt impactUnique patternHumansActivationAstrocytes
2014
Hypertension alters phosphorylation of VASP in brain endothelial cells
Arlier Z, Basar M, Kocamaz E, Kiraz K, Tanriover G, Kocer G, Arlier S, Giray S, Nasırcılar S, Gunduz F, Senturk U, Demir N. Hypertension alters phosphorylation of VASP in brain endothelial cells. International Journal Of Neuroscience 2014, 125: 288-297. PMID: 24894047, DOI: 10.3109/00207454.2014.930740.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood PressureBrainCase-Control StudiesCell Adhesion MoleculesCells, CulturedDisease Models, AnimalEndothelial CellsExercise TherapyGene Expression RegulationHumansHypertensionHypoxiaMicrofilament ProteinsOxygenPhosphoproteinsPhosphorylationRatsRats, Inbred SHRRats, Inbred WKYSerineStatistics, NonparametricSwimmingTime FactorsConceptsBrain endothelial cellsVASP expressionEndothelial cellsVasodilator-stimulated phosphoproteinVASP phosphorylationWestern blottingHypertension-induced alterationsIndirect salutary effectsEffects of hypertensionEffects of exerciseNormoxic endothelial cellsEndothelial barrier functionWKY ratsEndothelial changesTissue hypoxiaCerebral vasculatureHypertensionSalutary effectsExercise conditionsBarrier functionVascular systemExerciseAlters phosphorylationImmunocytochemistryBlotting
2013
Gene–environment interactions in severe intraventricular hemorrhage of preterm neonates
Ment LR, Ådén U, Lin A, Kwon SH, Choi M, Hallman M, Lifton RP, Zhang H, Bauer CR. Gene–environment interactions in severe intraventricular hemorrhage of preterm neonates. Pediatric Research 2013, 75: 241-250. PMID: 24192699, PMCID: PMC3946468, DOI: 10.1038/pr.2013.195.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApgar ScoreBlood CoagulationCerebral VentriclesCerebrovascular CirculationCollagen Type IVFactor VGene-Environment InteractionGenetic Predisposition to DiseaseGenetic VariationGestational AgeHumansHypoxia, BrainInfantInfant, PrematureInflammation MediatorsIntracranial HemorrhagesMethylenetetrahydrofolate Reductase (NADPH2)PhenotypePremature BirthPrognosisRisk FactorsConceptsIntraventricular hemorrhageCerebral injuryPreterm neonatesFactor V Leiden geneRisk of IVHEnvironmental triggersSevere intraventricular hemorrhageCerebral blood flowMethylenetetrahydrofolate reductase (MTHFR) variantsUnknown environmental triggersPresence of mutationsPeriventricular infarctionApgar scorePerinatal hypoxiaPreclinical dataFetal environmentGerminal matrixCerebral vasculatureBlood flowT polymorphismGene-environment interactionsMTHFR 677CHemorrhageNeonatesVascular pathwaysMaintained consciousness during witnessed asystole after spinal anesthesia for Cesarean section
Rajput K, Woehlck H, Riess M. Maintained consciousness during witnessed asystole after spinal anesthesia for Cesarean section. F1000Research 2013, 2: 11. DOI: 10.12688/f1000research.2-11.v1.Peer-Reviewed Case Reports and Technical NotesSpinal anesthesiaCesarean sectionSupine positionHeart rateHigh mortalityOnset of asystoleElective cesarean sectionCerebral blood flowRegular sinus rhythmLoss of consciousnessSpontaneous cardiac activityApgar scoreCerebral hypoxiaVenous poolingCardiac arrestEpinephrine administrationHealthy patientsSinus rhythmVenous bloodLower incidenceCerebral vasculatureBlood flowVagal toneChest compressionsResuscitative drugs
2012
Acute Effects of Nimodipine on Cerebral Vasculature and Brain Metabolism in High Grade Subarachnoid Hemorrhage Patients
Choi HA, Ko SB, Chen H, Gilmore E, Carpenter AM, Lee D, Claassen J, Mayer SA, Schmidt JM, Lee K, Connelly ES, Paik M, Badjatia N. Acute Effects of Nimodipine on Cerebral Vasculature and Brain Metabolism in High Grade Subarachnoid Hemorrhage Patients. Neurocritical Care 2012, 16: 363-367. PMID: 22262041, DOI: 10.1007/s12028-012-9670-8.Peer-Reviewed Original ResearchConceptsPoor-grade subarachnoid hemorrhageOral nimodipineSubarachnoid hemorrhageMmHg decreasePoor-grade SAH patientsDoses of nimodipineAdministration of nimodipineAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhage patientsRoutine clinical careAcute PhysiologicAdequate CBFNimodipine administrationOnly medicationHemorrhage patientsMultimodality monitoringSAH patientsVasopressor medicationsBrain metabolismAcute effectsObservational studyMetabolic effectsCerebral vasculatureClinical careNimodipine
2009
Fractal Characterization of Complexity in Dynamic Signals: Application to Cerebral Hemodynamics
Herman P, Kocsis L, Eke A. Fractal Characterization of Complexity in Dynamic Signals: Application to Cerebral Hemodynamics. Methods In Molecular Biology 2009, 489: 23-40. PMID: 18839086, DOI: 10.1007/978-1-59745-543-5_2.Peer-Reviewed Original ResearchConceptsCerebral hemodynamicsBrain cortexRat brain cortexLaser Doppler flowmetryAge-related stiffeningFunctional magnetic resonanceHemodynamic brain signalsDoppler flowmetryCerebral vasculatureTemporal lobeHuman studiesState of pathologyGray matterParenchymal regionsHemodynamic signalsHemodynamicsHuman brainCortexMagnetic resonanceMedical significance
1998
Changes in Cerebral Perfusion Pressure in Puerperal Women With Preeclampsia
WILLIAMS K, GALERNEAU F, WILSON S. Changes in Cerebral Perfusion Pressure in Puerperal Women With Preeclampsia. Obstetrics And Gynecology 1998, 92: 1016-1019. DOI: 10.1097/00006250-199812000-00025.Peer-Reviewed Original ResearchConceptsCerebral perfusion pressureCerebral blood flow velocityWeeks postpartumBlood flow velocityPerfusion pressureCerebrovascular resistanceCerebral perfusionMaternal middle cerebral arteryMiddle cerebral blood flow velocityCerebral blood flow indexWomen 2 daysMiddle cerebral arteryCerebral blood flowTranscranial Doppler ultrasoundBlood flow indexArea productMild preeclampsiaCerebral arteryPuerperal womenEarly laborHours postpartumCerebral vasculatureDoppler ultrasoundBlood flowPostpartum
1995
The Blood-Retinal Barrier in Immune-Mediated Diseases of the Retina
Greenwood J, Bamforth S, Wang Y, Devine L. The Blood-Retinal Barrier in Immune-Mediated Diseases of the Retina. 1995, 315-326. DOI: 10.1007/978-1-4899-1054-7_31.Peer-Reviewed Original ResearchBlood-brain barrierBlood-retinal barrierBlood-CSF barrierCentral nervous systemTight junctionsBlood-tissue barriersFenestrated vasculatureCerebral parenchymaCerebral vasculatureChoroid plexusNervous systemEndothelial cellsChoroidal epitheliumExtracellular fluidDelicate homeostasisRetinaSystemic influencesBrainVasculatureCellular barriersPlexusNeuroretinaDiseaseBloodParenchyma
1993
Nuclear magnetic resonance imaging and spectroscopy of human brain function.
Shulman R, Blamire A, Rothman D, McCarthy G. Nuclear magnetic resonance imaging and spectroscopy of human brain function. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 3127-3133. PMID: 8475050, PMCID: PMC46253, DOI: 10.1073/pnas.90.8.3127.Peer-Reviewed Original ResearchConceptsRegional cerebral blood volumeMagnetic resonance imagingMR spectroscopyResonance imagingBrain functionHuman brain functionCerebral glutamate poolPositron emission tomography studyBrain glucose concentrationsEmission tomography studiesCerebral blood volumeBlood oxygenation levelVivo magnetic resonance imagingConcentration of lactateBrain metabolismMotor cortexCerebral vasculatureSubsequent glucose metabolismBlood flowGlucose metabolismBlood volumeFrontal lobeVisual cortexBrain tissueTomography study
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