2025
Sociodemographic correlates of hypertension prevalence, awareness, and control in the Eastern Caribbean
Oladele C, Miller M, Adams O, Maharaj R, Nazario C, Nunez M, Nunez-Smith M, Desai M. Sociodemographic correlates of hypertension prevalence, awareness, and control in the Eastern Caribbean. The Lancet Regional Health - Americas 2025, 43: 101012. PMID: 40093852, PMCID: PMC11910123, DOI: 10.1016/j.lana.2025.101012.Peer-Reviewed Original ResearchPrevalence of hypertensionMinority healthSociodemographic correlatesHypertension prevalenceSelf-administered health surveyHypertension care cascadeLow physical activityCommunity-dwelling personsEducational attainmentSelf-reported hypertensionJoint National Committee on PreventionSource of healthcareHigher prevalence of hypertensionAssociated with awarenessLower educational attainmentPredictors of hypertensionAge of participantsControl of hypertensionTreatment of High Blood PressureNational InstitutePhysical activityHealth disparitiesHigh blood pressureCare cascadeHealth Survey379. Potential clinical and economic impact of cutbacks in the United States President's Emergency Plan for AIDS Relief Program in South Africa: a modelling analysis
Gandhi A, Bekker L, Paltiel A, Hyle E, Ciaranello A, Pillay Y, Freedberg K, Neilan A. 379. Potential clinical and economic impact of cutbacks in the United States President's Emergency Plan for AIDS Relief Program in South Africa: a modelling analysis. Open Forum Infectious Diseases 2025, 12: ofae631.010. PMCID: PMC11778235, DOI: 10.1093/ofid/ofae631.010.Peer-Reviewed Original ResearchHIV care cascadeHIV-related deathsCost-effectiveness of Preventing AIDS ComplicationsCare cascadeHIV infectionPEPFAR fundingHIV care continuum outcomesCare continuum outcomesHIV epidemic controlLife expectancyNew HIV infectionsGlobal health initiativesModified societal perspectiveLifetime costsSouth African adultsHealth initiativesHIV diagnosisHIV programsHIV statusPrimary preventionAIDS complicationsPWHPEPFARHIV budgetLife years
2024
Transformation of the HIV treatment cascade for people who inject drugs in Ukraine
Bromberg D, Rhoades D, Madden L, Ivasiy R, Meteliuk A, Pykalo I, Filippovych M, Nikitin B, Farnum S, Fomenko T, Dvoriak S, Altice F. Transformation of the HIV treatment cascade for people who inject drugs in Ukraine. AIDS 2024, 39: 306-311. PMID: 39589135, DOI: 10.1097/qad.0000000000004056.Peer-Reviewed Original ResearchOpioid agonist therapyAntiretroviral therapyImprove HIV treatment outcomesHIV treatment outcomesHIV care cascadeCross-sectional biobehavioral surveyTreatment outcomesCare cascadeUkraine's HIV epidemicPrescription of antiretroviral therapyPrescribed antiretroviral therapyAdherence to antiretroviral therapyHIV treatment cascadeAgonist therapyBiobehavioral surveyOpioid dependenceHIV diagnosisTreatment cascadeHIV epidemicHIVOpioidPWIDTherapyDrugOutcomesQuantifying gaps in the tuberculosis care cascade in Brazil: A mathematical model study using national program data
Emani S, Alves K, Alves L, da Silva D, Oliveira P, Castro M, Cohen T, de Macedo Couto R, Sanchez M, Menzies N. Quantifying gaps in the tuberculosis care cascade in Brazil: A mathematical model study using national program data. PLOS Medicine 2024, 21: e1004361. PMID: 38512968, PMCID: PMC10994550, DOI: 10.1371/journal.pmed.1004361.Peer-Reviewed Original ResearchDisability-adjusted life yearsLoss to follow-upTreatment loss to follow-upCare cascadeHealth lossDelay to diagnosisTB diseaseTB diagnosisReduce delays to diagnosisHuman immunodeficiency virusContribution of social factorsTotal health system costsCare cascade outcomesTB care cascadeMortality Information SystemBurden of TB diseaseHealth system costsLifetime health outcomesNotifiable Diseases Information SystemBurden of diseaseIncident TB casesState of residenceNational program dataFollow-upHealth outcomesBarriers and facilitators to improving the cascade of HIV care in Ontario: a mixed method study
Mbuagbaw L, Fernando S, Lee C, Owino M, Youssef C, Snow M. Barriers and facilitators to improving the cascade of HIV care in Ontario: a mixed method study. BMC Health Services Research 2024, 24: 48. PMID: 38200516, PMCID: PMC10782539, DOI: 10.1186/s12913-023-10481-z.Peer-Reviewed Original ResearchConceptsAdherence to antiretroviral therapyMobile health interventionsTheoretical Domains FrameworkHealth workersHealth interventionsVirtual careEffective interventionsCascade of HIV careAdherence to ARTSequential explanatory mixed methods studyInitiation of ARTExplanatory mixed methods studyHIV care cascadeMixed methods studyEvidence-based strategiesClient preparednessDomains FrameworkCare cascadeHIV careTailored careHealthcare deliveryElectronic interventionPeer supportHIV clinicInvestigate barriers
2023
Hepatitis B care cascade among people with HIV/HBV coinfection in the North American AIDS Cohort Collaboration on Research and Design, 2012–2016
Kim J, Newcomb C, Carbonari D, Torgersen J, Althoff K, Kitahata M, Klein M, Moore R, Reddy K, Silverberg M, Mayor A, Horberg M, Cachay E, Lim J, Gill M, Chew K, Sterling T, Hull M, Seaberg E, Kirk G, Coburn S, Lang R, McGinnis K, Gebo K, Napravnik S, Kim H, Re V, Research and Design of IeDEA F. Hepatitis B care cascade among people with HIV/HBV coinfection in the North American AIDS Cohort Collaboration on Research and Design, 2012–2016. PLOS ONE 2023, 18: e0290889. PMID: 37656704, PMCID: PMC10473492, DOI: 10.1371/journal.pone.0290889.Peer-Reviewed Original ResearchConceptsNorth American AIDS Cohort CollaborationUndetectable HBV DNAHBV coinfectionHBV DNACare cascadeCohort CollaborationViral suppressionHIV/HBV coinfectionTenofovir-based antiretroviral therapyHIV/HBVAntiretroviral therapy regimenCross-sectional studyDelivery of careHBV therapyHBV treatmentHBV viremiaAntiretroviral therapyHBV infectionHIV infectionTherapy regimenChronic infectionClinical cohortCoinfectionTherapyInfectionEvaluation of the diabetes care cascade and compliance with WHO global coverage targets in Iran based on STEPS survey 2021
Azadnajafabad S, Ahmadi N, Rezaei N, Rashidi M, Saeedi Moghaddam S, Mohammadi E, Abbasi-Kangevari M, Naderian M, Ghasemi E, Farzi Y, Kazemi A, Dilmaghani-Marand A, Yoosefi M, Rezaei S, Nasserinejad M, Fattahi N, Rezaei N, Haghshenas R, Foroutan Mehr E, Koolaji S, Razi F, Djalalinia S, Larijani B, Farzadfar F. Evaluation of the diabetes care cascade and compliance with WHO global coverage targets in Iran based on STEPS survey 2021. Scientific Reports 2023, 13: 13528. PMID: 37598214, PMCID: PMC10439917, DOI: 10.1038/s41598-023-39433-7.Peer-Reviewed Original ResearchConceptsCare cascadeSTEPS surveyCoverage targetsDM diagnosisDiabetes care cascadeTreatment coverageSub-optimal careGlycemic controlPrevalence of DMDiabetes mellitusDiabetes awarenessNational prevalenceWorld Health OrganizationControl statusCareGood glycemic controlIranian populationPrediabetesHealth OrganizationGlobal targetsDiabetesPrevalenceSurveyPopulationComplianceCreating a Longitudinal HCV Care Cascade for Persons With HIV/HCV Coinfection in Selected HIV Clinics Using Data to Care Methods
Brooks R, Wegener M, Speers S, Nichols L, Sideleau R, Valeriano T, Buchelli M, Villanueva M. Creating a Longitudinal HCV Care Cascade for Persons With HIV/HCV Coinfection in Selected HIV Clinics Using Data to Care Methods. Health Promotion Practice 2023, 24: 1039-1049. PMID: 37439600, DOI: 10.1177/15248399231169792.Peer-Reviewed Original ResearchConceptsHIV/HCV coinfectionHCV coinfectionHepatitis C virusSVR ratesHCV treatmentHIV clinicTreatment cascadeTreatment statusSustained virologic response ratesHCV care cascadeHCV treatment cascadeHCV treatment statusVirologic response ratesHIV viral suppressionPatient treatment statusPublic health approachCare cascadeHepatitis CViral suppressionActing antiviralsTreatment initiationC virusResponse rateClinical staffCoinfectionDiabetes mellitus care cascade among a cohort of persons living with HIV and hypertension in Uganda: A retrospective cohort study
Ambangira F, Sharman J, Muddu M, Kimera I, Namara D, Musimbaggo D, Namugenyi C, Ssenyonjo R, Mbuliro M, Katwesigye R, Schwartz J, Semitala F, Ssinabulya I. Diabetes mellitus care cascade among a cohort of persons living with HIV and hypertension in Uganda: A retrospective cohort study. International Journal Of STD & AIDS 2023, 34: 728-734. PMID: 37269360, DOI: 10.1177/09564624231179497.Peer-Reviewed Original ResearchConceptsDiabetes mellitusLarge urban HIV clinicNon-suppressed viral loadNon-communicable disease burdenUrban HIV clinicHIV care programsRetrospective cohort studyCohort of personsAppropriate diabetes careDiabetes mellitus careNon-communicable diseasesDual HIVCare cascadeHIV clinicCohort studyGlycaemic controlMedian ageViral loadRetrospective studyDiabetes careDisease burdenMellitus careCare programHIVHypertension
2022
The cascade of care in testing and treatment of latent tuberculosis infection in liver transplant candidates
Palacios C, Medvedeva N, Cheung H, Cohen E, Azar M, Malinis M. The cascade of care in testing and treatment of latent tuberculosis infection in liver transplant candidates. Transplant Infectious Disease 2022, 25: e13999. PMID: 36484433, DOI: 10.1111/tid.13999.Peer-Reviewed Original ResearchConceptsLatent tuberculosis infectionLT candidatesIndeterminate IGRALTBI testingTuberculosis infectionCascade of carePost-liver transplantLiver transplant candidatesProportion of patientsRetrospective chart reviewTB-endemic countriesInterferon-gamma releaseTreatment completion ratesCompletion ratesLTBI treatmentPositive IGRATB reactivationCare cascadeTreatment-naïveChart reviewSecondary outcomesTransplant candidatesPrimary outcomeTreatment initiationChest imagingSimplifying the Diagnosis and Treatment of Hepatitis B Infection: One Step for Addressing Deficits in the Care Cascade, One Leap for Elimination
Rabiee A, Lim J. Simplifying the Diagnosis and Treatment of Hepatitis B Infection: One Step for Addressing Deficits in the Care Cascade, One Leap for Elimination. Gastro Hep Advances 2022, 2: 277-278. PMID: 39132614, PMCID: PMC11307652, DOI: 10.1016/j.gastha.2022.12.002.Commentaries, Editorials and LettersIs aggregated surveillance data a reliable method for constructing tuberculosis care cascades? A secondary data analysis from Uganda
White E, Hernández-Ramírez R, Majwala R, Nalugwa T, Reza T, Cattamanchi A, Katamba A, Davis J. Is aggregated surveillance data a reliable method for constructing tuberculosis care cascades? A secondary data analysis from Uganda. PLOS Global Public Health 2022, 2: e0000716. PMID: 36962541, PMCID: PMC10045605, DOI: 10.1371/journal.pgph.0000716.Peer-Reviewed Original ResearchNational TB ProgrammeTreatment initiationAntiretroviral therapySurveillance dataLimits of agreementFacility characteristicsTB surveillance dataTuberculosis care cascadeNumber of peopleXpert-positivesCare cascadeTB careTB treatmentTB programsTuberculosis controlQuality improvement toolsSecondary data analysisHealth facilitiesPositive diagnosisAddress reasonsLinear mixed modelsConcordance correlation coefficientHIVTherapyDiagnosisEvaluation of the Impact of HIV Serostatus on the Hepatitis C Virus Care Cascade and Injection Drug Use Among Persons Initiating Medication Treatment for Opioid Use Disorder
Lier A, Vander Wyk B, Di Paola A, Springer S. Evaluation of the Impact of HIV Serostatus on the Hepatitis C Virus Care Cascade and Injection Drug Use Among Persons Initiating Medication Treatment for Opioid Use Disorder. Open Forum Infectious Diseases 2022, 9: ofac624. PMID: 36467300, PMCID: PMC9709708, DOI: 10.1093/ofid/ofac624.Peer-Reviewed Original ResearchOpioid use disorderHepatitis C virusHCV treatment ratesHIV serostatusUse disordersHepatitis C virus (HCV) care cascadeHCV viral load testingTreatment ratesHCV treatment uptakeProspective cohort studyInjection drug useViral load testingGreater reductionDrug use frequencyHCV testingCare cascadeHCV antibodiesHIV screeningCohort studyHIV statusTreatment uptakeEntire cohortMedication treatmentC virusSerostatusProjected outcomes of universal testing and treatment in a generalised HIV epidemic in Zambia and South Africa (the HPTN 071 [PopART] trial): a modelling study
Probert W, Sauter R, Pickles M, Cori A, Bell-Mandla N, Bwalya J, Abeler-Dörner L, Bock P, Donnell D, Floyd S, Macleod D, Piwowar-Manning E, Skalland T, Shanaube K, Wilson E, Yang B, Ayles H, Fidler S, Hayes R, Fraser C, Team H, Hayes R, Fidler S, Beyers N, Ayles H, Bock P, El-Sadr W, Cohen M, Eshleman S, Agyei Y, Piwowar-Manning E, Bond V, Hoddinott G, Donnell D, Floyd S, Wilson E, Emel L, Noble H, Macleod D, Burns D, Fraser C, Cori A, Sista N, Griffith S, Moore A, Headen T, White R, Miller E, Hargreaves J, Hauck K, Thomas R, Limbada M, Bwalya J, Pickles M, Sabapathy K, Schaap, Dunbar R, Shanaube K, Yang B, Simwinga M, Smith P, Vermund S, Mandla N, Makola N, van Deventer A, James A, Jennings K, Kruger J, Phiri M, Kosloff B, Mwenge L, Kanema S, Sauter R, Probert W, Kumar R, Sakala E, Silumesi A, Skalland T, Yuhas K. Projected outcomes of universal testing and treatment in a generalised HIV epidemic in Zambia and South Africa (the HPTN 071 [PopART] trial): a modelling study. The Lancet HIV 2022, 9: e771-e780. PMID: 36332654, PMCID: PMC9646978, DOI: 10.1016/s2352-3018(22)00259-4.Peer-Reviewed Original ResearchConceptsStandard of careHome-based testingCluster-randomised trialHigh-prevalence communitiesHIV incidenceHIV epidemicNational guidelinesNational InstituteUniversal testingHIV care cascadeAntiretroviral therapy uptakeUS President's Emergency PlanGeneralised HIV epidemicPresident's Emergency PlanPopART interventionCare cascadeART eligibilityArm BTherapy uptakeTrial interventionTrial dataInfectious diseasesAIDS ReliefIntervention impactDrug abuseAssessing the quality of tuberculosis care using routine surveillance data: a process evaluation employing the Zero TB Indicator Framework in Mongolia
Saranjav A, Parisi C, Zhou X, Dorjnamjil K, Samdan T, Erdenebaatar S, Chuluun A, Dalkh T, Ganbaatar G, Brooks MB, Spiegelman D, Ganmaa D, Davis JL. Assessing the quality of tuberculosis care using routine surveillance data: a process evaluation employing the Zero TB Indicator Framework in Mongolia. BMJ Open 2022, 12: e061229. PMID: 35973702, PMCID: PMC9386240, DOI: 10.1136/bmjopen-2022-061229.Peer-Reviewed Original ResearchConceptsPrimary health centersTB preventive therapyRoutine surveillance dataHealth centersHousehold contactsCohort studyPreventive therapyTB careTB dispensariesRetrospective cross-sectional cohort studyCross-sectional cohort studySurveillance dataActive TB treatmentGuideline-adherent careHealth system predictorsQuality of tuberculosisOdds of patientsHealth system factorsQuality improvement interventionsLow-quality careCare cascadeTB screeningTB treatmentTuberculosis careIndex patientsUnderstanding the role of traditional healers in the HIV care cascade: Findings from a qualitative study among stakeholders in Mwanza, Tanzania
Matungwa D, Hong R, Kidola J, Pungu D, Ponticiello M, Peck R, Sundararajan R. Understanding the role of traditional healers in the HIV care cascade: Findings from a qualitative study among stakeholders in Mwanza, Tanzania. PLOS Global Public Health 2022, 2: e0000674. PMID: 36962758, PMCID: PMC10021224, DOI: 10.1371/journal.pgph.0000674.Peer-Reviewed Original ResearchHIV care cascadeCare cascadeTraditional healersHIV careQualitative studyPerceptions of traditional healersImprove HIV treatment outcomesInformal healthcare providersHIV care continuumAntiretroviral therapyHealthcare facility staffPost-HIV diagnosisCommunity focus groupsHIV treatment outcomesContent analysis approachART nonadherenceCare continuumHIV testingHIV symptomsFacility staffHealthcare professionalsHealthcare providersHIV-endemicFocus groupsAdult TanzaniansImproved hypertension control at six months using an adapted WHO HEARTS-based implementation strategy at a large urban HIV clinic in Uganda
Muddu M, Semitala FC, Kimera I, Mbuliro M, Ssennyonjo R, Kigozi SP, Katwesigye R, Ayebare F, Namugenyi C, Mugabe F, Mutungi G, Longenecker CT, Katahoire AR, Ssinabulya I, Schwartz JI. Improved hypertension control at six months using an adapted WHO HEARTS-based implementation strategy at a large urban HIV clinic in Uganda. BMC Health Services Research 2022, 22: 699. PMID: 35610717, PMCID: PMC9131679, DOI: 10.1186/s12913-022-08045-8.Peer-Reviewed Original ResearchConceptsLarge urban HIV clinicUrban HIV clinicHTN outcomesHIV clinicHypertension controlViral suppressionHIV outcomesHTN treatmentFurther implementation researchHIV viral suppressionProportion of patientsPre-post studyVaried clinical settingsAdult PLHIVBP controlHTN controlHTN screeningCare cascadeHIV careLifestyle counselingClinic visitsDiastolic BPHIV controlIndependent predictorsSystolic BP
2021
Pulmonary and Physical Function Limitations in Aging Men with and without HIV from the Multicenter AIDS Cohort Study
Abdo M, Kunisaki K, Stosor V, D'Souza G, Abdel-Maksoud M, Brown T, MaWhinney S, Erlandson K. Pulmonary and Physical Function Limitations in Aging Men with and without HIV from the Multicenter AIDS Cohort Study. Innovation In Aging 2021, 5: 612-612. PMCID: PMC8968408, DOI: 10.1093/geroni/igab046.2328.Peer-Reviewed Original ResearchHypertension careBlood pressureMulticenter AIDS Cohort StudyHypertension care cascadeControl of hypertensionElevated blood pressureMajor risk factorPhysical function limitationsAIDS Cohort StudyCause of deathLevel of diagnosisRetirement Longitudinal StudyPersons age 75Care cascadeCohort studyRisk factorsCardiovascular diseaseAge 75High riskFunction limitationsOlder personsHypertensionChina HealthModern medicationsOlder populationHypertension care cascade at a large urban HIV clinic in Uganda: a mixed methods study using the Capability, Opportunity, Motivation for Behavior change (COM-B) model
Muddu M, Ssinabulya I, Kigozi SP, Ssennyonjo R, Ayebare F, Katwesigye R, Mbuliro M, Kimera I, Longenecker CT, Kamya MR, Schwartz JI, Katahoire AR, Semitala FC. Hypertension care cascade at a large urban HIV clinic in Uganda: a mixed methods study using the Capability, Opportunity, Motivation for Behavior change (COM-B) model. Implementation Science Communications 2021, 2: 121. PMID: 34670624, PMCID: PMC8690902, DOI: 10.1186/s43058-021-00223-9.Peer-Reviewed Original ResearchAntiretroviral therapyHIV clinicHIV integrationCare cascadeHIV careHTN treatmentLarge urban HIV clinicART adherence counselingHypertension care cascadeLarge HIV clinicLow patient knowledgeUrban HIV clinicProportion of patientsAnti-hypertensive medicinesRisk of mortalityAdult PLHIVHTN careHTN complicationsHTN screeningConclusionThe prevalenceAdherence counselingMiddle-income countriesTreatment initiationPatient knowledgeBP machinesA hepatitis C elimination model in healthcare for the homeless organization: A novel reflexive laboratory algorithm and equity assessment
Seaman A, King C, Kaser T, Geduldig A, Ronan W, Cook R, Chan B, Levander X, Priest K, Korthuis P. A hepatitis C elimination model in healthcare for the homeless organization: A novel reflexive laboratory algorithm and equity assessment. International Journal Of Drug Policy 2021, 96: 103359. PMID: 34325969, PMCID: PMC8720290, DOI: 10.1016/j.drugpo.2021.103359.Peer-Reviewed Original ResearchConceptsDirect acting antiviralsLogistic regression modelsCascade progressionHepatitis C elimination targetsCox proportional hazards modelMultiple logistic regression modelHCV care cascadeHCV treatment cascadeSingle blood drawPresence of opioidsLikelihood of screeningProportional hazards modelTreatment of peopleHCV screeningCare cascadeHCV treatmentActing antiviralsBundle interventionsMultinomial logistic regression modelsPatient characteristicsHCV PCRTreatment cascadeTreatment initiationHomeless clinicRegression models
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