2025
Simplified methods for SERT occupancy estimation measured with [11C]DASB PET bolus plus infusion
Ponce de León M, Murgaš M, Silberbauer L, Hacker M, Gryglewski G, Hahn A, Lanzenberger R. Simplified methods for SERT occupancy estimation measured with [11C]DASB PET bolus plus infusion. NeuroImage 2025, 311: 121208. PMID: 40221064, DOI: 10.1016/j.neuroimage.2025.121208.Peer-Reviewed Original ResearchSerotonin transporterBolus plus constant infusionSerotonin transporter occupancyDepressive disorderBinding potentialBolus plus infusionReference regionCitalopramHealthy controlsArterial blood samplesPET/MRI scansPET scansOccupational valuesIntravenous applicationConstant infusionBlood samplesIn vivoAntidepressantsInfusionSaline solutionSerotoninHighest agreementDisordersRadioligandPlaceboPositron Emission Tomography Brain Imaging Methodologies
Hillmer A, Cosgrove K, Carson R. Positron Emission Tomography Brain Imaging Methodologies. 2025, 107-120. DOI: 10.1093/med/9780197640654.003.0009.Peer-Reviewed Original ResearchPositron emission tomographyBrain imaging studiesStudy of mental illnessDrug occupancyGroup differencesBinding potentialMental illnessSynaptic densityPET imaging dataBrain imagingPositron emission tomography imagingAbstract Positron emission tomographyMethodological considerationsNeurotransmitter synthesisEmission tomographyImaging studiesNeurotransmitter releaseVolume of distributionOutcome measuresClinical researchBPNDNeurotransmitterBrainIllnessImage data
2024
Exploration of (R)-[11C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates
He Y, Zheng M, Gu J, Reichert L, Trimborn J, Zhang H, Keller C, Crosby M, Collin L, Heer D, Pavlovic A, Topp A, Wittwer M, Grether U, Gobbi L, Schibli R, Huang Y, Mu L. Exploration of (R)-[11C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates. European Journal Of Nuclear Medicine And Molecular Imaging 2024, 52: 1556-1565. PMID: 39673602, PMCID: PMC11839854, DOI: 10.1007/s00259-024-07013-0.Peer-Reviewed Original ResearchMonoacylglycerol lipaseNon-human primatesIn vitro autoradiographyBrain regionsMice to non-human primatesMAGL knockoutNon-displaceable binding potentialRhesus monkeysNon-human primate brainRegional non-displaceable binding potentialsRegional time-activity curvesMouse brainCingulate cortexFrontal cortexEndocannabinoid systemLevels of radioactive uptakeMouse brain slicesOccipital cortexBrains of miceOne-tissue compartment modelBinding potentialMAGL expressionPET scansKnockout micePrimate brainModeling PET Data Acquired During Nonsteady Conditions: What If Brain Conditions Change During the Scan?
Morris E, Emvalomenos G, Hoye J, Meikle S. Modeling PET Data Acquired During Nonsteady Conditions: What If Brain Conditions Change During the Scan? Journal Of Nuclear Medicine 2024, 65: 1824-1837. PMID: 39448268, PMCID: PMC11619587, DOI: 10.2967/jnumed.124.267494.Peer-Reviewed Original Research11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults
Matuskey D, Yang Y, Naganawa M, Koohsari S, Toyonaga T, Gravel P, Pittman B, Torres K, Pisani L, Finn C, Cramer-Benjamin S, Herman N, Rosenthal L, Franke C, Walicki B, Esterlis I, Skosnik P, Radhakrishnan R, Wolf J, Nabulsi N, Ropchan J, Huang Y, Carson R, Naples A, McPartland J. 11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults. Molecular Psychiatry 2024, 30: 1610-1616. PMID: 39367053, DOI: 10.1038/s41380-024-02776-2.Peer-Reviewed Original ResearchPositron emission tomographySynaptic densityAutistic adultsBrain regionsAutistic featuresClinical phenotype of autismNon-autistic participantsPhenotype of autismNon-autistic individualsRelationship to clinical characteristicsSynaptic vesicle glycoprotein 2AAssociated with clinical measuresPost-mortem studiesPositron emission tomography scanPrefrontal cortexClinician ratingsAutism groupNeural basisBrain areasNeural processesBetween-group differencesVolumetric differencesBinding potentialDensity of synapsesAutismPET Imaging of Kappa Opioid Receptors in Socially Housed Female and Male Monkeys: Effects of Chronic Cocaine Self-Administration
Johnson B, Nader S, Sai K, Li S, Huang Y, Nader M. PET Imaging of Kappa Opioid Receptors in Socially Housed Female and Male Monkeys: Effects of Chronic Cocaine Self-Administration. Drug And Alcohol Dependence 2024, 260: 109961. DOI: 10.1016/j.drugalcdep.2023.109961.Peer-Reviewed Original ResearchCocaine use disorderKappa-opioid receptorsCocaine self-administrationCocaine-induced changesCocaine SASelf-administrationBinding potentialPositron emission tomographySocial rank differencesChronic cocaine self-administrationSocial rankDrug-naive monkeysKappa-opioid receptor antagonistKappa-opioid receptor agonistFDA-approved pharmacotherapiesOpioid receptorsRegulation of stressPositron emission tomography imagingCocaine intakeDynorphin/KOR systemKOR systemFood pelletsUse disorderExperiment 1Brain regionsPET imaging of M4 muscarinic acetylcholine receptors in rhesus macaques using [11C]MK-6884: Quantification with kinetic modeling and receptor occupancy by CVL-231 (emraclidine), a novel positive allosteric modulator
Belov V, Guehl N, Duvvuri S, Iredale P, Moon S, Dhaynaut M, Chakilam S, MacDonagh A, Rice P, Yokell D, Renger J, Fakhri G, Normandin M. PET imaging of M4 muscarinic acetylcholine receptors in rhesus macaques using [11C]MK-6884: Quantification with kinetic modeling and receptor occupancy by CVL-231 (emraclidine), a novel positive allosteric modulator. Cerebrovascular And Brain Metabolism Reviews 2024, 44: 1329-1342. PMID: 38477292, PMCID: PMC11342722, DOI: 10.1177/0271678x241238820.Peer-Reviewed Original ResearchConceptsPositive allosteric modulatorsReceptor occupancyNon-human primatesBinding potentialPositron emission tomographyMuscarinic acetylcholine receptorsAllosteric modulatorsNon-human primate brainM4 muscarinic acetylcholine receptorStriatal hyperdopaminergiaAcetylcholine receptorsBrain regionsCaudate nucleusTotal volume of distributionDose-dependent blockReference regionVolume of distributionPositron emission tomography imagingEmission tomographyReceptor levelsFunction of dosePET scansClinical trialsBlood-basedRhesus macaques
2022
Harmonization of [11C]raclopride brain PET images from the HR+ and HRRT: method development and validation in human subjects
Hoye J, Toyonaga T, Zakiniaeiz Y, Stanley G, Hampson M, Morris ED. Harmonization of [11C]raclopride brain PET images from the HR+ and HRRT: method development and validation in human subjects. EJNMMI Physics 2022, 9: 27. PMID: 35416555, PMCID: PMC9008103, DOI: 10.1186/s40658-022-00457-z.Peer-Reviewed Original ResearchHuman subjectsNon-displaceable binding potentialPET imaging studiesTest-retest variabilityHarmonization studyStriatal BPNDPercent differenceImaging studiesResultsExperiment 1Inter-scanner variabilityBrain PET imagesBPND estimatesSubjectsOngoing needPET imagesRT variabilityBinding potentialPD resultsBackgroundThereBPNDRTA multi-pronged investigation of option generation using depression, PET and modafinil
Ang Y, Cusin C, Petibon Y, Dillon D, Breiger M, Belleau E, Normandin M, Schroder H, Boyden S, Hayden E, Levine M, Jahan A, Meyer A, Kang M, Brunner D, Gelda S, Hooker J, Fakhri G, Fava M, Pizzagalli D. A multi-pronged investigation of option generation using depression, PET and modafinil. Brain 2022, 145: 1854-1865. PMID: 35150243, PMCID: PMC9166534, DOI: 10.1093/brain/awab429.Peer-Reviewed Original ResearchConceptsD2/D3 receptor availabilitySelf-generated optionsDepressive disorderDepressed individualsReceptor availabilityDopamine D2/D3 receptor availabilityNon-depressed adultsEffects of modafinilPutamen of patientsAssociated with uniquenessOption generationD2/D3 receptorsDopaminergic activityClinical depressionBinding potentialModafinilHealthy participantsPutamenPlacebo-controlledSamples of healthy peopleDouble-blindDisordersSelf-generationHealthy controlsDopamine
2020
Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia
DuBois J, Mathotaarachchi S, Rousset O, Sziklas V, Sepulcre J, Guiot M, Hall J, Massarweh G, Soucy J, Rosa-Neto P, Kobayashi E. Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia. NeuroImage Clinical 2020, 29: 102552. PMID: 33401137, PMCID: PMC7787952, DOI: 10.1016/j.nicl.2020.102552.Peer-Reviewed Original ResearchConceptsFocal cortical dysplasia patientsFocal cortical dysplasiaHealthy controlsCortical dysplasiaFCD patientsMetabotropic glutamate receptor type 5Contralateral hemisphereEpileptic activityPersistent epileptic activityDuration of epilepsySmall-world connectivityHigh centrality nodesMGluR5 availabilityIn vivo evidenceEpilepsy durationPatientsType 5Assess group differencesNetwork integrationMGluR5Binding potentialDysplasiaNetwork abnormalitiesGraph theoretical analysisEpilepsy
2017
PET Brain Imaging Methodologies
Hillmer A, Cosgrove K, Carson R. PET Brain Imaging Methodologies. 2017, 108-120. DOI: 10.1093/med/9780190681425.003.0009.Peer-Reviewed Original ResearchPositron emission tomographyBrain imaging studiesStudy of mental illnessMolecular imaging studiesImaging studiesDrug occupancyGroup differencesBinding potentialMental illnessPET imaging dataBrain imagingMethodological considerationsEmission tomographySpecific aspectsVolume of distributionNeurotransmitter releaseOutcome measuresClinical researchBPNDBrainPharmacologyIllnessImage dataFrontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation
Kaiser R, Treadway M, Wooten D, Kumar P, Goer F, Murray L, Beltzer M, Pechtel P, Whitton A, Cohen A, Alpert N, Fakhri G, Normandin M, Pizzagalli D. Frontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation. Cerebral Cortex 2017, 28: 4281-4290. PMID: 29121332, PMCID: PMC6454484, DOI: 10.1093/cercor/bhx281.Peer-Reviewed Original ResearchConceptsDA transporterRL behaviourVentral striatumDA clearanceFunctional connectivityBinding potentialLevel of neurocognitive functioningIncreased intrinsic functional connectivityMulti-modal neuroimaging studiesResting-state functional connectivityPhasic DA activityStriatal DA transporterIntrinsic functional connectivityReinforcement learning behaviorMulti-modal investigationsFrontostriatal circuitsFrontostriatal connectivityFrontostriatal regionsOrbitofrontal cortexDA activityNeuroimaging studiesOrbitofrontal regionsDopamine markersNeurocognitive functionDopamine
2013
Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI
Sander C, Hooker J, Catana C, Normandin M, Alpert N, Knudsen G, Vanduffel W, Rosen B, Mandeville J. Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 11169-11174. PMID: 23723346, PMCID: PMC3703969, DOI: 10.1073/pnas.1220512110.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingDopamine receptor occupancyReceptor occupancyPositron emission tomographyFunctional magnetic resonance imaging measuresDose of racloprideBasal dopamine levelsDopamine-rich striatumInvestigation of neurovascular couplingDomains of spaceAnesthetized nonhuman primatesSimultaneous PET/fMRIDopamine levelsBrain activitySimultaneous neuroimagingBinding potentialBasal gangliaReceptor systemNonhuman primatesPositron emission tomography tracersMagnetic resonance imagingLiterature differencesEmission tomographyMap associationsNeurovascular coupling
2005
Quantitative simultaneous 99mTc-ECD/123I-FP-CIT SPECT in Parkinson’s disease and multiple system atrophy
El Fakhri G, Habert M, Maksud P, Kas A, Malek Z, Kijewski M, Lacomblez L. Quantitative simultaneous 99mTc-ECD/123I-FP-CIT SPECT in Parkinson’s disease and multiple system atrophy. European Journal Of Nuclear Medicine And Molecular Imaging 2005, 33: 87-92. PMID: 16180033, DOI: 10.1007/s00259-005-1920-y.Peer-Reviewed Original ResearchConceptsMultiple system atrophyIdiopathic Parkinson's diseaseDopamine transporterDopamine transporter binding potentialNormal controlsVoxel-based statistical parametric mappingAsymmetry indexMultiple system atrophy patientsCompared to normal controlsCaudate nucleusDifferential diagnosis of idiopathic Parkinson’s diseaseDiagnosis of parkinsonian syndromesPatient-specific attenuationDiagnosis of idiopathic Parkinson's diseaseBinding potentialIdiopathic Parkinson's disease patientsDual-isotope SPECTVariable collimator responseParkinson's diseaseDifferential diagnosisDecreased perfusionStatistical parametric mappingPurposeThe purposeSystem atrophyParkinsonian syndromes
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